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Q9NYW1

- TA2R9_HUMAN

UniProt

Q9NYW1 - TA2R9_HUMAN

Protein

Taste receptor type 2 member 9

Gene

TAS2R9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 By similarity.By similarity

    GO - Molecular functioni

    1. taste receptor activity Source: UniProtKB

    GO - Biological processi

    1. detection of chemical stimulus involved in sensory perception of taste Source: GOC

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Sensory transduction, Taste

    Enzyme and pathway databases

    ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Taste receptor type 2 member 9
    Short name:
    T2R9
    Alternative name(s):
    Taste receptor family B member 6
    Short name:
    TRB6
    Gene namesi
    Name:TAS2R9
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:14917. TAS2R9.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37927.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 312312Taste receptor type 2 member 9PRO_0000082232Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ9NYW1.

    PTM databases

    PhosphoSiteiQ9NYW1.

    Expressioni

    Tissue specificityi

    Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.

    Gene expression databases

    BgeeiQ9NYW1.
    CleanExiHS_TAS2R9.
    GenevestigatoriQ9NYW1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NYW1.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 99ExtracellularSequence Analysis
    Topological domaini33 – 5220CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini73 – 8614ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini110 – 12819CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini147 – 18034ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini204 – 23431CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini258 – 2614ExtracellularSequence Analysis
    Topological domaini285 – 31228CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei10 – 3223Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei53 – 7220Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei87 – 10923Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei129 – 14618Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei181 – 20323Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei235 – 25723Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei262 – 28423Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45213.
    HOGENOMiHOG000234595.
    HOVERGENiHBG060698.
    InParanoidiQ9NYW1.
    KOiK08474.
    OMAiLWFTSCL.
    OrthoDBiEOG72C512.
    PhylomeDBiQ9NYW1.
    TreeFamiTF335891.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR017452. GPCR_Rhodpsn_7TM.
    IPR007960. TAS2_rcpt.
    [Graphical view]
    PfamiPF05296. TAS2R. 1 hit.
    [Graphical view]
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NYW1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPSAIEAIYI ILIAGELTIG IWGNGFIVLV NCIDWLKRRD ISLIDIILIS    50
    LAISRICLLC VISLDGFFML LFPGTYGNSV LVSIVNVVWT FANNSSLWFT 100
    SCLSIFYLLK IANISHPFFF WLKLKINKVM LAILLGSFLI SLIISVPKND 150
    DMWYHLFKVS HEENITWKFK VSKIPGTFKQ LTLNLGVMVP FILCLISFFL 200
    LLFSLVRHTK QIRLHATGFR DPSTEAHMRA IKAVIIFLLL LIVYYPVFLV 250
    MTSSALIPQG KLVLMIGDIV TVIFPSSHSF ILIMGNSKLR EAFLKMLRFV 300
    KCFLRRRKPF VP 312
    Length:312
    Mass (Da):35,611
    Last modified:October 1, 2000 - v1
    Checksum:iCCE66F1E31051F49
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti170 – 1701K → Q.
    Corresponds to variant rs11054043 [ dbSNP | Ensembl ].
    VAR_053345
    Natural varianti187 – 1871V → A.2 Publications
    Corresponds to variant rs3741845 [ dbSNP | Ensembl ].
    VAR_020204
    Natural varianti238 – 2381L → V.
    Corresponds to variant rs11054042 [ dbSNP | Ensembl ].
    VAR_053346

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF227135 Genomic DNA. Translation: AAF43908.1.
    AY724954 Genomic DNA. Translation: AAU21150.1.
    BC069066 mRNA. Translation: AAH69066.1.
    BC095519 mRNA. Translation: AAH95519.1.
    AB199063 Genomic DNA. Translation: BAD97966.1.
    AB199064 Genomic DNA. Translation: BAD97967.1.
    AB199065 Genomic DNA. Translation: BAD97968.1.
    CCDSiCCDS8633.1.
    RefSeqiNP_076406.1. NM_023917.2.
    UniGeneiHs.272391.

    Genome annotation databases

    EnsembliENST00000240691; ENSP00000240691; ENSG00000121381.
    ENST00000573524; ENSP00000460247; ENSG00000273086.
    GeneIDi50835.
    KEGGihsa:50835.
    UCSCiuc001qyx.3. human.

    Polymorphism databases

    DMDMi29839661.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF227135 Genomic DNA. Translation: AAF43908.1 .
    AY724954 Genomic DNA. Translation: AAU21150.1 .
    BC069066 mRNA. Translation: AAH69066.1 .
    BC095519 mRNA. Translation: AAH95519.1 .
    AB199063 Genomic DNA. Translation: BAD97966.1 .
    AB199064 Genomic DNA. Translation: BAD97967.1 .
    AB199065 Genomic DNA. Translation: BAD97968.1 .
    CCDSi CCDS8633.1.
    RefSeqi NP_076406.1. NM_023917.2.
    UniGenei Hs.272391.

    3D structure databases

    ProteinModelPortali Q9NYW1.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9NYW1.

    Polymorphism databases

    DMDMi 29839661.

    Proteomic databases

    PRIDEi Q9NYW1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000240691 ; ENSP00000240691 ; ENSG00000121381 .
    ENST00000573524 ; ENSP00000460247 ; ENSG00000273086 .
    GeneIDi 50835.
    KEGGi hsa:50835.
    UCSCi uc001qyx.3. human.

    Organism-specific databases

    CTDi 50835.
    GeneCardsi GC12M010968.
    H-InvDB HIX0171597.
    HGNCi HGNC:14917. TAS2R9.
    MIMi 604795. gene.
    neXtProti NX_Q9NYW1.
    PharmGKBi PA37927.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45213.
    HOGENOMi HOG000234595.
    HOVERGENi HBG060698.
    InParanoidi Q9NYW1.
    KOi K08474.
    OMAi LWFTSCL.
    OrthoDBi EOG72C512.
    PhylomeDBi Q9NYW1.
    TreeFami TF335891.

    Enzyme and pathway databases

    Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii TAS2R9.
    GenomeRNAii 50835.
    NextBioi 53289.
    PROi Q9NYW1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9NYW1.
    CleanExi HS_TAS2R9.
    Genevestigatori Q9NYW1.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR017452. GPCR_Rhodpsn_7TM.
    IPR007960. TAS2_rcpt.
    [Graphical view ]
    Pfami PF05296. TAS2R. 1 hit.
    [Graphical view ]
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TOPOLOGY.
    2. "Evolution of bitter taste receptors in humans and apes."
      Fischer A., Gilad Y., Man O., Paeaebo S.
      Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-187.
    4. "Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates."
      Go Y., Satta Y., Takenaka O., Takahata N.
      Genetics 170:313-326(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 9-298, VARIANT ALA-187.
    5. Cited for: CHARACTERIZATION.
    6. Cited for: REVIEW.
    7. "Molecular mechanisms of bitter and sweet taste transduction."
      Margolskee R.F.
      J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    8. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
      Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
      Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiTA2R9_HUMAN
    AccessioniPrimary (citable) accession number: Q9NYW1
    Secondary accession number(s): Q502V7
    , Q50KT0, Q50KT1, Q645W9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 11, 2003
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Several bitter taste receptors are expressed in a single taste receptor cell.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3