Interleukin-20 precursor - Homo sapiens (Human)

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Q9NYY1 (IL20_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 110. History...

Clusters with 100%, 90%, 50% identity |

Documents (6) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Interleukin-20
Short name=IL-20

Alternative name(s):
Cytokine Zcyto10

Gene names

Name:	IL20
Synonyms:	ZCYTO10
ORF Names:	UNQ852/PRO1801

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	176 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3.
Subcellular location	Secreted.
Tissue specificity	Expressed at very low levels in skin, trachea, and other tissues.
Sequence similarities	Belongs to the IL-10 family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Cytokine
PTM	Disulfide bond
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of keratinocyte differentiation Traceable author statement PubMed 11470428. Source: UniProtKB positive regulation of tyrosine phosphorylation of Stat3 protein Traceable author statement PubMed 11470428. Source: UniProtKB regulation of inflammatory response Traceable author statement PubMed 11470428. Source: UniProtKB
Cellular_component	extracellular region Traceable author statement PubMed 11470428. Source: UniProtKB extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	interleukin-20 receptor binding Traceable author statement PubMed 11470428. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 24

Ref.5

Chain

25 – 176

152

Interleukin-20

PRO_0000015381

Amino acid modifications

Disulfide bond

33 ↔ 126

Potential

Disulfide bond

80 ↔ 132

Potential

Disulfide bond

81 ↔ 134

Potential

Natural variations

Natural variant

107

R → Q.
Corresponds to variant rs35856950 [ dbSNP | Ensembl ].

VAR_049577

Experimental info

Sequence conflict

E → D in AAF36679. Ref.1

Sequence conflict

126

C → S in AAQ88686. Ref.2

Secondary structure

176

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

Q9NYY1 [UniParc].

Last modified October 31, 2003. Version 2.
Checksum: 8385992500B6C447
Show »

FASTA

176

20,072

        10         20         30         40         50         60 
MKASSLAFSL LSAAFYLLWT PSTGLKTLNL GSCVIATNLQ EIRNGFSEIR GSVQAKDGNI 

        70         80         90        100        110        120 
DIRILRRTES LQDTKPANRC CLLRHLLRLY LDRVFKNYQT PDHYTLRKIS SLANSFLTIK 

       130        140        150        160        170 
KDLRLCHAHM TCHCGEEAMK KYSQILSHFE KLEPQAAVVK ALGELDILLQ WMEETE

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Interleukin 20: discovery, receptor identification, and role in epidermal function." Blumberg H., Conklin D., Xu W.F., Grossmann A., Brender T., Carollo S., Eagan M., Foster D., Haldeman B.A., Hammond A., Haugen H., Jelinek L., Kelly J.D., Madden K., Maurer M.F., Parrish-Novak J., Prunkard D., Sexson S. Chandrasekher Y.A. Cell 104:9-19(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	SeattleSNPs variation discovery resource Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[5]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 25-39.
+	Additional computationally mapped references.

Web resources

SeattleSNPs

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF224266 mRNA. Translation: AAF36679.1.
AY358320 mRNA. Translation: AAQ88686.1.
AF402002 Genomic DNA. Translation: AAK84423.1.
BC069311 mRNA. Translation: AAH69311.1.
BC069364 mRNA. Translation: AAH69364.1.
BC069398 mRNA. Translation: AAH69398.1.
BC069425 mRNA. Translation: AAH69425.1.
BC069449 mRNA. Translation: AAH69449.1.
BC069487 mRNA. Translation: AAH69487.1.
BC069523 mRNA. Translation: AAH69523.1.
BC069559 mRNA. Translation: AAH69559.1.
BC074948 mRNA. Translation: AAH74948.1.
BC074949 mRNA. Translation: AAH74949.1.
BC117386 mRNA. Translation: AAI17387.1.
BC117390 mRNA. Translation: AAI17391.1.

IPI

IPI00000048.

RefSeq

NP_061194.2. NM_018724.3.

UniGene

Hs.272373.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4DOH	X-ray	2.80	A/C	25-176	[»]

ProteinModelPortal

Q9NYY1.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000356063.

Polymorphism databases

DMDM

38258955.

Proteomic databases

PaxDb

Q9NYY1.

PRIDE

Q9NYY1.

Protocols and materials databases

DNASU

50604.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000367096; ENSP00000356063; ENSG00000162891.
ENST00000367098; ENSP00000356065; ENSG00000162891.

GeneID

50604.

KEGG

hsa:50604.

UCSC

uc001her.3. human.

Organism-specific databases

CTD

50604.

GeneCards

GC01P207038.

HGNC

HGNC:6002. IL20.

HPA

CAB025802.

MIM

605619. gene.

neXtProt

NX_Q9NYY1.

PharmGKB

PA29817.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG45485.

HOGENOM

HOG000113033.

HOVERGEN

HBG108002.

InParanoid

Q9NYY1.

K05444.

OMA

YQTPDHH.

OrthoDB

EOG4D26RF.

PhylomeDB

Q9NYY1.

Gene expression databases

ArrayExpress

Q9NYY1.

Bgee

Q9NYY1.

CleanEx

HS_IL20.

Genevestigator

Q9NYY1.

GermOnline

ENSG00000162891. Homo sapiens.

Family and domain databases

Gene3D

1.20.1250.10. 1 hit.

InterPro

IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020443. Interleukin-10/19/20/24.
IPR020423. Interleukin-10_CS.
IPR020442. Interleukin-20.
[Graphical view]

PANTHER

PTHR11585. PTHR11585. 1 hit.

Pfam

PF00726. IL10. 1 hit.
[Graphical view]

PRINTS

PR01935. INTRLEUKIN20.

SMART

SM00188. IL10. 1 hit.
[Graphical view]

SUPFAM

SSF47266. 4_helix_cytokine. 1 hit.

PROSITE

PS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

GenomeRNAi

50604.

NextBio

53100.

SOURCE

Search...

Entry information

Entry name

IL20_HUMAN

Accession

Primary (citable) accession number: Q9NYY1
Secondary accession number(s): Q17RB3, Q96QZ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 16, 2001
Last sequence update:	October 31, 2003
Last modified:	May 1, 2013
This is version 110 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Amino acid modifications

Natural variations

Experimental info

Secondary structure

Sequences

References

Web resources

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents