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Protein

Taste receptor type 2 member 4

Gene

TAS2R4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Gustducin-coupled receptor for denatonium and N(6)-propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentration and stimulates ciliary beat frequency.1 Publication

GO - Molecular functioni

  • bitter taste receptor activity Source: UniProtKB
  • G-protein coupled receptor activity Source: UniProtKB-KW
  • taste receptor activity Source: UniProtKB

GO - Biological processi

  • detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProtKB
  • respiratory gaseous exchange Source: Ensembl
  • sensory perception of taste Source: ProtInc
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Enzyme and pathway databases

BioCyciZFISH:ENSG00000127364-MONOMER.
ReactomeiR-HSA-418594. G alpha (i) signalling events.
R-HSA-420499. Class C/3 (Metabotropic glutamate/pheromone receptors).

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 4
Short name:
T2R4
Gene namesi
Name:TAS2R4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:14911. TAS2R4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9ExtracellularSequence analysis9
Transmembranei10 – 30Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini31 – 46CytoplasmicSequence analysisAdd BLAST16
Transmembranei47 – 67Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini68 – 81ExtracellularSequence analysisAdd BLAST14
Transmembranei82 – 102Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini103 – 131CytoplasmicSequence analysisAdd BLAST29
Transmembranei132 – 152Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini153 – 172ExtracellularSequence analysisAdd BLAST20
Transmembranei173 – 193Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini194 – 230CytoplasmicSequence analysisAdd BLAST37
Transmembranei231 – 251Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini252 – 262ExtracellularSequence analysisAdd BLAST11
Transmembranei263 – 283Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini284 – 299CytoplasmicSequence analysisAdd BLAST16

GO - Cellular componenti

  • ciliary membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000127364.
PharmGKBiPA37923.

Chemistry databases

ChEMBLiCHEMBL3309107.

Polymorphism and mutation databases

BioMutaiTAS2R4.
DMDMi29839665.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000822051 – 299Taste receptor type 2 member 4Add BLAST299

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi164N-linked (GlcNAc...)Sequence analysis1
Glycosylationi165N-linked (GlcNAc...)Sequence analysis1
Glycosylationi169N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9NYW5.
PeptideAtlasiQ9NYW5.
PRIDEiQ9NYW5.

Expressioni

Tissue specificityi

Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed on airway ciliated epithelium.1 Publication

Gene expression databases

BgeeiENSG00000127364.
CleanExiHS_TAS2R4.
GenevisibleiQ9NYW5. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000247881.

Chemistry databases

BindingDBiQ9NYW5.

Structurei

3D structure databases

ProteinModelPortaliQ9NYW5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKCN. Eukaryota.
ENOG4111DWC. LUCA.
GeneTreeiENSGT00760000119096.
HOGENOMiHOG000126900.
HOVERGENiHBG098740.
InParanoidiQ9NYW5.
KOiK08474.
OMAiKMQKNAT.
OrthoDBiEOG091G0IPR.
PhylomeDBiQ9NYW5.
TreeFamiTF335891.

