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Q9NYW3

- TA2R7_HUMAN

UniProt

Q9NYW3 - TA2R7_HUMAN

Protein

Taste receptor type 2 member 7

Gene

TAS2R7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.

    GO - Molecular functioni

    1. bitter taste receptor activity Source: UniProt
    2. taste receptor activity Source: UniProtKB

    GO - Biological processi

    1. detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProt

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Sensory transduction, Taste

    Enzyme and pathway databases

    ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Taste receptor type 2 member 7
    Short name:
    T2R7
    Alternative name(s):
    Taste receptor family B member 4
    Short name:
    TRB4
    Gene namesi
    Name:TAS2R7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:14913. TAS2R7.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProt
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37925.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 318318Taste receptor type 2 member 7PRO_0000082220Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi175 – 1751N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9NYW3.
    PRIDEiQ9NYW3.

    PTM databases

    PhosphoSiteiQ9NYW3.

    Expressioni

    Tissue specificityi

    Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.

    Gene expression databases

    ArrayExpressiQ9NYW3.
    CleanExiHS_TAS2R7.
    GenevestigatoriQ9NYW3.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000240687.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NYW3.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 99ExtracellularSequence Analysis
    Topological domaini31 – 5525CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini77 – 9418ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini116 – 12813CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini150 – 18738ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini209 – 23527CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini257 – 26610ExtracellularSequence Analysis
    Topological domaini288 – 31831CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei10 – 3021Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei56 – 7621Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei95 – 11521Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei129 – 14921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei188 – 20821Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei236 – 25621Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei267 – 28721Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45213.
    HOGENOMiHOG000234595.
    HOVERGENiHBG060698.
    InParanoidiQ9NYW3.
    KOiK08474.
    OMAiDRVISWI.
    OrthoDBiEOG72C512.
    PhylomeDBiQ9NYW3.
    TreeFamiTF335891.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR017452. GPCR_Rhodpsn_7TM.
    IPR007960. TAS2_rcpt.
    [Graphical view]
    PfamiPF05296. TAS2R. 1 hit.
    [Graphical view]
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NYW3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADKVQTTLL FLAVGEFSVG ILGNAFIGLV NCMDWVKKRK IASIDLILTS    50
    LAISRICLLC VILLDCFILV LYPDVYATGK EMRIIDFFWT LTNHLSIWFA 100
    TCLSIYYFFK IGNFFHPLFL WMKWRIDRVI SWILLGCVVL SVFISLPATE 150
    NLNADFRFCV KAKRKTNLTW SCRVNKTQHA STKLFLNLAT LLPFCVCLMS 200
    FFLLILSLRR HIRRMQLSAT GCRDPSTEAH VRALKAVISF LLLFIAYYLS 250
    FLIATSSYFM PETELAVIFG ESIALIYPSS HSFILILGNN KLRHASLKVI 300
    WKVMSILKGR KFQQHKQI 318
    Length:318
    Mass (Da):36,550
    Last modified:October 1, 2000 - v1
    Checksum:iF187ADB2D8274B8A
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti263 – 2631T → M.
    Corresponds to variant rs11838055 [ dbSNP | Ensembl ].
    VAR_062084
    Natural varianti263 – 2631T → S.
    Corresponds to variant rs3759251 [ dbSNP | Ensembl ].
    VAR_021852
    Natural varianti304 – 3041M → I.
    Corresponds to variant rs619381 [ dbSNP | Ensembl ].
    VAR_024185

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF227133 Genomic DNA. Translation: AAF43906.1.
    AY724936 Genomic DNA. Translation: AAU21138.1.
    BC069091 mRNA. Translation: AAH69091.1.
    BC093992 mRNA. Translation: AAH93992.1.
    BC113561 mRNA. Translation: AAI13562.1.
    CCDSiCCDS8631.1.
    RefSeqiNP_076408.1. NM_023919.2.
    UniGeneiHs.533754.

    Genome annotation databases

    EnsembliENST00000240687; ENSP00000240687; ENSG00000121377.
    ENST00000574656; ENSP00000458498; ENSG00000273326.
    GeneIDi50837.
    KEGGihsa:50837.
    UCSCiuc001qyv.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF227133 Genomic DNA. Translation: AAF43906.1 .
    AY724936 Genomic DNA. Translation: AAU21138.1 .
    BC069091 mRNA. Translation: AAH69091.1 .
    BC093992 mRNA. Translation: AAH93992.1 .
    BC113561 mRNA. Translation: AAI13562.1 .
    CCDSi CCDS8631.1.
    RefSeqi NP_076408.1. NM_023919.2.
    UniGenei Hs.533754.

    3D structure databases

    ProteinModelPortali Q9NYW3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000240687.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9NYW3.

    Proteomic databases

    PaxDbi Q9NYW3.
    PRIDEi Q9NYW3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000240687 ; ENSP00000240687 ; ENSG00000121377 .
    ENST00000574656 ; ENSP00000458498 ; ENSG00000273326 .
    GeneIDi 50837.
    KEGGi hsa:50837.
    UCSCi uc001qyv.3. human.

    Organism-specific databases

    CTDi 50837.
    GeneCardsi GC12M010854.
    HGNCi HGNC:14913. TAS2R7.
    MIMi 604793. gene.
    neXtProti NX_Q9NYW3.
    PharmGKBi PA37925.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45213.
    HOGENOMi HOG000234595.
    HOVERGENi HBG060698.
    InParanoidi Q9NYW3.
    KOi K08474.
    OMAi DRVISWI.
    OrthoDBi EOG72C512.
    PhylomeDBi Q9NYW3.
    TreeFami TF335891.

    Enzyme and pathway databases

    Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii TAS2R7.
    GenomeRNAii 50837.
    NextBioi 53297.
    PROi Q9NYW3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NYW3.
    CleanExi HS_TAS2R7.
    Genevestigatori Q9NYW3.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR017452. GPCR_Rhodpsn_7TM.
    IPR007960. TAS2_rcpt.
    [Graphical view ]
    Pfami PF05296. TAS2R. 1 hit.
    [Graphical view ]
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TOPOLOGY.
    2. "Evolution of bitter taste receptors in humans and apes."
      Fischer A., Gilad Y., Man O., Paeaebo S.
      Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Cited for: CHARACTERIZATION.
    5. Cited for: REVIEW.
    6. "Molecular mechanisms of bitter and sweet taste transduction."
      Margolskee R.F.
      J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    7. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
      Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
      Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiTA2R7_HUMAN
    AccessioniPrimary (citable) accession number: Q9NYW3
    Secondary accession number(s): Q645Y1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 11, 2003
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Several bitter taste receptors are expressed in a single taste receptor cell.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3