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Protein

Taste receptor type 2 member 7

Gene

TAS2R7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.

GO - Molecular functioni

  • bitter taste receptor activity Source: UniProtKB
  • G-protein coupled receptor activity Source: UniProtKB-KW
  • taste receptor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Enzyme and pathway databases

BioCyciZFISH:ENSG00000121377-MONOMER.
ReactomeiR-HSA-418594. G alpha (i) signalling events.
R-HSA-420499. Class C/3 (Metabotropic glutamate/pheromone receptors).

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 7
Short name:
T2R7
Alternative name(s):
Taste receptor family B member 4
Short name:
TRB4
Gene namesi
Name:TAS2R7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:14913. TAS2R7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9ExtracellularSequence analysis9
Transmembranei10 – 30Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini31 – 55CytoplasmicSequence analysisAdd BLAST25
Transmembranei56 – 76Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini77 – 94ExtracellularSequence analysisAdd BLAST18
Transmembranei95 – 115Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini116 – 128CytoplasmicSequence analysisAdd BLAST13
Transmembranei129 – 149Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini150 – 187ExtracellularSequence analysisAdd BLAST38
Transmembranei188 – 208Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini209 – 235CytoplasmicSequence analysisAdd BLAST27
Transmembranei236 – 256Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini257 – 266ExtracellularSequence analysis10
Transmembranei267 – 287Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini288 – 318CytoplasmicSequence analysisAdd BLAST31

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000121377.
ENSG00000273326.
ENSG00000274327.
PharmGKBiPA37925.

Polymorphism and mutation databases

BioMutaiTAS2R7.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000822201 – 318Taste receptor type 2 member 7Add BLAST318

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi167N-linked (GlcNAc...)Sequence analysis1
Glycosylationi175N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9NYW3.
PRIDEiQ9NYW3.
TopDownProteomicsiQ9NYW3.

PTM databases

iPTMnetiQ9NYW3.
PhosphoSitePlusiQ9NYW3.

Expressioni

Tissue specificityi

Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.

Gene expression databases

CleanExiHS_TAS2R7.
GenevisibleiQ9NYW3. HS.

Interactioni

Protein-protein interaction databases

BioGridi119147. 14 interactors.
STRINGi9606.ENSP00000240687.

Structurei

3D structure databases

ProteinModelPortaliQ9NYW3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFAT. Eukaryota.
ENOG410YQIB. LUCA.
GeneTreeiENSGT00760000119096.
HOGENOMiHOG000234595.
HOVERGENiHBG060698.
InParanoidiQ9NYW3.
KOiK08474.
OMAiIDRVISW.
OrthoDBiEOG091G0G0Q.
PhylomeDBiQ9NYW3.
TreeFamiTF335891.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR007960. T2R.
IPR030053. TAS2R7.
[Graphical view]
PANTHERiPTHR11394. PTHR11394. 1 hit.
PTHR11394:SF58. PTHR11394:SF58. 1 hit.
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NYW3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADKVQTTLL FLAVGEFSVG ILGNAFIGLV NCMDWVKKRK IASIDLILTS
60 70 80 90 100
LAISRICLLC VILLDCFILV LYPDVYATGK EMRIIDFFWT LTNHLSIWFA
110 120 130 140 150
TCLSIYYFFK IGNFFHPLFL WMKWRIDRVI SWILLGCVVL SVFISLPATE
160 170 180 190 200
NLNADFRFCV KAKRKTNLTW SCRVNKTQHA STKLFLNLAT LLPFCVCLMS
210 220 230 240 250
FFLLILSLRR HIRRMQLSAT GCRDPSTEAH VRALKAVISF LLLFIAYYLS
260 270 280 290 300
FLIATSSYFM PETELAVIFG ESIALIYPSS HSFILILGNN KLRHASLKVI
310
WKVMSILKGR KFQQHKQI
Length:318
Mass (Da):36,550
Last modified:October 1, 2000 - v1
Checksum:iF187ADB2D8274B8A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_062084263T → M.Corresponds to variant rs11838055dbSNPEnsembl.1
Natural variantiVAR_021852263T → S.Corresponds to variant rs3759251dbSNPEnsembl.1
Natural variantiVAR_024185304M → I.Corresponds to variant rs619381dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF227133 Genomic DNA. Translation: AAF43906.1.
AY724936 Genomic DNA. Translation: AAU21138.1.
BC069091 mRNA. Translation: AAH69091.1.
BC093992 mRNA. Translation: AAH93992.1.
BC113561 mRNA. Translation: AAI13562.1.
CCDSiCCDS8631.1.
RefSeqiNP_076408.1. NM_023919.2.
UniGeneiHs.533754.

