Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9NYW4

- TA2R5_HUMAN

UniProt

Q9NYW4 - TA2R5_HUMAN

Protein

Taste receptor type 2 member 5

Gene

TAS2R5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.

    GO - Molecular functioni

    1. bitter taste receptor activity Source: UniProt
    2. taste receptor activity Source: UniProtKB

    GO - Biological processi

    1. chemosensory behavior Source: ProtInc
    2. detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProt
    3. sensory perception of taste Source: ProtInc
    4. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Sensory transduction, Taste

    Enzyme and pathway databases

    ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Taste receptor type 2 member 5
    Short name:
    T2R5
    Gene namesi
    Name:TAS2R5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:14912. TAS2R5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37924.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 299299Taste receptor type 2 member 5PRO_0000082212Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi155 – 1551N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ9NYW4.

    PTM databases

    PhosphoSiteiQ9NYW4.

    Expressioni

    Tissue specificityi

    Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.

    Gene expression databases

    ArrayExpressiQ9NYW4.
    BgeeiQ9NYW4.
    CleanExiHS_TAS2R5.
    GenevestigatoriQ9NYW4.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NYW4.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 11ExtracellularSequence Analysis
    Topological domaini23 – 4523CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini67 – 8216ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini104 – 12724CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini149 – 17527ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini197 – 22327CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini245 – 2539ExtracellularSequence Analysis
    Topological domaini275 – 29925CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei2 – 2221Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei46 – 6621Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei83 – 10321Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei128 – 14821Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei176 – 19621Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei224 – 24421Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei254 – 27421Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG133822.
    HOGENOMiHOG000234595.
    HOVERGENiHBG098555.
    InParanoidiQ9NYW4.
    KOiK08474.
    OMAiQWLIILD.
    OrthoDBiEOG7H4DV2.
    PhylomeDBiQ9NYW4.
    TreeFamiTF335891.

    Family and domain databases

    InterProiIPR007960. TAS2_rcpt.
    [Graphical view]
    PfamiPF05296. TAS2R. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NYW4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLSAGLGLLM LVAVVEFLIG LIGNGSLVVW SFREWIRKFN WSSYNLIILG    50
    LAGCRFLLQW LIILDLSLFP LFQSSRWLRY LSIFWVLVSQ ASLWFATFLS 100
    VFYCKKITTF DRPAYLWLKQ RAYNLSLWCL LGYFIINLLL TVQIGLTFYH 150
    PPQGNSSIRY PFESWQYLYA FQLNSGSYLP LVVFLVSSGM LIVSLYTHHK 200
    KMKVHSAGRR DVRAKAHITA LKSLGCFLLL HLVYIMASPF SITSKTYPPD 250
    LTSVFIWETL MAAYPSLHSL ILIMGIPRVK QTCQKILWKT VCARRCWGP 299
    Length:299
    Mass (Da):34,505
    Last modified:October 1, 2000 - v1
    Checksum:iF85064A07E9018C7
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti20 – 201G → S.
    Corresponds to variant rs2234013 [ dbSNP | Ensembl ].
    VAR_053343
    Natural varianti26 – 261S → I.
    Corresponds to variant rs2227264 [ dbSNP | Ensembl ].
    VAR_020203
    Natural varianti113 – 1131P → L.
    Corresponds to variant rs2234014 [ dbSNP | Ensembl ].
    VAR_034537
    Natural varianti167 – 1671Y → C.
    Corresponds to variant rs34529840 [ dbSNP | Ensembl ].
    VAR_034538
    Natural varianti213 – 2131R → Q.
    Corresponds to variant rs2234015 [ dbSNP | Ensembl ].
    VAR_024184
    Natural varianti294 – 2941R → L.
    Corresponds to variant rs2234016 [ dbSNP | Ensembl ].
    VAR_053344

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF227132 Genomic DNA. Translation: AAF43905.1.
    AY724966 Genomic DNA. Translation: AAU21159.1.
    AC004979 Genomic DNA. Translation: AAS02040.1.
    BC069509 mRNA. Translation: AAH69509.1.
    BC101586 mRNA. Translation: AAI01587.1.
    BC101588 mRNA. Translation: AAI01589.1.
    CCDSiCCDS5869.1.
    RefSeqiNP_061853.1. NM_018980.2.
    UniGeneiHs.675370.

    Genome annotation databases

    EnsembliENST00000247883; ENSP00000247883; ENSG00000127366.
    GeneIDi54429.
    KEGGihsa:54429.
    UCSCiuc003vwr.1. human.

    Polymorphism databases

    DMDMi29839664.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF227132 Genomic DNA. Translation: AAF43905.1 .
    AY724966 Genomic DNA. Translation: AAU21159.1 .
    AC004979 Genomic DNA. Translation: AAS02040.1 .
    BC069509 mRNA. Translation: AAH69509.1 .
    BC101586 mRNA. Translation: AAI01587.1 .
    BC101588 mRNA. Translation: AAI01589.1 .
    CCDSi CCDS5869.1.
    RefSeqi NP_061853.1. NM_018980.2.
    UniGenei Hs.675370.

    3D structure databases

    ProteinModelPortali Q9NYW4.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9NYW4.

    Polymorphism databases

    DMDMi 29839664.

    Proteomic databases

    PRIDEi Q9NYW4.

    Protocols and materials databases

    DNASUi 54429.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000247883 ; ENSP00000247883 ; ENSG00000127366 .
    GeneIDi 54429.
    KEGGi hsa:54429.
    UCSCi uc003vwr.1. human.

    Organism-specific databases

    CTDi 54429.
    GeneCardsi GC07P141490.
    HGNCi HGNC:14912. TAS2R5.
    MIMi 605062. gene.
    neXtProti NX_Q9NYW4.
    PharmGKBi PA37924.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG133822.
    HOGENOMi HOG000234595.
    HOVERGENi HBG098555.
    InParanoidi Q9NYW4.
    KOi K08474.
    OMAi QWLIILD.
    OrthoDBi EOG7H4DV2.
    PhylomeDBi Q9NYW4.
    TreeFami TF335891.

    Enzyme and pathway databases

    Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii TAS2R5.
    GenomeRNAii 54429.
    NextBioi 56625.
    PROi Q9NYW4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NYW4.
    Bgeei Q9NYW4.
    CleanExi HS_TAS2R5.
    Genevestigatori Q9NYW4.

    Family and domain databases

    InterProi IPR007960. TAS2_rcpt.
    [Graphical view ]
    Pfami PF05296. TAS2R. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TOPOLOGY.
    2. "Evolution of bitter taste receptors in humans and apes."
      Fischer A., Gilad Y., Man O., Paeaebo S.
      Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    5. Cited for: CHARACTERIZATION.
    6. Cited for: REVIEW.
    7. "Molecular mechanisms of bitter and sweet taste transduction."
      Margolskee R.F.
      J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    8. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
      Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
      Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiTA2R5_HUMAN
    AccessioniPrimary (citable) accession number: Q9NYW4
    Secondary accession number(s): Q645W0, Q75MV7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 11, 2003
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3