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Protein

FAST kinase domain-containing protein 2, mitochondrial

Gene

FASTKD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in assembly of the mitochondrial large ribosomal subunit (PubMed:25683715).1 Publication

Caution

It is uncertain whether Met-1 or Met-17 is the initiator.Curated

GO - Molecular functioni

  • protein kinase activity Source: InterPro
  • RNA binding Source: UniProtKB
  • rRNA binding Source: UniProtKB

GO - Biological processi

  • cellular respiration Source: UniProtKB
  • mitochondrial large ribosomal subunit assembly Source: UniProtKB

Keywordsi

Molecular functionRNA-binding, rRNA-binding
Biological processRibosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
FAST kinase domain-containing protein 2, mitochondrial
Gene namesi
Name:FASTKD2
Synonyms:KIAA0971
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000118246.13
HGNCiHGNC:29160 FASTKD2
MIMi612322 gene
neXtProtiNX_Q9NYY8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion, Mitochondrion nucleoid

Pathology & Biotechi

Organism-specific databases

DisGeNETi22868
MalaCardsiFASTKD2
OpenTargetsiENSG00000118246
Orphaneti166105 FASTKD2-related infantile mitochondrial encephalomyopathy
254905 Isolated cytochrome C oxidase deficiency
PharmGKBiPA134974924

Polymorphism and mutation databases

BioMutaiFASTKD2
DMDMi74734717

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000050783? – 710FAST kinase domain-containing protein 2, mitochondrial
Transit peptidei1 – ?MitochondrionCurated

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei126PhosphoserineCombined sources1
Modified residuei140PhosphoserineCombined sources1
Modified residuei708PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NYY8
MaxQBiQ9NYY8
PaxDbiQ9NYY8
PeptideAtlasiQ9NYY8
PRIDEiQ9NYY8

PTM databases

iPTMnetiQ9NYY8
PhosphoSitePlusiQ9NYY8

Expressioni

Tissue specificityi

Expression detected in spleen, thymus, testis, ovary, colon, heart, smooth muscle, kidney, brain, lung, liver and white adipose tissue with highest expression in heart, smooth muscle and thyroid.1 Publication

Gene expression databases

BgeeiENSG00000118246
CleanExiHS_FASTKD2
ExpressionAtlasiQ9NYY8 baseline and differential
GenevisibleiQ9NYY8 HS

Organism-specific databases

HPAiHPA067191

Interactioni

Subunit structurei

Monomer. Found in a complex with GRSF1, DDX28, DHX30 and FASTKD5. Associates with the 16S mitochondrial rRNA (16S mt-rRNA).1 Publication

Protein-protein interaction databases

BioGridi116535, 31 interactors
CORUMiQ9NYY8
IntActiQ9NYY8, 7 interactors
MINTiQ9NYY8
STRINGi9606.ENSP00000236980

Structurei

3D structure databases

ProteinModelPortaliQ9NYY8
SMRiQ9NYY8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini634 – 691RAPPROSITE-ProRule annotationAdd BLAST58

Sequence similaritiesi

Belongs to the FAST kinase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IH1K Eukaryota
ENOG410ZQHV LUCA
GeneTreeiENSGT00510000048773
HOGENOMiHOG000112491
HOVERGENiHBG081516
InParanoidiQ9NYY8
KOiK18190
OMAiFDIWKLK
OrthoDBiEOG091G0WV6
PhylomeDBiQ9NYY8
TreeFamiTF352875

