Q9NYV9 (T2R13_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Taste receptor type 2 member 13
Short name=T2R13

Alternative name(s):
Taste receptor family B member 3
Short name=TRB3

Gene names

Name:

TAS2R13

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	303 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.
Miscellaneous	Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.
Sequence similarities	Belongs to the G-protein coupled receptor T2R family.

Ontologies

Keywords
Biological process	Sensory transduction Taste
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Non-traceable author statement. Source: UniProtKB
Molecular_function	taste receptor activity Traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 303	303	Taste receptor type 2 member 13		PRO_0000082247
Regions
	Topological domain	1 – 7	7	Extracellular Potential
	Transmembrane	8 – 28	21	Helical; Name=1; Potential
	Topological domain	29 – 55	27	Cytoplasmic Potential
	Transmembrane	56 – 76	21	Helical; Name=2; Potential
	Topological domain	77 – 85	9	Extracellular Potential
	Transmembrane	86 – 106	21	Helical; Name=3; Potential
	Topological domain	107 – 128	22	Cytoplasmic Potential
	Transmembrane	129 – 149	21	Helical; Name=4; Potential
	Topological domain	150 – 184	35	Extracellular Potential
	Transmembrane	185 – 205	21	Helical; Name=5; Potential
	Topological domain	206 – 232	27	Cytoplasmic Potential
	Transmembrane	233 – 253	21	Helical; Name=6; Potential
	Topological domain	254 – 261	8	Extracellular Potential
	Transmembrane	262 – 282	21	Helical; Name=7; Potential
	Topological domain	283 – 303	21	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	162	1	N-linked (GlcNAc...) Potential
	Glycosylation	166	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	149	1	N → S in a breast cancer sample; somatic mutation. Ref.8		VAR_036432
	Natural variant	259	1	N → S. Ref.3 Corresponds to variant rs1015443 [ dbSNP | Ensembl ].		VAR_021853

Sequences

	Sequence		Length	Mass (Da)
	Q9NYV9 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 756BF5382E36BFB5	FASTA	303	35,118
	10 20 30 40 50 60 MESALPSIFT LVIIAEFIIG NLSNGFIVLI NCIDWVSKRE LSSVDKLLII LAISRIGLIW 70 80 90 100 110 120 EILVSWFLAL HYLAIFVSGT GLRIMIFSWI VSNHFNLWLA TIFSIFYLLK IASFSSPAFL 130 140 150 160 170 180 YLKWRVNKVI LMILLGTLVF LFLNLIQINM HIKDWLDRYE RNTTWNFSMS DFETFSVSVK 190 200 210 220 230 240 FTMTMFSLTP FTVAFISFLL LIFSLQKHLQ KMQLNYKGHR DPRTKVHTNA LKIVISFLLF 250 260 270 280 290 300 YASFFLCVLI SWISELYQNT VIYMLCETIG VFSPSSHSFL LILGNAKLRQ AFLLVAAKVW AKR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel family of mammalian taste receptors." Adler E., Hoon M.A., Mueller K.L., Chandrashekar J., Ryba N.J.P., Zuker C.S. Cell 100:693-702(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TOPOLOGY.
[2]	"Evolution of bitter taste receptors in humans and apes." Fischer A., Gilad Y., Man O., Paeaebo S. Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-259.
[4]	"T2Rs function as bitter taste receptors." Chandrashekar J., Mueller K.L., Hoon M.A., Adler E., Feng L., Guo W., Zuker C.S., Ryba N.J.P. Cell 100:703-711(2000) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION.
[5]	"Receptors for bitter and sweet taste." Montmayeur J.-P., Matsunami H. Curr. Opin. Neurobiol. 12:366-371(2002) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[6]	"Molecular mechanisms of bitter and sweet taste transduction." Margolskee R.F. J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[7]	"Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways." Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J. Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[8]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-149.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF227137 Genomic DNA. Translation: AAF43910.1. AY724945 Genomic DNA. Translation: AAU21147.1. BC069376 mRNA. Translation: AAH69376.1. BC095518 mRNA. Translation: AAH95518.1.
IPI	IPI00028332.
RefSeq	NP_076409.1. NM_023920.2.
UniGene	Hs.679407.
3D structure databases
ProteinModelPortal	Q9NYV9.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000375095.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	29839659.
Proteomic databases
PaxDb	Q9NYV9.
PRIDE	Q9NYV9.
Protocols and materials databases
DNASU	50838.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000390677; ENSP00000375095; ENSG00000212128. ENST00000574870; ENSP00000461365; ENSG00000269598. ENST00000575183; ENSP00000460588; ENSG00000269046.
GeneID	50838.
KEGG	hsa:50838.
UCSC	uc001qzg.1. human.
Organism-specific databases
CTD	50838.
GeneCards	GC12M011060.
HGNC	HGNC:14919. TAS2R13.
MIM	604792. gene.
neXtProt	NX_Q9NYV9.
PharmGKB	PA37929.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG42620.
HOGENOM	HOG000234595.
HOVERGEN	HBG060698.
InParanoid	Q9NYV9.
KO	K08474.
OMA	LNLIQIN.
OrthoDB	EOG42822D.
PhylomeDB	Q9NYV9.
Gene expression databases
ArrayExpress	Q9NYV9.
CleanEx	HS_TAS2R13.
Genevestigator	Q9NYV9.
Family and domain databases
InterPro	IPR007960. TAS2_rcpt. [Graphical view]
Pfam	PF05296. TAS2R. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	50838.
NextBio	53301.
SOURCE	Search...

Entry information

Entry name

T2R13_HUMAN

Accession

Primary (citable) accession number: Q9NYV9
Secondary accession number(s): Q4G0I5, Q502V8, Q645X2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 11, 2003
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.