Q9NYW1 (TA2R9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Taste receptor type 2 member 9
Short name=T2R9

Alternative name(s):
Taste receptor family B member 6
Short name=TRB6

Gene names

Name:

TAS2R9

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	312 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 By similarity.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.
Miscellaneous	Several bitter taste receptors are expressed in a single taste receptor cell.
Sequence similarities	Belongs to the G-protein coupled receptor T2R family.

Ontologies

Keywords
Biological process	Sensory transduction Taste
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Non-traceable author statement. Source: UniProtKB
Molecular_function	taste receptor activity Traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 312	312	Taste receptor type 2 member 9		PRO_0000082232
Regions
	Topological domain	1 – 9	9	Extracellular Potential
	Transmembrane	10 – 32	23	Helical; Name=1; Potential
	Topological domain	33 – 52	20	Cytoplasmic Potential
	Transmembrane	53 – 72	20	Helical; Name=2; Potential
	Topological domain	73 – 86	14	Extracellular Potential
	Transmembrane	87 – 109	23	Helical; Name=3; Potential
	Topological domain	110 – 128	19	Cytoplasmic Potential
	Transmembrane	129 – 146	18	Helical; Name=4; Potential
	Topological domain	147 – 180	34	Extracellular Potential
	Transmembrane	181 – 203	23	Helical; Name=5; Potential
	Topological domain	204 – 234	31	Cytoplasmic Potential
	Transmembrane	235 – 257	23	Helical; Name=6; Potential
	Topological domain	258 – 261	4	Extracellular Potential
	Transmembrane	262 – 284	23	Helical; Name=7; Potential
	Topological domain	285 – 312	28	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	164	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	170	1	K → Q. Corresponds to variant rs11054043 [ dbSNP | Ensembl ].		VAR_053345
	Natural variant	187	1	V → A. Ref.3 Ref.4 Corresponds to variant rs3741845 [ dbSNP | Ensembl ].		VAR_020204
	Natural variant	238	1	L → V. Corresponds to variant rs11054042 [ dbSNP | Ensembl ].		VAR_053346

Sequences

	Sequence		Length	Mass (Da)
	Q9NYW1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: CCE66F1E31051F49	FASTA	312	35,611
	10 20 30 40 50 60 MPSAIEAIYI ILIAGELTIG IWGNGFIVLV NCIDWLKRRD ISLIDIILIS LAISRICLLC 70 80 90 100 110 120 VISLDGFFML LFPGTYGNSV LVSIVNVVWT FANNSSLWFT SCLSIFYLLK IANISHPFFF 130 140 150 160 170 180 WLKLKINKVM LAILLGSFLI SLIISVPKND DMWYHLFKVS HEENITWKFK VSKIPGTFKQ 190 200 210 220 230 240 LTLNLGVMVP FILCLISFFL LLFSLVRHTK QIRLHATGFR DPSTEAHMRA IKAVIIFLLL 250 260 270 280 290 300 LIVYYPVFLV MTSSALIPQG KLVLMIGDIV TVIFPSSHSF ILIMGNSKLR EAFLKMLRFV 310 KCFLRRRKPF VP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel family of mammalian taste receptors." Adler E., Hoon M.A., Mueller K.L., Chandrashekar J., Ryba N.J.P., Zuker C.S. Cell 100:693-702(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TOPOLOGY.
[2]	"Evolution of bitter taste receptors in humans and apes." Fischer A., Gilad Y., Man O., Paeaebo S. Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-187.
[4]	"Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates." Go Y., Satta Y., Takenaka O., Takahata N. Genetics 170:313-326(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 9-298, VARIANT ALA-187.
[5]	"T2Rs function as bitter taste receptors." Chandrashekar J., Mueller K.L., Hoon M.A., Adler E., Feng L., Guo W., Zuker C.S., Ryba N.J.P. Cell 100:703-711(2000) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION.
[6]	"Receptors for bitter and sweet taste." Montmayeur J.-P., Matsunami H. Curr. Opin. Neurobiol. 12:366-371(2002) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[7]	"Molecular mechanisms of bitter and sweet taste transduction." Margolskee R.F. J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[8]	"Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways." Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J. Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF227135 Genomic DNA. Translation: AAF43908.1. AY724954 Genomic DNA. Translation: AAU21150.1. BC069066 mRNA. Translation: AAH69066.1. BC095519 mRNA. Translation: AAH95519.1. AB199063 Genomic DNA. Translation: BAD97966.1. AB199064 Genomic DNA. Translation: BAD97967.1. AB199065 Genomic DNA. Translation: BAD97968.1.
IPI	IPI00028323.
RefSeq	NP_076406.1. NM_023917.2.
UniGene	Hs.272391.
3D structure databases
ProteinModelPortal	Q9NYW1.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q9NYW1.
Polymorphism databases
DMDM	29839661.
Proteomic databases
PRIDE	Q9NYW1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000240691; ENSP00000240691; ENSG00000121381. ENST00000573524; ENSP00000460247; ENSG00000268769. ENST00000576440; ENSP00000459255; ENSG00000269248.
GeneID	50835.
KEGG	hsa:50835.
UCSC	uc001qyx.3. human.
Organism-specific databases
CTD	50835.
GeneCards	GC12M010963.
H-InvDB	HIX0171597.
HGNC	HGNC:14917. TAS2R9.
MIM	604795. gene.
neXtProt	NX_Q9NYW1.
PharmGKB	PA37927.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG45213.
HOGENOM	HOG000234595.
HOVERGEN	HBG060698.
InParanoid	Q9NYW1.
KO	K08474.
OMA	LWFTSCL.
OrthoDB	EOG4NZTTR.
PhylomeDB	Q9NYW1.
Gene expression databases
Bgee	Q9NYW1.
CleanEx	HS_TAS2R9.
Genevestigator	Q9NYW1.
GermOnline	ENSG00000121381. Homo sapiens.
Family and domain databases
InterPro	IPR017452. GPCR_Rhodpsn_7TM. IPR007960. TAS2_rcpt. [Graphical view]
Pfam	PF05296. TAS2R. 1 hit. [Graphical view]
PROSITE	PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. Uncertain. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	50835.
NextBio	53289.
SOURCE	Search...

Entry information

Entry name

TA2R9_HUMAN

Accession

Primary (citable) accession number: Q9NYW1
Secondary accession number(s): Q502V7 , Q50KT0, Q50KT1, Q645W9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 11, 2003
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.