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Q9NYW3 (TA2R7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Taste receptor type 2 member 7

Short name=T2R7
Alternative name(s):
Taste receptor family B member 4
Short name=TRB4
Gene names
Name:TAS2R7
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length318 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.

Miscellaneous

Several bitter taste receptors are expressed in a single taste receptor cell.

Sequence similarities

Belongs to the G-protein coupled receptor T2R family.

Ontologies

Keywords
   Biological processSensory transduction
Taste
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdetection of chemical stimulus involved in sensory perception of taste

Traceable author statement Ref.1. Source: GOC

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functiontaste receptor activity

Traceable author statement Ref.1. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 318318Taste receptor type 2 member 7
PRO_0000082220

Regions

Topological domain1 – 99Extracellular Potential
Transmembrane10 – 3021Helical; Name=1; Potential
Topological domain31 – 5525Cytoplasmic Potential
Transmembrane56 – 7621Helical; Name=2; Potential
Topological domain77 – 9418Extracellular Potential
Transmembrane95 – 11521Helical; Name=3; Potential
Topological domain116 – 12813Cytoplasmic Potential
Transmembrane129 – 14921Helical; Name=4; Potential
Topological domain150 – 18738Extracellular Potential
Transmembrane188 – 20821Helical; Name=5; Potential
Topological domain209 – 23527Cytoplasmic Potential
Transmembrane236 – 25621Helical; Name=6; Potential
Topological domain257 – 26610Extracellular Potential
Transmembrane267 – 28721Helical; Name=7; Potential
Topological domain288 – 31831Cytoplasmic Potential

Amino acid modifications

Glycosylation1671N-linked (GlcNAc...) Potential
Glycosylation1751N-linked (GlcNAc...) Potential

Natural variations

Natural variant2631T → M.
Corresponds to variant rs11838055 [ dbSNP | Ensembl ].
VAR_062084
Natural variant2631T → S.
Corresponds to variant rs3759251 [ dbSNP | Ensembl ].
VAR_021852
Natural variant3041M → I.
Corresponds to variant rs619381 [ dbSNP | Ensembl ].
VAR_024185

Sequences

Sequence LengthMass (Da)Tools
Q9NYW3 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: F187ADB2D8274B8A

FASTA31836,550
        10         20         30         40         50         60 
MADKVQTTLL FLAVGEFSVG ILGNAFIGLV NCMDWVKKRK IASIDLILTS LAISRICLLC 

        70         80         90        100        110        120 
VILLDCFILV LYPDVYATGK EMRIIDFFWT LTNHLSIWFA TCLSIYYFFK IGNFFHPLFL 

       130        140        150        160        170        180 
WMKWRIDRVI SWILLGCVVL SVFISLPATE NLNADFRFCV KAKRKTNLTW SCRVNKTQHA 

       190        200        210        220        230        240 
STKLFLNLAT LLPFCVCLMS FFLLILSLRR HIRRMQLSAT GCRDPSTEAH VRALKAVISF 

       250        260        270        280        290        300 
LLLFIAYYLS FLIATSSYFM PETELAVIFG ESIALIYPSS HSFILILGNN KLRHASLKVI 

       310 
WKVMSILKGR KFQQHKQI 

« Hide

References

« Hide 'large scale' references
[1]"A novel family of mammalian taste receptors."
Adler E., Hoon M.A., Mueller K.L., Chandrashekar J., Ryba N.J.P., Zuker C.S.
Cell 100:693-702(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TOPOLOGY.
[2]"Evolution of bitter taste receptors in humans and apes."
Fischer A., Gilad Y., Man O., Paeaebo S.
Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"T2Rs function as bitter taste receptors."
Chandrashekar J., Mueller K.L., Hoon M.A., Adler E., Feng L., Guo W., Zuker C.S., Ryba N.J.P.
Cell 100:703-711(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[5]"Receptors for bitter and sweet taste."
Montmayeur J.-P., Matsunami H.
Curr. Opin. Neurobiol. 12:366-371(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[6]"Molecular mechanisms of bitter and sweet taste transduction."
Margolskee R.F.
J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[7]"Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF227133 Genomic DNA. Translation: AAF43906.1.
AY724936 Genomic DNA. Translation: AAU21138.1.
BC069091 mRNA. Translation: AAH69091.1.
BC093992 mRNA. Translation: AAH93992.1.
BC113561 mRNA. Translation: AAI13562.1.
RefSeqNP_076408.1. NM_023919.2.
UniGeneHs.533754.

3D structure databases

ProteinModelPortalQ9NYW3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000240687.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ9NYW3.

Proteomic databases

PaxDbQ9NYW3.
PRIDEQ9NYW3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000240687; ENSP00000240687; ENSG00000121377.
ENST00000571546; ENSP00000458761; ENSG00000273404.
ENST00000574656; ENSP00000458498; ENSG00000273326.
GeneID50837.
KEGGhsa:50837.
UCSCuc001qyv.3. human.

Organism-specific databases

CTD50837.
GeneCardsGC12M010854.
HGNCHGNC:14913. TAS2R7.
MIM604793. gene.
neXtProtNX_Q9NYW3.
PharmGKBPA37925.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG45213.
HOGENOMHOG000234595.
HOVERGENHBG060698.
InParanoidQ9NYW3.
KOK08474.
OMADRVISWI.
OrthoDBEOG72C512.
PhylomeDBQ9NYW3.
TreeFamTF335891.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressQ9NYW3.
CleanExHS_TAS2R7.
GenevestigatorQ9NYW3.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR017452. GPCR_Rhodpsn_7TM.
IPR007960. TAS2_rcpt.
[Graphical view]
PfamPF05296. TAS2R. 1 hit.
[Graphical view]
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiTAS2R7.
GenomeRNAi50837.
NextBio53297.
PROQ9NYW3.
SOURCESearch...

Entry information

Entry nameTA2R7_HUMAN
AccessionPrimary (citable) accession number: Q9NYW3
Secondary accession number(s): Q645Y1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries