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Protein

Taste receptor type 2 member 5

Gene

TAS2R5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.

GO - Molecular functioni

  1. bitter taste receptor activity Source: UniProtKB
  2. taste receptor activity Source: UniProtKB

GO - Biological processi

  1. chemosensory behavior Source: ProtInc
  2. detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProtKB
  3. sensory perception of taste Source: ProtInc
  4. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Enzyme and pathway databases

ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 5
Short name:
T2R5
Gene namesi
Name:TAS2R5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:14912. TAS2R5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 11ExtracellularSequence Analysis
Transmembranei2 – 2221Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini23 – 4523CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei46 – 6621Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini67 – 8216ExtracellularSequence AnalysisAdd
BLAST
Transmembranei83 – 10321Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini104 – 12724CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei128 – 14821Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini149 – 17527ExtracellularSequence AnalysisAdd
BLAST
Transmembranei176 – 19621Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini197 – 22327CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei224 – 24421Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini245 – 2539ExtracellularSequence Analysis
Transmembranei254 – 27421Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini275 – 29925CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37924.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299Taste receptor type 2 member 5PRO_0000082212Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi155 – 1551N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9NYW4.

PTM databases

PhosphoSiteiQ9NYW4.

Expressioni

Tissue specificityi

Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.

Gene expression databases

BgeeiQ9NYW4.
CleanExiHS_TAS2R5.
ExpressionAtlasiQ9NYW4. baseline and differential.
GenevestigatoriQ9NYW4.

Structurei

3D structure databases

ProteinModelPortaliQ9NYW4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG133822.
GeneTreeiENSGT00760000119096.
HOGENOMiHOG000234595.
HOVERGENiHBG098555.
InParanoidiQ9NYW4.
KOiK08474.
OMAiQWLIILD.
OrthoDBiEOG7H4DV2.
PhylomeDBiQ9NYW4.
TreeFamiTF335891.

Family and domain databases

InterProiIPR007960. T2R.
[Graphical view]
PANTHERiPTHR11394. PTHR11394. 1 hit.
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NYW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSAGLGLLM LVAVVEFLIG LIGNGSLVVW SFREWIRKFN WSSYNLIILG
60 70 80 90 100
LAGCRFLLQW LIILDLSLFP LFQSSRWLRY LSIFWVLVSQ ASLWFATFLS
110 120 130 140 150
VFYCKKITTF DRPAYLWLKQ RAYNLSLWCL LGYFIINLLL TVQIGLTFYH
160 170 180 190 200
PPQGNSSIRY PFESWQYLYA FQLNSGSYLP LVVFLVSSGM LIVSLYTHHK
210 220 230 240 250
KMKVHSAGRR DVRAKAHITA LKSLGCFLLL HLVYIMASPF SITSKTYPPD
260 270 280 290
LTSVFIWETL MAAYPSLHSL ILIMGIPRVK QTCQKILWKT VCARRCWGP
Length:299
Mass (Da):34,505
Last modified:October 1, 2000 - v1
Checksum:iF85064A07E9018C7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti20 – 201G → S.
Corresponds to variant rs2234013 [ dbSNP | Ensembl ].
VAR_053343
Natural varianti26 – 261S → I.
Corresponds to variant rs2227264 [ dbSNP | Ensembl ].
VAR_020203
Natural varianti113 – 1131P → L.
Corresponds to variant rs2234014 [ dbSNP | Ensembl ].
VAR_034537
Natural varianti167 – 1671Y → C.
Corresponds to variant rs34529840 [ dbSNP | Ensembl ].
VAR_034538
Natural varianti213 – 2131R → Q.
Corresponds to variant rs2234015 [ dbSNP | Ensembl ].
VAR_024184
Natural varianti294 – 2941R → L.
Corresponds to variant rs2234016 [ dbSNP | Ensembl ].
VAR_053344

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF227132 Genomic DNA. Translation: AAF43905.1.
AY724966 Genomic DNA. Translation: AAU21159.1.
AC004979 Genomic DNA. Translation: AAS02040.1.
BC069509 mRNA. Translation: AAH69509.1.
BC101586 mRNA. Translation: AAI01587.1.
BC101588 mRNA. Translation: AAI01589.1.
CCDSiCCDS5869.1.
RefSeqiNP_061853.1. NM_018980.2.
UniGeneiHs.675370.

Genome annotation databases

EnsembliENST00000247883; ENSP00000247883; ENSG00000127366.
GeneIDi54429.
KEGGihsa:54429.
UCSCiuc003vwr.1. human.

Polymorphism databases

DMDMi29839664.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF227132 Genomic DNA. Translation: AAF43905.1.
AY724966 Genomic DNA. Translation: AAU21159.1.
AC004979 Genomic DNA. Translation: AAS02040.1.
BC069509 mRNA. Translation: AAH69509.1.
BC101586 mRNA. Translation: AAI01587.1.
BC101588 mRNA. Translation: AAI01589.1.
CCDSiCCDS5869.1.
RefSeqiNP_061853.1. NM_018980.2.
UniGeneiHs.675370.

3D structure databases

ProteinModelPortaliQ9NYW4.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ9NYW4.

Polymorphism databases

DMDMi29839664.

Proteomic databases

PRIDEiQ9NYW4.

Protocols and materials databases

DNASUi54429.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000247883; ENSP00000247883; ENSG00000127366.
GeneIDi54429.
KEGGihsa:54429.
UCSCiuc003vwr.1. human.

Organism-specific databases

CTDi54429.
GeneCardsiGC07P141490.
HGNCiHGNC:14912. TAS2R5.
MIMi605062. gene.
neXtProtiNX_Q9NYW4.
PharmGKBiPA37924.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG133822.
GeneTreeiENSGT00760000119096.
HOGENOMiHOG000234595.
HOVERGENiHBG098555.
InParanoidiQ9NYW4.
KOiK08474.
OMAiQWLIILD.
OrthoDBiEOG7H4DV2.
PhylomeDBiQ9NYW4.
TreeFamiTF335891.

Enzyme and pathway databases

ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikiiTAS2R5.
GenomeRNAii54429.
NextBioi56625.
PROiQ9NYW4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NYW4.
CleanExiHS_TAS2R5.
ExpressionAtlasiQ9NYW4. baseline and differential.
GenevestigatoriQ9NYW4.

Family and domain databases

InterProiIPR007960. T2R.
[Graphical view]
PANTHERiPTHR11394. PTHR11394. 1 hit.
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TOPOLOGY.
  2. "Evolution of bitter taste receptors in humans and apes."
    Fischer A., Gilad Y., Man O., Paeaebo S.
    Mol. Biol. Evol. 22:432-436(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. Cited for: CHARACTERIZATION.
  6. Cited for: REVIEW.
  7. "Molecular mechanisms of bitter and sweet taste transduction."
    Margolskee R.F.
    J. Biol. Chem. 277:1-4(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  8. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
    Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
    Cell 112:293-301(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiTA2R5_HUMAN
AccessioniPrimary (citable) accession number: Q9NYW4
Secondary accession number(s): Q645W0, Q75MV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: October 1, 2000
Last modified: February 4, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.