Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9NYW7 (TA2R1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Taste receptor type 2 member 1

Short name=T2R1
Alternative name(s):
Taste receptor family B member 7
Short name=TRB7
Gene names
Name:TAS2R1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length299 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

Sequence similarities

Belongs to the G-protein coupled receptor T2R family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 299299Taste receptor type 2 member 1
PRO_0000082188

Regions

Topological domain1 – 99Extracellular Potential
Transmembrane10 – 3021Helical; Name=1; Potential
Topological domain31 – 5525Cytoplasmic Potential
Transmembrane56 – 7621Helical; Name=2; Potential
Topological domain77 – 815Extracellular Potential
Transmembrane82 – 10221Helical; Name=3; Potential
Topological domain103 – 12422Cytoplasmic Potential
Transmembrane125 – 14521Helical; Name=4; Potential
Topological domain146 – 17833Extracellular Potential
Transmembrane179 – 19921Helical; Name=5; Potential
Topological domain200 – 22223Cytoplasmic Potential
Transmembrane223 – 24321Helical; Name=6; Potential
Topological domain244 – 25714Extracellular Potential
Transmembrane258 – 27821Helical; Name=7; Potential
Topological domain279 – 29921Cytoplasmic Potential

Amino acid modifications

Glycosylation1631N-linked (GlcNAc...) Potential

Natural variations

Natural variant1111R → H.
Corresponds to variant rs41469 [ dbSNP | Ensembl ].
VAR_020198
Natural variant1411C → Y.
Corresponds to variant rs2234232 [ dbSNP | Ensembl ].
VAR_053340
Natural variant2061R → W.
Corresponds to variant rs2234233 [ dbSNP | Ensembl ].
VAR_020199

Sequences

Sequence LengthMass (Da)Tools
Q9NYW7 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: CFB17DD15645392C

FASTA29934,333
        10         20         30         40         50         60 
MLESHLIIYF LLAVIQFLLG IFTNGIIVVV NGIDLIKHRK MAPLDLLLSC LAVSRIFLQL 

        70         80         90        100        110        120 
FIFYVNVIVI FFIEFIMCSA NCAILLFINE LELWLATWLG VFYCAKVASV RHPLFIWLKM 

       130        140        150        160        170        180 
RISKLVPWMI LGSLLYVSMI CVFHSKYAGF MVPYFLRKFF SQNATIQKED TLAIQIFSFV 

       190        200        210        220        230        240 
AEFSVPLLIF LFAVLLLIFS LGRHTRQMRN TVAGSRVPGR GAPISALLSI LSFLILYFSH 

       250        260        270        280        290 
CMIKVFLSSL KFHIRRFIFL FFILVIGIYP SGHSLILILG NPKLKQNAKK FLLHSKCCQ 

« Hide

References

« Hide 'large scale' references
[1]"A novel family of mammalian taste receptors."
Adler E., Hoon M.A., Mueller K.L., Chandrashekar J., Ryba N.J.P., Zuker C.S.
Cell 100:693-702(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TOPOLOGY.
[2]"Evolution of bitter taste receptors in humans and apes."
Fischer A., Gilad Y., Man O., Paeaebo S.
Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain cortex.
[4]"T2Rs function as bitter taste receptors."
Chandrashekar J., Mueller K.L., Hoon M.A., Adler E., Feng L., Guo W., Zuker C.S., Ryba N.J.P.
Cell 100:703-711(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[5]"Receptors for bitter and sweet taste."
Montmayeur J.-P., Matsunami H.
Curr. Opin. Neurobiol. 12:366-371(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[6]"Molecular mechanisms of bitter and sweet taste transduction."
Margolskee R.F.
J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[7]"Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF227129 Genomic DNA. Translation: AAF43902.1.
AY724812 Genomic DNA. Translation: AAU21051.1.
BC101729 mRNA. Translation: AAI01730.1.
BC101731 mRNA. Translation: AAI01732.1.
RefSeqNP_062545.1. NM_019599.2.
UniGeneHs.567492.

3D structure databases

ProteinModelPortalQ9NYW7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000371932.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM29839667.

Proteomic databases

PaxDbQ9NYW7.
PRIDEQ9NYW7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000382492; ENSP00000371932; ENSG00000169777.
GeneID50834.
KEGGhsa:50834.
UCSCuc003jem.1. human.

Organism-specific databases

CTD50834.
GeneCardsGC05M009630.
HGNCHGNC:14909. TAS2R1.
HPAHPA051879.
MIM604796. gene.
neXtProtNX_Q9NYW7.
PharmGKBPA37921.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG48043.
HOGENOMHOG000234595.
HOVERGENHBG060698.
InParanoidQ9NYW7.
KOK08474.
OMAHRKMAPL.
OrthoDBEOG7C8GHV.
PhylomeDBQ9NYW7.
TreeFamTF335891.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressQ9NYW7.
BgeeQ9NYW7.
CleanExHS_TAS2R1.
GenevestigatorQ9NYW7.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR017452. GPCR_Rhodpsn_7TM.
IPR007960. TAS2_rcpt.
[Graphical view]
PfamPF05296. TAS2R. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiTAS2R1.
GenomeRNAi50834.
NextBio53285.
PROQ9NYW7.
SOURCESearch...

Entry information

Entry nameTA2R1_HUMAN
AccessionPrimary (citable) accession number: Q9NYW7
Secondary accession number(s): Q646G8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries