Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9NYW2

- TA2R8_HUMAN

UniProt

Q9NYW2 - TA2R8_HUMAN

Protein

Taste receptor type 2 member 8

Gene

TAS2R8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.

    GO - Molecular functioni

    1. bitter taste receptor activity Source: UniProt
    2. taste receptor activity Source: UniProtKB

    GO - Biological processi

    1. detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProt

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Sensory transduction, Taste

    Enzyme and pathway databases

    ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Taste receptor type 2 member 8
    Short name:
    T2R8
    Alternative name(s):
    Taste receptor family B member 5
    Short name:
    TRB5
    Gene namesi
    Name:TAS2R8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:14915. TAS2R8.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProt
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37926.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 309309Taste receptor type 2 member 8PRO_0000082227Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9NYW2.
    PRIDEiQ9NYW2.

    PTM databases

    PhosphoSiteiQ9NYW2.

    Expressioni

    Tissue specificityi

    Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.

    Gene expression databases

    CleanExiHS_TAS2R8.
    GenevestigatoriQ9NYW2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NYW2.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 77ExtracellularSequence Analysis
    Topological domaini29 – 5022CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini72 – 8211ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini104 – 13128CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini153 – 18432ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini206 – 23934CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini261 – 2666ExtracellularSequence Analysis
    Topological domaini288 – 30922CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8 – 2821Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei51 – 7121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei83 – 10321Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei132 – 15221Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei185 – 20521Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei240 – 26021Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei267 – 28721Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG249394.
    HOGENOMiHOG000234595.
    HOVERGENiHBG060698.
    InParanoidiQ9NYW2.
    KOiK08474.
    OMAiSPADNIF.
    OrthoDBiEOG72C512.
    PhylomeDBiQ9NYW2.
    TreeFamiTF335891.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR017452. GPCR_Rhodpsn_7TM.
    IPR007960. TAS2_rcpt.
    [Graphical view]
    PfamiPF05296. TAS2R. 1 hit.
    [Graphical view]
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NYW2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFSPADNIFI ILITGEFILG ILGNGYIALV NWIDWIKKKK ISTVDYILTN    50
    LVIARICLIS VMVVNGIVIV LNPDVYTKNK QQIVIFTFWT FANYLNMWIT 100
    TCLNVFYFLK IASSSHPLFL WLKWKIDMVV HWILLGCFAI SLLVSLIAAI 150
    VLSCDYRFHA IAKHKRNITE MFHVSKIPYF EPLTLFNLFA IVPFIVSLIS 200
    FFLLVRSLWR HTKQIKLYAT GSRDPSTEVH VRAIKTMTSF IFFFFLYYIS 250
    SILMTFSYLM TKYKLAVEFG EIAAILYPLG HSLILIVLNN KLRQTFVRML 300
    TCRKIACMI 309
    Length:309
    Mass (Da):35,877
    Last modified:October 1, 2000 - v1
    Checksum:i5E3D94B726A52413
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti308 – 3081M → V.1 Publication
    Corresponds to variant rs2537817 [ dbSNP | Ensembl ].
    VAR_024186

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF227134 Genomic DNA. Translation: AAF43907.1.
    AY724935 Genomic DNA. Translation: AAU21137.1.
    BC069084 mRNA. Translation: AAH69084.1.
    BC069551 mRNA. Translation: AAH69551.1.
    BC096701 mRNA. Translation: AAH96701.1.
    BC096735 mRNA. Translation: AAH96735.1.
    BC098353 mRNA. Translation: AAH98353.1.
    CCDSiCCDS8632.1.
    RefSeqiNP_076407.1. NM_023918.1.
    UniGeneiHs.533755.

    Genome annotation databases

    EnsembliENST00000240615; ENSP00000240615; ENSG00000121314.
    ENST00000572823; ENSP00000461158; ENSG00000272712.
    GeneIDi50836.
    KEGGihsa:50836.
    UCSCiuc010shh.2. human.

    Polymorphism databases

    DMDMi29839662.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF227134 Genomic DNA. Translation: AAF43907.1 .
    AY724935 Genomic DNA. Translation: AAU21137.1 .
    BC069084 mRNA. Translation: AAH69084.1 .
    BC069551 mRNA. Translation: AAH69551.1 .
    BC096701 mRNA. Translation: AAH96701.1 .
    BC096735 mRNA. Translation: AAH96735.1 .
    BC098353 mRNA. Translation: AAH98353.1 .
    CCDSi CCDS8632.1.
    RefSeqi NP_076407.1. NM_023918.1.
    UniGenei Hs.533755.

    3D structure databases

    ProteinModelPortali Q9NYW2.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9NYW2.

    Polymorphism databases

    DMDMi 29839662.

    Proteomic databases

    PaxDbi Q9NYW2.
    PRIDEi Q9NYW2.

    Protocols and materials databases

    DNASUi 50836.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000240615 ; ENSP00000240615 ; ENSG00000121314 .
    ENST00000572823 ; ENSP00000461158 ; ENSG00000272712 .
    GeneIDi 50836.
    KEGGi hsa:50836.
    UCSCi uc010shh.2. human.

    Organism-specific databases

    CTDi 50836.
    GeneCardsi GC12M010858.
    HGNCi HGNC:14915. TAS2R8.
    MIMi 604794. gene.
    neXtProti NX_Q9NYW2.
    PharmGKBi PA37926.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG249394.
    HOGENOMi HOG000234595.
    HOVERGENi HBG060698.
    InParanoidi Q9NYW2.
    KOi K08474.
    OMAi SPADNIF.
    OrthoDBi EOG72C512.
    PhylomeDBi Q9NYW2.
    TreeFami TF335891.

    Enzyme and pathway databases

    Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii TAS2R8.
    GenomeRNAii 50836.
    NextBioi 53293.
    PROi Q9NYW2.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_TAS2R8.
    Genevestigatori Q9NYW2.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR017452. GPCR_Rhodpsn_7TM.
    IPR007960. TAS2_rcpt.
    [Graphical view ]
    Pfami PF05296. TAS2R. 1 hit.
    [Graphical view ]
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TOPOLOGY.
    2. "Evolution of bitter taste receptors in humans and apes."
      Fischer A., Gilad Y., Man O., Paeaebo S.
      Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-308.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Cited for: CHARACTERIZATION.
    5. Cited for: REVIEW.
    6. "Molecular mechanisms of bitter and sweet taste transduction."
      Margolskee R.F.
      J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    7. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
      Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
      Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiTA2R8_HUMAN
    AccessioniPrimary (citable) accession number: Q9NYW2
    Secondary accession number(s): Q4KN29, Q645Y2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 11, 2003
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3