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Protein

Golgi apparatus membrane protein TVP23 homolog B

Gene

TVP23B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Golgi apparatus membrane protein TVP23 homolog B
Gene namesi
Name:TVP23B
Synonyms:FAM18B, FAM18B1
ORF Names:CGI-148, NPD008
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:20399. TVP23B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei34 – 5320HelicalSequence analysisAdd
BLAST
Transmembranei54 – 7219HelicalSequence analysisAdd
BLAST
Transmembranei126 – 14621HelicalSequence analysisAdd
BLAST
Transmembranei152 – 17221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134871046.

Polymorphism and mutation databases

BioMutaiTVP23B.
DMDMi296434501.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 205205Golgi apparatus membrane protein TVP23 homolog BPRO_0000212828Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9NYZ1.
MaxQBiQ9NYZ1.
PaxDbiQ9NYZ1.
PRIDEiQ9NYZ1.

PTM databases

iPTMnetiQ9NYZ1.
PhosphoSiteiQ9NYZ1.

Expressioni

Gene expression databases

BgeeiQ9NYZ1.
CleanExiHS_FAM18B.
ExpressionAtlasiQ9NYZ1. baseline and differential.
GenevisibleiQ9NYZ1. HS.

Organism-specific databases

HPAiHPA019585.

Interactioni

Protein-protein interaction databases

BioGridi119236. 1 interaction.
IntActiQ9NYZ1. 2 interactions.
STRINGi9606.ENSP00000305654.

Structurei

3D structure databases

ProteinModelPortaliQ9NYZ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TVP23 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3195. Eukaryota.
ENOG4111GAN. LUCA.
GeneTreeiENSGT00390000004428.
HOVERGENiHBG051531.
InParanoidiQ9NYZ1.
OMAiSESYQSR.
OrthoDBiEOG783MWT.
PhylomeDBiQ9NYZ1.
TreeFamiTF312906.

Family and domain databases

InterProiIPR008564. DUF846_euk.
[Graphical view]
PANTHERiPTHR13019. PTHR13019. 1 hit.
PfamiPF05832. DUF846. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NYZ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQQDSNDDT EDVSLFDAEE ETTNRPRKAK IRHPVASFFH LFFRVSAIIV
60 70 80 90 100
YLLCGLLSSS FITCMVTIIL LLSCDFWAVK NVTGRLMVGL RWWNHIDEDG
110 120 130 140 150
KSHWVFESRK ESSQENKTVS EAESRIFWLG LIACPVLWVI FAFSALFSFR
160 170 180 190 200
VKWLAVVIMG VVLQGANLYG YIRCKVRSRK HLTSMATSYF GKQFLRQNTG

DDQTS
Length:205
Mass (Da):23,576
Last modified:May 18, 2010 - v2
Checksum:iE221C320822187FC
GO

Sequence cautioni

The sequence AAD34143.1 differs from that shown. Reason: Frameshift at position 178. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti48 – 481I → T in BAF83502 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti55 – 551G → E.4 Publications
Corresponds to variant rs61075345 [ dbSNP | Ensembl ].
VAR_060476

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151906 mRNA. Translation: AAD34143.1. Frameshift.
AF223467 mRNA. Translation: AAF64142.1.
BX537929 mRNA. Translation: CAD97906.1.
AK290813 mRNA. Translation: BAF83502.1.
AC107982 Genomic DNA. No translation available.
BC008430 mRNA. Translation: AAH08430.1.
CCDSiCCDS42274.1.
RefSeqiNP_001303848.1. NM_001316919.1.
NP_001303849.1. NM_001316920.1.
NP_001303850.1. NM_001316921.1.
NP_001303851.1. NM_001316922.1.
NP_001303852.1. NM_001316923.1.
NP_001303853.1. NM_001316924.1.
NP_057162.4. NM_016078.5.
UniGeneiHs.87295.

Genome annotation databases

EnsembliENST00000307767; ENSP00000305654; ENSG00000171928.
GeneIDi51030.
KEGGihsa:51030.
UCSCiuc002gum.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151906 mRNA. Translation: AAD34143.1. Frameshift.
AF223467 mRNA. Translation: AAF64142.1.
BX537929 mRNA. Translation: CAD97906.1.
AK290813 mRNA. Translation: BAF83502.1.
AC107982 Genomic DNA. No translation available.
BC008430 mRNA. Translation: AAH08430.1.
CCDSiCCDS42274.1.
RefSeqiNP_001303848.1. NM_001316919.1.
NP_001303849.1. NM_001316920.1.
NP_001303850.1. NM_001316921.1.
NP_001303851.1. NM_001316922.1.
NP_001303852.1. NM_001316923.1.
NP_001303853.1. NM_001316924.1.
NP_057162.4. NM_016078.5.
UniGeneiHs.87295.

3D structure databases

ProteinModelPortaliQ9NYZ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119236. 1 interaction.
IntActiQ9NYZ1. 2 interactions.
STRINGi9606.ENSP00000305654.

PTM databases

iPTMnetiQ9NYZ1.
PhosphoSiteiQ9NYZ1.

Polymorphism and mutation databases

BioMutaiTVP23B.
DMDMi296434501.

Proteomic databases

EPDiQ9NYZ1.
MaxQBiQ9NYZ1.
PaxDbiQ9NYZ1.
PRIDEiQ9NYZ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307767; ENSP00000305654; ENSG00000171928.
GeneIDi51030.
KEGGihsa:51030.
UCSCiuc002gum.3. human.

Organism-specific databases

CTDi51030.
GeneCardsiTVP23B.
H-InvDBHIX0202397.
HGNCiHGNC:20399. TVP23B.
HPAiHPA019585.
neXtProtiNX_Q9NYZ1.
PharmGKBiPA134871046.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3195. Eukaryota.
ENOG4111GAN. LUCA.
GeneTreeiENSGT00390000004428.
HOVERGENiHBG051531.
InParanoidiQ9NYZ1.
OMAiSESYQSR.
OrthoDBiEOG783MWT.
PhylomeDBiQ9NYZ1.
TreeFamiTF312906.

Miscellaneous databases

GeneWikiiFAM18B1.
GenomeRNAii51030.
PROiQ9NYZ1.

Gene expression databases

BgeeiQ9NYZ1.
CleanExiHS_FAM18B.
ExpressionAtlasiQ9NYZ1. baseline and differential.
GenevisibleiQ9NYZ1. HS.

Family and domain databases

InterProiIPR008564. DUF846_euk.
[Graphical view]
PANTHERiPTHR13019. PTHR13019. 1 hit.
PfamiPF05832. DUF846. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLU-55.
  2. "A novel gene expressed in normal human pituitary."
    Song H., Gao G., Peng Y., Ren S., Chen Z., Han Z.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-55.
    Tissue: Pituitary.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLU-55.
    Tissue: Fetal kidney.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLU-55.
    Tissue: Kidney.
  5. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skeletal muscle.
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTV23B_HUMAN
AccessioniPrimary (citable) accession number: Q9NYZ1
Secondary accession number(s): A8K448, Q96HK5, Q9Y3E6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: May 18, 2010
Last modified: June 8, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.