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Q9NYW0

- T2R10_HUMAN

UniProt

Q9NYW0 - T2R10_HUMAN

Protein

Taste receptor type 2 member 10

Gene

TAS2R10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 3 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Gustducin-coupled strychnine receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.1 Publication

    GO - Molecular functioni

    1. bitter taste receptor activity Source: UniProt
    2. taste receptor activity Source: UniProtKB

    GO - Biological processi

    1. detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProt

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Sensory transduction, Taste

    Enzyme and pathway databases

    ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Taste receptor type 2 member 10
    Short name:
    T2R10
    Alternative name(s):
    Taste receptor family B member 2
    Short name:
    TRB2
    Gene namesi
    Name:TAS2R10
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:14918. TAS2R10.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProt
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37928.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 307307Taste receptor type 2 member 10PRO_0000082238Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi92 – 921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi158 – 1581N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9NYW0.
    PRIDEiQ9NYW0.

    Expressioni

    Tissue specificityi

    Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.

    Gene expression databases

    ArrayExpressiQ9NYW0.
    BgeeiQ9NYW0.
    CleanExiHS_TAS2R10.
    GenevestigatoriQ9NYW0.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000240619.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NYW0.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 66ExtracellularSequence Analysis
    Topological domaini28 – 4215CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini64 – 10037ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini122 – 1265CytoplasmicSequence Analysis
    Topological domaini148 – 17932ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini201 – 22727CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini249 – 2579ExtracellularSequence Analysis
    Topological domaini279 – 30729CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2721Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei43 – 6321Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei101 – 12121Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei127 – 14721Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei180 – 20021Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei228 – 24821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei258 – 27821Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46344.
    HOGENOMiHOG000234595.
    HOVERGENiHBG060698.
    InParanoidiQ9NYW0.
    KOiK08474.
    OMAiDSNTEAH.
    OrthoDBiEOG744T9S.
    PhylomeDBiQ9NYW0.
    TreeFamiTF335891.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR017452. GPCR_Rhodpsn_7TM.
    IPR007960. TAS2_rcpt.
    [Graphical view]
    PfamiPF05296. TAS2R. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NYW0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRVVEGIFI FVVVSESVFG VLGNGFIGLV NCIDCAKNKL STIGFILTGL    50
    AISRIFLIWI IITDGFIQIF SPNIYASGNL IEYISYFWVI GNQSSMWFAT 100
    SLSIFYFLKI ANFSNYIFLW LKSRTNMVLP FMIVFLLISS LLNFAYIAKI 150
    LNDYKTKNDT VWDLNMYKSE YFIKQILLNL GVIFFFTLSL ITCIFLIISL 200
    WRHNRQMQSN VTGLRDSNTE AHVKAMKVLI SFIILFILYF IGMAIEISCF 250
    TVRENKLLLM FGMTTTAIYP WGHSFILILG NSKLKQASLR VLQQLKCCEK 300
    RKNLRVT 307
    Length:307
    Mass (Da):35,365
    Last modified:November 2, 2010 - v3
    Checksum:i058DD69A55AE71C6
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti156 – 1561T → M.2 Publications
    Corresponds to variant rs597468 [ dbSNP | Ensembl ].
    VAR_030009

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF227136 Genomic DNA. Translation: AAF43909.1.
    AY724946 Genomic DNA. Translation: AAU21148.1.
    AC006518 Genomic DNA. No translation available.
    BC069089 mRNA. Translation: AAH69089.1.
    BC101762 mRNA. Translation: AAI01763.1.
    BC101764 mRNA. Translation: AAI01765.1.
    CCDSiCCDS8634.1.
    RefSeqiNP_076410.1. NM_023921.1.
    XP_006719145.1. XM_006719082.1.
    XP_006725598.1. XM_006725535.1.
    XP_006726299.1. XM_006726236.1.
    UniGeneiHs.533756.

    Genome annotation databases

    EnsembliENST00000240619; ENSP00000240619; ENSG00000121318.
    ENST00000576159; ENSP00000461683; ENSG00000272805.
    GeneIDi50839.
    KEGGihsa:50839.
    UCSCiuc001qyy.1. human.

    Polymorphism databases

    DMDMi311033532.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF227136 Genomic DNA. Translation: AAF43909.1 .
    AY724946 Genomic DNA. Translation: AAU21148.1 .
    AC006518 Genomic DNA. No translation available.
    BC069089 mRNA. Translation: AAH69089.1 .
    BC101762 mRNA. Translation: AAI01763.1 .
    BC101764 mRNA. Translation: AAI01765.1 .
    CCDSi CCDS8634.1.
    RefSeqi NP_076410.1. NM_023921.1.
    XP_006719145.1. XM_006719082.1.
    XP_006725598.1. XM_006725535.1.
    XP_006726299.1. XM_006726236.1.
    UniGenei Hs.533756.

    3D structure databases

    ProteinModelPortali Q9NYW0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000240619.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 311033532.

    Proteomic databases

    PaxDbi Q9NYW0.
    PRIDEi Q9NYW0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000240619 ; ENSP00000240619 ; ENSG00000121318 .
    ENST00000576159 ; ENSP00000461683 ; ENSG00000272805 .
    GeneIDi 50839.
    KEGGi hsa:50839.
    UCSCi uc001qyy.1. human.

    Organism-specific databases

    CTDi 50839.
    GeneCardsi GC12M010977.
    HGNCi HGNC:14918. TAS2R10.
    MIMi 604791. gene.
    neXtProti NX_Q9NYW0.
    PharmGKBi PA37928.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46344.
    HOGENOMi HOG000234595.
    HOVERGENi HBG060698.
    InParanoidi Q9NYW0.
    KOi K08474.
    OMAi DSNTEAH.
    OrthoDBi EOG744T9S.
    PhylomeDBi Q9NYW0.
    TreeFami TF335891.

    Enzyme and pathway databases

    Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii TAS2R10.
    GenomeRNAii 50839.
    NextBioi 53305.
    PROi Q9NYW0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NYW0.
    Bgeei Q9NYW0.
    CleanExi HS_TAS2R10.
    Genevestigatori Q9NYW0.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR017452. GPCR_Rhodpsn_7TM.
    IPR007960. TAS2_rcpt.
    [Graphical view ]
    Pfami PF05296. TAS2R. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TOPOLOGY.
    2. "Evolution of bitter taste receptors in humans and apes."
      Fischer A., Gilad Y., Man O., Paeaebo S.
      Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT MET-156.
    3. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-156.
      Tissue: Brain.
    5. Cited for: CHARACTERIZATION.
    6. Cited for: FUNCTION.
    7. Cited for: REVIEW.
    8. "Molecular mechanisms of bitter and sweet taste transduction."
      Margolskee R.F.
      J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    9. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
      Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
      Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiT2R10_HUMAN
    AccessioniPrimary (citable) accession number: Q9NYW0
    Secondary accession number(s): Q3MIM9, Q6NTD9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 11, 2003
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 102 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Several bitter taste receptors are expressed in a single taste receptor cell.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3