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Protein

Interleukin-20

Gene

IL20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Proinflammatory and angiogenic cytokine that may be involved in epidermal function and psoriasis. Angiogenic and proliferative activities are antagonized by IL10. May act through STAT3.1 Publication

GO - Molecular functioni

  1. cytokine activity Source: GO_Central
  2. interleukin-20 receptor binding Source: UniProtKB
  3. interleukin-22 receptor binding Source: GO_Central

GO - Biological processi

  1. immune response Source: GO_Central
  2. inflammatory response Source: GO_Central
  3. positive regulation of epidermal cell differentiation Source: UniProtKB
  4. positive regulation of JAK-STAT cascade Source: GO_Central
  5. positive regulation of keratinocyte differentiation Source: UniProtKB
  6. positive regulation of osteoclast differentiation Source: Ensembl
  7. positive regulation of tyrosine phosphorylation of Stat3 protein Source: UniProtKB
  8. regulation of inflammatory response Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Enzyme and pathway databases

SignaLinkiQ9NYY1.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-20
Short name:
IL-20
Alternative name(s):
Cytokine Zcyto10
Gene namesi
Name:IL20
Synonyms:ZCYTO10
ORF Names:UNQ852/PRO1801
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:6002. IL20.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
  2. extracellular space Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29817.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 24241 PublicationAdd
BLAST
Chaini25 – 176152Interleukin-20PRO_0000015381Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 1261 Publication
Disulfide bondi80 ↔ 1321 Publication
Disulfide bondi81 ↔ 1341 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9NYY1.
PRIDEiQ9NYY1.

Expressioni

Tissue specificityi

Expressed in most tissues and five major cell types: epithelial cells (primarily skin, buccal mucosa, tongue, nasal mucosa, lung, ureter, breast, prostate, fallopian tube, and adrenal gland), myoepithelial cells (mainly prostate), endothelial cells (mainly in small vessels or capillaries), macrophages, and skeletal muscle. Isoform 2 was detected in the lung tissue only.1 Publication

Inductioni

Up-regulated by UV-B irradiation in epithelial keratinocytes.1 Publication

Gene expression databases

BgeeiQ9NYY1.
CleanExiHS_IL20.
GenevestigatoriQ9NYY1.

Organism-specific databases

HPAiCAB025802.

Interactioni

Subunit structurei

Forms a 1:1:1 heterotrimeric complex with its primary high-affinity heterodimeric receptor IL20RA/IL20RB.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000356063.

Structurei

Secondary structure

1
176
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi26 – 305Combined sources
Beta strandi33 – 375Combined sources
Helixi39 – 479Combined sources
Helixi50 – 556Combined sources
Beta strandi67 – 693Combined sources
Helixi76 – 9318Combined sources
Helixi95 – 973Combined sources
Helixi103 – 12826Combined sources
Helixi136 – 15116Combined sources
Helixi154 – 1629Combined sources
Helixi165 – 17410Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4DOHX-ray2.80A/C25-176[»]
ProteinModelPortaliQ9NYY1.
SMRiQ9NYY1. Positions 24-176.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG45485.
GeneTreeiENSGT00410000025637.
HOGENOMiHOG000113033.
HOVERGENiHBG108002.
InParanoidiQ9NYY1.
KOiK05444.
OMAiQCCLLRH.
OrthoDBiEOG7060SK.
PhylomeDBiQ9NYY1.
TreeFamiTF333253.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020443. IL-10/19/20/24/26_fam.
IPR020423. IL-10_CS.
IPR020442. IL-20.
[Graphical view]
PANTHERiPTHR11585. PTHR11585. 1 hit.
PfamiPF00726. IL10. 1 hit.
[Graphical view]
PRINTSiPR01935. INTRLEUKIN20.
SMARTiSM00188. IL10. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NYY1-1) [UniParc]FASTAAdd to basket

