Q9NYW0 (T2R10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Taste receptor type 2 member 10
Short name=T2R10

Alternative name(s):
Taste receptor family B member 2
Short name=TRB2

Gene names

Name:

TAS2R10

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	307 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Gustducin-coupled strychnine receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. Ref.6
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.
Miscellaneous	Several bitter taste receptors are expressed in a single taste receptor cell.
Sequence similarities	Belongs to the G-protein coupled receptor T2R family.

Ontologies

Keywords
Biological process	Sensory transduction Taste
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Non-traceable author statement. Source: UniProtKB
Molecular_function	taste receptor activity Traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 307	307	Taste receptor type 2 member 10		PRO_0000082238
Regions
	Topological domain	1 – 6	6	Extracellular Potential
	Transmembrane	7 – 27	21	Helical; Name=1; Potential
	Topological domain	28 – 42	15	Cytoplasmic Potential
	Transmembrane	43 – 63	21	Helical; Name=2; Potential
	Topological domain	64 – 100	37	Extracellular Potential
	Transmembrane	101 – 121	21	Helical; Name=3; Potential
	Topological domain	122 – 126	5	Cytoplasmic Potential
	Transmembrane	127 – 147	21	Helical; Name=4; Potential
	Topological domain	148 – 179	32	Extracellular Potential
	Transmembrane	180 – 200	21	Helical; Name=5; Potential
	Topological domain	201 – 227	27	Cytoplasmic Potential
	Transmembrane	228 – 248	21	Helical; Name=6; Potential
	Topological domain	249 – 257	9	Extracellular Potential
	Transmembrane	258 – 278	21	Helical; Name=7; Potential
	Topological domain	279 – 307	29	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	92	1	N-linked (GlcNAc...) Potential
	Glycosylation	158	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	156	1	T → M. Ref.2 Ref.4 Corresponds to variant rs597468 [ dbSNP | Ensembl ].		VAR_030009

Sequences

	Sequence		Length	Mass (Da)
	Q9NYW0 [UniParc]. Last modified November 2, 2010. Version 3. Checksum: 058DD69A55AE71C6	FASTA	307	35,365
	10 20 30 40 50 60 MLRVVEGIFI FVVVSESVFG VLGNGFIGLV NCIDCAKNKL STIGFILTGL AISRIFLIWI 70 80 90 100 110 120 IITDGFIQIF SPNIYASGNL IEYISYFWVI GNQSSMWFAT SLSIFYFLKI ANFSNYIFLW 130 140 150 160 170 180 LKSRTNMVLP FMIVFLLISS LLNFAYIAKI LNDYKTKNDT VWDLNMYKSE YFIKQILLNL 190 200 210 220 230 240 GVIFFFTLSL ITCIFLIISL WRHNRQMQSN VTGLRDSNTE AHVKAMKVLI SFIILFILYF 250 260 270 280 290 300 IGMAIEISCF TVRENKLLLM FGMTTTAIYP WGHSFILILG NSKLKQASLR VLQQLKCCEK RKNLRVT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel family of mammalian taste receptors." Adler E., Hoon M.A., Mueller K.L., Chandrashekar J., Ryba N.J.P., Zuker C.S. Cell 100:693-702(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TOPOLOGY.
[2]	"Evolution of bitter taste receptors in humans and apes." Fischer A., Gilad Y., Man O., Paeaebo S. Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT MET-156.
[3]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-156. Tissue: Brain.
[5]	"T2Rs function as bitter taste receptors." Chandrashekar J., Mueller K.L., Hoon M.A., Adler E., Feng L., Guo W., Zuker C.S., Ryba N.J.P. Cell 100:703-711(2000) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION.
[6]	"The receptors and coding logic for bitter taste." Mueller K.L., Hoon M.A., Erlenbach I., Chandrashekar J., Zuker C.S., Ryba N.J. Nature 434:225-229(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[7]	"Receptors for bitter and sweet taste." Montmayeur J.-P., Matsunami H. Curr. Opin. Neurobiol. 12:366-371(2002) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[8]	"Molecular mechanisms of bitter and sweet taste transduction." Margolskee R.F. J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[9]	"Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways." Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J. Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF227136 Genomic DNA. Translation: AAF43909.1. AY724946 Genomic DNA. Translation: AAU21148.1. AC006518 Genomic DNA. No translation available. BC069089 mRNA. Translation: AAH69089.1. BC101762 mRNA. Translation: AAI01763.1. BC101764 mRNA. Translation: AAI01765.1.
IPI	IPI00028349.
RefSeq	NP_076410.1. NM_023921.1.
UniGene	Hs.533756.
3D structure databases
ProteinModelPortal	Q9NYW0.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000240619.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	311033532.
Proteomic databases
PaxDb	Q9NYW0.
PRIDE	Q9NYW0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000240619; ENSP00000240619; ENSG00000121318. ENST00000571357; ENSP00000460246; ENSG00000268303. ENST00000576159; ENSP00000461683; ENSG00000269660.
GeneID	50839.
KEGG	hsa:50839.
UCSC	uc001qyy.1. human.
Organism-specific databases
CTD	50839.
GeneCards	GC12M010977.
HGNC	HGNC:14918. TAS2R10.
MIM	604791. gene.
neXtProt	NX_Q9NYW0.
PharmGKB	PA37928.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG46344.
HOGENOM	HOG000234595.
HOVERGEN	HBG060698.
InParanoid	Q9NYW0.
KO	K08474.
OMA	LYFIGMA.
OrthoDB	EOG4NZTTR.
PhylomeDB	Q9NYW0.
Gene expression databases
ArrayExpress	Q9NYW0.
Bgee	Q9NYW0.
CleanEx	HS_TAS2R10.
Genevestigator	Q9NYW0.
GermOnline	ENSG00000121318. Homo sapiens.
Family and domain databases
InterPro	IPR007960. TAS2_rcpt. [Graphical view]
Pfam	PF05296. TAS2R. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	50839.
NextBio	53305.
SOURCE	Search...

Entry information

Entry name

T2R10_HUMAN

Accession

Primary (citable) accession number: Q9NYW0
Secondary accession number(s): Q3MIM9, Q6NTD9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 11, 2003
Last sequence update:	November 2, 2010
Last modified:	May 1, 2013
This is version 89 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.