Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9NYW4 (TA2R5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Taste receptor type 2 member 5

Short name=T2R5
Gene names
Name:TAS2R5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length299 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

Sequence similarities

Belongs to the G-protein coupled receptor T2R family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 299299Taste receptor type 2 member 5
PRO_0000082212

Regions

Topological domain11Extracellular Potential
Transmembrane2 – 2221Helical; Name=1; Potential
Topological domain23 – 4523Cytoplasmic Potential
Transmembrane46 – 6621Helical; Name=2; Potential
Topological domain67 – 8216Extracellular Potential
Transmembrane83 – 10321Helical; Name=3; Potential
Topological domain104 – 12724Cytoplasmic Potential
Transmembrane128 – 14821Helical; Name=4; Potential
Topological domain149 – 17527Extracellular Potential
Transmembrane176 – 19621Helical; Name=5; Potential
Topological domain197 – 22327Cytoplasmic Potential
Transmembrane224 – 24421Helical; Name=6; Potential
Topological domain245 – 2539Extracellular Potential
Transmembrane254 – 27421Helical; Name=7; Potential
Topological domain275 – 29925Cytoplasmic Potential

Amino acid modifications

Glycosylation1551N-linked (GlcNAc...) Potential

Natural variations

Natural variant201G → S.
Corresponds to variant rs2234013 [ dbSNP | Ensembl ].
VAR_053343
Natural variant261S → I.
Corresponds to variant rs2227264 [ dbSNP | Ensembl ].
VAR_020203
Natural variant1131P → L.
Corresponds to variant rs2234014 [ dbSNP | Ensembl ].
VAR_034537
Natural variant1671Y → C.
Corresponds to variant rs34529840 [ dbSNP | Ensembl ].
VAR_034538
Natural variant2131R → Q.
Corresponds to variant rs2234015 [ dbSNP | Ensembl ].
VAR_024184
Natural variant2941R → L.
Corresponds to variant rs2234016 [ dbSNP | Ensembl ].
VAR_053344

Sequences

Sequence LengthMass (Da)Tools
Q9NYW4 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: F85064A07E9018C7

FASTA29934,505
        10         20         30         40         50         60 
MLSAGLGLLM LVAVVEFLIG LIGNGSLVVW SFREWIRKFN WSSYNLIILG LAGCRFLLQW 

        70         80         90        100        110        120 
LIILDLSLFP LFQSSRWLRY LSIFWVLVSQ ASLWFATFLS VFYCKKITTF DRPAYLWLKQ 

       130        140        150        160        170        180 
RAYNLSLWCL LGYFIINLLL TVQIGLTFYH PPQGNSSIRY PFESWQYLYA FQLNSGSYLP 

       190        200        210        220        230        240 
LVVFLVSSGM LIVSLYTHHK KMKVHSAGRR DVRAKAHITA LKSLGCFLLL HLVYIMASPF 

       250        260        270        280        290 
SITSKTYPPD LTSVFIWETL MAAYPSLHSL ILIMGIPRVK QTCQKILWKT VCARRCWGP 

« Hide

References

« Hide 'large scale' references
[1]"A novel family of mammalian taste receptors."
Adler E., Hoon M.A., Mueller K.L., Chandrashekar J., Ryba N.J.P., Zuker C.S.
Cell 100:693-702(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TOPOLOGY.
[2]"Evolution of bitter taste receptors in humans and apes."
Fischer A., Gilad Y., Man O., Paeaebo S.
Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[5]"T2Rs function as bitter taste receptors."
Chandrashekar J., Mueller K.L., Hoon M.A., Adler E., Feng L., Guo W., Zuker C.S., Ryba N.J.P.
Cell 100:703-711(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[6]"Receptors for bitter and sweet taste."
Montmayeur J.-P., Matsunami H.
Curr. Opin. Neurobiol. 12:366-371(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[7]"Molecular mechanisms of bitter and sweet taste transduction."
Margolskee R.F.
J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[8]"Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF227132 Genomic DNA. Translation: AAF43905.1.
AY724966 Genomic DNA. Translation: AAU21159.1.
AC004979 Genomic DNA. Translation: AAS02040.1.
BC069509 mRNA. Translation: AAH69509.1.
BC101586 mRNA. Translation: AAI01587.1.
BC101588 mRNA. Translation: AAI01589.1.
RefSeqNP_061853.1. NM_018980.2.
UniGeneHs.675370.

3D structure databases

ProteinModelPortalQ9NYW4.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ9NYW4.

Polymorphism databases

DMDM29839664.

Proteomic databases

PRIDEQ9NYW4.

Protocols and materials databases

DNASU54429.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000247883; ENSP00000247883; ENSG00000127366.
GeneID54429.
KEGGhsa:54429.
UCSCuc003vwr.1. human.

Organism-specific databases

CTD54429.
GeneCardsGC07P141490.
HGNCHGNC:14912. TAS2R5.
MIM605062. gene.
neXtProtNX_Q9NYW4.
PharmGKBPA37924.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG133822.
HOGENOMHOG000234595.
HOVERGENHBG098555.
InParanoidQ9NYW4.
KOK08474.
OMAQWLIILD.
OrthoDBEOG7H4DV2.
PhylomeDBQ9NYW4.
TreeFamTF335891.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressQ9NYW4.
BgeeQ9NYW4.
CleanExHS_TAS2R5.
GenevestigatorQ9NYW4.

Family and domain databases

InterProIPR007960. TAS2_rcpt.
[Graphical view]
PfamPF05296. TAS2R. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiTAS2R5.
GenomeRNAi54429.
NextBio56625.
PROQ9NYW4.
SOURCESearch...

Entry information

Entry nameTA2R5_HUMAN
AccessionPrimary (citable) accession number: Q9NYW4
Secondary accession number(s): Q645W0, Q75MV7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries