Reviewed,
UniProtKB/Swiss-Prot Q9NYY3 (PLK2_HUMAN)
Last modified
June 16, 2009.
Version 79.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Serine/threonine-protein kinase PLK2 Short name=PLK-2 EC=2.7.11.21 Alternative name(s): Polo-like kinase 1 Serine/threonine-protein kinase SNK Serum-inducible kinase | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 685 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | May play a role in the division of at least some cell types, such as fibroblasts, and could function in embryogenesis, wound healing or neoplasia By similarity. |
| Catalytic activity | ATP + a protein = ADP + a phosphoprotein. |
| Sequence similarities | Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. Contains 2 POLO box domains. Contains 1 protein kinase domain. |
Ontologies
| Keywords | |
|---|---|
| Coding sequence diversity | Polymorphism |
| Domain | Repeat |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Serine/threonine-protein kinase Transferase |
| Gene Ontology (GO) | |
| Biological process | positive regulation of I-kappaB kinase/NF-kappaB cascade Inferred from mutant phenotype. Source: UniProtKB protein amino acid phosphorylationInferred from electronic annotation. Source: InterPro |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW polo kinase kinase activityInferred from electronic annotation. Source: InterPro protein bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 685 | 685 | Serine/threonine-protein kinase PLK2 | PRO_0000086561 | |||||
Regions | |||||||||
| Domain | 82 – 334 | 253 | Protein kinase | ||||||
| Domain | 510 – 573 | 64 | POLO box 1 | ||||||
| Domain | 606 – 677 | 72 | POLO box 2 | ||||||
| Nucleotide binding | 88 – 96 | 9 | ATP By similarity | ||||||
| Compositional bias | 57 – 64 | 8 | Poly-His | ||||||
Sites | |||||||||
| Active site | 205 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 111 | 1 | ATP By similarity | ||||||
Natural variations | |||||||||
| Natural variant | 14 | 1 | S → T in an ovarian Endometrioid carcinoma sample; somatic mutation. Ref.5 | VAR_041023 | |||||
| Natural variant | 92 | 1 | G → S in a lung adenocarcinoma sample; somatic mutation. Ref.5 | VAR_041024 | |||||
| Natural variant | 436 | 1 | E → K Ref.5 | VAR_041025 | |||||
| Natural variant | 487 | 1 | P → L Ref.5 | VAR_041026 | |||||
Experimental info | |||||||||
| Sequence conflict | 28 | 1 | A → G in AAC14573. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | Ouyang B., Dai W. Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Identification and characterization of human serum-inducible kinase (SNK), a novel member of the polo-kinase family of cell cycle regulators: potential implication for regulation of vascular smooth muscle proliferation." Anderson K.M., Nerurkar S.S., Hansbury M.J., Fornwald J., Scott G., Bouzyk M., Mui P., Imbrugia C.S., Carlson K., Marshall L.A., Roshak A.K. Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Colon. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin. |
| [4] | Fidler C., Boultwood J., Wang Jabs E., Wainscoat J.S. Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 110-408. |
| [5] | "Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. Stratton M.R.Nature 446:153-158(2007) [PubMed: 17344846] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-14; SER-92; LYS-436 AND LEU-487. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AF059617 mRNA. Translation: AAC14573.1. AF223574 mRNA. Translation: AAF62897.1. U85755 mRNA. Translation: AAD00575.1. BC013879 mRNA. Translation: AAH13879.1. | |
| IPI | IPI00302787. |
| RefSeq | NP_006613.2. |
| UniGene | Hs.398157 Hs.658132 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1MRU based on UniProtKB P71584. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q9NYY3. 3 interactions. |
PTM databases | |
| PhosphoSite | Q9NYY3. |
Proteomic databases | |
| PRIDE | Q9NYY3. |
Genome annotation databases | |
| Ensembl | ENSG00000145632. Homo sapiens. [Contig view] |
| GeneID | 10769. |
| KEGG | hsa:10769. |
Organism-specific databases | |
| GeneCards | GC05M057785. |
| HGNC | HGNC:19699. PLK2. |
| HPA | CAB009624. |
| MIM | 607023. gene. |
| PharmGKB | PA134940798. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | Q9NYY3. |
| HOVERGEN | Q9NYY3. |
| OMA | Q9NYY3. VTDIRRP. |
Enzyme and pathway databases | |
| BRENDA | 2.7.11.21. 247. |
Gene expression databases | |
| ArrayExpress | Q9NYY3. |
| Bgee | Q9NYY3. |
| CleanEx | HS_PLK2. |
| GermOnline | ENSG00000145632. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR015728. Polo-like_kinase-related. IPR017450. POLO_box. IPR000959. POLO_box_duplicated. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. [Graphical view] |
| PANTHER | PTHR22982:SF10. Polo-like_kinase. 1 hit. |
| Pfam | PF00069. Pkinase. 1 hit. PF00659. POLO_box. 2 hits. [Graphical view] |
| ProDom | PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00220. S_TKc. 1 hit. [Graphical view] |
| PROSITE | PS50078. POLO_BOX. 2 hits. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 40893. |
| SOURCE | Search... |
Entry information
| Entry name | PLK2_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9NYY3 Secondary accession number(s): O60679, Q96CV7, Q9UE61 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 5 Human chromosome 5: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| Human and mouse protein kinases Human and mouse protein kinases: classification and index |
| SIMILARITY comments Index of protein domains and families |

Clusters with


