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Protein

Taste receptor type 2 member 9

Gene

TAS2R9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity).By similarity

GO - Molecular functioni

  • bitter taste receptor activity Source: GO_Central
  • G-protein coupled receptor activity Source: UniProtKB-KW
  • taste receptor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Enzyme and pathway databases

BioCyciZFISH:ENSG00000121381-MONOMER.
ReactomeiR-HSA-418594. G alpha (i) signalling events.
R-HSA-420499. Class C/3 (Metabotropic glutamate/pheromone receptors).

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 9
Short name:
T2R9
Alternative name(s):
Taste receptor family B member 6
Short name:
TRB6
Gene namesi
Name:TAS2R9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:14917. TAS2R9.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9ExtracellularSequence analysis9
Transmembranei10 – 32Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini33 – 52CytoplasmicSequence analysisAdd BLAST20
Transmembranei53 – 72Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini73 – 86ExtracellularSequence analysisAdd BLAST14
Transmembranei87 – 109Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini110 – 128CytoplasmicSequence analysisAdd BLAST19
Transmembranei129 – 146Helical; Name=4Sequence analysisAdd BLAST18
Topological domaini147 – 180ExtracellularSequence analysisAdd BLAST34
Transmembranei181 – 203Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini204 – 234CytoplasmicSequence analysisAdd BLAST31
Transmembranei235 – 257Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini258 – 261ExtracellularSequence analysis4
Transmembranei262 – 284Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini285 – 312CytoplasmicSequence analysisAdd BLAST28

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi50835.
OpenTargetsiENSG00000121381.
ENSG00000273086.
ENSG00000273713.
PharmGKBiPA37927.

Chemistry databases

ChEMBLiCHEMBL3309110.

Polymorphism and mutation databases

BioMutaiTAS2R9.
DMDMi29839661.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000822321 – 312Taste receptor type 2 member 9Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi164N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9NYW1.
PRIDEiQ9NYW1.

PTM databases

iPTMnetiQ9NYW1.
PhosphoSitePlusiQ9NYW1.

Expressioni

Tissue specificityi

Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.

Gene expression databases

BgeeiENSG00000121381.
CleanExiHS_TAS2R9.
GenevisibleiQ9NYW1. HS.

Interactioni

Chemistry databases

BindingDBiQ9NYW1.

Structurei

3D structure databases

ProteinModelPortaliQ9NYW1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J23M. Eukaryota.
ENOG410Z5AI. LUCA.
GeneTreeiENSGT00760000119096.
HOGENOMiHOG000234595.
HOVERGENiHBG060698.
InParanoidiQ9NYW1.
KOiK08474.
OMAiLWFTSCL.
OrthoDBiEOG091G0G0Q.
PhylomeDBiQ9NYW1.
TreeFamiTF335891.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR007960. T2R.
[Graphical view]
PANTHERiPTHR11394. PTHR11394. 1 hit.
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NYW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSAIEAIYI ILIAGELTIG IWGNGFIVLV NCIDWLKRRD ISLIDIILIS
60 70 80 90 100
LAISRICLLC VISLDGFFML LFPGTYGNSV LVSIVNVVWT FANNSSLWFT
110 120 130 140 150
SCLSIFYLLK IANISHPFFF WLKLKINKVM LAILLGSFLI SLIISVPKND
160 170 180 190 200
DMWYHLFKVS HEENITWKFK VSKIPGTFKQ LTLNLGVMVP FILCLISFFL
210 220 230 240 250
LLFSLVRHTK QIRLHATGFR DPSTEAHMRA IKAVIIFLLL LIVYYPVFLV
260 270 280 290 300
MTSSALIPQG KLVLMIGDIV TVIFPSSHSF ILIMGNSKLR EAFLKMLRFV
310
KCFLRRRKPF VP
Length:312
Mass (Da):35,611
Last modified:October 1, 2000 - v1
Checksum:iCCE66F1E31051F49
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053345170K → Q.Corresponds to variant rs11054043dbSNPEnsembl.1
Natural variantiVAR_020204187V → A.2 PublicationsCorresponds to variant rs3741845dbSNPEnsembl.1
Natural variantiVAR_053346238L → V.Corresponds to variant rs11054042dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF227135 Genomic DNA. Translation: AAF43908.1.
AY724954 Genomic DNA. Translation: AAU21150.1.
BC069066 mRNA. Translation: AAH69066.1.
BC095519 mRNA. Translation: AAH95519.1.
AB199063 Genomic DNA. Translation: BAD97966.1.
AB199064 Genomic DNA. Translation: BAD97967.1.
AB199065 Genomic DNA. Translation: BAD97968.1.
CCDSiCCDS8633.1.
RefSeqiNP_076406.1. NM_023917.2.
UniGeneiHs.272391.

