Calcium channel alpha1E subunit, delta39 splice variant

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Unreviewed, UniProtKB/TrEMBL Q9NYZ6 (Q9NYZ6_HUMAN)

Last modified January 19, 2010. Version 51. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information

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Names and origin

Protein names

Submitted name:
Calcium channel alpha1E subunit, delta39 splice variant EMBL AAF37687.1

Gene names

Name:

CACNA1E EMBL AAF37687.1

Organism

Homo sapiens (Human) EMBL AAF37687.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	2224 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein By similarity RuleBase RU003808V0.
Sequence similarities	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]

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Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Domain	Transmembrane RuleBase RU003378V0
Ligand	Calcium
Molecular function	Calcium channel RuleBase RU003808V0 Ionic channel Voltage-gated channel RuleBase RU003808V0
Gene Ontology (GO)
Biological process	calcium ion transport Inferred from electronic annotation. Source: UniProtKB-KW glucose homeostasis Inferred from electronic annotation. Source: Compara transmembrane transport Inferred from electronic annotation. Source: InterPro
Cellular component	perikaryon Inferred from electronic annotation. Source: Compara voltage-gated calcium channel complex Inferred from electronic annotation. Source: InterPro
Molecular function	calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW voltage-gated calcium channel activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Experimental info

Non-terminal residue

EMBL AAF37687.1

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Sequences

Sequence

Length

Mass (Da)

Tools

Q9NYZ6-1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 67D34234924F6690
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FASTA

2,224

251,891

        10         20         30         40         50         60 
PFEYMILATI IANCIVLALE QHLPEDDKTP MSRRLEKTEP YFIGIFCFEA GIKIVALGFI 

        70         80         90        100        110        120 
FHKGSYLRNG WNVMDFIVVL SGILATAGTH FNTHVDLRTL RAVRVLRPLK LVSGIPSLQI 

       130        140        150        160        170        180 
VLKSIMKAMV PLLQIGLLLF FAILMFAIIG LEFYSGKLHR ACFMNNSGIL EGFDPPHPCG 

       190        200        210        220        230        240 
VQGCPAGYEC KDWIGPNDGI TQFDNILFAV LTVFQCITME GWTTVLYNTN DALGATWNWL 

       250        260        270        280        290        300 
YFIPLIIIGS FFVLNLVLGV LSGEFAKERE RVENRRAFMK LRRQQQIERE LNGYRAWIDK 

       310        320        330        340        350        360 
AEEVMLAEEN KNAGTSALEV LRRATIKRSR TEAMTRDSSD EHCVDISSVG TPLARASIKS 

       370        380        390        400        410        420 
AKVDGVSYFR HKERLLRISI RHMVKSQVFY WIVLSLVALN TACVAIVHHN QPQWLTHLLY 

       430        440        450        460        470        480 
YAEFLFLGLF LLEMSLKMYG MGPRLYFHSS FNCFDFGVTV GSIFEVVWAI FRPGTSFGIS 

       490        500        510        520        530        540 
VLRALRLLRI FKITKYWASL RNLVVSLMSS MKSIISLLFL LFLFIVVFAL LGMQLFGGRF 

       550        560        570        580        590        600 
NFNDGTPSAN FDTFPAAIMT VFQILTGEDW NEVMYNGIRS QGGVSSGMWS AIYFIVLTLF 

       610        620        630        640        650        660 
GNYTLLNVFL AIAVDNLANA QELTKDEQEE EEAFNQKHAL QKAKEVSPMS APNMPSIERD 

       670        680        690        700        710        720 
RRRRHHMSMW EPRSSHLRER RRRHHMSVWE QRTSQLRKHM QMSSQEALNR EEAPTMNPLN 

       730        740        750        760        770        780 
PLNPLSSLNP LNAHPSLYRR PRAIEGLALG LALEKFEEER ISRGGSLKGD GGDRSSALDN 

       790        800        810        820        830        840 
QRTPLSLGQR EPPWLARPCH GNCDPTQQEA GGGEAVVTFE DRARHRQSQR RSRHRRVRTE 

       850        860        870        880        890        900 
GKESSSASRS RSASQERSLD EAMPTEGEKD HELRGNHGAK EPTIQEERAQ DLRRTNSLMV 

       910        920        930        940        950        960 
SRGSGLAGGL DEADTPLVLP HPELEVGKHV VLTEQEPEGS SEQALLGNVQ LDMGRVISQS 

       970        980        990       1000       1010       1020 
EPDLSCITAN TDKATTESTS VTVAIPDVDP LVDSTVVHIS NKTDGEASPL KEAEIREDEE 

      1030       1040       1050       1060       1070       1080 
EVEKKKQKKE KRETGKAMVP HSSMFIFSTT NPIRRACHYI VNLRYFEMCI LLVIAASSIA 

      1090       1100       1110       1120       1130       1140 
LAAEDPVLTN SERNKVLRYF DYVFTGVFTF EMVIKMIDQG LILQDGSYFR DLWNILDFVV 

      1150       1160       1170       1180       1190       1200 
VVGALVAFAL ANALGTNKGR DIKTIKSLRV LRVLRPLKTI KRLPKLKAVF DCVVTSLKNV 