Also known as: IL-20W, Wild type

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKASSLAFSL LSAAFYLLWT PSTGLKTLNL GSCVIATNLQ EIRNGFSEIR
60 70 80 90 100
GSVQAKDGNI DIRILRRTES LQDTKPANRC CLLRHLLRLY LDRVFKNYQT
110 120 130 140 150
PDHYTLRKIS SLANSFLTIK KDLRLCHAHM TCHCGEEAMK KYSQILSHFE
160 170
KLEPQAAVVK ALGELDILLQ WMEETE
Length:176
Mass (Da):20,072
Last modified:October 31, 2003 - v2
Checksum:i8385992500B6C447
GO
Isoform 2 (identifier: Q9NYY1-2) [UniParc]FASTAAdd to basket

Also known as: IL-20S, ex4-del, Short

The sequence of this isoform differs from the canonical sequence as follows:
     127-151: Missing.

Note: Lung-specific.

Show »
Length:151
Mass (Da):17,144
Checksum:i417BF88DDD9E5DCA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti48 – 481E → D in AAF36679 (PubMed:11163236).Curated
Sequence conflicti126 – 1261C → S in AAQ88686 (PubMed:12975309).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti107 – 1071R → Q.
Corresponds to variant rs35856950 [ dbSNP | Ensembl ].
VAR_049577

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei127 – 15125Missing in isoform 2. 1 PublicationVSP_054904Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF224266 mRNA. Translation: AAF36679.1.
AY876922 mRNA. Translation: AAW78348.1.
AY358320 mRNA. Translation: AAQ88686.1.
AF402002 Genomic DNA. Translation: AAK84423.1.
AC098935 Genomic DNA. No translation available.
BC069311 mRNA. Translation: AAH69311.1.
BC069364 mRNA. Translation: AAH69364.1.
BC069398 mRNA. Translation: AAH69398.1.
BC069425 mRNA. Translation: AAH69425.1.
BC069449 mRNA. Translation: AAH69449.1.
BC069487 mRNA. Translation: AAH69487.1.
BC069523 mRNA. Translation: AAH69523.1.
BC069559 mRNA. Translation: AAH69559.1.
BC074948 mRNA. Translation: AAH74948.1.
BC074949 mRNA. Translation: AAH74949.1.
BC117386 mRNA. Translation: AAI17387.1.
BC117390 mRNA. Translation: AAI17391.1.
CCDSiCCDS1470.1. [Q9NYY1-1]
RefSeqiNP_061194.2. NM_018724.3. [Q9NYY1-1]
XP_005273210.1. XM_005273153.1. [Q9NYY1-2]
UniGeneiHs.272373.

Genome annotation databases

EnsembliENST00000367096; ENSP00000356063; ENSG00000162891. [Q9NYY1-1]
ENST00000367098; ENSP00000356065; ENSG00000162891. [Q9NYY1-1]
ENST00000391930; ENSP00000375796; ENSG00000162891. [Q9NYY1-2]
GeneIDi50604.
KEGGihsa:50604.
UCSCiuc001her.3. human. [Q9NYY1-1]
uc009xby.3. human.

Polymorphism databases

DMDMi38258955.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF224266 mRNA. Translation: AAF36679.1.
AY876922 mRNA. Translation: AAW78348.1.
AY358320 mRNA. Translation: AAQ88686.1.
AF402002 Genomic DNA. Translation: AAK84423.1.
AC098935 Genomic DNA. No translation available.
BC069311 mRNA. Translation: AAH69311.1.
BC069364 mRNA. Translation: AAH69364.1.
BC069398 mRNA. Translation: AAH69398.1.
BC069425 mRNA. Translation: AAH69425.1.
BC069449 mRNA. Translation: AAH69449.1.
BC069487 mRNA. Translation: AAH69487.1.
BC069523 mRNA. Translation: AAH69523.1.
BC069559 mRNA. Translation: AAH69559.1.
BC074948 mRNA. Translation: AAH74948.1.
BC074949 mRNA. Translation: AAH74949.1.
BC117386 mRNA. Translation: AAI17387.1.
BC117390 mRNA. Translation: AAI17391.1.
CCDSiCCDS1470.1. [Q9NYY1-1]
RefSeqiNP_061194.2. NM_018724.3. [Q9NYY1-1]
XP_005273210.1. XM_005273153.1. [Q9NYY1-2]
UniGeneiHs.272373.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4DOHX-ray2.80A/C25-176[»]
ProteinModelPortaliQ9NYY1.
SMRiQ9NYY1. Positions 24-176.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000356063.

