Reviewed, UniProtKB/Swiss-Prot Q9NYY3 (PLK2_HUMAN)

Names and origin

Protein names

Recommended name:
    Serine/threonine-protein kinase PLK2
      Short name=PLK-2
    EC=2.7.11.21
Alternative name(s):
    Polo-like kinase 1
    Serine/threonine-protein kinase SNK
    Serum-inducible kinase

Gene names

Name:	PLK2
Synonyms:	SNK

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	685 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May play a role in the division of at least some cell types, such as fibroblasts, and could function in embryogenesis, wound healing or neoplasia By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. Contains 2 POLO box domains. Contains 1 protein kinase domain.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Repeat
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Gene Ontology (GO)
Biological process	positive regulation of I-kappaB kinase/NF-kappaB cascade Inferred from mutant phenotype. Source: UniProtKB protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW polo kinase kinase activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 685	685	Serine/threonine-protein kinase PLK2		PRO_0000086561
Regions
	Domain	82 – 334	253	Protein kinase
	Domain	510 – 573	64	POLO box 1
	Domain	606 – 677	72	POLO box 2
	Nucleotide binding	88 – 96	9	ATP By similarity
	Compositional bias	57 – 64	8	Poly-His
Sites
	Active site	205	1	Proton acceptor By similarity
	Binding site	111	1	ATP By similarity
Natural variations
	Natural variant	14	1	S → T in an ovarian Endometrioid carcinoma sample; somatic mutation. Ref.5		VAR_041023
	Natural variant	92	1	G → S in a lung adenocarcinoma sample; somatic mutation. Ref.5		VAR_041024
	Natural variant	436	1	E → K Ref.5		VAR_041025
	Natural variant	487	1	P → L Ref.5		VAR_041026
Experimental info
	Sequence conflict	28	1	A → G in AAC14573. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9NYY3-1 [UniParc]. Last modified August 2, 2002. Version 3. Checksum: 6429F6EFD830B333	FASTA	685	78,237
	10 20 30 40 50 60 MELLRTITYQ PAASTKMCEQ ALGKGCGADS KKKRPPQPPE ESQPPQSQAQ VPPAAPHHHH 70 80 90 100 110 120 HHSHSGPEIS RIIVDPTTGK RYCRGKVLGK GGFAKCYEMT DLTNNKVYAA KIIPHSRVAK 130 140 150 160 170 180 PHQREKIDKE IELHRILHHK HVVQFYHYFE DKENIYILLE YCSRRSMAHI LKARKVLTEP 190 200 210 220 230 240 EVRYYLRQIV SGLKYLHEQE ILHRDLKLGN FFINEAMELK VGDFGLAARL EPLEHRRRTI 250 260 270 280 290 300 CGTPNYLSPE VLNKQGHGCE SDIWALGCVM YTMLLGRPPF ETTNLKETYR CIREARYTMP 310 320 330 340 350 360 SSLLAPAKHL IASMLSKNPE DRPSLDDIIR HDFFLQGFTP DRLSSSCCHT VPDFHLSSPA 370 380 390 400 410 420 KNFFKKAAAA LFGGKKDKAR YIDTHNRVSK EDEDIYKLRH DLKKTSITQQ PSKHRTDEEL 430 440 450 460 470 480 QPPTTTVARS GTPAVENKQQ IGDAIRMIVR GTLGSCSSSS ECLEDSTMGS VADTVARVLR 490 500 510 520 530 540 GCLENMPEAD CIPKEQLSTS FQWVTKWVDY SNKYGFGYQL SDHTVGVLFN NGAHMSLLPD 550 560 570 580 590 600 KKTVHYYAEL GQCSVFPATD APEQFISQVT VLKYFSHYME ENLMDGGDLP SVTDIRRPRL 610 620 630 640 650 660 YLLQWLKSDK ALMMLFNDGT FQVNFYHDHT KIIICSQNEE YLLTYINEDR ISTTFRLTTL 670 680 LMSGCSSELK NRMEYALNML LQRCN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Ouyang B., Dai W. Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Identification and characterization of human serum-inducible kinase (SNK), a novel member of the polo-kinase family of cell cycle regulators: potential implication for regulation of vascular smooth muscle proliferation." Anderson K.M., Nerurkar S.S., Hansbury M.J., Fornwald J., Scott G., Bouzyk M., Mui P., Imbrugia C.S., Carlson K., Marshall L.A., Roshak A.K. Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Colon.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.
[4]	Fidler C., Boultwood J., Wang Jabs E., Wainscoat J.S. Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 110-408.
[5]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed: 17344846] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-14; SER-92; LYS-436 AND LEU-487.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF059617 mRNA. Translation: AAC14573.1. AF223574 mRNA. Translation: AAF62897.1. U85755 mRNA. Translation: AAD00575.1. BC013879 mRNA. Translation: AAH13879.1.
IPI	IPI00302787.
RefSeq	NP_006613.2.
UniGene	Hs.398157 Hs.658132
3D structure databases
HSSP	HSSP built from PDB template 1MRU based on UniProtKB P71584.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NYY3. 3 interactions.
PTM databases
PhosphoSite	Q9NYY3.
Proteomic databases
PRIDE	Q9NYY3.
Genome annotation databases
Ensembl	ENSG00000145632. Homo sapiens. [Contig view]
GeneID	10769.
KEGG	hsa:10769.
Organism-specific databases
GeneCards	GC05M057785.
HGNC	HGNC:19699. PLK2.
HPA	CAB009624.
MIM	607023. gene.
PharmGKB	PA134940798.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9NYY3.
HOVERGEN	Q9NYY3.
OMA	Q9NYY3. VTDIRRP.
Enzyme and pathway databases
BRENDA	2.7.11.21. 247.
Gene expression databases
ArrayExpress	Q9NYY3.
Bgee	Q9NYY3.
CleanEx	HS_PLK2.
GermOnline	ENSG00000145632. Homo sapiens.
Family and domain databases
InterPro	IPR015728. Polo-like_kinase-related. IPR017450. POLO_box. IPR000959. POLO_box_duplicated. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. [Graphical view]
PANTHER	PTHR22982:SF10. Polo-like_kinase. 1 hit.
Pfam	PF00069. Pkinase. 1 hit. PF00659. POLO_box. 2 hits. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS50078. POLO_BOX. 2 hits. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	40893.
SOURCE	Search...

Entry information

Entry name

PLK2_HUMAN

Accession

Primary (citable) accession number: Q9NYY3
Secondary accession number(s): O60679, Q96CV7, Q9UE61

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	August 2, 2002
Last modified:	June 16, 2009
This is version 79 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)