      1210       1220       1230       1240       1250       1260 
FNILIVYKLF MFIFAVIAVQ LFKGKFFYCT DSSKDTEKEC IGNYVDHEKN KMEVKGREWK 

      1270       1280       1290       1300       1310       1320 
RHEFHYDNII WALLTLFTVS TGEGWPQVLQ HSVDVTEEDR GPSRSNRMEM SIFYVVYFVV 

      1330       1340       1350       1360       1370       1380 
FPFFFVNIFV ALIIITFQEQ GDKMMEECSL EKNERACIDF AISAKPLTRY MPQNRHTFQY 

      1390       1400       1410       1420       1430       1440 
RVWHFVVSPS FEYTIMAMIA LNTVVLMMKY YSAPCTYELA LKYLNIAFTM VFSLECVLKV 

      1450       1460       1470       1480       1490       1500 
IAFGFLNYFR DTWNIFDFIT VIGSITEIIL TDSKLVNTSG FNMSFLKLFR AARLIKLLRQ 

      1510       1520       1530       1540       1550       1560 
GYTIRILLWT FVQSFKALPY VCLLIAMLFF IYAIIGMQVF GNIKLDEESH INRHNNFRSF 

      1570       1580       1590       1600       1610       1620 
FGSLMLLFRS ATGEAWQEIM LSCLGEKGCE PDTTAPSGQN ENERCGTDLA YVYFVSFIFF 

      1630       1640       1650       1660       1670       1680 
CSFLMLNLFV AVIMDNFEYL TRDSSILGPH HLDEFVRVWA EYDRAACGRI HYTEMYEMLT 

      1690       1700       1710       1720       1730       1740 
LMSPPLGLGK RCPSKVAYKR LVLMNMPVAE DMTVHFTSTL MALIRTALDI KIAKGGADRQ 

      1750       1760       1770       1780       1790       1800 
QLDSELQKET LAIWPHLSQK MLDLLVPMPK ASDLTVGKIY AAMMIMDYYK QSKVKKQRQQ 

      1810       1820       1830       1840       1850       1860 
LEEQKNAPMF QRMEPSSLPQ EIIANAKALP YLQQDPVSGL SGRSGYPSMS PLSPQDIFQL 

      1870       1880       1890       1900       1910       1920 
ACMDPADDGQ FQERQSLEPE VSELKSVQPS NHGIYLPSDT QEHAGSGRAS SMPRLTVDPQ 

      1930       1940       1950       1960       1970       1980 
VVTDPSSMRR SFSTIRDKRS NSSWLEEFSM ERSSENTYKS RRRSYHSSLR LSAHRLNSDS 

      1990       2000       2010       2020       2030       2040 
GHKSDTHRSG GRERGRSKER KHLLSPDVSR CNSEERGTQA DWESPERRQS RSPSEGRSQT 

      2050       2060       2070       2080       2090       2100 
PNRQGTGSLS ESSIPSVSDT STPRRSRRQL PPVPPKPRPL LSYSSLIRHA GSISPPADGS 

      2110       2120       2130       2140       2150       2160 
EEGSPLTSQA LESNNACLTE SSNSPHPQQS QHASPQRYIS EPYLALHEDS HASDCGEEET 

      2170       2180       2190       2200       2210       2220 
LTFEAAVATS LGRSNTIGSA PPLRHSWQMP NGHYRRRRRG GPGPGMMCGA VNNLLSDTEE 


DDKC

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References

[1]	"Exon Organization and Alternative Splicing of CACNA1E." Mittman S., Agnew W.S., Malek J.A. Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
EMBL GenBank DDBJ	AF223391, AF239258, AF239259 Genomic DNA. Translation: AAF37687.1.
IPI	IPI00472283.
UniGene	Hs.437444
3D structure databases
SMR	Q9NYZ6. Positions 1061-1135, 1383-1638.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9NYZ6.
Genome annotation databases
Ensembl	ENST00000357570; ENSP00000350183; ENSG00000198216; Homo sapiens. [Genome view] ENST00000367573; ENSP00000356545; ENSG00000198216; Homo sapiens. [Genome view]
Organism-specific databases
HGNC	HGNC:1392. CACNA1E.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q9NYZ6.
Gene expression databases
ArrayExpress	Q9NYZ6.
Bgee	Q9NYZ6.
Family and domain databases
InterPro	IPR018249. EF_HAND_2. IPR005821. Ion_trans. IPR014873. VDCC_a1su_IQ. IPR005449. VDCC_R_a1su. IPR002077. VDCCAlpha1. [Graphical view]
PANTHER	PTHR10037:SF57. RVDCCAlpha1. 1 hit.
Pfam	PF08763. Ca_chan_IQ. 1 hit. PF00520. Ion_trans. 4 hits. [Graphical view]
PRINTS	PR00167. CACHANNEL. PR01633. RVDCCALPHA1.
PROSITE	PS50222. EF_HAND_2. 1 hit. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

Q9NYZ6_HUMAN

Accession

Primary (citable) accession number: Q9NYZ6

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2000
Last sequence update:	October 1, 2000
Last modified:	January 19, 2010
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Entry information