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Q9NYW7

- TA2R1_HUMAN

UniProt

Q9NYW7 - TA2R1_HUMAN

Protein

Taste receptor type 2 member 1

Gene

TAS2R1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.

    GO - Molecular functioni

    1. bitter taste receptor activity Source: UniProt
    2. taste receptor activity Source: UniProtKB

    GO - Biological processi

    1. chemosensory behavior Source: ProtInc
    2. detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProt
    3. G-protein coupled receptor signaling pathway Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Sensory transduction, Taste

    Enzyme and pathway databases

    ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Taste receptor type 2 member 1
    Short name:
    T2R1
    Alternative name(s):
    Taste receptor family B member 7
    Short name:
    TRB7
    Gene namesi
    Name:TAS2R1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:14909. TAS2R1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProt
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37921.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 299299Taste receptor type 2 member 1PRO_0000082188Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9NYW7.
    PRIDEiQ9NYW7.

    Expressioni

    Tissue specificityi

    Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.

    Gene expression databases

    ArrayExpressiQ9NYW7.
    BgeeiQ9NYW7.
    CleanExiHS_TAS2R1.
    GenevestigatoriQ9NYW7.

    Organism-specific databases

    HPAiHPA051879.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000371932.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NYW7.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 99ExtracellularSequence Analysis
    Topological domaini31 – 5525CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini77 – 815ExtracellularSequence Analysis
    Topological domaini103 – 12422CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini146 – 17833ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini200 – 22223CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini244 – 25714ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini279 – 29921CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei10 – 3021Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei56 – 7621Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei82 – 10221Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei125 – 14521Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei179 – 19921Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei223 – 24321Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei258 – 27821Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG48043.
    HOGENOMiHOG000234595.
    HOVERGENiHBG060698.
    InParanoidiQ9NYW7.
    KOiK08474.
    OMAiHRKMAPL.
    OrthoDBiEOG7C8GHV.
    PhylomeDBiQ9NYW7.
    TreeFamiTF335891.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR017452. GPCR_Rhodpsn_7TM.
    IPR007960. TAS2_rcpt.
    [Graphical view]
    PfamiPF05296. TAS2R. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NYW7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLESHLIIYF LLAVIQFLLG IFTNGIIVVV NGIDLIKHRK MAPLDLLLSC    50
    LAVSRIFLQL FIFYVNVIVI FFIEFIMCSA NCAILLFINE LELWLATWLG 100
    VFYCAKVASV RHPLFIWLKM RISKLVPWMI LGSLLYVSMI CVFHSKYAGF 150
    MVPYFLRKFF SQNATIQKED TLAIQIFSFV AEFSVPLLIF LFAVLLLIFS 200
    LGRHTRQMRN TVAGSRVPGR GAPISALLSI LSFLILYFSH CMIKVFLSSL 250
    KFHIRRFIFL FFILVIGIYP SGHSLILILG NPKLKQNAKK FLLHSKCCQ 299
    Length:299
    Mass (Da):34,333
    Last modified:October 1, 2000 - v1
    Checksum:iCFB17DD15645392C
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti111 – 1111R → H.
    Corresponds to variant rs41469 [ dbSNP | Ensembl ].
    VAR_020198
    Natural varianti141 – 1411C → Y.
    Corresponds to variant rs2234232 [ dbSNP | Ensembl ].
    VAR_053340
    Natural varianti206 – 2061R → W.
    Corresponds to variant rs2234233 [ dbSNP | Ensembl ].
    VAR_020199

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF227129 Genomic DNA. Translation: AAF43902.1.
    AY724812 Genomic DNA. Translation: AAU21051.1.
    BC101729 mRNA. Translation: AAI01730.1.
    BC101731 mRNA. Translation: AAI01732.1.
    CCDSiCCDS3876.1.
    RefSeqiNP_062545.1. NM_019599.2.
    UniGeneiHs.567492.

    Genome annotation databases

    EnsembliENST00000382492; ENSP00000371932; ENSG00000169777.
    GeneIDi50834.
    KEGGihsa:50834.
    UCSCiuc003jem.1. human.

    Polymorphism databases

    DMDMi29839667.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF227129 Genomic DNA. Translation: AAF43902.1 .
    AY724812 Genomic DNA. Translation: AAU21051.1 .
    BC101729 mRNA. Translation: AAI01730.1 .
    BC101731 mRNA. Translation: AAI01732.1 .
    CCDSi CCDS3876.1.
    RefSeqi NP_062545.1. NM_019599.2.
    UniGenei Hs.567492.

    3D structure databases

    ProteinModelPortali Q9NYW7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000371932.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 29839667.

    Proteomic databases

    PaxDbi Q9NYW7.
    PRIDEi Q9NYW7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000382492 ; ENSP00000371932 ; ENSG00000169777 .
    GeneIDi 50834.
    KEGGi hsa:50834.
    UCSCi uc003jem.1. human.

    Organism-specific databases

    CTDi 50834.
    GeneCardsi GC05M009630.
    HGNCi HGNC:14909. TAS2R1.
    HPAi HPA051879.
    MIMi 604796. gene.
    neXtProti NX_Q9NYW7.
    PharmGKBi PA37921.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG48043.
    HOGENOMi HOG000234595.
    HOVERGENi HBG060698.
    InParanoidi Q9NYW7.
    KOi K08474.
    OMAi HRKMAPL.
    OrthoDBi EOG7C8GHV.
    PhylomeDBi Q9NYW7.
    TreeFami TF335891.

    Enzyme and pathway databases

    Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii TAS2R1.
    GenomeRNAii 50834.
    NextBioi 53285.
    PROi Q9NYW7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NYW7.
    Bgeei Q9NYW7.
    CleanExi HS_TAS2R1.
    Genevestigatori Q9NYW7.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR017452. GPCR_Rhodpsn_7TM.
    IPR007960. TAS2_rcpt.
    [Graphical view ]
    Pfami PF05296. TAS2R. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TOPOLOGY.
    2. "Evolution of bitter taste receptors in humans and apes."
      Fischer A., Gilad Y., Man O., Paeaebo S.
      Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain cortex.
    4. Cited for: CHARACTERIZATION.
    5. Cited for: REVIEW.
    6. "Molecular mechanisms of bitter and sweet taste transduction."
      Margolskee R.F.
      J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    7. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
      Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
      Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiTA2R1_HUMAN
    AccessioniPrimary (citable) accession number: Q9NYW7
    Secondary accession number(s): Q646G8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 11, 2003
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3