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Q9NYY1

- IL20_HUMAN

UniProt

Q9NYY1 - IL20_HUMAN

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Protein

Interleukin-20

Gene
IL20, ZCYTO10, UNQ852/PRO1801
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Proinflammatory and angiogenic cytokine that may be involved in epidermal function and psoriasis. Angiogenic and proliferative activities are antagonized by IL10. May act through STAT3.1 Publication

GO - Molecular functioni

  1. interleukin-20 receptor binding Source: UniProtKB

GO - Biological processi

  1. positive regulation of epidermal cell differentiation Source: UniProtKB
  2. positive regulation of keratinocyte differentiation Source: UniProtKB
  3. positive regulation of osteoclast differentiation Source: Ensembl
  4. positive regulation of tyrosine phosphorylation of Stat3 protein Source: UniProtKB
  5. regulation of inflammatory response Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Enzyme and pathway databases

SignaLinkiQ9NYY1.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-20
Short name:
IL-20
Alternative name(s):
Cytokine Zcyto10
Gene namesi
Name:IL20
Synonyms:ZCYTO10
ORF Names:UNQ852/PRO1801
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:6002. IL20.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
  2. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29817.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 24241 PublicationAdd
BLAST
Chaini25 – 176152Interleukin-20PRO_0000015381Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 1261 Publication
Disulfide bondi80 ↔ 1321 Publication
Disulfide bondi81 ↔ 1341 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9NYY1.
PRIDEiQ9NYY1.

Expressioni

Tissue specificityi

Expressed in most tissues and five major cell types: epithelial cells (primarily skin, buccal mucosa, tongue, nasal mucosa, lung, ureter, breast, prostate, fallopian tube, and adrenal gland), myoepithelial cells (mainly prostate), endothelial cells (mainly in small vessels or capillaries), macrophages, and skeletal muscle. Isoform 2 was detected in the lung tissue only.2 Publications

Inductioni

Up-regulated by UV-B irradiation in epithelial keratinocytes.1 Publication

Gene expression databases

ArrayExpressiQ9NYY1.
BgeeiQ9NYY1.
CleanExiHS_IL20.
GenevestigatoriQ9NYY1.

Organism-specific databases

HPAiCAB025802.

Interactioni

Subunit structurei

Forms a 1:1:1 heterotrimeric complex with its primary high-affinity heterodimeric receptor IL20RA/IL20RB.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000356063.

Structurei

Secondary structure

1
176
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi26 – 305
Beta strandi33 – 375
Helixi39 – 479
Helixi50 – 556
Beta strandi67 – 693
Helixi76 – 9318
Helixi95 – 973
Helixi103 – 12826
Helixi136 – 15116
Helixi154 – 1629
Helixi165 – 17410

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4DOHX-ray2.80A/C25-176[»]
ProteinModelPortaliQ9NYY1.
SMRiQ9NYY1. Positions 24-176.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-10 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG45485.
HOGENOMiHOG000113033.
HOVERGENiHBG108002.
InParanoidiQ9NYY1.
KOiK05444.
OMAiQCCLLRH.
OrthoDBiEOG7060SK.
PhylomeDBiQ9NYY1.
TreeFamiTF333253.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020443. IL-10/19/20/24/26_fam.
IPR020423. IL-10_CS.
IPR020442. IL-20.
[Graphical view]
PANTHERiPTHR11585. PTHR11585. 1 hit.
PfamiPF00726. IL10. 1 hit.
[Graphical view]
PRINTSiPR01935. INTRLEUKIN20.
SMARTiSM00188. IL10. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NYY1-1) [UniParc]FASTAAdd to Basket

Also known as: IL-20W, Wild type

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKASSLAFSL LSAAFYLLWT PSTGLKTLNL GSCVIATNLQ EIRNGFSEIR    50
GSVQAKDGNI DIRILRRTES LQDTKPANRC CLLRHLLRLY LDRVFKNYQT 100
PDHYTLRKIS SLANSFLTIK KDLRLCHAHM TCHCGEEAMK KYSQILSHFE 150
KLEPQAAVVK ALGELDILLQ WMEETE 176
Length:176
Mass (Da):20,072
Last modified:October 31, 2003 - v2
Checksum:i8385992500B6C447
GO
Isoform 2 (identifier: Q9NYY1-2) [UniParc]FASTAAdd to Basket

Also known as: IL-20S, ex4-del, Short

The sequence of this isoform differs from the canonical sequence as follows:
     127-151: Missing.

Note: Lung-specific.

Show »
Length:151
Mass (Da):17,144
Checksum:i417BF88DDD9E5DCA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti107 – 1071R → Q.
Corresponds to variant rs35856950 [ dbSNP | Ensembl ].
VAR_049577

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei127 – 15125Missing in isoform 2. VSP_054904Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti48 – 481E → D in AAF36679. 1 Publication
Sequence conflicti126 – 1261C → S in AAQ88686. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF224266 mRNA. Translation: AAF36679.1.
AY876922 mRNA. Translation: AAW78348.1.
AY358320 mRNA. Translation: AAQ88686.1.
AF402002 Genomic DNA. Translation: AAK84423.1.
AC098935 Genomic DNA. No translation available.
BC069311 mRNA. Translation: AAH69311.1.
BC069364 mRNA. Translation: AAH69364.1.
BC069398 mRNA. Translation: AAH69398.1.
BC069425 mRNA. Translation: AAH69425.1.
BC069449 mRNA. Translation: AAH69449.1.
BC069487 mRNA. Translation: AAH69487.1.
BC069523 mRNA. Translation: AAH69523.1.
BC069559 mRNA. Translation: AAH69559.1.
BC074948 mRNA. Translation: AAH74948.1.
BC074949 mRNA. Translation: AAH74949.1.
BC117386 mRNA. Translation: AAI17387.1.
BC117390 mRNA. Translation: AAI17391.1.
CCDSiCCDS1470.1. [Q9NYY1-1]
RefSeqiNP_061194.2. NM_018724.3. [Q9NYY1-1]
XP_005273210.1. XM_005273153.1. [Q9NYY1-2]
UniGeneiHs.272373.

