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Q9NYW1 (TA2R9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Taste receptor type 2 member 9

Short name=T2R9
Alternative name(s):
Taste receptor family B member 6
Short name=TRB6
Gene names
Name:TAS2R9
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length312 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.

Miscellaneous

Several bitter taste receptors are expressed in a single taste receptor cell.

Sequence similarities

Belongs to the G-protein coupled receptor T2R family.

Ontologies

Keywords
   Biological processSensory transduction
Taste
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdetection of chemical stimulus involved in sensory perception of taste

Traceable author statement Ref.1. Source: GOC

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functiontaste receptor activity

Traceable author statement Ref.1. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 312312Taste receptor type 2 member 9
PRO_0000082232

Regions

Topological domain1 – 99Extracellular Potential
Transmembrane10 – 3223Helical; Name=1; Potential
Topological domain33 – 5220Cytoplasmic Potential
Transmembrane53 – 7220Helical; Name=2; Potential
Topological domain73 – 8614Extracellular Potential
Transmembrane87 – 10923Helical; Name=3; Potential
Topological domain110 – 12819Cytoplasmic Potential
Transmembrane129 – 14618Helical; Name=4; Potential
Topological domain147 – 18034Extracellular Potential
Transmembrane181 – 20323Helical; Name=5; Potential
Topological domain204 – 23431Cytoplasmic Potential
Transmembrane235 – 25723Helical; Name=6; Potential
Topological domain258 – 2614Extracellular Potential
Transmembrane262 – 28423Helical; Name=7; Potential
Topological domain285 – 31228Cytoplasmic Potential

Amino acid modifications

Glycosylation1641N-linked (GlcNAc...) Potential

Natural variations

Natural variant1701K → Q.
Corresponds to variant rs11054043 [ dbSNP | Ensembl ].
VAR_053345
Natural variant1871V → A. Ref.3 Ref.4
Corresponds to variant rs3741845 [ dbSNP | Ensembl ].
VAR_020204
Natural variant2381L → V.
Corresponds to variant rs11054042 [ dbSNP | Ensembl ].
VAR_053346

Sequences

Sequence LengthMass (Da)Tools
Q9NYW1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: CCE66F1E31051F49

FASTA31235,611
        10         20         30         40         50         60 
MPSAIEAIYI ILIAGELTIG IWGNGFIVLV NCIDWLKRRD ISLIDIILIS LAISRICLLC 

        70         80         90        100        110        120 
VISLDGFFML LFPGTYGNSV LVSIVNVVWT FANNSSLWFT SCLSIFYLLK IANISHPFFF 

       130        140        150        160        170        180 
WLKLKINKVM LAILLGSFLI SLIISVPKND DMWYHLFKVS HEENITWKFK VSKIPGTFKQ 

       190        200        210        220        230        240 
LTLNLGVMVP FILCLISFFL LLFSLVRHTK QIRLHATGFR DPSTEAHMRA IKAVIIFLLL 

       250        260        270        280        290        300 
LIVYYPVFLV MTSSALIPQG KLVLMIGDIV TVIFPSSHSF ILIMGNSKLR EAFLKMLRFV 

       310 
KCFLRRRKPF VP 

« Hide

References

« Hide 'large scale' references
[1]"A novel family of mammalian taste receptors."
Adler E., Hoon M.A., Mueller K.L., Chandrashekar J., Ryba N.J.P., Zuker C.S.
Cell 100:693-702(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TOPOLOGY.
[2]"Evolution of bitter taste receptors in humans and apes."
Fischer A., Gilad Y., Man O., Paeaebo S.
Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-187.
[4]"Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates."
Go Y., Satta Y., Takenaka O., Takahata N.
Genetics 170:313-326(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 9-298, VARIANT ALA-187.
[5]"T2Rs function as bitter taste receptors."
Chandrashekar J., Mueller K.L., Hoon M.A., Adler E., Feng L., Guo W., Zuker C.S., Ryba N.J.P.
Cell 100:703-711(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[6]"Receptors for bitter and sweet taste."
Montmayeur J.-P., Matsunami H.
Curr. Opin. Neurobiol. 12:366-371(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[7]"Molecular mechanisms of bitter and sweet taste transduction."
Margolskee R.F.
J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[8]"Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF227135 Genomic DNA. Translation: AAF43908.1.
AY724954 Genomic DNA. Translation: AAU21150.1.
BC069066 mRNA. Translation: AAH69066.1.
BC095519 mRNA. Translation: AAH95519.1.
AB199063 Genomic DNA. Translation: BAD97966.1.
AB199064 Genomic DNA. Translation: BAD97967.1.
AB199065 Genomic DNA. Translation: BAD97968.1.
RefSeqNP_076406.1. NM_023917.2.
UniGeneHs.272391.

3D structure databases

ProteinModelPortalQ9NYW1.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ9NYW1.

Polymorphism databases

DMDM29839661.

Proteomic databases

PRIDEQ9NYW1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000240691; ENSP00000240691; ENSG00000121381.
ENST00000573524; ENSP00000460247; ENSG00000273086.
ENST00000576440; ENSP00000459255; ENSG00000272930.
GeneID50835.
KEGGhsa:50835.
UCSCuc001qyx.3. human.

Organism-specific databases

CTD50835.
GeneCardsGC12M010968.
H-InvDBHIX0171597.
HGNCHGNC:14917. TAS2R9.
MIM604795. gene.
neXtProtNX_Q9NYW1.
PharmGKBPA37927.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG45213.
HOGENOMHOG000234595.
HOVERGENHBG060698.
InParanoidQ9NYW1.
KOK08474.
OMALWFTSCL.
OrthoDBEOG72C512.
PhylomeDBQ9NYW1.
TreeFamTF335891.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeQ9NYW1.
CleanExHS_TAS2R9.
GenevestigatorQ9NYW1.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR017452. GPCR_Rhodpsn_7TM.
IPR007960. TAS2_rcpt.
[Graphical view]
PfamPF05296. TAS2R. 1 hit.
[Graphical view]
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiTAS2R9.
GenomeRNAi50835.
NextBio53289.
PROQ9NYW1.
SOURCESearch...

Entry information

Entry nameTA2R9_HUMAN
AccessionPrimary (citable) accession number: Q9NYW1
Secondary accession number(s): Q502V7 expand/collapse secondary AC list , Q50KT0, Q50KT1, Q645W9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries