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Q9NYW6

- TA2R3_HUMAN

UniProt

Q9NYW6 - TA2R3_HUMAN

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Protein

Taste receptor type 2 member 3

Gene

TAS2R3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.2 Publications

GO - Molecular functioni

  1. bitter taste receptor activity Source: UniProt
  2. taste receptor activity Source: UniProtKB

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProt
  2. sensory perception of taste Source: ProtInc
  3. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Enzyme and pathway databases

ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 3
Short name:
T2R3
Gene namesi
Name:TAS2R3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:14910. TAS2R3.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37922.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316Taste receptor type 2 member 3PRO_0000082197Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9NYW6.
PRIDEiQ9NYW6.

PTM databases

PhosphoSiteiQ9NYW6.

Expressioni

Tissue specificityi

Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed in the antrum and fundus (part of the stomach), duodenum and in gastric endocrine cells.1 Publication

Gene expression databases

BgeeiQ9NYW6.
CleanExiHS_TAS2R3.
ExpressionAtlasiQ9NYW6. baseline.
GenevestigatoriQ9NYW6.

Structurei

3D structure databases

ProteinModelPortaliQ9NYW6.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 66ExtracellularSequence Analysis
Topological domaini28 – 4215CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini64 – 9431ExtracellularSequence AnalysisAdd
BLAST
Topological domaini116 – 12813CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini150 – 18637ExtracellularSequence AnalysisAdd
BLAST
Topological domaini208 – 23427CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini256 – 26611ExtracellularSequence AnalysisAdd
BLAST
Topological domaini288 – 31629CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei43 – 6321Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei95 – 11521Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei129 – 14921Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei187 – 20721Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei235 – 25521Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei267 – 28721Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG27838.
GeneTreeiENSGT00760000119096.
HOGENOMiHOG000234595.
HOVERGENiHBG060698.
InParanoidiQ9NYW6.
KOiK08474.
OMAiRIILSFF.
OrthoDBiEOG72C512.
PhylomeDBiQ9NYW6.
TreeFamiTF335891.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR007960. TAS2_rcpt.
[Graphical view]
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NYW6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMGLTEGVFL ILSGTQFTLG ILVNCFIELV NGSSWFKTKR MSLSDFIITT
60 70 80 90 100
LALLRIILLC IILTDSFLIE FSPNTHDSGI IMQIIDVSWT FTNHLSIWLA
110 120 130 140 150
TCLGVLYCLK IASFSHPTFL WLKWRVSRVM VWMLLGALLL SCGSTASLIN
160 170 180 190 200
EFKLYSVFRG IEATRNVTEH FRKKRSEYYL IHVLGTLWYL PPLIVSLASY
210 220 230 240 250
SLLIFSLGRH TRQMLQNGTS SRDPTTEAHK RAIRIILSFF FLFLLYFLAF
260 270 280 290 300
LIASFGNFLP KTKMAKMIGE VMTMFYPAGH SFILILGNSK LKQTFVVMLR
310
CESGHLKPGS KGPIFS
Length:316
Mass (Da):35,915
Last modified:September 5, 2006 - v3
Checksum:i6A7BA3C6497ABC5B
GO

Sequence cautioni

The sequence AAU21157.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF227130 Genomic DNA. Translation: AAF43903.1.
AY724961 Genomic DNA. Translation: AAU21157.1. Different initiation.
AC004979 Genomic DNA. Translation: AAS02038.1.
BC069337 mRNA. Translation: AAH69337.1.
CH236950 Genomic DNA. Translation: EAL24017.1.
CH471070 Genomic DNA. Translation: EAW83982.1.
BC095523 mRNA. Translation: AAH95523.1.
CCDSiCCDS5867.1.
RefSeqiNP_058639.1. NM_016943.2.
UniGeneiHs.676011.

Genome annotation databases

EnsembliENST00000247879; ENSP00000247879; ENSG00000127362.
GeneIDi50831.
KEGGihsa:50831.
UCSCiuc003vwp.1. human.

Polymorphism databases

DMDMi114152888.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF227130 Genomic DNA. Translation: AAF43903.1 .
AY724961 Genomic DNA. Translation: AAU21157.1 . Different initiation.
AC004979 Genomic DNA. Translation: AAS02038.1 .
BC069337 mRNA. Translation: AAH69337.1 .
CH236950 Genomic DNA. Translation: EAL24017.1 .
CH471070 Genomic DNA. Translation: EAW83982.1 .
BC095523 mRNA. Translation: AAH95523.1 .
CCDSi CCDS5867.1.
RefSeqi NP_058639.1. NM_016943.2.
UniGenei Hs.676011.

3D structure databases

ProteinModelPortali Q9NYW6.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q9NYW6.

Polymorphism databases

DMDMi 114152888.

Proteomic databases

PaxDbi Q9NYW6.
PRIDEi Q9NYW6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000247879 ; ENSP00000247879 ; ENSG00000127362 .
GeneIDi 50831.
KEGGi hsa:50831.
UCSCi uc003vwp.1. human.

Organism-specific databases

CTDi 50831.
GeneCardsi GC07P141463.
HGNCi HGNC:14910. TAS2R3.
MIMi 604868. gene.
neXtProti NX_Q9NYW6.
PharmGKBi PA37922.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG27838.
GeneTreei ENSGT00760000119096.
HOGENOMi HOG000234595.
HOVERGENi HBG060698.
InParanoidi Q9NYW6.
KOi K08474.
OMAi RIILSFF.
OrthoDBi EOG72C512.
PhylomeDBi Q9NYW6.
TreeFami TF335891.

Enzyme and pathway databases

Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii TAS2R3.
GenomeRNAii 50831.
NextBioi 53273.
PROi Q9NYW6.
SOURCEi Search...

Gene expression databases

Bgeei Q9NYW6.
CleanExi HS_TAS2R3.
ExpressionAtlasi Q9NYW6. baseline.
Genevestigatori Q9NYW6.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR017452. GPCR_Rhodpsn_7TM.
IPR007960. TAS2_rcpt.
[Graphical view ]
Pfami PF05296. TAS2R. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY.
  2. "Evolution of bitter taste receptors in humans and apes."
    Fischer A., Gilad Y., Man O., Paeaebo S.
    Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. Cited for: FUNCTION.
  8. Cited for: REVIEW.
  9. "Molecular mechanisms of bitter and sweet taste transduction."
    Margolskee R.F.
    J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  10. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
    Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
    Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiTA2R3_HUMAN
AccessioniPrimary (citable) accession number: Q9NYW6
Secondary accession number(s): A4D1U2, Q645W2, Q75MV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: September 5, 2006
Last modified: October 29, 2014
This is version 106 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Several bitter taste receptors are expressed in a single taste receptor cell.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3