Genome annotation databases

EnsembliENST00000240687; ENSP00000240687; ENSG00000121377.
ENST00000574656; ENSP00000458498; ENSG00000273326.
ENST00000613239; ENSP00000484743; ENSG00000274327.
GeneIDi50837.
KEGGihsa:50837.
UCSCiuc001qyv.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF227133 Genomic DNA. Translation: AAF43906.1.
AY724936 Genomic DNA. Translation: AAU21138.1.
BC069091 mRNA. Translation: AAH69091.1.
BC093992 mRNA. Translation: AAH93992.1.
BC113561 mRNA. Translation: AAI13562.1.
CCDSiCCDS8631.1.
RefSeqiNP_076408.1. NM_023919.2.
UniGeneiHs.533754.

3D structure databases

ProteinModelPortaliQ9NYW3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119147. 14 interactors.
STRINGi9606.ENSP00000240687.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9NYW3.
PhosphoSitePlusiQ9NYW3.

Polymorphism and mutation databases

BioMutaiTAS2R7.

Proteomic databases

PaxDbiQ9NYW3.
PRIDEiQ9NYW3.
TopDownProteomicsiQ9NYW3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000240687; ENSP00000240687; ENSG00000121377.
ENST00000574656; ENSP00000458498; ENSG00000273326.
ENST00000613239; ENSP00000484743; ENSG00000274327.
GeneIDi50837.
KEGGihsa:50837.
UCSCiuc001qyv.3. human.

Organism-specific databases

CTDi50837.
GeneCardsiTAS2R7.
HGNCiHGNC:14913. TAS2R7.
MIMi604793. gene.
neXtProtiNX_Q9NYW3.
OpenTargetsiENSG00000121377.
ENSG00000273326.
ENSG00000274327.
PharmGKBiPA37925.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFAT. Eukaryota.
ENOG410YQIB. LUCA.
GeneTreeiENSGT00760000119096.
HOGENOMiHOG000234595.
HOVERGENiHBG060698.
InParanoidiQ9NYW3.
KOiK08474.
OMAiIDRVISW.
OrthoDBiEOG091G0G0Q.
PhylomeDBiQ9NYW3.
TreeFamiTF335891.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000121377-MONOMER.
ReactomeiR-HSA-418594. G alpha (i) signalling events.
R-HSA-420499. Class C/3 (Metabotropic glutamate/pheromone receptors).

Miscellaneous databases

GeneWikiiTAS2R7.
GenomeRNAii50837.
PROiQ9NYW3.
SOURCEiSearch...

Gene expression databases

CleanExiHS_TAS2R7.
GenevisibleiQ9NYW3. HS.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR007960. T2R.
IPR030053. TAS2R7.
[Graphical view]
PANTHERiPTHR11394. PTHR11394. 1 hit.
PTHR11394:SF58. PTHR11394:SF58. 1 hit.
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTA2R7_HUMAN
AccessioniPrimary (citable) accession number: Q9NYW3
Secondary accession number(s): Q645Y1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Several bitter taste receptors are expressed in a single taste receptor cell.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.