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Q9NYV9

- T2R13_HUMAN

UniProt

Q9NYV9 - T2R13_HUMAN

Protein

Taste receptor type 2 member 13

Gene

TAS2R13

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.

    GO - Molecular functioni

    1. bitter taste receptor activity Source: UniProt
    2. taste receptor activity Source: UniProtKB

    GO - Biological processi

    1. detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProt
    2. positive regulation of cytokinesis Source: UniProt

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Sensory transduction, Taste

    Enzyme and pathway databases

    ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Taste receptor type 2 member 13
    Short name:
    T2R13
    Alternative name(s):
    Taste receptor family B member 3
    Short name:
    TRB3
    Gene namesi
    Name:TAS2R13
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:14919. TAS2R13.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProt
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37929.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 303303Taste receptor type 2 member 13PRO_0000082247Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi162 – 1621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9NYV9.
    PRIDEiQ9NYV9.

    Expressioni

    Tissue specificityi

    Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.

    Gene expression databases

    ArrayExpressiQ9NYV9.
    CleanExiHS_TAS2R13.
    GenevestigatoriQ9NYV9.

    Interactioni

    Protein-protein interaction databases

    BioGridi119148. 3 interactions.
    STRINGi9606.ENSP00000375095.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NYV9.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 77ExtracellularSequence Analysis
    Topological domaini29 – 5527CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini77 – 859ExtracellularSequence Analysis
    Topological domaini107 – 12822CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini150 – 18435ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini206 – 23227CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini254 – 2618ExtracellularSequence Analysis
    Topological domaini283 – 30321CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8 – 2821Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei56 – 7621Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei86 – 10621Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei129 – 14921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei185 – 20521Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei233 – 25321Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei262 – 28221Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG42620.
    HOGENOMiHOG000234595.
    HOVERGENiHBG060698.
    InParanoidiQ9NYV9.
    KOiK08474.
    OMAiLNLIQIN.
    OrthoDBiEOG741Z3C.
    PhylomeDBiQ9NYV9.
    TreeFamiTF335891.

    Family and domain databases

    InterProiIPR007960. TAS2_rcpt.
    [Graphical view]
    PfamiPF05296. TAS2R. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NYV9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESALPSIFT LVIIAEFIIG NLSNGFIVLI NCIDWVSKRE LSSVDKLLII    50
    LAISRIGLIW EILVSWFLAL HYLAIFVSGT GLRIMIFSWI VSNHFNLWLA 100
    TIFSIFYLLK IASFSSPAFL YLKWRVNKVI LMILLGTLVF LFLNLIQINM 150
    HIKDWLDRYE RNTTWNFSMS DFETFSVSVK FTMTMFSLTP FTVAFISFLL 200
    LIFSLQKHLQ KMQLNYKGHR DPRTKVHTNA LKIVISFLLF YASFFLCVLI 250
    SWISELYQNT VIYMLCETIG VFSPSSHSFL LILGNAKLRQ AFLLVAAKVW 300
    AKR 303
    Length:303
    Mass (Da):35,118
    Last modified:October 1, 2000 - v1
    Checksum:i756BF5382E36BFB5
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti149 – 1491N → S in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036432
    Natural varianti259 – 2591N → S.1 Publication
    Corresponds to variant rs1015443 [ dbSNP | Ensembl ].
    VAR_021853

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF227137 Genomic DNA. Translation: AAF43910.1.
    AY724945 Genomic DNA. Translation: AAU21147.1.
    BC069376 mRNA. Translation: AAH69376.1.
    BC095518 mRNA. Translation: AAH95518.1.
    CCDSiCCDS8635.1.
    RefSeqiNP_076409.1. NM_023920.2.
    UniGeneiHs.679407.

    Genome annotation databases

    EnsembliENST00000390677; ENSP00000375095; ENSG00000212128.
    ENST00000574870; ENSP00000461365; ENSG00000273457.
    GeneIDi50838.
    KEGGihsa:50838.
    UCSCiuc001qzg.1. human.

    Polymorphism databases

    DMDMi29839659.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF227137 Genomic DNA. Translation: AAF43910.1 .
    AY724945 Genomic DNA. Translation: AAU21147.1 .
    BC069376 mRNA. Translation: AAH69376.1 .
    BC095518 mRNA. Translation: AAH95518.1 .
    CCDSi CCDS8635.1.
    RefSeqi NP_076409.1. NM_023920.2.
    UniGenei Hs.679407.

    3D structure databases

    ProteinModelPortali Q9NYV9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119148. 3 interactions.
    STRINGi 9606.ENSP00000375095.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 29839659.

    Proteomic databases

    PaxDbi Q9NYV9.
    PRIDEi Q9NYV9.

    Protocols and materials databases

    DNASUi 50838.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000390677 ; ENSP00000375095 ; ENSG00000212128 .
    ENST00000574870 ; ENSP00000461365 ; ENSG00000273457 .
    GeneIDi 50838.
    KEGGi hsa:50838.
    UCSCi uc001qzg.1. human.

    Organism-specific databases

    CTDi 50838.
    GeneCardsi GC12M011060.
    HGNCi HGNC:14919. TAS2R13.
    MIMi 604792. gene.
    neXtProti NX_Q9NYV9.
    PharmGKBi PA37929.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42620.
    HOGENOMi HOG000234595.
    HOVERGENi HBG060698.
    InParanoidi Q9NYV9.
    KOi K08474.
    OMAi LNLIQIN.
    OrthoDBi EOG741Z3C.
    PhylomeDBi Q9NYV9.
    TreeFami TF335891.

    Enzyme and pathway databases

    Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii TAS2R13.
    GenomeRNAii 50838.
    NextBioi 53301.
    PROi Q9NYV9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NYV9.
    CleanExi HS_TAS2R13.
    Genevestigatori Q9NYV9.

    Family and domain databases

    InterProi IPR007960. TAS2_rcpt.
    [Graphical view ]
    Pfami PF05296. TAS2R. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TOPOLOGY.
    2. "Evolution of bitter taste receptors in humans and apes."
      Fischer A., Gilad Y., Man O., Paeaebo S.
      Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-259.
    4. Cited for: CHARACTERIZATION.
    5. Cited for: REVIEW.
    6. "Molecular mechanisms of bitter and sweet taste transduction."
      Margolskee R.F.
      J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    7. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
      Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
      Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    8. Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-149.

    Entry informationi

    Entry nameiT2R13_HUMAN
    AccessioniPrimary (citable) accession number: Q9NYV9
    Secondary accession number(s): Q4G0I5, Q502V8, Q645X2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 11, 2003
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3