Genome annotation databases

EnsembliENST00000240691; ENSP00000240691; ENSG00000121381.
ENST00000573524; ENSP00000460247; ENSG00000273086.
ENST00000616297; ENSP00000480069; ENSG00000273713.
GeneIDi50835.
KEGGihsa:50835.
UCSCiuc001qyx.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF227135 Genomic DNA. Translation: AAF43908.1.
AY724954 Genomic DNA. Translation: AAU21150.1.
BC069066 mRNA. Translation: AAH69066.1.
BC095519 mRNA. Translation: AAH95519.1.
AB199063 Genomic DNA. Translation: BAD97966.1.
AB199064 Genomic DNA. Translation: BAD97967.1.
AB199065 Genomic DNA. Translation: BAD97968.1.
CCDSiCCDS8633.1.
RefSeqiNP_076406.1. NM_023917.2.
UniGeneiHs.272391.

3D structure databases

ProteinModelPortaliQ9NYW1.
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

BindingDBiQ9NYW1.
ChEMBLiCHEMBL3309110.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9NYW1.
PhosphoSitePlusiQ9NYW1.

Polymorphism and mutation databases

BioMutaiTAS2R9.
DMDMi29839661.

Proteomic databases

PaxDbiQ9NYW1.
PRIDEiQ9NYW1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000240691; ENSP00000240691; ENSG00000121381.
ENST00000573524; ENSP00000460247; ENSG00000273086.
ENST00000616297; ENSP00000480069; ENSG00000273713.
GeneIDi50835.
KEGGihsa:50835.
UCSCiuc001qyx.4. human.

Organism-specific databases

CTDi50835.
DisGeNETi50835.
GeneCardsiTAS2R9.
H-InvDBHIX0171597.
HGNCiHGNC:14917. TAS2R9.
MIMi604795. gene.
neXtProtiNX_Q9NYW1.
OpenTargetsiENSG00000121381.
ENSG00000273086.
ENSG00000273713.
PharmGKBiPA37927.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J23M. Eukaryota.
ENOG410Z5AI. LUCA.
GeneTreeiENSGT00760000119096.
HOGENOMiHOG000234595.
HOVERGENiHBG060698.
InParanoidiQ9NYW1.
KOiK08474.
OMAiLWFTSCL.
OrthoDBiEOG091G0G0Q.
PhylomeDBiQ9NYW1.
TreeFamiTF335891.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000121381-MONOMER.
ReactomeiR-HSA-418594. G alpha (i) signalling events.
R-HSA-420499. Class C/3 (Metabotropic glutamate/pheromone receptors).

Miscellaneous databases

GeneWikiiTAS2R9.
GenomeRNAii50835.
PROiQ9NYW1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000121381.
CleanExiHS_TAS2R9.
GenevisibleiQ9NYW1. HS.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR007960. T2R.
[Graphical view]
PANTHERiPTHR11394. PTHR11394. 1 hit.
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTA2R9_HUMAN
AccessioniPrimary (citable) accession number: Q9NYW1
Secondary accession number(s): Q502V7
, Q50KT0, Q50KT1, Q645W9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Several bitter taste receptors are expressed in a single taste receptor cell.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.