Q9NYW4 (TA2R5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Taste receptor type 2 member 5
Short name=T2R5

Gene names

Name:

TAS2R5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	299 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.
Miscellaneous	Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.
Sequence similarities	Belongs to the G-protein coupled receptor T2R family.

Ontologies

Keywords
Biological process	Sensory transduction Taste
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chemosensory behavior Traceable author statement Ref.5. Source: ProtInc
Cellular_component	integral to membrane Inferred by curator Ref.1. Source: UniProtKB
Molecular_function	taste receptor activity Traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 299	299	Taste receptor type 2 member 5		PRO_0000082212
Regions
	Topological domain	1	1	Extracellular Potential
	Transmembrane	2 – 22	21	Helical; Name=1; Potential
	Topological domain	23 – 45	23	Cytoplasmic Potential
	Transmembrane	46 – 66	21	Helical; Name=2; Potential
	Topological domain	67 – 82	16	Extracellular Potential
	Transmembrane	83 – 103	21	Helical; Name=3; Potential
	Topological domain	104 – 127	24	Cytoplasmic Potential
	Transmembrane	128 – 148	21	Helical; Name=4; Potential
	Topological domain	149 – 175	27	Extracellular Potential
	Transmembrane	176 – 196	21	Helical; Name=5; Potential
	Topological domain	197 – 223	27	Cytoplasmic Potential
	Transmembrane	224 – 244	21	Helical; Name=6; Potential
	Topological domain	245 – 253	9	Extracellular Potential
	Transmembrane	254 – 274	21	Helical; Name=7; Potential
	Topological domain	275 – 299	25	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	155	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	20	1	G → S. Corresponds to variant rs2234013 [ dbSNP | Ensembl ].		VAR_053343
	Natural variant	26	1	S → I. Corresponds to variant rs2227264 [ dbSNP | Ensembl ].		VAR_020203
	Natural variant	113	1	P → L. Corresponds to variant rs2234014 [ dbSNP | Ensembl ].		VAR_034537
	Natural variant	167	1	Y → C. Corresponds to variant rs34529840 [ dbSNP | Ensembl ].		VAR_034538
	Natural variant	213	1	R → Q. Corresponds to variant rs2234015 [ dbSNP | Ensembl ].		VAR_024184
	Natural variant	294	1	R → L. Corresponds to variant rs2234016 [ dbSNP | Ensembl ].		VAR_053344

Sequences

	Sequence		Length	Mass (Da)
	Q9NYW4 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: F85064A07E9018C7	FASTA	299	34,505
	10 20 30 40 50 60 MLSAGLGLLM LVAVVEFLIG LIGNGSLVVW SFREWIRKFN WSSYNLIILG LAGCRFLLQW 70 80 90 100 110 120 LIILDLSLFP LFQSSRWLRY LSIFWVLVSQ ASLWFATFLS VFYCKKITTF DRPAYLWLKQ 130 140 150 160 170 180 RAYNLSLWCL LGYFIINLLL TVQIGLTFYH PPQGNSSIRY PFESWQYLYA FQLNSGSYLP 190 200 210 220 230 240 LVVFLVSSGM LIVSLYTHHK KMKVHSAGRR DVRAKAHITA LKSLGCFLLL HLVYIMASPF 250 260 270 280 290 SITSKTYPPD LTSVFIWETL MAAYPSLHSL ILIMGIPRVK QTCQKILWKT VCARRCWGP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel family of mammalian taste receptors." Adler E., Hoon M.A., Mueller K.L., Chandrashekar J., Ryba N.J.P., Zuker C.S. Cell 100:693-702(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TOPOLOGY.
[2]	"Evolution of bitter taste receptors in humans and apes." Fischer A., Gilad Y., Man O., Paeaebo S. Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[5]	"T2Rs function as bitter taste receptors." Chandrashekar J., Mueller K.L., Hoon M.A., Adler E., Feng L., Guo W., Zuker C.S., Ryba N.J.P. Cell 100:703-711(2000) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION.
[6]	"Receptors for bitter and sweet taste." Montmayeur J.-P., Matsunami H. Curr. Opin. Neurobiol. 12:366-371(2002) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[7]	"Molecular mechanisms of bitter and sweet taste transduction." Margolskee R.F. J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[8]	"Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways." Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J. Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF227132 Genomic DNA. Translation: AAF43905.1. AY724966 Genomic DNA. Translation: AAU21159.1. AC004979 Genomic DNA. Translation: AAS02040.1. BC069509 mRNA. Translation: AAH69509.1. BC101586 mRNA. Translation: AAI01587.1. BC101588 mRNA. Translation: AAI01589.1.
IPI	IPI00004476.
RefSeq	NP_061853.1. NM_018980.2.
UniGene	Hs.675370.
3D structure databases
ProteinModelPortal	Q9NYW4.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q9NYW4.
Polymorphism databases
DMDM	29839664.
Proteomic databases
PRIDE	Q9NYW4.
Protocols and materials databases
DNASU	54429.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000247883; ENSP00000247883; ENSG00000127366.
GeneID	54429.
KEGG	hsa:54429.
UCSC	uc003vwr.1. human.
Organism-specific databases
CTD	54429.
GeneCards	GC07P141490.
HGNC	HGNC:14912. TAS2R5.
MIM	605062. gene.
neXtProt	NX_Q9NYW4.
PharmGKB	PA37924.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG133822.
HOGENOM	HOG000234595.
HOVERGEN	HBG098555.
InParanoid	Q9NYW4.
KO	K08474.
OMA	QWLIILD.
OrthoDB	EOG4KD6MX.
PhylomeDB	Q9NYW4.
Gene expression databases
ArrayExpress	Q9NYW4.
Bgee	Q9NYW4.
CleanEx	HS_TAS2R5.
Genevestigator	Q9NYW4.
GermOnline	ENSG00000127366. Homo sapiens.
Family and domain databases
InterPro	IPR007960. TAS2_rcpt. [Graphical view]
Pfam	PF05296. TAS2R. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	54429.
NextBio	56625.
SOURCE	Search...

Entry information

Entry name

TA2R5_HUMAN

Accession

Primary (citable) accession number: Q9NYW4
Secondary accession number(s): Q645W0, Q75MV7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 11, 2003
Last sequence update:	October 1, 2000
Last modified:	April 3, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.