Genome annotation databases

EnsembliENST00000367096; ENSP00000356063; ENSG00000162891.
ENST00000367098; ENSP00000356065; ENSG00000162891.
ENST00000391930; ENSP00000375796; ENSG00000162891.
GeneIDi50604.
KEGGihsa:50604.
UCSCiuc001her.3. human. [Q9NYY1-1]

Polymorphism databases

DMDMi38258955.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF224266 mRNA. Translation: AAF36679.1 .
AY876922 mRNA. Translation: AAW78348.1 .
AY358320 mRNA. Translation: AAQ88686.1 .
AF402002 Genomic DNA. Translation: AAK84423.1 .
AC098935 Genomic DNA. No translation available.
BC069311 mRNA. Translation: AAH69311.1 .
BC069364 mRNA. Translation: AAH69364.1 .
BC069398 mRNA. Translation: AAH69398.1 .
BC069425 mRNA. Translation: AAH69425.1 .
BC069449 mRNA. Translation: AAH69449.1 .
BC069487 mRNA. Translation: AAH69487.1 .
BC069523 mRNA. Translation: AAH69523.1 .
BC069559 mRNA. Translation: AAH69559.1 .
BC074948 mRNA. Translation: AAH74948.1 .
BC074949 mRNA. Translation: AAH74949.1 .
BC117386 mRNA. Translation: AAI17387.1 .
BC117390 mRNA. Translation: AAI17391.1 .
CCDSi CCDS1470.1. [Q9NYY1-1 ]
RefSeqi NP_061194.2. NM_018724.3. [Q9NYY1-1 ]
XP_005273210.1. XM_005273153.1. [Q9NYY1-2 ]
UniGenei Hs.272373.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4DOH X-ray 2.80 A/C 25-176 [» ]
ProteinModelPortali Q9NYY1.
SMRi Q9NYY1. Positions 24-176.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000356063.

Polymorphism databases

DMDMi 38258955.

Proteomic databases

PaxDbi Q9NYY1.
PRIDEi Q9NYY1.

Protocols and materials databases

DNASUi 50604.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000367096 ; ENSP00000356063 ; ENSG00000162891 .
ENST00000367098 ; ENSP00000356065 ; ENSG00000162891 .
ENST00000391930 ; ENSP00000375796 ; ENSG00000162891 .
GeneIDi 50604.
KEGGi hsa:50604.
UCSCi uc001her.3. human. [Q9NYY1-1 ]

Organism-specific databases

CTDi 50604.
GeneCardsi GC01P207038.
HGNCi HGNC:6002. IL20.
HPAi CAB025802.
MIMi 605619. gene.
neXtProti NX_Q9NYY1.
PharmGKBi PA29817.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG45485.
HOGENOMi HOG000113033.
HOVERGENi HBG108002.
InParanoidi Q9NYY1.
KOi K05444.
OMAi QCCLLRH.
OrthoDBi EOG7060SK.
PhylomeDBi Q9NYY1.
TreeFami TF333253.

Enzyme and pathway databases

SignaLinki Q9NYY1.

Miscellaneous databases

GenomeRNAii 50604.
NextBioi 53100.
PROi Q9NYY1.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9NYY1.
Bgeei Q9NYY1.
CleanExi HS_IL20.
Genevestigatori Q9NYY1.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020443. IL-10/19/20/24/26_fam.
IPR020423. IL-10_CS.
IPR020442. IL-20.
[Graphical view ]
PANTHERi PTHR11585. PTHR11585. 1 hit.
Pfami PF00726. IL10. 1 hit.
[Graphical view ]
PRINTSi PR01935. INTRLEUKIN20.
SMARTi SM00188. IL10. 1 hit.
[Graphical view ]
SUPFAMi SSF47266. SSF47266. 1 hit.
PROSITEi PS00520. INTERLEUKIN_10. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Interleukin-20 promotes angiogenesis in a direct and indirect manner."
    Hsieh M.Y., Chen W.Y., Jiang M.J., Cheng B.C., Huang T.Y., Chang M.S.
    Genes Immun. 7:234-242(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, ALTERNATIVE SPLICING, TISSUE SPECIFICITY (ISOFORM 2).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. SeattleSNPs variation discovery resource
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-39.
  8. "Tissue microarray analysis of interleukin-20 expression."
    Hsing C.H., Ho C.L., Chang L.Y., Lee Y.L., Chuang S.S., Chang M.S.
    Cytokine 35:44-52(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  9. "Ultraviolet B light stimulates interleukin-20 expression by human epithelial keratinocytes."
    Hunt D.W., Boivin W.A., Fairley L.A., Jovanovic M.M., King D.E., Salmon R.A., Utting O.B.
    Photochem. Photobiol. 82:1292-1300(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY UV-B.
  10. "Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines."
    Logsdon N.J., Deshpande A., Harris B.D., Rajashankar K.R., Walter M.R.
    Proc. Natl. Acad. Sci. U.S.A. 109:12704-12709(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 25-176 IN COMPLEX WITH IL20RA AND IL20RB, SUBUNIT, DISULFIDE BONDS.

Entry informationi

Entry nameiIL20_HUMAN
AccessioniPrimary (citable) accession number: Q9NYY1
Secondary accession number(s): Q17RB3, Q2THG6, Q96QZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: October 31, 2003
Last modified: September 3, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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