Q9NYW7 (TA2R1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Taste receptor type 2 member 1
Short name=T2R1

Alternative name(s):
Taste receptor family B member 7
Short name=TRB7

Gene names

Name:

TAS2R1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	299 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.
Miscellaneous	Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.
Sequence similarities	Belongs to the G-protein coupled receptor T2R family.

Ontologies

Keywords
Biological process	Sensory transduction Taste
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chemosensory behavior Traceable author statement Ref.1. Source: ProtInc
Cellular_component	integral to membrane Non-traceable author statement. Source: UniProtKB
Molecular_function	taste receptor activity Traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 299	299	Taste receptor type 2 member 1		PRO_0000082188
Regions
	Topological domain	1 – 9	9	Extracellular Potential
	Transmembrane	10 – 30	21	Helical; Name=1; Potential
	Topological domain	31 – 55	25	Cytoplasmic Potential
	Transmembrane	56 – 76	21	Helical; Name=2; Potential
	Topological domain	77 – 81	5	Extracellular Potential
	Transmembrane	82 – 102	21	Helical; Name=3; Potential
	Topological domain	103 – 124	22	Cytoplasmic Potential
	Transmembrane	125 – 145	21	Helical; Name=4; Potential
	Topological domain	146 – 178	33	Extracellular Potential
	Transmembrane	179 – 199	21	Helical; Name=5; Potential
	Topological domain	200 – 222	23	Cytoplasmic Potential
	Transmembrane	223 – 243	21	Helical; Name=6; Potential
	Topological domain	244 – 257	14	Extracellular Potential
	Transmembrane	258 – 278	21	Helical; Name=7; Potential
	Topological domain	279 – 299	21	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	163	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	111	1	R → H. Corresponds to variant rs41469 [ dbSNP | Ensembl ].		VAR_020198
	Natural variant	141	1	C → Y. Corresponds to variant rs2234232 [ dbSNP | Ensembl ].		VAR_053340
	Natural variant	206	1	R → W. Corresponds to variant rs2234233 [ dbSNP | Ensembl ].		VAR_020199

Sequences

	Sequence		Length	Mass (Da)
	Q9NYW7 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: CFB17DD15645392C	FASTA	299	34,333
	10 20 30 40 50 60 MLESHLIIYF LLAVIQFLLG IFTNGIIVVV NGIDLIKHRK MAPLDLLLSC LAVSRIFLQL 70 80 90 100 110 120 FIFYVNVIVI FFIEFIMCSA NCAILLFINE LELWLATWLG VFYCAKVASV RHPLFIWLKM 130 140 150 160 170 180 RISKLVPWMI LGSLLYVSMI CVFHSKYAGF MVPYFLRKFF SQNATIQKED TLAIQIFSFV 190 200 210 220 230 240 AEFSVPLLIF LFAVLLLIFS LGRHTRQMRN TVAGSRVPGR GAPISALLSI LSFLILYFSH 250 260 270 280 290 CMIKVFLSSL KFHIRRFIFL FFILVIGIYP SGHSLILILG NPKLKQNAKK FLLHSKCCQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel family of mammalian taste receptors." Adler E., Hoon M.A., Mueller K.L., Chandrashekar J., Ryba N.J.P., Zuker C.S. Cell 100:693-702(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TOPOLOGY.
[2]	"Evolution of bitter taste receptors in humans and apes." Fischer A., Gilad Y., Man O., Paeaebo S. Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain cortex.
[4]	"T2Rs function as bitter taste receptors." Chandrashekar J., Mueller K.L., Hoon M.A., Adler E., Feng L., Guo W., Zuker C.S., Ryba N.J.P. Cell 100:703-711(2000) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION.
[5]	"Receptors for bitter and sweet taste." Montmayeur J.-P., Matsunami H. Curr. Opin. Neurobiol. 12:366-371(2002) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[6]	"Molecular mechanisms of bitter and sweet taste transduction." Margolskee R.F. J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[7]	"Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways." Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J. Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF227129 Genomic DNA. Translation: AAF43902.1. AY724812 Genomic DNA. Translation: AAU21051.1. BC101729 mRNA. Translation: AAI01730.1. BC101731 mRNA. Translation: AAI01732.1.
IPI	IPI00021300.
RefSeq	NP_062545.1. NM_019599.2.
UniGene	Hs.567492.
3D structure databases
ProteinModelPortal	Q9NYW7.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000371932.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	29839667.
Proteomic databases
PaxDb	Q9NYW7.
PRIDE	Q9NYW7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000382492; ENSP00000371932; ENSG00000169777.
GeneID	50834.
KEGG	hsa:50834.
UCSC	uc003jem.1. human.
Organism-specific databases
CTD	50834.
GeneCards	GC05M009630.
HGNC	HGNC:14909. TAS2R1.
MIM	604796. gene.
neXtProt	NX_Q9NYW7.
PharmGKB	PA37921.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG48043.
HOGENOM	HOG000234595.
HOVERGEN	HBG060698.
InParanoid	Q9NYW7.
KO	K08474.
OMA	HRKMAPL.
OrthoDB	EOG4JWVFK.
PhylomeDB	Q9NYW7.
Gene expression databases
ArrayExpress	Q9NYW7.
Bgee	Q9NYW7.
CleanEx	HS_TAS2R1.
Genevestigator	Q9NYW7.
GermOnline	ENSG00000169777. Homo sapiens.
Family and domain databases
InterPro	IPR007960. TAS2_rcpt. [Graphical view]
Pfam	PF05296. TAS2R. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	50834.
NextBio	53285.
SOURCE	Search...

Entry information

Entry name

TA2R1_HUMAN

Accession

Primary (citable) accession number: Q9NYW7
Secondary accession number(s): Q646G8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 11, 2003
Last sequence update:	October 1, 2000
Last modified:	April 3, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.