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Protein

G2 and S phase-expressed protein 1

Gene

GTSE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression delays G2/M phase progression.

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000075218-MONOMER.
ReactomeiR-HSA-69481. G2/M Checkpoints.
R-HSA-8852276. The role of GTSE1 in G2/M progression after G2 checkpoint.
SIGNORiQ9NYZ3.

Names & Taxonomyi

Protein namesi
Recommended name:
G2 and S phase-expressed protein 1
Short name:
GTSE-1
Alternative name(s):
Protein B99 homolog
Gene namesi
Name:GTSE1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:13698. GTSE1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic microtubule Source: UniProtKB
  • cytosol Source: Reactome
  • membrane Source: UniProtKB
  • nucleoplasm Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29061.

Polymorphism and mutation databases

BioMutaiGTSE1.
DMDMi317373439.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000838751 – 720G2 and S phase-expressed protein 1Add BLAST720

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei72PhosphoserineCombined sources1
Modified residuei138PhosphoserineCombined sources1
Modified residuei140PhosphothreonineCombined sources1
Modified residuei152PhosphoserineCombined sources1
Modified residuei168PhosphoserineCombined sources1
Modified residuei189PhosphoserineCombined sources1
Modified residuei228PhosphoserineCombined sources1
Modified residuei243PhosphoserineCombined sources1
Modified residuei312PhosphoserineCombined sources1
Modified residuei461PhosphoserineCombined sources1
Modified residuei466PhosphothreonineBy similarity1
Modified residuei477PhosphoserineCombined sources1
Modified residuei480PhosphoserineCombined sources1
Modified residuei495PhosphoserineCombined sources1
Modified residuei501PhosphoserineCombined sources1
Modified residuei504PhosphoserineCombined sources1
Modified residuei509PhosphoserineCombined sources1
Modified residuei513PhosphothreonineCombined sources1
Modified residuei516PhosphoserineCombined sources1
Modified residuei536PhosphoserineCombined sources1
Modified residuei575PhosphoserineCombined sources1
Modified residuei592PhosphoserineCombined sources1
Modified residuei677PhosphothreonineCombined sources1
Modified residuei688PhosphoserineCombined sources1
Modified residuei698PhosphoserineCombined sources1
Modified residuei699PhosphoserineCombined sources1
Modified residuei705PhosphoserineCombined sources1
Modified residuei715PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated in mitosis.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NYZ3.
MaxQBiQ9NYZ3.
PaxDbiQ9NYZ3.
PeptideAtlasiQ9NYZ3.
PRIDEiQ9NYZ3.

PTM databases

iPTMnetiQ9NYZ3.
PhosphoSitePlusiQ9NYZ3.

Expressioni

Developmental stagei

Expressed in G2/M phase. Not detected in quiescent cells.

Gene expression databases

BgeeiENSG00000075218.
GenevisibleiQ9NYZ3. HS.

Organism-specific databases

HPAiHPA060544.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PLK1P533506EBI-2511327,EBI-476768

Protein-protein interaction databases

BioGridi119580. 139 interactors.
IntActiQ9NYZ3. 130 interactors.
MINTiMINT-7988145.
STRINGi9606.ENSP00000415430.

Structurei

3D structure databases

ProteinModelPortaliQ9NYZ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi22 – 27Poly-Ser6

Phylogenomic databases

eggNOGiENOG410IHTJ. Eukaryota.
ENOG410ZUTK. LUCA.
HOVERGENiHBG103867.
InParanoidiQ9NYZ3.
KOiK10129.
OrthoDBiEOG091G0890.
PhylomeDBiQ9NYZ3.
TreeFamiTF332555.

