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Q9NYW3

- TA2R7_HUMAN

UniProt

Q9NYW3 - TA2R7_HUMAN

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Protein

Taste receptor type 2 member 7

Gene
TAS2R7
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.

GO - Molecular functioni

  1. bitter taste receptor activity Source: UniProt
  2. taste receptor activity Source: UniProtKB

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProt
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Enzyme and pathway databases

ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 7
Short name:
T2R7
Alternative name(s):
Taste receptor family B member 4
Short name:
TRB4
Gene namesi
Name:TAS2R7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:14913. TAS2R7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99Extracellular Reviewed prediction
Transmembranei10 – 3021Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini31 – 5525Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei56 – 7621Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini77 – 9418Extracellular Reviewed predictionAdd
BLAST
Transmembranei95 – 11521Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini116 – 12813Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei129 – 14921Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini150 – 18738Extracellular Reviewed predictionAdd
BLAST
Transmembranei188 – 20821Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini209 – 23527Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei236 – 25621Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini257 – 26610Extracellular Reviewed prediction
Transmembranei267 – 28721Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini288 – 31831Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProt
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37925.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Taste receptor type 2 member 7PRO_0000082220Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi167 – 1671N-linked (GlcNAc...) Reviewed prediction
Glycosylationi175 – 1751N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9NYW3.
PRIDEiQ9NYW3.

PTM databases

PhosphoSiteiQ9NYW3.

Expressioni

Tissue specificityi

Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.

Gene expression databases

ArrayExpressiQ9NYW3.
CleanExiHS_TAS2R7.
GenevestigatoriQ9NYW3.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000240687.

Structurei

3D structure databases

ProteinModelPortaliQ9NYW3.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45213.
HOGENOMiHOG000234595.
HOVERGENiHBG060698.
InParanoidiQ9NYW3.
KOiK08474.
OMAiDRVISWI.
OrthoDBiEOG72C512.
PhylomeDBiQ9NYW3.
TreeFamiTF335891.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR007960. TAS2_rcpt.
[Graphical view]
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NYW3-1 [UniParc]FASTAAdd to Basket

« Hide

MADKVQTTLL FLAVGEFSVG ILGNAFIGLV NCMDWVKKRK IASIDLILTS    50
LAISRICLLC VILLDCFILV LYPDVYATGK EMRIIDFFWT LTNHLSIWFA 100
TCLSIYYFFK IGNFFHPLFL WMKWRIDRVI SWILLGCVVL SVFISLPATE 150
NLNADFRFCV KAKRKTNLTW SCRVNKTQHA STKLFLNLAT LLPFCVCLMS 200
FFLLILSLRR HIRRMQLSAT GCRDPSTEAH VRALKAVISF LLLFIAYYLS 250
FLIATSSYFM PETELAVIFG ESIALIYPSS HSFILILGNN KLRHASLKVI 300
WKVMSILKGR KFQQHKQI 318
Length:318
Mass (Da):36,550
Last modified:October 1, 2000 - v1
Checksum:iF187ADB2D8274B8A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti263 – 2631T → M.
Corresponds to variant rs11838055 [ dbSNP | Ensembl ].
VAR_062084
Natural varianti263 – 2631T → S.
Corresponds to variant rs3759251 [ dbSNP | Ensembl ].
VAR_021852
Natural varianti304 – 3041M → I.
Corresponds to variant rs619381 [ dbSNP | Ensembl ].
VAR_024185

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF227133 Genomic DNA. Translation: AAF43906.1.
AY724936 Genomic DNA. Translation: AAU21138.1.
BC069091 mRNA. Translation: AAH69091.1.
BC093992 mRNA. Translation: AAH93992.1.
BC113561 mRNA. Translation: AAI13562.1.
CCDSiCCDS8631.1.
RefSeqiNP_076408.1. NM_023919.2.
UniGeneiHs.533754.

Genome annotation databases

EnsembliENST00000240687; ENSP00000240687; ENSG00000121377.
ENST00000571546; ENSP00000458761; ENSG00000273404.
ENST00000574656; ENSP00000458498; ENSG00000273326.
GeneIDi50837.
KEGGihsa:50837.
UCSCiuc001qyv.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF227133 Genomic DNA. Translation: AAF43906.1 .
AY724936 Genomic DNA. Translation: AAU21138.1 .
BC069091 mRNA. Translation: AAH69091.1 .
BC093992 mRNA. Translation: AAH93992.1 .
BC113561 mRNA. Translation: AAI13562.1 .
CCDSi CCDS8631.1.
RefSeqi NP_076408.1. NM_023919.2.
UniGenei Hs.533754.

3D structure databases

ProteinModelPortali Q9NYW3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000240687.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q9NYW3.

Proteomic databases

PaxDbi Q9NYW3.
PRIDEi Q9NYW3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000240687 ; ENSP00000240687 ; ENSG00000121377 .
ENST00000571546 ; ENSP00000458761 ; ENSG00000273404 .
ENST00000574656 ; ENSP00000458498 ; ENSG00000273326 .
GeneIDi 50837.
KEGGi hsa:50837.
UCSCi uc001qyv.3. human.

Organism-specific databases

CTDi 50837.
GeneCardsi GC12M010854.
HGNCi HGNC:14913. TAS2R7.
MIMi 604793. gene.
neXtProti NX_Q9NYW3.
PharmGKBi PA37925.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG45213.
HOGENOMi HOG000234595.
HOVERGENi HBG060698.
InParanoidi Q9NYW3.
KOi K08474.
OMAi DRVISWI.
OrthoDBi EOG72C512.
PhylomeDBi Q9NYW3.
TreeFami TF335891.

Enzyme and pathway databases

Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii TAS2R7.
GenomeRNAii 50837.
NextBioi 53297.
PROi Q9NYW3.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9NYW3.
CleanExi HS_TAS2R7.
Genevestigatori Q9NYW3.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR017452. GPCR_Rhodpsn_7TM.
IPR007960. TAS2_rcpt.
[Graphical view ]
Pfami PF05296. TAS2R. 1 hit.
[Graphical view ]
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TOPOLOGY.
  2. "Evolution of bitter taste receptors in humans and apes."
    Fischer A., Gilad Y., Man O., Paeaebo S.
    Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: CHARACTERIZATION.
  5. Cited for: REVIEW.
  6. "Molecular mechanisms of bitter and sweet taste transduction."
    Margolskee R.F.
    J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  7. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
    Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
    Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiTA2R7_HUMAN
AccessioniPrimary (citable) accession number: Q9NYW3
Secondary accession number(s): Q645Y1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Several bitter taste receptors are expressed in a single taste receptor cell.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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