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Q9NYY1 (IL20_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-20

Short name=IL-20
Alternative name(s):
Cytokine Zcyto10
Gene names
Name:IL20
Synonyms:ZCYTO10
ORF Names:UNQ852/PRO1801
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length176 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3.

Subcellular location

Secreted.

Tissue specificity

Expressed at very low levels in skin, trachea, and other tissues.

Sequence similarities

Belongs to the IL-10 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Ref.5
Chain25 – 176152Interleukin-20
PRO_0000015381

Amino acid modifications

Disulfide bond33 ↔ 126 Potential
Disulfide bond80 ↔ 132 Potential
Disulfide bond81 ↔ 134 Potential

Natural variations

Natural variant1071R → Q.
Corresponds to variant rs35856950 [ dbSNP | Ensembl ].
VAR_049577

Experimental info

Sequence conflict481E → D in AAF36679. Ref.1
Sequence conflict1261C → S in AAQ88686. Ref.2

Secondary structure

....................... 176
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9NYY1 [UniParc].

Last modified October 31, 2003. Version 2.
Checksum: 8385992500B6C447

FASTA17620,072
        10         20         30         40         50         60 
MKASSLAFSL LSAAFYLLWT PSTGLKTLNL GSCVIATNLQ EIRNGFSEIR GSVQAKDGNI 

        70         80         90        100        110        120 
DIRILRRTES LQDTKPANRC CLLRHLLRLY LDRVFKNYQT PDHYTLRKIS SLANSFLTIK 

       130        140        150        160        170 
KDLRLCHAHM TCHCGEEAMK KYSQILSHFE KLEPQAAVVK ALGELDILLQ WMEETE 

« Hide

References

« Hide 'large scale' references
[1]"Interleukin 20: discovery, receptor identification, and role in epidermal function."
Blumberg H., Conklin D., Xu W.F., Grossmann A., Brender T., Carollo S., Eagan M., Foster D., Haldeman B.A., Hammond A., Haugen H., Jelinek L., Kelly J.D., Madden K., Maurer M.F., Parrish-Novak J., Prunkard D., Sexson S. expand/collapse author list , Sprecher C., Waggie K., West J., Whitmore T.E., Yao L., Kuechle M.K., Dale B.A., Chandrasekher Y.A.
Cell 104:9-19(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]SeattleSNPs variation discovery resource
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[5]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 25-39.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF224266 mRNA. Translation: AAF36679.1.
AY358320 mRNA. Translation: AAQ88686.1.
AF402002 Genomic DNA. Translation: AAK84423.1.
BC069311 mRNA. Translation: AAH69311.1.
BC069364 mRNA. Translation: AAH69364.1.
BC069398 mRNA. Translation: AAH69398.1.
BC069425 mRNA. Translation: AAH69425.1.
BC069449 mRNA. Translation: AAH69449.1.
BC069487 mRNA. Translation: AAH69487.1.
BC069523 mRNA. Translation: AAH69523.1.
BC069559 mRNA. Translation: AAH69559.1.
BC074948 mRNA. Translation: AAH74948.1.
BC074949 mRNA. Translation: AAH74949.1.
BC117386 mRNA. Translation: AAI17387.1.
BC117390 mRNA. Translation: AAI17391.1.
RefSeqNP_061194.2. NM_018724.3.
UniGeneHs.272373.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4DOHX-ray2.80A/C25-176[»]
ProteinModelPortalQ9NYY1.
SMRQ9NYY1. Positions 24-176.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000356063.

Polymorphism databases

DMDM38258955.

Proteomic databases

PaxDbQ9NYY1.
PRIDEQ9NYY1.

Protocols and materials databases

DNASU50604.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000367096; ENSP00000356063; ENSG00000162891.
ENST00000367098; ENSP00000356065; ENSG00000162891.
GeneID50604.
KEGGhsa:50604.
UCSCuc001her.3. human.

Organism-specific databases

CTD50604.
GeneCardsGC01P207038.
HGNCHGNC:6002. IL20.
HPACAB025802.
MIM605619. gene.
neXtProtNX_Q9NYY1.
PharmGKBPA29817.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG45485.
HOGENOMHOG000113033.
HOVERGENHBG108002.
InParanoidQ9NYY1.
KOK05444.
OMACVITTNL.
OrthoDBEOG7060SK.
PhylomeDBQ9NYY1.
TreeFamTF333253.

Enzyme and pathway databases

SignaLinkQ9NYY1.

Gene expression databases

ArrayExpressQ9NYY1.
BgeeQ9NYY1.
CleanExHS_IL20.
GenevestigatorQ9NYY1.

Family and domain databases

Gene3D1.20.1250.10. 1 hit.
InterProIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020443. IL-10/19/20/24/26_fam.
IPR020423. IL-10_CS.
IPR020442. IL-20.
[Graphical view]
PANTHERPTHR11585. PTHR11585. 1 hit.
PfamPF00726. IL10. 1 hit.
[Graphical view]
PRINTSPR01935. INTRLEUKIN20.
SMARTSM00188. IL10. 1 hit.
[Graphical view]
SUPFAMSSF47266. SSF47266. 1 hit.
PROSITEPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi50604.
NextBio53100.
PROQ9NYY1.
SOURCESearch...

Entry information

Entry nameIL20_HUMAN
AccessionPrimary (citable) accession number: Q9NYY1
Secondary accession number(s): Q17RB3, Q96QZ6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: October 31, 2003
Last modified: April 16, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM