ID   TA2R1_HUMAN             Reviewed;         299 AA.
AC   Q9NYW7; Q646G8;
DT   11-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   24-JAN-2024, entry version 153.
DE   RecName: Full=Taste receptor type 2 member 1;
DE            Short=T2R1;
DE   AltName: Full=Taste receptor family B member 7;
DE            Short=TRB7;
GN   Name=TAS2R1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TOPOLOGY.
RX   PubMed=10761934; DOI=10.1016/s0092-8674(00)80705-9;
RA   Adler E., Hoon M.A., Mueller K.L., Chandrashekar J., Ryba N.J.P.,
RA   Zuker C.S.;
RT   "A novel family of mammalian taste receptors.";
RL   Cell 100:693-702(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=15496549; DOI=10.1093/molbev/msi027;
RA   Fischer A., Gilad Y., Man O., Paeaebo S.;
RT   "Evolution of bitter taste receptors in humans and apes.";
RL   Mol. Biol. Evol. 22:432-436(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   CHARACTERIZATION.
RX   PubMed=10761935; DOI=10.1016/s0092-8674(00)80706-0;
RA   Chandrashekar J., Mueller K.L., Hoon M.A., Adler E., Feng L., Guo W.,
RA   Zuker C.S., Ryba N.J.P.;
RT   "T2Rs function as bitter taste receptors.";
RL   Cell 100:703-711(2000).
RN   [5]
RP   REVIEW.
RX   PubMed=12139982; DOI=10.1016/s0959-4388(02)00345-8;
RA   Montmayeur J.-P., Matsunami H.;
RT   "Receptors for bitter and sweet taste.";
RL   Curr. Opin. Neurobiol. 12:366-371(2002).
RN   [6]
RP   REVIEW.
RX   PubMed=11696554; DOI=10.1074/jbc.r100054200;
RA   Margolskee R.F.;
RT   "Molecular mechanisms of bitter and sweet taste transduction.";
RL   J. Biol. Chem. 277:1-4(2002).
RN   [7]
RP   REVIEW.
RX   PubMed=12581520; DOI=10.1016/s0092-8674(03)00071-0;
RA   Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D.,
RA   Zuker C.S., Ryba N.J.;
RT   "Coding of sweet, bitter, and umami tastes: different receptor cells
RT   sharing similar signaling pathways.";
RL   Cell 112:293-301(2003).
CC   -!- FUNCTION: Receptor that may play a role in the perception of bitterness
CC       and is gustducin-linked. May play a role in sensing the chemical
CC       composition of the gastrointestinal content. The activity of this
CC       receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation
CC       and lead to the gating of TRPM5.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Expressed in subsets of taste receptor cells of the
CC       tongue and palate epithelium and exclusively in gustducin-positive
CC       cells.
CC   -!- MISCELLANEOUS: Most taste cells may be activated by a limited number of
CC       bitter compounds; individual taste cells can discriminate among bitter
CC       stimuli.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF227129; AAF43902.1; -; Genomic_DNA.
DR   EMBL; AY724812; AAU21051.1; -; Genomic_DNA.
DR   EMBL; BC101729; AAI01730.1; -; mRNA.
DR   EMBL; BC101731; AAI01732.1; -; mRNA.
DR   CCDS; CCDS3876.1; -.
DR   RefSeq; NP_062545.1; NM_019599.2.
DR   AlphaFoldDB; Q9NYW7; -.
DR   SMR; Q9NYW7; -.
DR   STRING; 9606.ENSP00000371932; -.
DR   BindingDB; Q9NYW7; -.
DR   ChEMBL; CHEMBL4523475; -.
DR   GuidetoPHARMACOLOGY; 659; -.
DR   GlyCosmos; Q9NYW7; 1 site, No reported glycans.
DR   GlyGen; Q9NYW7; 1 site.
DR   iPTMnet; Q9NYW7; -.
DR   PhosphoSitePlus; Q9NYW7; -.
DR   BioMuta; TAS2R1; -.
DR   DMDM; 29839667; -.
DR   PaxDb; 9606-ENSP00000371932; -.
DR   PeptideAtlas; Q9NYW7; -.
DR   Antibodypedia; 22446; 131 antibodies from 23 providers.
DR   DNASU; 50834; -.
DR   Ensembl; ENST00000382492.4; ENSP00000371932.2; ENSG00000169777.7.
