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Q9NYW7

- TA2R1_HUMAN

UniProt

Q9NYW7 - TA2R1_HUMAN

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Protein

Taste receptor type 2 member 1

Gene

TAS2R1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.

GO - Molecular functioni

  1. bitter taste receptor activity Source: UniProt
  2. taste receptor activity Source: UniProtKB

GO - Biological processi

  1. chemosensory behavior Source: ProtInc
  2. detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProt
  3. G-protein coupled receptor signaling pathway Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Enzyme and pathway databases

ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 1
Short name:
T2R1
Alternative name(s):
Taste receptor family B member 7
Short name:
TRB7
Gene namesi
Name:TAS2R1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:14909. TAS2R1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProt
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37921.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299Taste receptor type 2 member 1PRO_0000082188Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9NYW7.
PRIDEiQ9NYW7.

Expressioni

Tissue specificityi

Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.

Gene expression databases

BgeeiQ9NYW7.
CleanExiHS_TAS2R1.
ExpressionAtlasiQ9NYW7. baseline.
GenevestigatoriQ9NYW7.

Organism-specific databases

HPAiHPA051879.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000371932.

Structurei

3D structure databases

ProteinModelPortaliQ9NYW7.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99ExtracellularSequence Analysis
Topological domaini31 – 5525CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini77 – 815ExtracellularSequence Analysis
Topological domaini103 – 12422CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini146 – 17833ExtracellularSequence AnalysisAdd
BLAST
Topological domaini200 – 22223CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini244 – 25714ExtracellularSequence AnalysisAdd
BLAST
Topological domaini279 – 29921CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei10 – 3021Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei56 – 7621Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei82 – 10221Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei125 – 14521Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei179 – 19921Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei223 – 24321Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei258 – 27821Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG48043.
GeneTreeiENSGT00760000119096.
HOGENOMiHOG000234595.
HOVERGENiHBG060698.
InParanoidiQ9NYW7.
KOiK08474.
OMAiHRKMAPL.
OrthoDBiEOG7C8GHV.
PhylomeDBiQ9NYW7.
TreeFamiTF335891.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR007960. TAS2_rcpt.
[Graphical view]
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NYW7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLESHLIIYF LLAVIQFLLG IFTNGIIVVV NGIDLIKHRK MAPLDLLLSC
60 70 80 90 100
LAVSRIFLQL FIFYVNVIVI FFIEFIMCSA NCAILLFINE LELWLATWLG
110 120 130 140 150
VFYCAKVASV RHPLFIWLKM RISKLVPWMI LGSLLYVSMI CVFHSKYAGF
160 170 180 190 200
MVPYFLRKFF SQNATIQKED TLAIQIFSFV AEFSVPLLIF LFAVLLLIFS
210 220 230 240 250
LGRHTRQMRN TVAGSRVPGR GAPISALLSI LSFLILYFSH CMIKVFLSSL
260 270 280 290
KFHIRRFIFL FFILVIGIYP SGHSLILILG NPKLKQNAKK FLLHSKCCQ
Length:299
Mass (Da):34,333
Last modified:October 1, 2000 - v1
Checksum:iCFB17DD15645392C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti111 – 1111R → H.
Corresponds to variant rs41469 [ dbSNP | Ensembl ].
VAR_020198
Natural varianti141 – 1411C → Y.
Corresponds to variant rs2234232 [ dbSNP | Ensembl ].
VAR_053340
Natural varianti206 – 2061R → W.
Corresponds to variant rs2234233 [ dbSNP | Ensembl ].
VAR_020199

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF227129 Genomic DNA. Translation: AAF43902.1.
AY724812 Genomic DNA. Translation: AAU21051.1.
BC101729 mRNA. Translation: AAI01730.1.
BC101731 mRNA. Translation: AAI01732.1.
CCDSiCCDS3876.1.
RefSeqiNP_062545.1. NM_019599.2.
UniGeneiHs.567492.

Genome annotation databases

EnsembliENST00000382492; ENSP00000371932; ENSG00000169777.
GeneIDi50834.
KEGGihsa:50834.
UCSCiuc003jem.1. human.

Polymorphism databases

DMDMi29839667.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF227129 Genomic DNA. Translation: AAF43902.1 .
AY724812 Genomic DNA. Translation: AAU21051.1 .
BC101729 mRNA. Translation: AAI01730.1 .
BC101731 mRNA. Translation: AAI01732.1 .
CCDSi CCDS3876.1.
RefSeqi NP_062545.1. NM_019599.2.
UniGenei Hs.567492.

3D structure databases

ProteinModelPortali Q9NYW7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000371932.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 29839667.

Proteomic databases

PaxDbi Q9NYW7.
PRIDEi Q9NYW7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000382492 ; ENSP00000371932 ; ENSG00000169777 .
GeneIDi 50834.
KEGGi hsa:50834.
UCSCi uc003jem.1. human.

Organism-specific databases

CTDi 50834.
GeneCardsi GC05M009630.
HGNCi HGNC:14909. TAS2R1.
HPAi HPA051879.
MIMi 604796. gene.
neXtProti NX_Q9NYW7.
PharmGKBi PA37921.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG48043.
GeneTreei ENSGT00760000119096.
HOGENOMi HOG000234595.
HOVERGENi HBG060698.
InParanoidi Q9NYW7.
KOi K08474.
OMAi HRKMAPL.
OrthoDBi EOG7C8GHV.
PhylomeDBi Q9NYW7.
TreeFami TF335891.

Enzyme and pathway databases

Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii TAS2R1.
GenomeRNAii 50834.
NextBioi 53285.
PROi Q9NYW7.
SOURCEi Search...

Gene expression databases

Bgeei Q9NYW7.
CleanExi HS_TAS2R1.
ExpressionAtlasi Q9NYW7. baseline.
Genevestigatori Q9NYW7.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR017452. GPCR_Rhodpsn_7TM.
IPR007960. TAS2_rcpt.
[Graphical view ]
Pfami PF05296. TAS2R. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TOPOLOGY.
  2. "Evolution of bitter taste receptors in humans and apes."
    Fischer A., Gilad Y., Man O., Paeaebo S.
    Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain cortex.
  4. Cited for: CHARACTERIZATION.
  5. Cited for: REVIEW.
  6. "Molecular mechanisms of bitter and sweet taste transduction."
    Margolskee R.F.
    J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  7. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
    Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
    Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiTA2R1_HUMAN
AccessioniPrimary (citable) accession number: Q9NYW7
Secondary accession number(s): Q646G8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3