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Protein

Taste receptor type 2 member 9

Gene

TAS2R9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity).By similarity

Miscellaneous

Several bitter taste receptors are expressed in a single taste receptor cell.

GO - Molecular functioni

  • bitter taste receptor activity Source: GO_Central
  • G-protein coupled receptor activity Source: UniProtKB-KW
  • taste receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processSensory transduction, Taste

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 9
Short name:
T2R9
Alternative name(s):
Taste receptor family B member 6
Short name:
TRB6
Gene namesi
Name:TAS2R9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000121381.3
HGNCiHGNC:14917 TAS2R9
MIMi604795 gene
neXtProtiNX_Q9NYW1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9ExtracellularSequence analysis9
Transmembranei10 – 32Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini33 – 52CytoplasmicSequence analysisAdd BLAST20
Transmembranei53 – 72Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini73 – 86ExtracellularSequence analysisAdd BLAST14
Transmembranei87 – 109Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini110 – 128CytoplasmicSequence analysisAdd BLAST19
Transmembranei129 – 146Helical; Name=4Sequence analysisAdd BLAST18
Topological domaini147 – 180ExtracellularSequence analysisAdd BLAST34
Transmembranei181 – 203Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini204 – 234CytoplasmicSequence analysisAdd BLAST31
Transmembranei235 – 257Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini258 – 261ExtracellularSequence analysis4
Transmembranei262 – 284Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini285 – 312CytoplasmicSequence analysisAdd BLAST28

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi50835
OpenTargetsiENSG00000121381
PharmGKBiPA37927

Chemistry databases

ChEMBLiCHEMBL3309110

Polymorphism and mutation databases

BioMutaiTAS2R9
DMDMi29839661

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000822321 – 312Taste receptor type 2 member 9Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi164N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9NYW1
PeptideAtlasiQ9NYW1
PRIDEiQ9NYW1

PTM databases

iPTMnetiQ9NYW1
PhosphoSitePlusiQ9NYW1

Expressioni

Tissue specificityi

Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.

Gene expression databases

BgeeiENSG00000121381
CleanExiHS_TAS2R9
GenevisibleiQ9NYW1 HS

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000240691

Chemistry databases

BindingDBiQ9NYW1

Structurei

3D structure databases

ProteinModelPortaliQ9NYW1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J23M Eukaryota
ENOG410Z5AI LUCA
GeneTreeiENSGT00760000119096
HOGENOMiHOG000234595
HOVERGENiHBG060698
InParanoidiQ9NYW1
KOiK08474
OMAiMGNSKLR
OrthoDBiEOG091G0G0Q
PhylomeDBiQ9NYW1
TreeFamiTF335891

Family and domain databases

InterProiView protein in InterPro
IPR017452 GPCR_Rhodpsn_7TM
IPR007960 T2R
PANTHERiPTHR11394 PTHR11394, 1 hit
PfamiView protein in Pfam
PF05296 TAS2R, 1 hit
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NYW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSAIEAIYI ILIAGELTIG IWGNGFIVLV NCIDWLKRRD ISLIDIILIS
60 70 80 90 100
LAISRICLLC VISLDGFFML LFPGTYGNSV LVSIVNVVWT FANNSSLWFT
110 120 130 140 150
SCLSIFYLLK IANISHPFFF WLKLKINKVM LAILLGSFLI SLIISVPKND
160 170 180 190 200
DMWYHLFKVS HEENITWKFK VSKIPGTFKQ LTLNLGVMVP FILCLISFFL
210 220 230 240 250
LLFSLVRHTK QIRLHATGFR DPSTEAHMRA IKAVIIFLLL LIVYYPVFLV
260 270 280 290 300
MTSSALIPQG KLVLMIGDIV TVIFPSSHSF ILIMGNSKLR EAFLKMLRFV
310
KCFLRRRKPF VP
Length:312
Mass (Da):35,611
Last modified:October 1, 2000 - v1
Checksum:iCCE66F1E31051F49
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053345170K → Q. Corresponds to variant dbSNP:rs11054043Ensembl.1
Natural variantiVAR_020204187V → A2 PublicationsCorresponds to variant dbSNP:rs3741845Ensembl.1
Natural variantiVAR_053346238L → V. Corresponds to variant dbSNP:rs11054042Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF227135 Genomic DNA Translation: AAF43908.1
AY724954 Genomic DNA Translation: AAU21150.1
BC069066 mRNA Translation: AAH69066.1
BC095519 mRNA Translation: AAH95519.1
AB199063 Genomic DNA Translation: BAD97966.1
AB199064 Genomic DNA Translation: BAD97967.1
AB199065 Genomic DNA Translation: BAD97968.1
CCDSiCCDS8633.1
RefSeqiNP_076406.1, NM_023917.2
UniGeneiHs.272391

Genome annotation databases

EnsembliENST00000240691; ENSP00000240691; ENSG00000121381
ENST00000573524; ENSP00000460247; ENSG00000273086
ENST00000616297; ENSP00000480069; ENSG00000273713
GeneIDi50835
KEGGihsa:50835
UCSCiuc001qyx.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTA2R9_HUMAN
AccessioniPrimary (citable) accession number: Q9NYW1
Secondary accession number(s): Q502V7
, Q50KT0, Q50KT1, Q645W9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: October 1, 2000
Last modified: December 20, 2017
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health