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Protein

Taste receptor type 2 member 8

Gene

TAS2R8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.

GO - Molecular functioni

  1. bitter taste receptor activity Source: UniProtKB
  2. taste receptor activity Source: UniProtKB

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Enzyme and pathway databases

ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 8
Short name:
T2R8
Alternative name(s):
Taste receptor family B member 5
Short name:
TRB5
Gene namesi
Name:TAS2R8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12, UP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:14915. TAS2R8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77ExtracellularSequence Analysis
Transmembranei8 – 2821Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini29 – 5022CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei51 – 7121Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini72 – 8211ExtracellularSequence AnalysisAdd
BLAST
Transmembranei83 – 10321Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini104 – 13128CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei132 – 15221Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini153 – 18432ExtracellularSequence AnalysisAdd
BLAST
Transmembranei185 – 20521Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini206 – 23934CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei240 – 26021Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini261 – 2666ExtracellularSequence Analysis
Transmembranei267 – 28721Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini288 – 30922CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37926.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Taste receptor type 2 member 8PRO_0000082227Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9NYW2.
PRIDEiQ9NYW2.

PTM databases

PhosphoSiteiQ9NYW2.

Expressioni

Tissue specificityi

Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.

Gene expression databases

CleanExiHS_TAS2R8.
ExpressionAtlasiQ9NYW2. baseline.
GenevestigatoriQ9NYW2.

Structurei

3D structure databases

ProteinModelPortaliQ9NYW2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG249394.
GeneTreeiENSGT00760000119096.
HOGENOMiHOG000234595.
HOVERGENiHBG060698.
InParanoidiQ9NYW2.
KOiK08474.
OMAiSPADNIF.
OrthoDBiEOG72C512.
PhylomeDBiQ9NYW2.
TreeFamiTF335891.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR007960. T2R.
[Graphical view]
PANTHERiPTHR11394. PTHR11394. 1 hit.
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NYW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSPADNIFI ILITGEFILG ILGNGYIALV NWIDWIKKKK ISTVDYILTN
60 70 80 90 100
LVIARICLIS VMVVNGIVIV LNPDVYTKNK QQIVIFTFWT FANYLNMWIT
110 120 130 140 150
TCLNVFYFLK IASSSHPLFL WLKWKIDMVV HWILLGCFAI SLLVSLIAAI
160 170 180 190 200
VLSCDYRFHA IAKHKRNITE MFHVSKIPYF EPLTLFNLFA IVPFIVSLIS
210 220 230 240 250
FFLLVRSLWR HTKQIKLYAT GSRDPSTEVH VRAIKTMTSF IFFFFLYYIS
260 270 280 290 300
SILMTFSYLM TKYKLAVEFG EIAAILYPLG HSLILIVLNN KLRQTFVRML

TCRKIACMI
Length:309
Mass (Da):35,877
Last modified:October 1, 2000 - v1
Checksum:i5E3D94B726A52413
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti308 – 3081M → V.1 Publication
Corresponds to variant rs2537817 [ dbSNP | Ensembl ].
VAR_024186

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF227134 Genomic DNA. Translation: AAF43907.1.
AY724935 Genomic DNA. Translation: AAU21137.1.
BC069084 mRNA. Translation: AAH69084.1.
BC069551 mRNA. Translation: AAH69551.1.
BC096701 mRNA. Translation: AAH96701.1.
BC096735 mRNA. Translation: AAH96735.1.
BC098353 mRNA. Translation: AAH98353.1.
CCDSiCCDS8632.1.
RefSeqiNP_076407.1. NM_023918.1.
UniGeneiHs.533755.

Genome annotation databases

EnsembliENST00000240615; ENSP00000240615; ENSG00000121314.
ENST00000572823; ENSP00000461158; ENSG00000272712.
ENST00000610444; ENSP00000484163; ENSG00000277316.
GeneIDi50836.
KEGGihsa:50836.
UCSCiuc010shh.2. human.

Polymorphism databases

DMDMi29839662.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF227134 Genomic DNA. Translation: AAF43907.1.
AY724935 Genomic DNA. Translation: AAU21137.1.
BC069084 mRNA. Translation: AAH69084.1.
BC069551 mRNA. Translation: AAH69551.1.
BC096701 mRNA. Translation: AAH96701.1.
BC096735 mRNA. Translation: AAH96735.1.
BC098353 mRNA. Translation: AAH98353.1.
CCDSiCCDS8632.1.
RefSeqiNP_076407.1. NM_023918.1.
UniGeneiHs.533755.

3D structure databases

ProteinModelPortaliQ9NYW2.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ9NYW2.

Polymorphism databases

DMDMi29839662.

Proteomic databases

PaxDbiQ9NYW2.
PRIDEiQ9NYW2.

Protocols and materials databases

DNASUi50836.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000240615; ENSP00000240615; ENSG00000121314.
ENST00000572823; ENSP00000461158; ENSG00000272712.
ENST00000610444; ENSP00000484163; ENSG00000277316.
GeneIDi50836.
KEGGihsa:50836.
UCSCiuc010shh.2. human.

Organism-specific databases

CTDi50836.
GeneCardsiGC12M010971.
HGNCiHGNC:14915. TAS2R8.
MIMi604794. gene.
neXtProtiNX_Q9NYW2.
PharmGKBiPA37926.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG249394.
GeneTreeiENSGT00760000119096.
HOGENOMiHOG000234595.
HOVERGENiHBG060698.
InParanoidiQ9NYW2.
KOiK08474.
OMAiSPADNIF.
OrthoDBiEOG72C512.
PhylomeDBiQ9NYW2.
TreeFamiTF335891.

Enzyme and pathway databases

ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikiiTAS2R8.
GenomeRNAii50836.
NextBioi53293.
PROiQ9NYW2.
SOURCEiSearch...

Gene expression databases

CleanExiHS_TAS2R8.
ExpressionAtlasiQ9NYW2. baseline.
GenevestigatoriQ9NYW2.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR007960. T2R.
[Graphical view]
PANTHERiPTHR11394. PTHR11394. 1 hit.
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TOPOLOGY.
  2. "Evolution of bitter taste receptors in humans and apes."
    Fischer A., Gilad Y., Man O., Paeaebo S.
    Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-308.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: CHARACTERIZATION.
  5. Cited for: REVIEW.
  6. "Molecular mechanisms of bitter and sweet taste transduction."
    Margolskee R.F.
    J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  7. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
    Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
    Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiTA2R8_HUMAN
AccessioniPrimary (citable) accession number: Q9NYW2
Secondary accession number(s): Q4KN29, Q645Y2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: October 1, 2000
Last modified: March 4, 2015
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.