Family and domain databases

InterProiIPR026657. DDA3/GTSE-1.
IPR026659. GTSE1.
IPR032768. GTSE1_N.
[Graphical view]
PANTHERiPTHR21584. PTHR21584. 1 hit.
PTHR21584:SF10. PTHR21584:SF10. 1 hit.
PfamiPF15259. GTSE1_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NYZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDPKKEDIL LLADEKFDFD LSLSSSSANE DDEVFFGPFG HKERCIAASL
60 70 80 90 100
ELNNPVPEQP PLPTSESPFA WSPLAGEKFV EVYKEAHLLA LHIESSSRNQ
110 120 130 140 150
AAQAAKPEDP RSQGVERFIQ ESKLKINLFE KEKEMKKSPT SLKRETYYLS
160 170 180 190 200
DSPLLGPPVG EPRLLASSPA LPSSGAQARL TRAPGPPHSA HALPRESCTA
210 220 230 240 250
HAASQAATQR KPGTKLLLPR AASVRGRSIP GAAEKPKKEI PASPSRTKIP
260 270 280 290 300
AEKESHRDVL PDKPAPGAVN VPAAGSHLGQ GKRAIPVPNK LGLKKTLLKA
310 320 330 340 350
PGSTSNLARK SSSGPVWSGA SSACTSPAVG KAKSSEFASI PANSSRPLSN
360 370 380 390 400
ISKSGRMGPA MLRPALPAGP VGASSWQAKR VDVSELAAEQ LTAPPSASPT
410 420 430 440 450
QPQTPEGGGQ WLNSSCAWSE SSQLNKTRSI RRRDSCLNSK TKVMPTPTNQ
460 470 480 490 500
FKIPKFSIGD SPDSSTPKLS RAQRPQSCTS VGRVTVHSTP VRRSSGPAPQ
510 520 530 540 550
SLLSAWRVSA LPTPASRRCS GLPPMTPKTM PRAVGSPLCV PARRRSSEPR
560 570 580 590 600
KNSAMRTEPT RESNRKTDSR LVDVSPDRGS PPSRVPQALN FSPEESDSTF
610 620 630 640 650
SKSTATEVAR EEAKPGGDAA PSEALLVDIK LEPLAVTPDA ASQPLIDLPL
660 670 680 690 700
IDFCDTPEAH VAVGSESRPL IDLMTNTPDM NKNVAKPSPV VGQLIDLSSP
710 720
LIQLSPEADK ENVDSPLLKF
Length:720
Mass (Da):76,645
Last modified:January 11, 2011 - v3
Checksum:iDBAC3C9ED528FB29
GO

Sequence cautioni

The sequence CAQ09324 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAQ10552 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4P → S in AAH75828 (PubMed:15489334).Curated1
Sequence conflicti135M → V in BAD96526 (PubMed:14702039).Curated1
Sequence conflicti259V → I in AAF31459 (PubMed:10974554).Curated1
Sequence conflicti306N → D in BAD96526 (PubMed:14702039).Curated1
Sequence conflicti455K → R in BAD96526 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032816181T → A.Corresponds to variant rs6008600dbSNPEnsembl.1
Natural variantiVAR_032817200A → V.Corresponds to variant rs34404175dbSNPEnsembl.1
Natural variantiVAR_032818274A → T.Corresponds to variant rs35503220dbSNPEnsembl.1
Natural variantiVAR_056905303S → N.Corresponds to variant rs6008622dbSNPEnsembl.1
Natural variantiVAR_032819322S → N.Corresponds to variant rs6008622dbSNPEnsembl.1
Natural variantiVAR_032820463D → E.Corresponds to variant rs6008684dbSNPEnsembl.1
Natural variantiVAR_021973470S → L.Corresponds to variant rs2281192dbSNPEnsembl.1
Natural variantiVAR_024154506W → R.Combined sources4 PublicationsCorresponds to variant rs140054dbSNPEnsembl.1
Natural variantiVAR_032821635A → T.Corresponds to variant rs16995138dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF223408 mRNA. Translation: AAF31459.1.
CT841519 mRNA. Translation: CAJ86449.1.
AK222806 mRNA. Translation: BAD96526.1.
AK315550 mRNA. Translation: BAG37928.1.
AL031588, Z93024 Genomic DNA. Translation: CAQ09324.2. Different initiation.
Z93024, AL031588 Genomic DNA. Translation: CAQ10552.2. Different initiation.
BC006325 mRNA. Translation: AAH06325.1.
BC075828 mRNA. Translation: AAH75828.1.
RefSeqiNP_057510.4. NM_016426.6.
UniGeneiHs.386189.
Hs.439524.

