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Protein

Golgi apparatus membrane protein TVP23 homolog B

Gene

TVP23B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Golgi apparatus membrane protein TVP23 homolog B
Gene namesi
Name:TVP23B
Synonyms:FAM18B, FAM18B1
ORF Names:CGI-148, NPD008
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:20399. TVP23B.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei34 – 53HelicalSequence analysisAdd BLAST20
Transmembranei54 – 72HelicalSequence analysisAdd BLAST19
Transmembranei126 – 146HelicalSequence analysisAdd BLAST21
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi51030.
OpenTargetsiENSG00000171928.
PharmGKBiPA134871046.

Polymorphism and mutation databases

BioMutaiTVP23B.
DMDMi296434501.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002128281 – 205Golgi apparatus membrane protein TVP23 homolog BAdd BLAST205

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9NYZ1.
PaxDbiQ9NYZ1.
PeptideAtlasiQ9NYZ1.
PRIDEiQ9NYZ1.

PTM databases

iPTMnetiQ9NYZ1.
PhosphoSitePlusiQ9NYZ1.

Expressioni

Gene expression databases

BgeeiENSG00000171928.
CleanExiHS_FAM18B.
ExpressionAtlasiQ9NYZ1. baseline and differential.
GenevisibleiQ9NYZ1. HS.

Organism-specific databases

HPAiHPA019585.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
YIPF6Q96EC84EBI-11343401,EBI-751210

Protein-protein interaction databases

BioGridi119236. 1 interactor.
IntActiQ9NYZ1. 3 interactors.
STRINGi9606.ENSP00000305654.

Structurei

3D structure databases

ProteinModelPortaliQ9NYZ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TVP23 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3195. Eukaryota.
ENOG4111GAN. LUCA.
GeneTreeiENSGT00390000004428.
HOVERGENiHBG051531.
InParanoidiQ9NYZ1.
OMAiHEQRVFW.
OrthoDBiEOG091G0MH1.
PhylomeDBiQ9NYZ1.
TreeFamiTF312906.

Family and domain databases

InterProiIPR008564. DUF846_euk.
[Graphical view]
PANTHERiPTHR13019. PTHR13019. 1 hit.
PfamiPF05832. DUF846. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NYZ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQQDSNDDT EDVSLFDAEE ETTNRPRKAK IRHPVASFFH LFFRVSAIIV
60 70 80 90 100
YLLCGLLSSS FITCMVTIIL LLSCDFWAVK NVTGRLMVGL RWWNHIDEDG
110 120 130 140 150
KSHWVFESRK ESSQENKTVS EAESRIFWLG LIACPVLWVI FAFSALFSFR
160 170 180 190 200
VKWLAVVIMG VVLQGANLYG YIRCKVRSRK HLTSMATSYF GKQFLRQNTG

DDQTS
Length:205
Mass (Da):23,576
Last modified:May 18, 2010 - v2
Checksum:iE221C320822187FC
GO

Sequence cautioni

The sequence AAD34143 differs from that shown. Reason: Frameshift at position 178.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48I → T in BAF83502 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06047655G → E.4 PublicationsCorresponds to variant rs61075345dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151906 mRNA. Translation: AAD34143.1. Frameshift.
AF223467 mRNA. Translation: AAF64142.1.
BX537929 mRNA. Translation: CAD97906.1.
AK290813 mRNA. Translation: BAF83502.1.
AC107982 Genomic DNA. No translation available.
BC008430 mRNA. Translation: AAH08430.1.
CCDSiCCDS42274.1.
RefSeqiNP_001303848.1. NM_001316919.1.
NP_001303849.1. NM_001316920.1.
NP_001303850.1. NM_001316921.1.
NP_001303851.1. NM_001316922.1.
NP_001303852.1. NM_001316923.1.
NP_001303853.1. NM_001316924.1.
NP_057162.4. NM_016078.5.
UniGeneiHs.87295.

Genome annotation databases

EnsembliENST00000307767; ENSP00000305654; ENSG00000171928.
GeneIDi51030.
KEGGihsa:51030.
UCSCiuc002gum.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151906 mRNA. Translation: AAD34143.1. Frameshift.
AF223467 mRNA. Translation: AAF64142.1.
BX537929 mRNA. Translation: CAD97906.1.
AK290813 mRNA. Translation: BAF83502.1.
AC107982 Genomic DNA. No translation available.
BC008430 mRNA. Translation: AAH08430.1.
CCDSiCCDS42274.1.
RefSeqiNP_001303848.1. NM_001316919.1.
NP_001303849.1. NM_001316920.1.
NP_001303850.1. NM_001316921.1.
NP_001303851.1. NM_001316922.1.
NP_001303852.1. NM_001316923.1.
NP_001303853.1. NM_001316924.1.
NP_057162.4. NM_016078.5.
UniGeneiHs.87295.

3D structure databases

ProteinModelPortaliQ9NYZ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119236. 1 interactor.
IntActiQ9NYZ1. 3 interactors.
STRINGi9606.ENSP00000305654.

PTM databases

iPTMnetiQ9NYZ1.
PhosphoSitePlusiQ9NYZ1.

Polymorphism and mutation databases

BioMutaiTVP23B.
DMDMi296434501.

Proteomic databases

MaxQBiQ9NYZ1.
PaxDbiQ9NYZ1.
PeptideAtlasiQ9NYZ1.
PRIDEiQ9NYZ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307767; ENSP00000305654; ENSG00000171928.
GeneIDi51030.
KEGGihsa:51030.
UCSCiuc002gum.3. human.

Organism-specific databases

CTDi51030.
DisGeNETi51030.
GeneCardsiTVP23B.
H-InvDBHIX0202397.
HGNCiHGNC:20399. TVP23B.
HPAiHPA019585.
neXtProtiNX_Q9NYZ1.
OpenTargetsiENSG00000171928.
PharmGKBiPA134871046.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3195. Eukaryota.
ENOG4111GAN. LUCA.
GeneTreeiENSGT00390000004428.
HOVERGENiHBG051531.
InParanoidiQ9NYZ1.
OMAiHEQRVFW.
OrthoDBiEOG091G0MH1.
PhylomeDBiQ9NYZ1.
TreeFamiTF312906.

Miscellaneous databases

GeneWikiiFAM18B1.
GenomeRNAii51030.
PROiQ9NYZ1.

Gene expression databases

BgeeiENSG00000171928.
CleanExiHS_FAM18B.
ExpressionAtlasiQ9NYZ1. baseline and differential.
GenevisibleiQ9NYZ1. HS.

Family and domain databases

InterProiIPR008564. DUF846_euk.
[Graphical view]
PANTHERiPTHR13019. PTHR13019. 1 hit.
PfamiPF05832. DUF846. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTV23B_HUMAN
AccessioniPrimary (citable) accession number: Q9NYZ1
Secondary accession number(s): A8K448, Q96HK5, Q9Y3E6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.