ID   TA2R9_HUMAN             Reviewed;         312 AA.
AC   Q9NYW1; Q502V7; Q50KT0; Q50KT1; Q645W9;
DT   11-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   24-JAN-2024, entry version 164.
DE   RecName: Full=Taste receptor type 2 member 9;
DE            Short=T2R9;
DE   AltName: Full=Taste receptor family B member 6;
DE            Short=TRB6;
GN   Name=TAS2R9;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TOPOLOGY.
RX   PubMed=10761934; DOI=10.1016/s0092-8674(00)80705-9;
RA   Adler E., Hoon M.A., Mueller K.L., Chandrashekar J., Ryba N.J.P.,
RA   Zuker C.S.;
RT   "A novel family of mammalian taste receptors.";
RL   Cell 100:693-702(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=15496549; DOI=10.1093/molbev/msi027;
RA   Fischer A., Gilad Y., Man O., Paeaebo S.;
RT   "Evolution of bitter taste receptors in humans and apes.";
RL   Mol. Biol. Evol. 22:432-436(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-187.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 9-298, AND VARIANT ALA-187.
RX   PubMed=15744053; DOI=10.1534/genetics.104.037523;
RA   Go Y., Satta Y., Takenaka O., Takahata N.;
RT   "Lineage-specific loss of function of bitter taste receptor genes in humans
RT   and nonhuman primates.";
RL   Genetics 170:313-326(2005).
RN   [5]
RP   CHARACTERIZATION.
RX   PubMed=10761935; DOI=10.1016/s0092-8674(00)80706-0;
RA   Chandrashekar J., Mueller K.L., Hoon M.A., Adler E., Feng L., Guo W.,
RA   Zuker C.S., Ryba N.J.P.;
RT   "T2Rs function as bitter taste receptors.";
RL   Cell 100:703-711(2000).
RN   [6]
RP   REVIEW.
RX   PubMed=12139982; DOI=10.1016/s0959-4388(02)00345-8;
RA   Montmayeur J.-P., Matsunami H.;
RT   "Receptors for bitter and sweet taste.";
RL   Curr. Opin. Neurobiol. 12:366-371(2002).
RN   [7]
RP   REVIEW.
RX   PubMed=11696554; DOI=10.1074/jbc.r100054200;
RA   Margolskee R.F.;
RT   "Molecular mechanisms of bitter and sweet taste transduction.";
RL   J. Biol. Chem. 277:1-4(2002).
RN   [8]
RP   REVIEW.
RX   PubMed=12581520; DOI=10.1016/s0092-8674(03)00071-0;
RA   Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D.,
RA   Zuker C.S., Ryba N.J.;
RT   "Coding of sweet, bitter, and umami tastes: different receptor cells
RT   sharing similar signaling pathways.";
RL   Cell 112:293-301(2003).
CC   -!- FUNCTION: Gustducin-coupled receptor implicated in the perception of
CC       bitter compounds in the oral cavity and the gastrointestinal tract.
CC       Signals through PLCB2 and the calcium-regulated cation channel TRPM5
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Expressed in subsets of taste receptor cells of the
CC       tongue and palate epithelium and exclusively in gustducin-positive
CC       cells.
CC   -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC       taste receptor cell.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC       {ECO:0000305}.
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DR   EMBL; AF227135; AAF43908.1; -; Genomic_DNA.
DR   EMBL; AY724954; AAU21150.1; -; Genomic_DNA.
DR   EMBL; BC069066; AAH69066.1; -; mRNA.
DR   EMBL; BC095519; AAH95519.1; -; mRNA.
DR   EMBL; AB199063; BAD97966.1; -; Genomic_DNA.
DR   EMBL; AB199064; BAD97967.1; -; Genomic_DNA.
DR   EMBL; AB199065; BAD97968.1; -; Genomic_DNA.
DR   CCDS; CCDS8633.1; -.
DR   RefSeq; NP_076406.1; NM_023917.2.
DR   AlphaFoldDB; Q9NYW1; -.
DR   SMR; Q9NYW1; -.
DR   STRING; 9606.ENSP00000240691; -.
DR   BindingDB; Q9NYW1; -.
DR   ChEMBL; CHEMBL3309110; -.
DR   GuidetoPHARMACOLOGY; 665; -.
DR   GlyCosmos; Q9NYW1; 1 site, No reported glycans.
DR   GlyGen; Q9NYW1; 1 site.
DR   iPTMnet; Q9NYW1; -.
DR   PhosphoSitePlus; Q9NYW1; -.
DR   BioMuta; TAS2R9; -.
DR   DMDM; 29839661; -.
DR   PaxDb; 9606-ENSP00000240691; -.