Polymorphism databases

DMDMi38258955.

Proteomic databases

PaxDbiQ9NYY1.
PRIDEiQ9NYY1.

Protocols and materials databases

DNASUi50604.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367096; ENSP00000356063; ENSG00000162891. [Q9NYY1-1]
ENST00000367098; ENSP00000356065; ENSG00000162891. [Q9NYY1-1]
ENST00000391930; ENSP00000375796; ENSG00000162891. [Q9NYY1-2]
GeneIDi50604.
KEGGihsa:50604.
UCSCiuc001her.3. human. [Q9NYY1-1]
uc009xby.3. human.

Organism-specific databases

CTDi50604.
GeneCardsiGC01P207038.
HGNCiHGNC:6002. IL20.
HPAiCAB025802.
MIMi605619. gene.
neXtProtiNX_Q9NYY1.
PharmGKBiPA29817.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG45485.
GeneTreeiENSGT00410000025637.
HOGENOMiHOG000113033.
HOVERGENiHBG108002.
InParanoidiQ9NYY1.
KOiK05444.
OMAiQCCLLRH.
OrthoDBiEOG7060SK.
PhylomeDBiQ9NYY1.
TreeFamiTF333253.

Enzyme and pathway databases

SignaLinkiQ9NYY1.

Miscellaneous databases

GenomeRNAii50604.
NextBioi53100.
PROiQ9NYY1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NYY1.
CleanExiHS_IL20.
GenevestigatoriQ9NYY1.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020443. IL-10/19/20/24/26_fam.
IPR020423. IL-10_CS.
IPR020442. IL-20.
[Graphical view]
PANTHERiPTHR11585. PTHR11585. 1 hit.
PfamiPF00726. IL10. 1 hit.
[Graphical view]
PRINTSiPR01935. INTRLEUKIN20.
SMARTiSM00188. IL10. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Interleukin-20 promotes angiogenesis in a direct and indirect manner."
    Hsieh M.Y., Chen W.Y., Jiang M.J., Cheng B.C., Huang T.Y., Chang M.S.
    Genes Immun. 7:234-242(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, ALTERNATIVE SPLICING, TISSUE SPECIFICITY (ISOFORM 2).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. SeattleSNPs variation discovery resource
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-39.
  8. "Tissue microarray analysis of interleukin-20 expression."
    Hsing C.H., Ho C.L., Chang L.Y., Lee Y.L., Chuang S.S., Chang M.S.
    Cytokine 35:44-52(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  9. "Ultraviolet B light stimulates interleukin-20 expression by human epithelial keratinocytes."
    Hunt D.W., Boivin W.A., Fairley L.A., Jovanovic M.M., King D.E., Salmon R.A., Utting O.B.
    Photochem. Photobiol. 82:1292-1300(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY UV-B.
  10. "Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines."
    Logsdon N.J., Deshpande A., Harris B.D., Rajashankar K.R., Walter M.R.
    Proc. Natl. Acad. Sci. U.S.A. 109:12704-12709(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 25-176 IN COMPLEX WITH IL20RA AND IL20RB, SUBUNIT, DISULFIDE BONDS.

Entry informationi

Entry nameiIL20_HUMAN
AccessioniPrimary (citable) accession number: Q9NYY1
Secondary accession number(s): Q17RB3, Q2THG6, Q96QZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: October 31, 2003
Last modified: February 4, 2015
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.