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Protein

Taste receptor type 2 member 9

Gene

TAS2R9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity).By similarity

GO - Molecular functioni

  1. taste receptor activity Source: UniProtKB

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception of taste Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Enzyme and pathway databases

ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 9
Short name:
T2R9
Alternative name(s):
Taste receptor family B member 6
Short name:
TRB6
Gene namesi
Name:TAS2R9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componentsi: Chromosome 12, Unplaced

Organism-specific databases

HGNCiHGNC:14917. TAS2R9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99ExtracellularSequence Analysis
Transmembranei10 – 3223Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini33 – 5220CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei53 – 7220Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini73 – 8614ExtracellularSequence AnalysisAdd
BLAST
Transmembranei87 – 10923Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini110 – 12819CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei129 – 14618Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini147 – 18034ExtracellularSequence AnalysisAdd
BLAST
Transmembranei181 – 20323Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini204 – 23431CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei235 – 25723Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini258 – 2614ExtracellularSequence Analysis
Transmembranei262 – 28423Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini285 – 31228CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37927.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Taste receptor type 2 member 9PRO_0000082232Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9NYW1.

PTM databases

PhosphoSiteiQ9NYW1.

Expressioni

Tissue specificityi

Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.

Gene expression databases

BgeeiQ9NYW1.
CleanExiHS_TAS2R9.
GenevestigatoriQ9NYW1.

Structurei

3D structure databases

ProteinModelPortaliQ9NYW1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45213.
GeneTreeiENSGT00760000119096.
HOGENOMiHOG000234595.
HOVERGENiHBG060698.
InParanoidiQ9NYW1.
KOiK08474.
OMAiLWFTSCL.
OrthoDBiEOG72C512.
PhylomeDBiQ9NYW1.
TreeFamiTF335891.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR007960. T2R.
[Graphical view]
PANTHERiPTHR11394. PTHR11394. 1 hit.
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NYW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSAIEAIYI ILIAGELTIG IWGNGFIVLV NCIDWLKRRD ISLIDIILIS
60 70 80 90 100
LAISRICLLC VISLDGFFML LFPGTYGNSV LVSIVNVVWT FANNSSLWFT
110 120 130 140 150
SCLSIFYLLK IANISHPFFF WLKLKINKVM LAILLGSFLI SLIISVPKND
160 170 180 190 200
DMWYHLFKVS HEENITWKFK VSKIPGTFKQ LTLNLGVMVP FILCLISFFL
210 220 230 240 250
LLFSLVRHTK QIRLHATGFR DPSTEAHMRA IKAVIIFLLL LIVYYPVFLV
260 270 280 290 300
MTSSALIPQG KLVLMIGDIV TVIFPSSHSF ILIMGNSKLR EAFLKMLRFV
310
KCFLRRRKPF VP
Length:312
Mass (Da):35,611
Last modified:October 1, 2000 - v1
Checksum:iCCE66F1E31051F49
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti170 – 1701K → Q.
Corresponds to variant rs11054043 [ dbSNP | Ensembl ].
VAR_053345
Natural varianti187 – 1871V → A.2 Publications
Corresponds to variant rs3741845 [ dbSNP | Ensembl ].
VAR_020204
Natural varianti238 – 2381L → V.
Corresponds to variant rs11054042 [ dbSNP | Ensembl ].
VAR_053346

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF227135 Genomic DNA. Translation: AAF43908.1.
AY724954 Genomic DNA. Translation: AAU21150.1.
BC069066 mRNA. Translation: AAH69066.1.
BC095519 mRNA. Translation: AAH95519.1.
AB199063 Genomic DNA. Translation: BAD97966.1.
AB199064 Genomic DNA. Translation: BAD97967.1.
AB199065 Genomic DNA. Translation: BAD97968.1.
CCDSiCCDS8633.1.
RefSeqiNP_076406.1. NM_023917.2.
UniGeneiHs.272391.

Genome annotation databases

EnsembliENST00000240691; ENSP00000240691; ENSG00000121381.
ENST00000573524; ENSP00000460247; ENSG00000273086.
ENST00000616297; ENSP00000480069; ENSG00000273713.
GeneIDi50835.
KEGGihsa:50835.
UCSCiuc001qyx.3. human.

Polymorphism databases

DMDMi29839661.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF227135 Genomic DNA. Translation: AAF43908.1.
AY724954 Genomic DNA. Translation: AAU21150.1.
BC069066 mRNA. Translation: AAH69066.1.
BC095519 mRNA. Translation: AAH95519.1.
AB199063 Genomic DNA. Translation: BAD97966.1.
AB199064 Genomic DNA. Translation: BAD97967.1.
AB199065 Genomic DNA. Translation: BAD97968.1.
CCDSiCCDS8633.1.
RefSeqiNP_076406.1. NM_023917.2.
UniGeneiHs.272391.

3D structure databases

ProteinModelPortaliQ9NYW1.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ9NYW1.

Polymorphism databases

DMDMi29839661.

Proteomic databases

PRIDEiQ9NYW1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000240691; ENSP00000240691; ENSG00000121381.
ENST00000573524; ENSP00000460247; ENSG00000273086.
ENST00000616297; ENSP00000480069; ENSG00000273713.
GeneIDi50835.
KEGGihsa:50835.
UCSCiuc001qyx.3. human.

Organism-specific databases

CTDi50835.
GeneCardsiGC12M010972.
H-InvDBHIX0171597.
HGNCiHGNC:14917. TAS2R9.
MIMi604795. gene.
neXtProtiNX_Q9NYW1.
PharmGKBiPA37927.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG45213.
GeneTreeiENSGT00760000119096.
HOGENOMiHOG000234595.
HOVERGENiHBG060698.
InParanoidiQ9NYW1.
KOiK08474.
OMAiLWFTSCL.
OrthoDBiEOG72C512.
PhylomeDBiQ9NYW1.
TreeFamiTF335891.

Enzyme and pathway databases

ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikiiTAS2R9.
GenomeRNAii50835.
NextBioi53289.
PROiQ9NYW1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NYW1.
CleanExiHS_TAS2R9.
GenevestigatoriQ9NYW1.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR007960. T2R.
[Graphical view]
PANTHERiPTHR11394. PTHR11394. 1 hit.
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TOPOLOGY.
  2. "Evolution of bitter taste receptors in humans and apes."
    Fischer A., Gilad Y., Man O., Paeaebo S.
    Mol. Biol. Evol. 22:432-436(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-187.
  4. "Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates."
    Go Y., Satta Y., Takenaka O., Takahata N.
    Genetics 170:313-326(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 9-298, VARIANT ALA-187.
  5. Cited for: CHARACTERIZATION.
  6. Cited for: REVIEW.
  7. "Molecular mechanisms of bitter and sweet taste transduction."
    Margolskee R.F.
    J. Biol. Chem. 277:1-4(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  8. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
    Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
    Cell 112:293-301(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiTA2R9_HUMAN
AccessioniPrimary (citable) accession number: Q9NYW1
Secondary accession number(s): Q502V7
, Q50KT0, Q50KT1, Q645W9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: October 1, 2000
Last modified: January 7, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Several bitter taste receptors are expressed in a single taste receptor cell.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.