DR   PeptideAtlas; Q9NYW1; -.
DR   Antibodypedia; 23398; 125 antibodies from 20 providers.
DR   DNASU; 50835; -.
DR   Ensembl; ENST00000240691.4; ENSP00000240691.2; ENSG00000121381.4.
DR   Ensembl; ENST00000573524.1; ENSP00000460247.1; ENSG00000273086.1.
DR   Ensembl; ENST00000616297.2; ENSP00000480069.1; ENSG00000273713.2.
DR   GeneID; 50835; -.
DR   KEGG; hsa:50835; -.
DR   MANE-Select; ENST00000240691.4; ENSP00000240691.2; NM_023917.2; NP_076406.1.
DR   UCSC; uc001qyx.4; human.
DR   AGR; HGNC:14917; -.
DR   CTD; 50835; -.
DR   DisGeNET; 50835; -.
DR   GeneCards; TAS2R9; -.
DR   HGNC; HGNC:14917; TAS2R9.
DR   HPA; ENSG00000121381; Not detected.
DR   MIM; 604795; gene.
DR   neXtProt; NX_Q9NYW1; -.
DR   OpenTargets; ENSG00000121381; -.
DR   PharmGKB; PA37927; -.
DR   VEuPathDB; HostDB:ENSG00000121381; -.
DR   eggNOG; ENOG502SY8P; Eukaryota.
DR   GeneTree; ENSGT01100000263477; -.
DR   HOGENOM; CLU_072337_3_0_1; -.
DR   InParanoid; Q9NYW1; -.
DR   OMA; TIGIWGN; -.
DR   OrthoDB; 5306466at2759; -.
DR   PhylomeDB; Q9NYW1; -.
DR   TreeFam; TF335891; -.
DR   PathwayCommons; Q9NYW1; -.
DR   Reactome; R-HSA-418594; G alpha (i) signalling events.
DR   Reactome; R-HSA-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
DR   BioGRID-ORCS; 50835; 12 hits in 1140 CRISPR screens.
DR   GeneWiki; TAS2R9; -.
DR   GenomeRNAi; 50835; -.
DR   Pharos; Q9NYW1; Tchem.
DR   PRO; PR:Q9NYW1; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   RNAct; Q9NYW1; Protein.
DR   Bgee; ENSG00000121381; Expressed in primordial germ cell in gonad and 4 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0033038; F:bitter taste receptor activity; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0008527; F:taste receptor activity; TAS:UniProtKB.
DR   GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IBA:GO_Central.
DR   CDD; cd15023; 7tm_TAS2R7-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR007960; TAS2R.
DR   PANTHER; PTHR11394; TASTE RECEPTOR TYPE 2; 1.
DR   PANTHER; PTHR11394:SF29; TASTE RECEPTOR TYPE 2 MEMBER 9; 1.
DR   Pfam; PF05296; TAS2R; 1.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   Genevisible; Q9NYW1; HS.
PE   1: Evidence at protein level;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW   Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..312
FT                   /note="Taste receptor type 2 member 9"
FT                   /id="PRO_0000082232"
FT   TOPO_DOM        1..9
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        10..32
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        33..52
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..72
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        73..86
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..109
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        110..128
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        129..146
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        147..180
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        181..203
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        204..234
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        235..257
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        258..261
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        262..284
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        285..312
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        164
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VARIANT         170
FT                   /note="K -> Q (in dbSNP:rs11054043)"
FT                   /id="VAR_053345"
FT   VARIANT         187
FT                   /note="V -> A (in dbSNP:rs3741845)"
FT                   /evidence="ECO:0000269|PubMed:15489334,
FT                   ECO:0000269|PubMed:15744053"
FT                   /id="VAR_020204"
FT   VARIANT         238
FT                   /note="L -> V (in dbSNP:rs11054042)"
FT                   /id="VAR_053346"
SQ   SEQUENCE   312 AA;  35611 MW;  CCE66F1E31051F49 CRC64;
     MPSAIEAIYI ILIAGELTIG IWGNGFIVLV NCIDWLKRRD ISLIDIILIS LAISRICLLC
     VISLDGFFML LFPGTYGNSV LVSIVNVVWT FANNSSLWFT SCLSIFYLLK IANISHPFFF
     WLKLKINKVM LAILLGSFLI SLIISVPKND DMWYHLFKVS HEENITWKFK VSKIPGTFKQ
     LTLNLGVMVP FILCLISFFL LLFSLVRHTK QIRLHATGFR DPSTEAHMRA IKAVIIFLLL
     LIVYYPVFLV MTSSALIPQG KLVLMIGDIV TVIFPSSHSF ILIMGNSKLR EAFLKMLRFV
     KCFLRRRKPF VP
//