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Protein

Taste receptor type 2 member 13

Gene

TAS2R13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

GO - Molecular functioni

  • bitter taste receptor activity Source: UniProtKB
  • G-protein coupled receptor activity Source: UniProtKB-KW
  • taste receptor activity Source: UniProtKB

GO - Biological processi

  • detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProtKB
  • positive regulation of cytokinesis Source: UniProtKB

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processSensory transduction, Taste

Enzyme and pathway databases

ReactomeiR-HSA-418594. G alpha (i) signalling events.
R-HSA-420499. Class C/3 (Metabotropic glutamate/pheromone receptors).

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 13
Short name:
T2R13
Alternative name(s):
Taste receptor family B member 3
Short name:
TRB3
Gene namesi
Name:TAS2R13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000212128.2.
HGNCiHGNC:14919. TAS2R13.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7ExtracellularSequence analysis7
Transmembranei8 – 28Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini29 – 55CytoplasmicSequence analysisAdd BLAST27
Transmembranei56 – 76Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini77 – 85ExtracellularSequence analysis9
Transmembranei86 – 106Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini107 – 128CytoplasmicSequence analysisAdd BLAST22
Transmembranei129 – 149Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini150 – 184ExtracellularSequence analysisAdd BLAST35
Transmembranei185 – 205Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini206 – 232CytoplasmicSequence analysisAdd BLAST27
Transmembranei233 – 253Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini254 – 261ExtracellularSequence analysis8
Transmembranei262 – 282Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini283 – 303CytoplasmicSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi50838.
OpenTargetsiENSG00000212128.
PharmGKBiPA37929.

Polymorphism and mutation databases

BioMutaiTAS2R13.
DMDMi29839659.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000822471 – 303Taste receptor type 2 member 13Add BLAST303

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi162N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi166N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9NYV9.
PeptideAtlasiQ9NYV9.
PRIDEiQ9NYV9.

PTM databases

iPTMnetiQ9NYV9.
PhosphoSitePlusiQ9NYV9.

Expressioni

Tissue specificityi

Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.

Gene expression databases

BgeeiENSG00000212128.
CleanExiHS_TAS2R13.
GenevisibleiQ9NYV9. HS.

Interactioni

Protein-protein interaction databases

BioGridi119148. 2 interactors.
STRINGi9606.ENSP00000375095.

Structurei

3D structure databases

ProteinModelPortaliQ9NYV9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9F7. Eukaryota.
ENOG4111BEG. LUCA.
GeneTreeiENSGT00760000119096.
HOGENOMiHOG000234595.
HOVERGENiHBG060698.
InParanoidiQ9NYV9.
KOiK08474.
OMAiIVLINCI.
OrthoDBiEOG091G0GT1.
PhylomeDBiQ9NYV9.
TreeFamiTF335891.

Family and domain databases

InterProiView protein in InterPro
IPR007960. T2R.
PANTHERiPTHR11394. PTHR11394. 1 hit.
PfamiView protein in Pfam
PF05296. TAS2R. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NYV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESALPSIFT LVIIAEFIIG NLSNGFIVLI NCIDWVSKRE LSSVDKLLII
60 70 80 90 100
LAISRIGLIW EILVSWFLAL HYLAIFVSGT GLRIMIFSWI VSNHFNLWLA
110 120 130 140 150
TIFSIFYLLK IASFSSPAFL YLKWRVNKVI LMILLGTLVF LFLNLIQINM
160 170 180 190 200
HIKDWLDRYE RNTTWNFSMS DFETFSVSVK FTMTMFSLTP FTVAFISFLL
210 220 230 240 250
LIFSLQKHLQ KMQLNYKGHR DPRTKVHTNA LKIVISFLLF YASFFLCVLI
260 270 280 290 300
SWISELYQNT VIYMLCETIG VFSPSSHSFL LILGNAKLRQ AFLLVAAKVW

AKR
Length:303
Mass (Da):35,118
Last modified:October 1, 2000 - v1
Checksum:i756BF5382E36BFB5
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036432149N → S in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_021853259N → S1 PublicationCorresponds to variant dbSNP:rs1015443Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF227137 Genomic DNA. Translation: AAF43910.1.
AY724945 Genomic DNA. Translation: AAU21147.1.
BC069376 mRNA. Translation: AAH69376.1.
BC095518 mRNA. Translation: AAH95518.1.
CCDSiCCDS8635.1.
RefSeqiNP_076409.1. NM_023920.2.
UniGeneiHs.679407.

Genome annotation databases

EnsembliENST00000390677; ENSP00000375095; ENSG00000212128.
ENST00000574870; ENSP00000461365; ENSG00000273457.
ENST00000613662; ENSP00000478277; ENSG00000277254.
GeneIDi50838.
KEGGihsa:50838.
UCSCiuc001qzg.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiT2R13_HUMAN
AccessioniPrimary (citable) accession number: Q9NYV9
Secondary accession number(s): Q4G0I5, Q502V8, Q645X2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: October 1, 2000
Last modified: September 27, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families