Q9NYW3 (TA2R7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Taste receptor type 2 member 7
Short name=T2R7

Alternative name(s):
Taste receptor family B member 4
Short name=TRB4

Gene names

Name:

TAS2R7

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	318 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.
Miscellaneous	Several bitter taste receptors are expressed in a single taste receptor cell.
Sequence similarities	Belongs to the G-protein coupled receptor T2R family.

Ontologies

Keywords
Biological process	Sensory transduction Taste
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Non-traceable author statement. Source: UniProtKB
Molecular_function	taste receptor activity Traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 318	318	Taste receptor type 2 member 7		PRO_0000082220
Regions
	Topological domain	1 – 9	9	Extracellular Potential
	Transmembrane	10 – 30	21	Helical; Name=1; Potential
	Topological domain	31 – 55	25	Cytoplasmic Potential
	Transmembrane	56 – 76	21	Helical; Name=2; Potential
	Topological domain	77 – 94	18	Extracellular Potential
	Transmembrane	95 – 115	21	Helical; Name=3; Potential
	Topological domain	116 – 128	13	Cytoplasmic Potential
	Transmembrane	129 – 149	21	Helical; Name=4; Potential
	Topological domain	150 – 187	38	Extracellular Potential
	Transmembrane	188 – 208	21	Helical; Name=5; Potential
	Topological domain	209 – 235	27	Cytoplasmic Potential
	Transmembrane	236 – 256	21	Helical; Name=6; Potential
	Topological domain	257 – 266	10	Extracellular Potential
	Transmembrane	267 – 287	21	Helical; Name=7; Potential
	Topological domain	288 – 318	31	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	167	1	N-linked (GlcNAc...) Potential
	Glycosylation	175	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	263	1	T → M. Corresponds to variant rs11838055 [ dbSNP | Ensembl ].		VAR_062084
	Natural variant	263	1	T → S. Corresponds to variant rs3759251 [ dbSNP | Ensembl ].		VAR_021852
	Natural variant	304	1	M → I. Corresponds to variant rs619381 [ dbSNP | Ensembl ].		VAR_024185

Sequences

	Sequence		Length	Mass (Da)
	Q9NYW3 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: F187ADB2D8274B8A	FASTA	318	36,550
	10 20 30 40 50 60 MADKVQTTLL FLAVGEFSVG ILGNAFIGLV NCMDWVKKRK IASIDLILTS LAISRICLLC 70 80 90 100 110 120 VILLDCFILV LYPDVYATGK EMRIIDFFWT LTNHLSIWFA TCLSIYYFFK IGNFFHPLFL 130 140 150 160 170 180 WMKWRIDRVI SWILLGCVVL SVFISLPATE NLNADFRFCV KAKRKTNLTW SCRVNKTQHA 190 200 210 220 230 240 STKLFLNLAT LLPFCVCLMS FFLLILSLRR HIRRMQLSAT GCRDPSTEAH VRALKAVISF 250 260 270 280 290 300 LLLFIAYYLS FLIATSSYFM PETELAVIFG ESIALIYPSS HSFILILGNN KLRHASLKVI 310 WKVMSILKGR KFQQHKQI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel family of mammalian taste receptors." Adler E., Hoon M.A., Mueller K.L., Chandrashekar J., Ryba N.J.P., Zuker C.S. Cell 100:693-702(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TOPOLOGY.
[2]	"Evolution of bitter taste receptors in humans and apes." Fischer A., Gilad Y., Man O., Paeaebo S. Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"T2Rs function as bitter taste receptors." Chandrashekar J., Mueller K.L., Hoon M.A., Adler E., Feng L., Guo W., Zuker C.S., Ryba N.J.P. Cell 100:703-711(2000) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION.
[5]	"Receptors for bitter and sweet taste." Montmayeur J.-P., Matsunami H. Curr. Opin. Neurobiol. 12:366-371(2002) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[6]	"Molecular mechanisms of bitter and sweet taste transduction." Margolskee R.F. J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[7]	"Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways." Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J. Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF227133 Genomic DNA. Translation: AAF43906.1. AY724936 Genomic DNA. Translation: AAU21138.1. BC069091 mRNA. Translation: AAH69091.1. BC093992 mRNA. Translation: AAH93992.1. BC113561 mRNA. Translation: AAI13562.1.
IPI	IPI00028328.
RefSeq	NP_076408.1. NM_023919.2.
UniGene	Hs.533754.
3D structure databases
ProteinModelPortal	Q9NYW3.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000240687.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q9NYW3.
Polymorphism databases
DMDM	29839663.
Proteomic databases
PaxDb	Q9NYW3.
PRIDE	Q9NYW3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000240687; ENSP00000240687; ENSG00000121377. ENST00000571546; ENSP00000458761; ENSG00000269294. ENST00000574656; ENSP00000458498; ENSG00000268395.
GeneID	50837.
KEGG	hsa:50837.
UCSC	uc001qyv.3. human.
Organism-specific databases
CTD	50837.
GeneCards	GC12M010854.
HGNC	HGNC:14913. TAS2R7.
MIM	604793. gene.
neXtProt	NX_Q9NYW3.
PharmGKB	PA37925.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG45213.
HOGENOM	HOG000234595.
HOVERGEN	HBG060698.
InParanoid	Q9NYW3.
KO	K08474.
OMA	IRRMQLS.
OrthoDB	EOG4NZTTR.
PhylomeDB	Q9NYW3.
Gene expression databases
ArrayExpress	Q9NYW3.
CleanEx	HS_TAS2R7.
Genevestigator	Q9NYW3.
GermOnline	ENSG00000121377. Homo sapiens.
Family and domain databases
InterPro	IPR017452. GPCR_Rhodpsn_7TM. IPR007960. TAS2_rcpt. [Graphical view]
Pfam	PF05296. TAS2R. 1 hit. [Graphical view]
PROSITE	PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. Uncertain. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	50837.
NextBio	53297.
SOURCE	Search...

Entry information

Entry name

TA2R7_HUMAN

Accession

Primary (citable) accession number: Q9NYW3
Secondary accession number(s): Q645Y1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 11, 2003
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 97 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.