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Q9NYW1

- TA2R9_HUMAN

UniProt

Q9NYW1 - TA2R9_HUMAN

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Protein
Taste receptor type 2 member 9
Gene
TAS2R9
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 By similarity.

GO - Molecular functioni

  1. taste receptor activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception of taste Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Enzyme and pathway databases

ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 9
Short name:
T2R9
Alternative name(s):
Taste receptor family B member 6
Short name:
TRB6
Gene namesi
Name:TAS2R9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:14917. TAS2R9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99Extracellular Reviewed prediction
Transmembranei10 – 3223Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini33 – 5220Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei53 – 7220Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini73 – 8614Extracellular Reviewed prediction
Add
BLAST
Transmembranei87 – 10923Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini110 – 12819Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei129 – 14618Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini147 – 18034Extracellular Reviewed prediction
Add
BLAST
Transmembranei181 – 20323Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini204 – 23431Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei235 – 25723Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini258 – 2614Extracellular Reviewed prediction
Transmembranei262 – 28423Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini285 – 31228Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37927.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Taste receptor type 2 member 9
PRO_0000082232Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi164 – 1641N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9NYW1.

PTM databases

PhosphoSiteiQ9NYW1.

Expressioni

Tissue specificityi

Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.

Gene expression databases

BgeeiQ9NYW1.
CleanExiHS_TAS2R9.
GenevestigatoriQ9NYW1.

Structurei

3D structure databases

ProteinModelPortaliQ9NYW1.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45213.
HOGENOMiHOG000234595.
HOVERGENiHBG060698.
InParanoidiQ9NYW1.
KOiK08474.
OMAiLWFTSCL.
OrthoDBiEOG72C512.
PhylomeDBiQ9NYW1.
TreeFamiTF335891.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR007960. TAS2_rcpt.
[Graphical view]
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NYW1-1 [UniParc]FASTAAdd to Basket

« Hide

MPSAIEAIYI ILIAGELTIG IWGNGFIVLV NCIDWLKRRD ISLIDIILIS    50
LAISRICLLC VISLDGFFML LFPGTYGNSV LVSIVNVVWT FANNSSLWFT 100
SCLSIFYLLK IANISHPFFF WLKLKINKVM LAILLGSFLI SLIISVPKND 150
DMWYHLFKVS HEENITWKFK VSKIPGTFKQ LTLNLGVMVP FILCLISFFL 200
LLFSLVRHTK QIRLHATGFR DPSTEAHMRA IKAVIIFLLL LIVYYPVFLV 250
MTSSALIPQG KLVLMIGDIV TVIFPSSHSF ILIMGNSKLR EAFLKMLRFV 300
KCFLRRRKPF VP 312
Length:312
Mass (Da):35,611
Last modified:October 1, 2000 - v1
Checksum:iCCE66F1E31051F49
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti170 – 1701K → Q.
Corresponds to variant rs11054043 [ dbSNP | Ensembl ].
VAR_053345
Natural varianti187 – 1871V → A.2 Publications
Corresponds to variant rs3741845 [ dbSNP | Ensembl ].
VAR_020204
Natural varianti238 – 2381L → V.
Corresponds to variant rs11054042 [ dbSNP | Ensembl ].
VAR_053346

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF227135 Genomic DNA. Translation: AAF43908.1.
AY724954 Genomic DNA. Translation: AAU21150.1.
BC069066 mRNA. Translation: AAH69066.1.
BC095519 mRNA. Translation: AAH95519.1.
AB199063 Genomic DNA. Translation: BAD97966.1.
AB199064 Genomic DNA. Translation: BAD97967.1.
AB199065 Genomic DNA. Translation: BAD97968.1.
CCDSiCCDS8633.1.
RefSeqiNP_076406.1. NM_023917.2.
UniGeneiHs.272391.

Genome annotation databases

EnsembliENST00000240691; ENSP00000240691; ENSG00000121381.
ENST00000573524; ENSP00000460247; ENSG00000273086.
ENST00000576440; ENSP00000459255; ENSG00000272930.
GeneIDi50835.
KEGGihsa:50835.
UCSCiuc001qyx.3. human.

Polymorphism databases

DMDMi29839661.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF227135 Genomic DNA. Translation: AAF43908.1 .
AY724954 Genomic DNA. Translation: AAU21150.1 .
BC069066 mRNA. Translation: AAH69066.1 .
BC095519 mRNA. Translation: AAH95519.1 .
AB199063 Genomic DNA. Translation: BAD97966.1 .
AB199064 Genomic DNA. Translation: BAD97967.1 .
AB199065 Genomic DNA. Translation: BAD97968.1 .
CCDSi CCDS8633.1.
RefSeqi NP_076406.1. NM_023917.2.
UniGenei Hs.272391.

3D structure databases

ProteinModelPortali Q9NYW1.
ModBasei Search...

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q9NYW1.

Polymorphism databases

DMDMi 29839661.

Proteomic databases

PRIDEi Q9NYW1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000240691 ; ENSP00000240691 ; ENSG00000121381 .
ENST00000573524 ; ENSP00000460247 ; ENSG00000273086 .
ENST00000576440 ; ENSP00000459255 ; ENSG00000272930 .
GeneIDi 50835.
KEGGi hsa:50835.
UCSCi uc001qyx.3. human.

Organism-specific databases

CTDi 50835.
GeneCardsi GC12M010968.
H-InvDB HIX0171597.
HGNCi HGNC:14917. TAS2R9.
MIMi 604795. gene.
neXtProti NX_Q9NYW1.
PharmGKBi PA37927.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG45213.
HOGENOMi HOG000234595.
HOVERGENi HBG060698.
InParanoidi Q9NYW1.
KOi K08474.
OMAi LWFTSCL.
OrthoDBi EOG72C512.
PhylomeDBi Q9NYW1.
TreeFami TF335891.

Enzyme and pathway databases

Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii TAS2R9.
GenomeRNAii 50835.
NextBioi 53289.
PROi Q9NYW1.
SOURCEi Search...

Gene expression databases

Bgeei Q9NYW1.
CleanExi HS_TAS2R9.
Genevestigatori Q9NYW1.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR017452. GPCR_Rhodpsn_7TM.
IPR007960. TAS2_rcpt.
[Graphical view ]
Pfami PF05296. TAS2R. 1 hit.
[Graphical view ]
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TOPOLOGY.
  2. "Evolution of bitter taste receptors in humans and apes."
    Fischer A., Gilad Y., Man O., Paeaebo S.
    Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-187.
  4. "Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates."
    Go Y., Satta Y., Takenaka O., Takahata N.
    Genetics 170:313-326(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 9-298, VARIANT ALA-187.
  5. Cited for: CHARACTERIZATION.
  6. Cited for: REVIEW.
  7. "Molecular mechanisms of bitter and sweet taste transduction."
    Margolskee R.F.
    J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  8. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
    Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
    Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiTA2R9_HUMAN
AccessioniPrimary (citable) accession number: Q9NYW1
Secondary accession number(s): Q502V7
, Q50KT0, Q50KT1, Q645W9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Several bitter taste receptors are expressed in a single taste receptor cell.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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