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Protein

RB-associated KRAB zinc finger protein

Gene

RBAK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May repress E2F-dependent transcription. May promote AR-dependent transcription.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri261 – 28323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri289 – 31123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri317 – 33923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri345 – 36723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri373 – 39523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri401 – 42323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri429 – 45123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri457 – 47923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri485 – 50521C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri511 – 53323C2H2-type 10; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri539 – 56123C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri567 – 58923C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri595 – 61723C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri623 – 64523C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri651 – 67323C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri679 – 70123C2H2-type 16PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • nucleic acid binding Source: InterPro
  • zinc ion binding Source: UniProtKB

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RB-associated KRAB zinc finger protein
Alternative name(s):
RB-associated KRAB repressor
Short name:
hRBaK
Zinc finger protein 769
Gene namesi
Name:RBAK
Synonyms:ZNF769
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:17680. RBAK.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162400745.

Polymorphism and mutation databases

BioMutaiRBAK.
DMDMi74761820.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 714714RB-associated KRAB zinc finger proteinPRO_0000316976Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki534 – 534Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ9NYW8.
MaxQBiQ9NYW8.
PaxDbiQ9NYW8.
PeptideAtlasiQ9NYW8.
PRIDEiQ9NYW8.

PTM databases

iPTMnetiQ9NYW8.
PhosphoSiteiQ9NYW8.

Expressioni

Tissue specificityi

Expressed in bone, brain, heart, kidney, liver, lung, pancreas and placenta.1 Publication

Gene expression databases

BgeeiQ9NYW8.
CleanExiHS_RBAK.
GenevisibleiQ9NYW8. HS.

Interactioni

Subunit structurei

Interacts with AR and RB1. May also interact with other nuclear hormone receptors such as NR3C1/GR.2 Publications

Protein-protein interaction databases

BioGridi121759. 10 interactions.
DIPiDIP-39336N.
IntActiQ9NYW8. 4 interactions.
STRINGi9606.ENSP00000275423.

Structurei

3D structure databases

ProteinModelPortaliQ9NYW8.
SMRiQ9NYW8. Positions 135-703.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 7972KRABPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni171 – 26090Required for interaction with RB1Add
BLAST
Regioni417 – 714298Interaction with ARAdd
BLAST

Sequence similaritiesi

Contains 16 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri261 – 28323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri289 – 31123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri317 – 33923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri345 – 36723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri373 – 39523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri401 – 42323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri429 – 45123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri457 – 47923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri485 – 50521C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri511 – 53323C2H2-type 10; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri539 – 56123C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri567 – 58923C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri595 – 61723C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri623 – 64523C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri651 – 67323C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri679 – 70123C2H2-type 16PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129694.
ENSGT00840000129857.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9NYW8.
KOiK09228.
OMAiPDFIQMS.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9NYW8.
TreeFamiTF350803.

Family and domain databases

Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 16 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NYW8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNTLQGPVSF KDVAVDFTQE EWQQLDPDEK ITYRDVMLEN YSHLVSVGYD
60 70 80 90 100
TTKPNVIIKL EQGEEPWIMG GEFPCQHSPE AWRVDDLIER IQENEDKHSR
110 120 130 140 150
QAACINSKTL TEEKENTFSQ IYMETSLVPS SIIAHNCVSC GKNLESISQL
160 170 180 190 200
ISSDGSYART KPDECNECGK TYHGEKMCEF NQNGDTYSHN EENILQKISI
210 220 230 240 250
LEKPFEYNEC MEALDNEAVF IAHKRAYIGE KPYEWNDSGP DFIQMSNFNA
260 270 280 290 300
YQRSQMEMKP FECSECGKSF CKKSKFIIHQ RAHTGEKPYE CNVCGKSFSQ
310 320 330 340 350
KGTLTVHRRS HLEEKPYKCN ECGKTFCQKL HLTQHLRTHS GEKPYECSEC
360 370 380 390 400
GKTFCQKTHL TLHQRNHSGE RPYPCNECGK SFSRKSALSD HQRTHTGEKL
410 420 430 440 450
YKCNECGKSY YRKSTLITHQ RTHTGEKPYQ CSECGKFFSR VSYLTIHYRS
460 470 480 490 500
HLEEKPYECN ECGKTFNLNS AFIRHRKVHT EEKSHECSEC GKFSQLYLTD
510 520 530 540 550
HHTAHLEEKP YECNECGKTF LVNSAFDGHQ PLPKGEKSYE CNVCGKLFNE
560 570 580 590 600
LSYYTEHYRS HSEEKPYGCS ECGKTFSHNS SLFRHQRVHT GEKPYECYEC
610 620 630 640 650
GKFFSQKSYL TIHHRIHSGE KPYECSKCGK VFSRMSNLTV HYRSHSGEKP
660 670 680 690 700
YECNECGKVF SQKSYLTVHY RTHSGEKPYE CNECGKKFHH RSAFNSHQRI
710
HRRGNMNVLD VENL
Length:714
Mass (Da):82,995
Last modified:October 1, 2000 - v1
Checksum:i36D90A6206118F8B
GO
Isoform 2 (identifier: Q9NYW8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     80-113: EAWRVDDLIERIQENEDKHSRQAACINSKTLTEE → AALPAGHVAPAVAAAAAAPGRPGPHRQSRSPPGC
     114-714: Missing.

