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Q9NYW5

- TA2R4_HUMAN

UniProt

Q9NYW5 - TA2R4_HUMAN

Protein

Taste receptor type 2 member 4

Gene

TAS2R4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Gustducin-coupled receptor for denatonium and N(6)-propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentration and stimulates ciliary beat frequency.1 Publication

    GO - Molecular functioni

    1. bitter taste receptor activity Source: UniProt
    2. taste receptor activity Source: UniProtKB

    GO - Biological processi

    1. detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProt
    2. respiratory gaseous exchange Source: Ensembl
    3. sensory perception of taste Source: ProtInc
    4. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Sensory transduction, Taste

    Enzyme and pathway databases

    ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Taste receptor type 2 member 4
    Short name:
    T2R4
    Gene namesi
    Name:TAS2R4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:14911. TAS2R4.

    Subcellular locationi

    Membrane 1 Publication; Multi-pass membrane protein 1 Publication. Cell projectioncilium membrane 1 Publication
    Note: In airway epithelial cells, localizes to motile cilia.

    GO - Cellular componenti

    1. ciliary membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Cilium, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37923.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 299299Taste receptor type 2 member 4PRO_0000082205Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi165 – 1651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9NYW5.
    PRIDEiQ9NYW5.

    Expressioni

    Tissue specificityi

    Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed on airway ciliated epithelium.1 Publication

    Gene expression databases

    ArrayExpressiQ9NYW5.
    BgeeiQ9NYW5.
    CleanExiHS_TAS2R4.
    GenevestigatoriQ9NYW5.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000247881.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NYW5.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 99ExtracellularSequence Analysis
    Topological domaini31 – 4616CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini68 – 8114ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini103 – 13129CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini153 – 17220ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini194 – 23037CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini252 – 26211ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini284 – 29916CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei10 – 3021Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei47 – 6721Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei82 – 10221Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei132 – 15221Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei173 – 19321Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei231 – 25121Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei263 – 28321Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG42218.
    HOGENOMiHOG000126900.
    HOVERGENiHBG098740.
    InParanoidiQ9NYW5.
    KOiK08474.
    OMAiVERSVYL.
    OrthoDBiEOG7HXCR9.
    PhylomeDBiQ9NYW5.
    TreeFamiTF335891.

    Family and domain databases

    InterProiIPR007960. TAS2_rcpt.
    [Graphical view]
    PfamiPF05296. TAS2R. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NYW5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRLFYFSAI IASVILNFVG IIMNLFITVV NCKTWVKSHR ISSSDRILFS    50
    LGITRFLMLG LFLVNTIYFV SSNTERSVYL SAFFVLCFMF LDSSSVWFVT 100
    LLNILYCVKI TNFQHSVFLL LKRNISPKIP RLLLACVLIS AFTTCLYITL 150
    SQASPFPELV TTRNNTSFNI SEGILSLVVS LVLSSSLQFI INVTSASLLI 200
    HSLRRHIQKM QKNATGFWNP QTEAHVGAMK LMVYFLILYI PYSVATLVQY 250
    LPFYAGMDMG TKSICLIFAT LYSPGHSVLI IITHPKLKTT AKKILCFKK 299
    Length:299
    Mass (Da):33,841
    Last modified:October 1, 2000 - v1
    Checksum:i8265610092B19945
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti3 – 31R → Q.
    Corresponds to variant rs2233995 [ dbSNP | Ensembl ].
    VAR_034535
    Natural varianti7 – 71F → S.
    Corresponds to variant rs2233998 [ dbSNP | Ensembl ].
    VAR_034536
    Natural varianti62 – 621F → L.
    Corresponds to variant rs2233999 [ dbSNP | Ensembl ].
    VAR_053341
    Natural varianti74 – 741T → M.
    Corresponds to variant rs2234000 [ dbSNP | Ensembl ].
    VAR_020200
    Natural varianti96 – 961V → L.
    Corresponds to variant rs2234001 [ dbSNP | Ensembl ].
    VAR_020201
    Natural varianti171 – 1711S → N.
    Corresponds to variant rs2234002 [ dbSNP | Ensembl ].
    VAR_020202
    Natural varianti191 – 1911I → V.
    Corresponds to variant rs2234003 [ dbSNP | Ensembl ].
    VAR_053342

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF227131 Genomic DNA. Translation: AAF43904.1.
    AY724958 Genomic DNA. Translation: AAU21154.1.
    AC004979 Genomic DNA. Translation: AAS02039.1.
    CCDSiCCDS5868.1.
    RefSeqiNP_058640.1. NM_016944.1.
    UniGeneiHs.735690.

    Genome annotation databases

    EnsembliENST00000247881; ENSP00000247881; ENSG00000127364.
    GeneIDi50832.
    KEGGihsa:50832.
    UCSCiuc003vwq.1. human.

    Polymorphism databases

    DMDMi29839665.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    A tail of protection - Issue 119 of July 2010

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF227131 Genomic DNA. Translation: AAF43904.1 .
    AY724958 Genomic DNA. Translation: AAU21154.1 .
    AC004979 Genomic DNA. Translation: AAS02039.1 .
    CCDSi CCDS5868.1.
    RefSeqi NP_058640.1. NM_016944.1.
    UniGenei Hs.735690.

    3D structure databases

    ProteinModelPortali Q9NYW5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000247881.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 29839665.

    Proteomic databases

    PaxDbi Q9NYW5.
    PRIDEi Q9NYW5.

    Protocols and materials databases

    DNASUi 50832.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000247881 ; ENSP00000247881 ; ENSG00000127364 .
    GeneIDi 50832.
    KEGGi hsa:50832.
    UCSCi uc003vwq.1. human.

    Organism-specific databases

    CTDi 50832.
    GeneCardsi GC07P141479.
    HGNCi HGNC:14911. TAS2R4.
    MIMi 604869. gene.
    neXtProti NX_Q9NYW5.
    PharmGKBi PA37923.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42218.
    HOGENOMi HOG000126900.
    HOVERGENi HBG098740.
    InParanoidi Q9NYW5.
    KOi K08474.
    OMAi VERSVYL.
    OrthoDBi EOG7HXCR9.
    PhylomeDBi Q9NYW5.
    TreeFami TF335891.

    Enzyme and pathway databases

    Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii TAS2R4.
    GenomeRNAii 50832.
    NextBioi 53277.
    PROi Q9NYW5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NYW5.
    Bgeei Q9NYW5.
    CleanExi HS_TAS2R4.
    Genevestigatori Q9NYW5.

    Family and domain databases

    InterProi IPR007960. TAS2_rcpt.
    [Graphical view ]
    Pfami PF05296. TAS2R. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TOPOLOGY.
    2. "Evolution of bitter taste receptors in humans and apes."
      Fischer A., Gilad Y., Man O., Paeaebo S.
      Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: CHARACTERIZATION.
    5. Cited for: REVIEW.
    6. "Molecular mechanisms of bitter and sweet taste transduction."
      Margolskee R.F.
      J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    7. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
      Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
      Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    8. "Motile cilia of human airway epithelia are chemosensory."
      Shah A.S., Ben-Shahar Y., Moninger T.O., Kline J.N., Welsh M.J.
      Science 325:1131-1134(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiTA2R4_HUMAN
    AccessioniPrimary (citable) accession number: Q9NYW5
    Secondary accession number(s): Q645W5, Q75MV8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 11, 2003
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Several bitter taste receptors are expressed in a single taste receptor cell.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3