Genome annotation databases

EnsembliENST00000454366; ENSP00000415430; ENSG00000075218.
GeneIDi51512.
KEGGihsa:51512.
UCSCiuc011aqy.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF223408 mRNA. Translation: AAF31459.1.
CT841519 mRNA. Translation: CAJ86449.1.
AK222806 mRNA. Translation: BAD96526.1.
AK315550 mRNA. Translation: BAG37928.1.
AL031588, Z93024 Genomic DNA. Translation: CAQ09324.2. Different initiation.
Z93024, AL031588 Genomic DNA. Translation: CAQ10552.2. Different initiation.
BC006325 mRNA. Translation: AAH06325.1.
BC075828 mRNA. Translation: AAH75828.1.
RefSeqiNP_057510.4. NM_016426.6.
UniGeneiHs.386189.
Hs.439524.

3D structure databases

ProteinModelPortaliQ9NYZ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119580. 139 interactors.
IntActiQ9NYZ3. 130 interactors.
MINTiMINT-7988145.
STRINGi9606.ENSP00000415430.

PTM databases

iPTMnetiQ9NYZ3.
PhosphoSitePlusiQ9NYZ3.

Polymorphism and mutation databases

BioMutaiGTSE1.
DMDMi317373439.

Proteomic databases

EPDiQ9NYZ3.
MaxQBiQ9NYZ3.
PaxDbiQ9NYZ3.
PeptideAtlasiQ9NYZ3.
PRIDEiQ9NYZ3.

Protocols and materials databases

DNASUi51512.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000454366; ENSP00000415430; ENSG00000075218.
GeneIDi51512.
KEGGihsa:51512.
UCSCiuc011aqy.2. human.

Organism-specific databases

CTDi51512.
GeneCardsiGTSE1.
HGNCiHGNC:13698. GTSE1.
HPAiHPA060544.
MIMi607477. gene.
neXtProtiNX_Q9NYZ3.
PharmGKBiPA29061.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHTJ. Eukaryota.
ENOG410ZUTK. LUCA.
HOVERGENiHBG103867.
InParanoidiQ9NYZ3.
KOiK10129.
OrthoDBiEOG091G0890.
PhylomeDBiQ9NYZ3.
TreeFamiTF332555.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000075218-MONOMER.
ReactomeiR-HSA-69481. G2/M Checkpoints.
R-HSA-8852276. The role of GTSE1 in G2/M progression after G2 checkpoint.
SIGNORiQ9NYZ3.

Miscellaneous databases

ChiTaRSiGTSE1. human.
GeneWikiiGTSE1.
GenomeRNAii51512.
PROiQ9NYZ3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000075218.
GenevisibleiQ9NYZ3. HS.

Family and domain databases

InterProiIPR026657. DDA3/GTSE-1.
IPR026659. GTSE1.
IPR032768. GTSE1_N.
[Graphical view]
PANTHERiPTHR21584. PTHR21584. 1 hit.
PTHR21584:SF10. PTHR21584:SF10. 1 hit.
PfamiPF15259. GTSE1_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGTSE1_HUMAN
AccessioniPrimary (citable) accession number: Q9NYZ3
Secondary accession number(s): B0QYM3
, Q20WK2, Q53GX5, Q5R3I6, Q6DHX4, Q9BRE0, Q9UGZ9, Q9Y557
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: January 11, 2011
Last modified: November 2, 2016
This is version 136 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.