Family and domain databases

InterProiView protein in InterPro
IPR013579 FAST_2
IPR010622 FAST_Leu-rich
IPR013584 RAP
PfamiView protein in Pfam
PF06743 FAST_1, 1 hit
PF08368 FAST_2, 1 hit
PF08373 RAP, 1 hit
SMARTiView protein in SMART
SM00952 RAP, 1 hit
PROSITEiView protein in PROSITE
PS51286 RAP, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NYY8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLTTLKPFGS VSVESKMNNK AGSFFWNLRQ FSTLVSTSRT MRLCCLGLCK
60 70 80 90 100
PKIVHSNWNI LNNFHNRMQS TDIIRYLFQD AFIFKSDVGF QTKGISTLTA
110 120 130 140 150
LRIERLLYAK RLFFDSKQSL VPVDKSDDEL KKVNLNHEVS NEDVLTKETK
160 170 180 190 200
PNRISSRKLS EECNSLSDVL DAFSKAPTFP SSNYFTAMWT IAKRLSDDQK
210 220 230 240 250
RFEKRLMFSH PAFNQLCEHM MREAKIMQYK YLLFSLHAIV KLGIPQNTIL
260 270 280 290 300
VQTLLRVTQE RINECDEICL SVLSTVLEAM EPCKNVHVLR TGFRILVDQQ
310 320 330 340 350
VWKIEDVFTL QVVMKCIGKD APIALKRKLE MKALRELDRF SVLNSQHMFE
360 370 380 390 400
VLAAMNHRSL ILLDECSKVV LDNIHGCPLR IMINILQSCK DLQYHNLDLF
410 420 430 440 450
KGLADYVAAT FDIWKFRKVL FILILFENLG FRPVGLMDLF MKRIVEDPES
460 470 480 490 500
LNMKNILSIL HTYSSLNHVY KCQNKEQFVE VMASALTGYL HTISSENLLD
510 520 530 540 550
AVYSFCLMNY FPLAPFNQLL QKDIISELLT SDDMKNAYKL HTLDTCLKLD
560 570 580 590 600
DTVYLRDIAL SLPQLPRELP SSHTNAKVAE VLSSLLGGEG HFSKDVHLPH
610 620 630 640 650
NYHIDFEIRM DTNRNQVLPL SDVDTTSATD IQRVAVLCVS RSAYCLGSSH
660 670 680 690 700
PRGFLAMKMR HLNAMGFHVI LVNNWEMDKL EMEDAVTFLK TKIYSVEALP
710
VAAVNVQSTQ
Length:710
Mass (Da):81,463
Last modified:October 1, 2000 - v1
Checksum:i11BF1D5A0CF1DA15
GO
Isoform 2 (identifier: Q9NYY8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     634-648: VAVLCVSRSAYCLGS → LLTYISFAGLSELKS
     649-710: Missing.

Show »
Length:648
Mass (Da):74,536
Checksum:i603D468791E4A804
GO

Sequence cautioni

The sequence BAA76815 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA91617 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05388915S → N. Corresponds to variant dbSNP:rs3762568EnsemblClinVar.1
Natural variantiVAR_053890445V → E. Corresponds to variant dbSNP:rs13003768Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017186634 – 648VAVLC…YCLGS → LLTYISFAGLSELKS in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_017187649 – 710Missing in isoform 2. 1 PublicationAdd BLAST62

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023188 mRNA Translation: BAA76815.2 Different initiation.
AF223470 mRNA Translation: AAF64145.1
AL833877 mRNA Translation: CAD38734.1
AC008269 Genomic DNA Translation: AAX93275.1
BC001544 mRNA Translation: AAH01544.1
AK001315 mRNA Translation: BAA91617.1 Different initiation.
CCDSiCCDS2371.1 [Q9NYY8-1]
RefSeqiNP_001129665.1, NM_001136193.1 [Q9NYY8-1]
NP_001129666.1, NM_001136194.1 [Q9NYY8-1]
NP_055744.2, NM_014929.3 [Q9NYY8-1]
UniGeneiHs.5930
Hs.722628

Genome annotation databases

EnsembliENST00000236980; ENSP00000236980; ENSG00000118246 [Q9NYY8-1]
ENST00000402774; ENSP00000385990; ENSG00000118246 [Q9NYY8-1]
ENST00000403094; ENSP00000384929; ENSG00000118246 [Q9NYY8-1]
GeneIDi22868
KEGGihsa:22868
UCSCiuc002vbu.4 human [Q9NYY8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFAKD2_HUMAN
AccessioniPrimary (citable) accession number: Q9NYY8
Secondary accession number(s): Q9NVX6, Q9Y2H7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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