Note: No experimental confirmation available.
Show »
Length:113
Mass (Da):12,251
Checksum:i57840FE5CD3D700C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti273 – 2731K → E in BAF85758 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti229 – 2291G → E.
Corresponds to variant rs35352738 [ dbSNP | Ensembl ].
VAR_038438

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei80 – 11334EAWRV…TLTEE → AALPAGHVAPAVAAAAAAPG RPGPHRQSRSPPGC in isoform 2. 1 PublicationVSP_044805Add
BLAST
Alternative sequencei114 – 714601Missing in isoform 2. 1 PublicationVSP_044806Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF226869 mRNA. Translation: AAF43389.1.
BM929719 mRNA. No translation available.
AK293069 mRNA. Translation: BAF85758.1.
AC092032 Genomic DNA. Translation: AAQ93364.1.
AC008167 Genomic DNA. No translation available.
CH471144 Genomic DNA. Translation: EAW87321.1.
BC136675 mRNA. Translation: AAI36676.1.
BC136676 mRNA. Translation: AAI36677.1.
CCDSiCCDS5337.1. [Q9NYW8-1]
RefSeqiNP_001191385.1. NM_001204456.1. [Q9NYW8-1]
NP_066986.1. NM_021163.3. [Q9NYW8-1]
UniGeneiHs.396178.

Genome annotation databases

EnsembliENST00000353796; ENSP00000275423; ENSG00000146587. [Q9NYW8-1]
ENST00000396912; ENSP00000380120; ENSG00000146587. [Q9NYW8-1]
GeneIDi57786.
KEGGihsa:57786.
UCSCiuc003sns.1. human. [Q9NYW8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF226869 mRNA. Translation: AAF43389.1.
BM929719 mRNA. No translation available.
AK293069 mRNA. Translation: BAF85758.1.
AC092032 Genomic DNA. Translation: AAQ93364.1.
AC008167 Genomic DNA. No translation available.
CH471144 Genomic DNA. Translation: EAW87321.1.
BC136675 mRNA. Translation: AAI36676.1.
BC136676 mRNA. Translation: AAI36677.1.
CCDSiCCDS5337.1. [Q9NYW8-1]
RefSeqiNP_001191385.1. NM_001204456.1. [Q9NYW8-1]
NP_066986.1. NM_021163.3. [Q9NYW8-1]
UniGeneiHs.396178.

3D structure databases

ProteinModelPortaliQ9NYW8.
SMRiQ9NYW8. Positions 135-703.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121759. 10 interactions.
DIPiDIP-39336N.
IntActiQ9NYW8. 4 interactions.
STRINGi9606.ENSP00000275423.

PTM databases

iPTMnetiQ9NYW8.
PhosphoSiteiQ9NYW8.

Polymorphism and mutation databases

BioMutaiRBAK.
DMDMi74761820.

Proteomic databases

EPDiQ9NYW8.
MaxQBiQ9NYW8.
PaxDbiQ9NYW8.
PeptideAtlasiQ9NYW8.
PRIDEiQ9NYW8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000353796; ENSP00000275423; ENSG00000146587. [Q9NYW8-1]
ENST00000396912; ENSP00000380120; ENSG00000146587. [Q9NYW8-1]
GeneIDi57786.
KEGGihsa:57786.
UCSCiuc003sns.1. human. [Q9NYW8-1]

Organism-specific databases

CTDi57786.
GeneCardsiRBAK.
HGNCiHGNC:17680. RBAK.
MIMi608191. gene.
neXtProtiNX_Q9NYW8.
PharmGKBiPA162400745.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129694.
ENSGT00840000129857.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9NYW8.
KOiK09228.
OMAiPDFIQMS.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9NYW8.
TreeFamiTF350803.

Miscellaneous databases

GenomeRNAii57786.
PROiQ9NYW8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NYW8.
CleanExiHS_RBAK.
GenevisibleiQ9NYW8. HS.

Family and domain databases

Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 16 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a novel Kruppel-associated box family transcriptional repressor that interacts with the retinoblastoma gene product, RB."
    Skapek S.X., Jansen D., Wei T.-F., McDermott T., Huang W., Olson E.N., Lee E.Y.-H.P.
    J. Biol. Chem. 275:7212-7223(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH RB1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "Normalization and subtraction: two approaches to facilitate gene discovery."
    Bonaldo M.F., Lennon G., Soares M.B.
    Genome Res. 6:791-806(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Uterus.
  4. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Testis.
  7. "The retinoblastoma protein-associated transcription repressor RBaK interacts with the androgen receptor and enhances its transcriptional activity."
    Hofman K., Swinnen J.V., Claessens F., Verhoeven G., Heyns W.
    J. Mol. Endocrinol. 31:583-596(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH AR.
  8. "Uncovering global SUMOylation signaling networks in a site-specific manner."
    Hendriks I.A., D'Souza R.C., Yang B., Verlaan-de Vries M., Mann M., Vertegaal A.C.
    Nat. Struct. Mol. Biol. 21:927-936(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-534, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability."
    Xiao Z., Chang J.G., Hendriks I.A., Sigurdsson J.O., Olsen J.V., Vertegaal A.C.
    Mol. Cell. Proteomics 14:1419-1434(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-534, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRBAK_HUMAN
AccessioniPrimary (citable) accession number: Q9NYW8
Secondary accession number(s): A6NDF2
, A8KAK4, B2RN44, B9EGS1, F8W6M7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2000
Last modified: July 6, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.