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Protein

RB-associated KRAB zinc finger protein

Gene

RBAK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May repress E2F-dependent transcription. May promote AR-dependent transcription.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri261 – 283C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri289 – 311C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 339C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri345 – 367C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 423C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri429 – 451C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri457 – 479C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri485 – 505C2H2-type 9PROSITE-ProRule annotationAdd BLAST21
Zinc fingeri511 – 533C2H2-type 10; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri539 – 561C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri567 – 589C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri595 – 617C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri623 – 645C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri651 – 673C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri679 – 701C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • nucleic acid binding Source: InterPro
  • zinc ion binding Source: UniProtKB

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RB-associated KRAB zinc finger protein
Alternative name(s):
RB-associated KRAB repressor
Short name:
hRBaK
Zinc finger protein 769
Gene namesi
Name:RBAK
Synonyms:ZNF769
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:17680. RBAK.

Subcellular locationi

GO - Cellular componenti

  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi57786.
OpenTargetsiENSG00000146587.
PharmGKBiPA162400745.

Polymorphism and mutation databases

BioMutaiRBAK.
DMDMi74761820.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003169761 – 714RB-associated KRAB zinc finger proteinAdd BLAST714

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki97Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki259Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki315Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki357Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki534Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki537Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ9NYW8.
MaxQBiQ9NYW8.
PaxDbiQ9NYW8.
PeptideAtlasiQ9NYW8.
PRIDEiQ9NYW8.

PTM databases

iPTMnetiQ9NYW8.
PhosphoSitePlusiQ9NYW8.

Expressioni

Tissue specificityi

Expressed in bone, brain, heart, kidney, liver, lung, pancreas and placenta.1 Publication

Gene expression databases

BgeeiENSG00000146587.
CleanExiHS_RBAK.
GenevisibleiQ9NYW8. HS.

Organism-specific databases

HPAiHPA071231.

Interactioni

Subunit structurei

Interacts with AR and RB1. May also interact with other nuclear hormone receptors such as NR3C1/GR.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi121759. 14 interactors.
DIPiDIP-39336N.
IntActiQ9NYW8. 30 interactors.
STRINGi9606.ENSP00000275423.

Structurei

3D structure databases

ProteinModelPortaliQ9NYW8.
SMRiQ9NYW8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 79KRABPROSITE-ProRule annotationAdd BLAST72

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni171 – 260Required for interaction with RB11 PublicationAdd BLAST90
Regioni417 – 714Interaction with AR1 PublicationAdd BLAST298

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri261 – 283C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri289 – 311C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 339C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri345 – 367C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 423C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri429 – 451C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri457 – 479C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri485 – 505C2H2-type 9PROSITE-ProRule annotationAdd BLAST21
Zinc fingeri511 – 533C2H2-type 10; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri539 – 561C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri567 – 589C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri595 – 617C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri623 – 645C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri651 – 673C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri679 – 701C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133681.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9NYW8.
KOiK09228.
OMAiLTIHYRS.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9NYW8.
TreeFamiTF350803.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.40.10. 4 hits.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 16 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 10 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NYW8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNTLQGPVSF KDVAVDFTQE EWQQLDPDEK ITYRDVMLEN YSHLVSVGYD
60 70 80 90 100
TTKPNVIIKL EQGEEPWIMG GEFPCQHSPE AWRVDDLIER IQENEDKHSR
110 120 130 140 150
QAACINSKTL TEEKENTFSQ IYMETSLVPS SIIAHNCVSC GKNLESISQL
160 170 180 190 200
ISSDGSYART KPDECNECGK TYHGEKMCEF NQNGDTYSHN EENILQKISI
210 220 230 240 250
LEKPFEYNEC MEALDNEAVF IAHKRAYIGE KPYEWNDSGP DFIQMSNFNA
260 270 280 290 300
YQRSQMEMKP FECSECGKSF CKKSKFIIHQ RAHTGEKPYE CNVCGKSFSQ
310 320 330 340 350
KGTLTVHRRS HLEEKPYKCN ECGKTFCQKL HLTQHLRTHS GEKPYECSEC
360 370 380 390 400
GKTFCQKTHL TLHQRNHSGE RPYPCNECGK SFSRKSALSD HQRTHTGEKL
410 420 430 440 450
YKCNECGKSY YRKSTLITHQ RTHTGEKPYQ CSECGKFFSR VSYLTIHYRS
460 470 480 490 500
HLEEKPYECN ECGKTFNLNS AFIRHRKVHT EEKSHECSEC GKFSQLYLTD
510 520 530 540 550
HHTAHLEEKP YECNECGKTF LVNSAFDGHQ PLPKGEKSYE CNVCGKLFNE
560 570 580 590 600
LSYYTEHYRS HSEEKPYGCS ECGKTFSHNS SLFRHQRVHT GEKPYECYEC
610 620 630 640 650
GKFFSQKSYL TIHHRIHSGE KPYECSKCGK VFSRMSNLTV HYRSHSGEKP
660 670 680 690 700
YECNECGKVF SQKSYLTVHY RTHSGEKPYE CNECGKKFHH RSAFNSHQRI
710
HRRGNMNVLD VENL
Length:714
Mass (Da):82,995
Last modified:October 1, 2000 - v1
Checksum:i36D90A6206118F8B
GO
Isoform 2 (identifier: Q9NYW8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     80-113: EAWRVDDLIERIQENEDKHSRQAACINSKTLTEE → AALPAGHVAPAVAAAAAAPGRPGPHRQSRSPPGC
     114-714: Missing.

Note: No experimental confirmation available.
Show »
Length:113
Mass (Da):12,251
Checksum:i57840FE5CD3D700C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti273K → E in BAF85758 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038438229G → E. Corresponds to variant dbSNP:rs35352738Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04480580 – 113EAWRV…TLTEE → AALPAGHVAPAVAAAAAAPG RPGPHRQSRSPPGC in isoform 2. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_044806114 – 714Missing in isoform 2. 1 PublicationAdd BLAST601

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF226869 mRNA. Translation: AAF43389.1.
BM929719 mRNA. No translation available.
AK293069 mRNA. Translation: BAF85758.1.
AC092032 Genomic DNA. Translation: AAQ93364.1.
AC008167 Genomic DNA. No translation available.
CH471144 Genomic DNA. Translation: EAW87321.1.
BC136675 mRNA. Translation: AAI36676.1.
BC136676 mRNA. Translation: AAI36677.1.
CCDSiCCDS5337.1. [Q9NYW8-1]
RefSeqiNP_001191385.1. NM_001204456.1. [Q9NYW8-1]
NP_066986.1. NM_021163.3. [Q9NYW8-1]
UniGeneiHs.396178.

Genome annotation databases

EnsembliENST00000353796; ENSP00000275423; ENSG00000146587. [Q9NYW8-1]
ENST00000396912; ENSP00000380120; ENSG00000146587. [Q9NYW8-1]
GeneIDi57786.
KEGGihsa:57786.
UCSCiuc003sns.1. human. [Q9NYW8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRBAK_HUMAN
AccessioniPrimary (citable) accession number: Q9NYW8
Secondary accession number(s): A6NDF2
, A8KAK4, B2RN44, B9EGS1, F8W6M7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2000
Last modified: August 30, 2017
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families