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Q9NYW4

- TA2R5_HUMAN

UniProt

Q9NYW4 - TA2R5_HUMAN

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Protein
Taste receptor type 2 member 5
Gene
TAS2R5
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.

GO - Molecular functioni

  1. bitter taste receptor activity Source: UniProt
  2. taste receptor activity Source: UniProtKB

GO - Biological processi

  1. chemosensory behavior Source: ProtInc
  2. detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProt
  3. sensory perception of taste Source: ProtInc
  4. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Enzyme and pathway databases

ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 5
Short name:
T2R5
Gene namesi
Name:TAS2R5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:14912. TAS2R5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 11Extracellular Reviewed prediction
Transmembranei2 – 2221Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini23 – 4523Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei46 – 6621Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini67 – 8216Extracellular Reviewed prediction
Add
BLAST
Transmembranei83 – 10321Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini104 – 12724Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei128 – 14821Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini149 – 17527Extracellular Reviewed prediction
Add
BLAST
Transmembranei176 – 19621Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini197 – 22327Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei224 – 24421Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini245 – 2539Extracellular Reviewed prediction
Transmembranei254 – 27421Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini275 – 29925Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37924.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299Taste receptor type 2 member 5
PRO_0000082212Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi155 – 1551N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9NYW4.

PTM databases

PhosphoSiteiQ9NYW4.

Expressioni

Tissue specificityi

Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.

Gene expression databases

ArrayExpressiQ9NYW4.
BgeeiQ9NYW4.
CleanExiHS_TAS2R5.
GenevestigatoriQ9NYW4.

Structurei

3D structure databases

ProteinModelPortaliQ9NYW4.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG133822.
HOGENOMiHOG000234595.
HOVERGENiHBG098555.
InParanoidiQ9NYW4.
KOiK08474.
OMAiQWLIILD.
OrthoDBiEOG7H4DV2.
PhylomeDBiQ9NYW4.
TreeFamiTF335891.

Family and domain databases

InterProiIPR007960. TAS2_rcpt.
[Graphical view]
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NYW4-1 [UniParc]FASTAAdd to Basket

« Hide

MLSAGLGLLM LVAVVEFLIG LIGNGSLVVW SFREWIRKFN WSSYNLIILG    50
LAGCRFLLQW LIILDLSLFP LFQSSRWLRY LSIFWVLVSQ ASLWFATFLS 100
VFYCKKITTF DRPAYLWLKQ RAYNLSLWCL LGYFIINLLL TVQIGLTFYH 150
PPQGNSSIRY PFESWQYLYA FQLNSGSYLP LVVFLVSSGM LIVSLYTHHK 200
KMKVHSAGRR DVRAKAHITA LKSLGCFLLL HLVYIMASPF SITSKTYPPD 250
LTSVFIWETL MAAYPSLHSL ILIMGIPRVK QTCQKILWKT VCARRCWGP 299
Length:299
Mass (Da):34,505
Last modified:October 1, 2000 - v1
Checksum:iF85064A07E9018C7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti20 – 201G → S.
Corresponds to variant rs2234013 [ dbSNP | Ensembl ].
VAR_053343
Natural varianti26 – 261S → I.
Corresponds to variant rs2227264 [ dbSNP | Ensembl ].
VAR_020203
Natural varianti113 – 1131P → L.
Corresponds to variant rs2234014 [ dbSNP | Ensembl ].
VAR_034537
Natural varianti167 – 1671Y → C.
Corresponds to variant rs34529840 [ dbSNP | Ensembl ].
VAR_034538
Natural varianti213 – 2131R → Q.
Corresponds to variant rs2234015 [ dbSNP | Ensembl ].
VAR_024184
Natural varianti294 – 2941R → L.
Corresponds to variant rs2234016 [ dbSNP | Ensembl ].
VAR_053344

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF227132 Genomic DNA. Translation: AAF43905.1.
AY724966 Genomic DNA. Translation: AAU21159.1.
AC004979 Genomic DNA. Translation: AAS02040.1.
BC069509 mRNA. Translation: AAH69509.1.
BC101586 mRNA. Translation: AAI01587.1.
BC101588 mRNA. Translation: AAI01589.1.
CCDSiCCDS5869.1.
RefSeqiNP_061853.1. NM_018980.2.
UniGeneiHs.675370.

Genome annotation databases

EnsembliENST00000247883; ENSP00000247883; ENSG00000127366.
GeneIDi54429.
KEGGihsa:54429.
UCSCiuc003vwr.1. human.

Polymorphism databases

DMDMi29839664.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF227132 Genomic DNA. Translation: AAF43905.1 .
AY724966 Genomic DNA. Translation: AAU21159.1 .
AC004979 Genomic DNA. Translation: AAS02040.1 .
BC069509 mRNA. Translation: AAH69509.1 .
BC101586 mRNA. Translation: AAI01587.1 .
BC101588 mRNA. Translation: AAI01589.1 .
CCDSi CCDS5869.1.
RefSeqi NP_061853.1. NM_018980.2.
UniGenei Hs.675370.

3D structure databases

ProteinModelPortali Q9NYW4.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q9NYW4.

Polymorphism databases

DMDMi 29839664.

Proteomic databases

PRIDEi Q9NYW4.

Protocols and materials databases

DNASUi 54429.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000247883 ; ENSP00000247883 ; ENSG00000127366 .
GeneIDi 54429.
KEGGi hsa:54429.
UCSCi uc003vwr.1. human.

Organism-specific databases

CTDi 54429.
GeneCardsi GC07P141490.
HGNCi HGNC:14912. TAS2R5.
MIMi 605062. gene.
neXtProti NX_Q9NYW4.
PharmGKBi PA37924.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG133822.
HOGENOMi HOG000234595.
HOVERGENi HBG098555.
InParanoidi Q9NYW4.
KOi K08474.
OMAi QWLIILD.
OrthoDBi EOG7H4DV2.
PhylomeDBi Q9NYW4.
TreeFami TF335891.

Enzyme and pathway databases

Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii TAS2R5.
GenomeRNAii 54429.
NextBioi 56625.
PROi Q9NYW4.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9NYW4.
Bgeei Q9NYW4.
CleanExi HS_TAS2R5.
Genevestigatori Q9NYW4.

Family and domain databases

InterProi IPR007960. TAS2_rcpt.
[Graphical view ]
Pfami PF05296. TAS2R. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TOPOLOGY.
  2. "Evolution of bitter taste receptors in humans and apes."
    Fischer A., Gilad Y., Man O., Paeaebo S.
    Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. Cited for: CHARACTERIZATION.
  6. Cited for: REVIEW.
  7. "Molecular mechanisms of bitter and sweet taste transduction."
    Margolskee R.F.
    J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  8. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
    Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
    Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiTA2R5_HUMAN
AccessioniPrimary (citable) accession number: Q9NYW4
Secondary accession number(s): Q645W0, Q75MV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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