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Protein

Taste receptor type 2 member 4

Gene

TAS2R4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Gustducin-coupled receptor for denatonium and N6-propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentration and stimulates ciliary beat frequency.1 Publication

Miscellaneous

Several bitter taste receptors are expressed in a single taste receptor cell.

GO - Molecular functioni

  • bitter taste receptor activity Source: UniProtKB
  • G-protein coupled receptor activity Source: UniProtKB-KW
  • taste receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processSensory transduction, Taste

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 4
Short name:
T2R4
Gene namesi
Name:TAS2R4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000127364.3
HGNCiHGNC:14911 TAS2R4
MIMi604869 gene
neXtProtiNX_Q9NYW5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9ExtracellularSequence analysis9
Transmembranei10 – 30Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini31 – 46CytoplasmicSequence analysisAdd BLAST16
Transmembranei47 – 67Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini68 – 81ExtracellularSequence analysisAdd BLAST14
Transmembranei82 – 102Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini103 – 131CytoplasmicSequence analysisAdd BLAST29
Transmembranei132 – 152Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini153 – 172ExtracellularSequence analysisAdd BLAST20
Transmembranei173 – 193Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini194 – 230CytoplasmicSequence analysisAdd BLAST37
Transmembranei231 – 251Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini252 – 262ExtracellularSequence analysisAdd BLAST11
Transmembranei263 – 283Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini284 – 299CytoplasmicSequence analysisAdd BLAST16

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000127364
PharmGKBiPA37923

Chemistry databases

ChEMBLiCHEMBL3309107

Polymorphism and mutation databases

BioMutaiTAS2R4
DMDMi29839665

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000822051 – 299Taste receptor type 2 member 4Add BLAST299

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi164N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi165N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi169N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9NYW5
PeptideAtlasiQ9NYW5
PRIDEiQ9NYW5

Expressioni

Tissue specificityi

Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed on airway ciliated epithelium.1 Publication

Gene expression databases

BgeeiENSG00000127364
CleanExiHS_TAS2R4
GenevisibleiQ9NYW5 HS

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000247881

Chemistry databases

BindingDBiQ9NYW5

Structurei

3D structure databases

ProteinModelPortaliQ9NYW5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKCN Eukaryota
ENOG4111DWC LUCA
GeneTreeiENSGT00760000119096
HOGENOMiHOG000126900
HOVERGENiHBG098740
InParanoidiQ9NYW5
KOiK08474
OMAiQTEAHVG
OrthoDBiEOG091G0IPR
PhylomeDBiQ9NYW5
TreeFamiTF335891

Family and domain databases

CDDicd15013 7tm_TAS2R4, 1 hit
InterProiView protein in InterPro
IPR007960 T2R
IPR030055 TAS2R4
PANTHERiPTHR11394 PTHR11394, 1 hit
PTHR11394:SF55 PTHR11394:SF55, 1 hit
PfamiView protein in Pfam
PF05296 TAS2R, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NYW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRLFYFSAI IASVILNFVG IIMNLFITVV NCKTWVKSHR ISSSDRILFS
60 70 80 90 100
LGITRFLMLG LFLVNTIYFV SSNTERSVYL SAFFVLCFMF LDSSSVWFVT
110 120 130 140 150
LLNILYCVKI TNFQHSVFLL LKRNISPKIP RLLLACVLIS AFTTCLYITL
160 170 180 190 200
SQASPFPELV TTRNNTSFNI SEGILSLVVS LVLSSSLQFI INVTSASLLI
210 220 230 240 250
HSLRRHIQKM QKNATGFWNP QTEAHVGAMK LMVYFLILYI PYSVATLVQY
260 270 280 290
LPFYAGMDMG TKSICLIFAT LYSPGHSVLI IITHPKLKTT AKKILCFKK
Length:299
Mass (Da):33,841
Last modified:October 1, 2000 - v1
Checksum:i8265610092B19945
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0345353R → Q. Corresponds to variant dbSNP:rs2233995Ensembl.1
Natural variantiVAR_0345367F → S. Corresponds to variant dbSNP:rs2233998Ensembl.1
Natural variantiVAR_05334162F → L. Corresponds to variant dbSNP:rs2233999Ensembl.1
Natural variantiVAR_02020074T → M. Corresponds to variant dbSNP:rs2234000Ensembl.1
Natural variantiVAR_02020196V → L. Corresponds to variant dbSNP:rs2234001Ensembl.1
Natural variantiVAR_020202171S → N. Corresponds to variant dbSNP:rs2234002Ensembl.1
Natural variantiVAR_053342191I → V. Corresponds to variant dbSNP:rs2234003Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF227131 Genomic DNA Translation: AAF43904.1
AY724958 Genomic DNA Translation: AAU21154.1
AC004979 Genomic DNA Translation: AAS02039.1
CCDSiCCDS5868.1
RefSeqiNP_058640.1, NM_016944.1
UniGeneiHs.735690

Genome annotation databases

EnsembliENST00000247881; ENSP00000247881; ENSG00000127364
GeneIDi50832
KEGGihsa:50832
UCSCiuc003vwq.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTA2R4_HUMAN
AccessioniPrimary (citable) accession number: Q9NYW5
Secondary accession number(s): Q645W5, Q75MV8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: October 1, 2000
Last modified: February 28, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  7. SIMILARITY comments
    Index of protein domains and families

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