Family and domain databases

InterProiIPR007960. T2R.
IPR030055. TAS2R4.
[Graphical view]
PANTHERiPTHR11394. PTHR11394. 1 hit.
PTHR11394:SF55. PTHR11394:SF55. 1 hit.
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NYW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRLFYFSAI IASVILNFVG IIMNLFITVV NCKTWVKSHR ISSSDRILFS
60 70 80 90 100
LGITRFLMLG LFLVNTIYFV SSNTERSVYL SAFFVLCFMF LDSSSVWFVT
110 120 130 140 150
LLNILYCVKI TNFQHSVFLL LKRNISPKIP RLLLACVLIS AFTTCLYITL
160 170 180 190 200
SQASPFPELV TTRNNTSFNI SEGILSLVVS LVLSSSLQFI INVTSASLLI
210 220 230 240 250
HSLRRHIQKM QKNATGFWNP QTEAHVGAMK LMVYFLILYI PYSVATLVQY
260 270 280 290
LPFYAGMDMG TKSICLIFAT LYSPGHSVLI IITHPKLKTT AKKILCFKK
Length:299
Mass (Da):33,841
Last modified:October 1, 2000 - v1
Checksum:i8265610092B19945
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0345353R → Q.Corresponds to variant rs2233995dbSNPEnsembl.1
Natural variantiVAR_0345367F → S.Corresponds to variant rs2233998dbSNPEnsembl.1
Natural variantiVAR_05334162F → L.Corresponds to variant rs2233999dbSNPEnsembl.1
Natural variantiVAR_02020074T → M.Corresponds to variant rs2234000dbSNPEnsembl.1
Natural variantiVAR_02020196V → L.Corresponds to variant rs2234001dbSNPEnsembl.1
Natural variantiVAR_020202171S → N.Corresponds to variant rs2234002dbSNPEnsembl.1
Natural variantiVAR_053342191I → V.Corresponds to variant rs2234003dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF227131 Genomic DNA. Translation: AAF43904.1.
AY724958 Genomic DNA. Translation: AAU21154.1.
AC004979 Genomic DNA. Translation: AAS02039.1.
CCDSiCCDS5868.1.
RefSeqiNP_058640.1. NM_016944.1.
UniGeneiHs.735690.

Genome annotation databases

EnsembliENST00000247881; ENSP00000247881; ENSG00000127364.
GeneIDi50832.
KEGGihsa:50832.
UCSCiuc003vwq.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Protein Spotlight

A tail of protection - Issue 119 of July 2010

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF227131 Genomic DNA. Translation: AAF43904.1.
AY724958 Genomic DNA. Translation: AAU21154.1.
AC004979 Genomic DNA. Translation: AAS02039.1.
CCDSiCCDS5868.1.
RefSeqiNP_058640.1. NM_016944.1.
UniGeneiHs.735690.

3D structure databases

ProteinModelPortaliQ9NYW5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000247881.

Chemistry databases

BindingDBiQ9NYW5.
ChEMBLiCHEMBL3309107.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiTAS2R4.
DMDMi29839665.

Proteomic databases

PaxDbiQ9NYW5.
PeptideAtlasiQ9NYW5.
PRIDEiQ9NYW5.

Protocols and materials databases

DNASUi50832.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000247881; ENSP00000247881; ENSG00000127364.
GeneIDi50832.
KEGGihsa:50832.
UCSCiuc003vwq.2. human.

Organism-specific databases

CTDi50832.
GeneCardsiTAS2R4.
HGNCiHGNC:14911. TAS2R4.
MIMi604869. gene.
neXtProtiNX_Q9NYW5.
OpenTargetsiENSG00000127364.
PharmGKBiPA37923.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKCN. Eukaryota.
ENOG4111DWC. LUCA.
GeneTreeiENSGT00760000119096.
HOGENOMiHOG000126900.
HOVERGENiHBG098740.
InParanoidiQ9NYW5.
KOiK08474.
OMAiKMQKNAT.
OrthoDBiEOG091G0IPR.
PhylomeDBiQ9NYW5.
TreeFamiTF335891.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000127364-MONOMER.
ReactomeiR-HSA-418594. G alpha (i) signalling events.
R-HSA-420499. Class C/3 (Metabotropic glutamate/pheromone receptors).

Miscellaneous databases

GeneWikiiTAS2R4.
GenomeRNAii50832.
PROiQ9NYW5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000127364.
CleanExiHS_TAS2R4.
GenevisibleiQ9NYW5. HS.

Family and domain databases

InterProiIPR007960. T2R.
IPR030055. TAS2R4.
[Graphical view]
PANTHERiPTHR11394. PTHR11394. 1 hit.
PTHR11394:SF55. PTHR11394:SF55. 1 hit.
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTA2R4_HUMAN
AccessioniPrimary (citable) accession number: Q9NYW5
Secondary accession number(s): Q645W5, Q75MV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Several bitter taste receptors are expressed in a single taste receptor cell.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.