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Q9NYW6

- TA2R3_HUMAN

UniProt

Q9NYW6 - TA2R3_HUMAN

Protein

Taste receptor type 2 member 3

Gene

TAS2R3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 3 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.2 Publications

    GO - Molecular functioni

    1. bitter taste receptor activity Source: UniProt
    2. taste receptor activity Source: UniProtKB

    GO - Biological processi

    1. detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProt
    2. sensory perception of taste Source: ProtInc
    3. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Sensory transduction, Taste

    Enzyme and pathway databases

    ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Taste receptor type 2 member 3
    Short name:
    T2R3
    Gene namesi
    Name:TAS2R3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:14910. TAS2R3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37922.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 316316Taste receptor type 2 member 3PRO_0000082197Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9NYW6.
    PRIDEiQ9NYW6.

    PTM databases

    PhosphoSiteiQ9NYW6.

    Expressioni

    Tissue specificityi

    Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed in the antrum and fundus (part of the stomach), duodenum and in gastric endocrine cells.1 Publication

    Gene expression databases

    ArrayExpressiQ9NYW6.
    BgeeiQ9NYW6.
    CleanExiHS_TAS2R3.
    GenevestigatoriQ9NYW6.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NYW6.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 66ExtracellularSequence Analysis
    Topological domaini28 – 4215CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini64 – 9431ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini116 – 12813CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini150 – 18637ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini208 – 23427CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini256 – 26611ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini288 – 31629CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2721Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei43 – 6321Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei95 – 11521Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei129 – 14921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei187 – 20721Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei235 – 25521Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei267 – 28721Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG27838.
    HOGENOMiHOG000234595.
    HOVERGENiHBG060698.
    InParanoidiQ9NYW6.
    KOiK08474.
    OMAiRIILSFF.
    OrthoDBiEOG72C512.
    PhylomeDBiQ9NYW6.
    TreeFamiTF335891.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR017452. GPCR_Rhodpsn_7TM.
    IPR007960. TAS2_rcpt.
    [Graphical view]
    PfamiPF05296. TAS2R. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NYW6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMGLTEGVFL ILSGTQFTLG ILVNCFIELV NGSSWFKTKR MSLSDFIITT    50
    LALLRIILLC IILTDSFLIE FSPNTHDSGI IMQIIDVSWT FTNHLSIWLA 100
    TCLGVLYCLK IASFSHPTFL WLKWRVSRVM VWMLLGALLL SCGSTASLIN 150
    EFKLYSVFRG IEATRNVTEH FRKKRSEYYL IHVLGTLWYL PPLIVSLASY 200
    SLLIFSLGRH TRQMLQNGTS SRDPTTEAHK RAIRIILSFF FLFLLYFLAF 250
    LIASFGNFLP KTKMAKMIGE VMTMFYPAGH SFILILGNSK LKQTFVVMLR 300
    CESGHLKPGS KGPIFS 316
    Length:316
    Mass (Da):35,915
    Last modified:September 5, 2006 - v3
    Checksum:i6A7BA3C6497ABC5B
    GO

    Sequence cautioni

    The sequence AAU21157.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF227130 Genomic DNA. Translation: AAF43903.1.
    AY724961 Genomic DNA. Translation: AAU21157.1. Different initiation.
    AC004979 Genomic DNA. Translation: AAS02038.1.
    BC069337 mRNA. Translation: AAH69337.1.
    CH236950 Genomic DNA. Translation: EAL24017.1.
    CH471070 Genomic DNA. Translation: EAW83982.1.
    BC095523 mRNA. Translation: AAH95523.1.
    CCDSiCCDS5867.1.
    RefSeqiNP_058639.1. NM_016943.2.
    UniGeneiHs.676011.

    Genome annotation databases

    EnsembliENST00000247879; ENSP00000247879; ENSG00000127362.
    GeneIDi50831.
    KEGGihsa:50831.
    UCSCiuc003vwp.1. human.

    Polymorphism databases

    DMDMi114152888.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF227130 Genomic DNA. Translation: AAF43903.1 .
    AY724961 Genomic DNA. Translation: AAU21157.1 . Different initiation.
    AC004979 Genomic DNA. Translation: AAS02038.1 .
    BC069337 mRNA. Translation: AAH69337.1 .
    CH236950 Genomic DNA. Translation: EAL24017.1 .
    CH471070 Genomic DNA. Translation: EAW83982.1 .
    BC095523 mRNA. Translation: AAH95523.1 .
    CCDSi CCDS5867.1.
    RefSeqi NP_058639.1. NM_016943.2.
    UniGenei Hs.676011.

    3D structure databases

    ProteinModelPortali Q9NYW6.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9NYW6.

    Polymorphism databases

    DMDMi 114152888.

    Proteomic databases

    PaxDbi Q9NYW6.
    PRIDEi Q9NYW6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000247879 ; ENSP00000247879 ; ENSG00000127362 .
    GeneIDi 50831.
    KEGGi hsa:50831.
    UCSCi uc003vwp.1. human.

    Organism-specific databases

    CTDi 50831.
    GeneCardsi GC07P141463.
    HGNCi HGNC:14910. TAS2R3.
    MIMi 604868. gene.
    neXtProti NX_Q9NYW6.
    PharmGKBi PA37922.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG27838.
    HOGENOMi HOG000234595.
    HOVERGENi HBG060698.
    InParanoidi Q9NYW6.
    KOi K08474.
    OMAi RIILSFF.
    OrthoDBi EOG72C512.
    PhylomeDBi Q9NYW6.
    TreeFami TF335891.

    Enzyme and pathway databases

    Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii TAS2R3.
    GenomeRNAii 50831.
    NextBioi 53273.
    PROi Q9NYW6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NYW6.
    Bgeei Q9NYW6.
    CleanExi HS_TAS2R3.
    Genevestigatori Q9NYW6.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR017452. GPCR_Rhodpsn_7TM.
    IPR007960. TAS2_rcpt.
    [Graphical view ]
    Pfami PF05296. TAS2R. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY.
    2. "Evolution of bitter taste receptors in humans and apes."
      Fischer A., Gilad Y., Man O., Paeaebo S.
      Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    7. Cited for: FUNCTION.
    8. Cited for: REVIEW.
    9. "Molecular mechanisms of bitter and sweet taste transduction."
      Margolskee R.F.
      J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    10. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
      Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
      Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiTA2R3_HUMAN
    AccessioniPrimary (citable) accession number: Q9NYW6
    Secondary accession number(s): A4D1U2, Q645W2, Q75MV6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 11, 2003
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 105 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Several bitter taste receptors are expressed in a single taste receptor cell.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3