Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9NYW0

- T2R10_HUMAN

UniProt

Q9NYW0 - T2R10_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Taste receptor type 2 member 10

Gene

TAS2R10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Gustducin-coupled strychnine receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.1 Publication

GO - Molecular functioni

  1. bitter taste receptor activity Source: UniProt
  2. taste receptor activity Source: UniProtKB

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProt
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Enzyme and pathway databases

ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 10
Short name:
T2R10
Alternative name(s):
Taste receptor family B member 2
Short name:
TRB2
Gene namesi
Name:TAS2R10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:14918. TAS2R10.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProt
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37928.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307Taste receptor type 2 member 10PRO_0000082238Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi92 – 921N-linked (GlcNAc...)Sequence Analysis
Glycosylationi158 – 1581N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9NYW0.
PRIDEiQ9NYW0.

Expressioni

Tissue specificityi

Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.

Gene expression databases

BgeeiQ9NYW0.
CleanExiHS_TAS2R10.
ExpressionAtlasiQ9NYW0. baseline and differential.
GenevestigatoriQ9NYW0.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000240619.

Structurei

3D structure databases

ProteinModelPortaliQ9NYW0.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 66ExtracellularSequence Analysis
Topological domaini28 – 4215CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini64 – 10037ExtracellularSequence AnalysisAdd
BLAST
Topological domaini122 – 1265CytoplasmicSequence Analysis
Topological domaini148 – 17932ExtracellularSequence AnalysisAdd
BLAST
Topological domaini201 – 22727CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini249 – 2579ExtracellularSequence Analysis
Topological domaini279 – 30729CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei43 – 6321Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei101 – 12121Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei127 – 14721Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei180 – 20021Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei228 – 24821Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei258 – 27821Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46344.
GeneTreeiENSGT00760000119096.
HOGENOMiHOG000234595.
HOVERGENiHBG060698.
InParanoidiQ9NYW0.
KOiK08474.
OMAiDSNTEAH.
OrthoDBiEOG744T9S.
PhylomeDBiQ9NYW0.
TreeFamiTF335891.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR007960. TAS2_rcpt.
[Graphical view]
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NYW0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRVVEGIFI FVVVSESVFG VLGNGFIGLV NCIDCAKNKL STIGFILTGL
60 70 80 90 100
AISRIFLIWI IITDGFIQIF SPNIYASGNL IEYISYFWVI GNQSSMWFAT
110 120 130 140 150
SLSIFYFLKI ANFSNYIFLW LKSRTNMVLP FMIVFLLISS LLNFAYIAKI
160 170 180 190 200
LNDYKTKNDT VWDLNMYKSE YFIKQILLNL GVIFFFTLSL ITCIFLIISL
210 220 230 240 250
WRHNRQMQSN VTGLRDSNTE AHVKAMKVLI SFIILFILYF IGMAIEISCF
260 270 280 290 300
TVRENKLLLM FGMTTTAIYP WGHSFILILG NSKLKQASLR VLQQLKCCEK

RKNLRVT
Length:307
Mass (Da):35,365
Last modified:November 2, 2010 - v3
Checksum:i058DD69A55AE71C6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti156 – 1561T → M.2 Publications
Corresponds to variant rs597468 [ dbSNP | Ensembl ].
VAR_030009

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF227136 Genomic DNA. Translation: AAF43909.1.
AY724946 Genomic DNA. Translation: AAU21148.1.
AC006518 Genomic DNA. No translation available.
BC069089 mRNA. Translation: AAH69089.1.
BC101762 mRNA. Translation: AAI01763.1.
BC101764 mRNA. Translation: AAI01765.1.
CCDSiCCDS8634.1.
RefSeqiNP_076410.1. NM_023921.1.
XP_006719145.1. XM_006719082.1.
XP_006725598.1. XM_006725535.1.
XP_006726299.1. XM_006726236.1.
UniGeneiHs.533756.

Genome annotation databases

EnsembliENST00000240619; ENSP00000240619; ENSG00000121318.
ENST00000576159; ENSP00000461683; ENSG00000272805.
GeneIDi50839.
KEGGihsa:50839.
UCSCiuc001qyy.1. human.

Polymorphism databases

DMDMi311033532.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF227136 Genomic DNA. Translation: AAF43909.1 .
AY724946 Genomic DNA. Translation: AAU21148.1 .
AC006518 Genomic DNA. No translation available.
BC069089 mRNA. Translation: AAH69089.1 .
BC101762 mRNA. Translation: AAI01763.1 .
BC101764 mRNA. Translation: AAI01765.1 .
CCDSi CCDS8634.1.
RefSeqi NP_076410.1. NM_023921.1.
XP_006719145.1. XM_006719082.1.
XP_006725598.1. XM_006725535.1.
XP_006726299.1. XM_006726236.1.
UniGenei Hs.533756.

3D structure databases

ProteinModelPortali Q9NYW0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000240619.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 311033532.

Proteomic databases

PaxDbi Q9NYW0.
PRIDEi Q9NYW0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000240619 ; ENSP00000240619 ; ENSG00000121318 .
ENST00000576159 ; ENSP00000461683 ; ENSG00000272805 .
GeneIDi 50839.
KEGGi hsa:50839.
UCSCi uc001qyy.1. human.

Organism-specific databases

CTDi 50839.
GeneCardsi GC12M010977.
HGNCi HGNC:14918. TAS2R10.
MIMi 604791. gene.
neXtProti NX_Q9NYW0.
PharmGKBi PA37928.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46344.
GeneTreei ENSGT00760000119096.
HOGENOMi HOG000234595.
HOVERGENi HBG060698.
InParanoidi Q9NYW0.
KOi K08474.
OMAi DSNTEAH.
OrthoDBi EOG744T9S.
PhylomeDBi Q9NYW0.
TreeFami TF335891.

Enzyme and pathway databases

Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii TAS2R10.
GenomeRNAii 50839.
NextBioi 53305.
PROi Q9NYW0.
SOURCEi Search...

Gene expression databases

Bgeei Q9NYW0.
CleanExi HS_TAS2R10.
ExpressionAtlasi Q9NYW0. baseline and differential.
Genevestigatori Q9NYW0.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR017452. GPCR_Rhodpsn_7TM.
IPR007960. TAS2_rcpt.
[Graphical view ]
Pfami PF05296. TAS2R. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TOPOLOGY.
  2. "Evolution of bitter taste receptors in humans and apes."
    Fischer A., Gilad Y., Man O., Paeaebo S.
    Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT MET-156.
  3. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-156.
    Tissue: Brain.
  5. Cited for: CHARACTERIZATION.
  6. Cited for: FUNCTION.
  7. Cited for: REVIEW.
  8. "Molecular mechanisms of bitter and sweet taste transduction."
    Margolskee R.F.
    J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  9. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
    Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
    Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiT2R10_HUMAN
AccessioniPrimary (citable) accession number: Q9NYW0
Secondary accession number(s): Q3MIM9, Q6NTD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: November 2, 2010
Last modified: October 29, 2014
This is version 103 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Several bitter taste receptors are expressed in a single taste receptor cell.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3