DR   GeneID; 50834; -.
DR   KEGG; hsa:50834; -.
DR   MANE-Select; ENST00000382492.4; ENSP00000371932.2; NM_019599.3; NP_062545.1.
DR   UCSC; uc003jem.2; human.
DR   AGR; HGNC:14909; -.
DR   CTD; 50834; -.
DR   DisGeNET; 50834; -.
DR   GeneCards; TAS2R1; -.
DR   HGNC; HGNC:14909; TAS2R1.
DR   HPA; ENSG00000169777; Tissue enriched (testis).
DR   MIM; 604796; gene.
DR   neXtProt; NX_Q9NYW7; -.
DR   OpenTargets; ENSG00000169777; -.
DR   PharmGKB; PA37921; -.
DR   VEuPathDB; HostDB:ENSG00000169777; -.
DR   eggNOG; ENOG502S2SI; Eukaryota.
DR   GeneTree; ENSGT01100000263477; -.
DR   HOGENOM; CLU_072337_1_1_1; -.
DR   InParanoid; Q9NYW7; -.
DR   OMA; KQRKMIP; -.
DR   OrthoDB; 5266232at2759; -.
DR   PhylomeDB; Q9NYW7; -.
DR   TreeFam; TF335891; -.
DR   PathwayCommons; Q9NYW7; -.
DR   Reactome; R-HSA-418594; G alpha (i) signalling events.
DR   Reactome; R-HSA-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
DR   Reactome; R-HSA-9717207; Sensory perception of sweet, bitter, and umami (glutamate) taste.
DR   BioGRID-ORCS; 50834; 9 hits in 1136 CRISPR screens.
DR   GeneWiki; TAS2R1; -.
DR   GenomeRNAi; 50834; -.
DR   Pharos; Q9NYW7; Tchem.
DR   PRO; PR:Q9NYW7; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   RNAct; Q9NYW7; Protein.
DR   Bgee; ENSG00000169777; Expressed in right testis and 39 other cell types or tissues.
DR   ExpressionAtlas; Q9NYW7; baseline and differential.
DR   GO; GO:0016020; C:membrane; IC:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0033038; F:bitter taste receptor activity; IDA:UniProtKB.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0008527; F:taste receptor activity; TAS:UniProtKB.
DR   GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IDA:UniProtKB.
DR   CDD; cd15016; 7tm_TAS2R1; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR007960; TAS2R.
DR   PANTHER; PTHR11394; TASTE RECEPTOR TYPE 2; 1.
DR   PANTHER; PTHR11394:SF47; TASTE RECEPTOR TYPE 2 MEMBER 1-RELATED; 1.
DR   Pfam; PF05296; TAS2R; 1.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   Genevisible; Q9NYW7; HS.
PE   1: Evidence at protein level;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW   Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..299
FT                   /note="Taste receptor type 2 member 1"
FT                   /id="PRO_0000082188"
FT   TOPO_DOM        1..9
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        10..30
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        31..55
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        56..76
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        77..81
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        103..124
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        125..145
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        146..178
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        179..199
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        200..222
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        223..243
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        244..257
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        258..278
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        279..299
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        163
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VARIANT         111
FT                   /note="R -> H (in dbSNP:rs41469)"
FT                   /id="VAR_020198"
FT   VARIANT         141
FT                   /note="C -> Y (in dbSNP:rs2234232)"
FT                   /id="VAR_053340"
FT   VARIANT         206
FT                   /note="R -> W (in dbSNP:rs2234233)"
FT                   /id="VAR_020199"
SQ   SEQUENCE   299 AA;  34333 MW;  CFB17DD15645392C CRC64;
     MLESHLIIYF LLAVIQFLLG IFTNGIIVVV NGIDLIKHRK MAPLDLLLSC LAVSRIFLQL
     FIFYVNVIVI FFIEFIMCSA NCAILLFINE LELWLATWLG VFYCAKVASV RHPLFIWLKM
     RISKLVPWMI LGSLLYVSMI CVFHSKYAGF MVPYFLRKFF SQNATIQKED TLAIQIFSFV
     AEFSVPLLIF LFAVLLLIFS LGRHTRQMRN TVAGSRVPGR GAPISALLSI LSFLILYFSH
     CMIKVFLSSL KFHIRRFIFL FFILVIGIYP SGHSLILILG NPKLKQNAKK FLLHSKCCQ
//