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Q9NYV9 (T2R13_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Taste receptor type 2 member 13

Short name=T2R13
Alternative name(s):
Taste receptor family B member 3
Short name=TRB3
Gene names
Name:TAS2R13
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length303 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

Sequence similarities

Belongs to the G-protein coupled receptor T2R family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 303303Taste receptor type 2 member 13
PRO_0000082247

Regions

Topological domain1 – 77Extracellular Potential
Transmembrane8 – 2821Helical; Name=1; Potential
Topological domain29 – 5527Cytoplasmic Potential
Transmembrane56 – 7621Helical; Name=2; Potential
Topological domain77 – 859Extracellular Potential
Transmembrane86 – 10621Helical; Name=3; Potential
Topological domain107 – 12822Cytoplasmic Potential
Transmembrane129 – 14921Helical; Name=4; Potential
Topological domain150 – 18435Extracellular Potential
Transmembrane185 – 20521Helical; Name=5; Potential
Topological domain206 – 23227Cytoplasmic Potential
Transmembrane233 – 25321Helical; Name=6; Potential
Topological domain254 – 2618Extracellular Potential
Transmembrane262 – 28221Helical; Name=7; Potential
Topological domain283 – 30321Cytoplasmic Potential

Amino acid modifications

Glycosylation1621N-linked (GlcNAc...) Potential
Glycosylation1661N-linked (GlcNAc...) Potential

Natural variations

Natural variant1491N → S in a breast cancer sample; somatic mutation. Ref.8
VAR_036432
Natural variant2591N → S. Ref.3
Corresponds to variant rs1015443 [ dbSNP | Ensembl ].
VAR_021853

Sequences

Sequence LengthMass (Da)Tools
Q9NYV9 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 756BF5382E36BFB5

FASTA30335,118
        10         20         30         40         50         60 
MESALPSIFT LVIIAEFIIG NLSNGFIVLI NCIDWVSKRE LSSVDKLLII LAISRIGLIW 

        70         80         90        100        110        120 
EILVSWFLAL HYLAIFVSGT GLRIMIFSWI VSNHFNLWLA TIFSIFYLLK IASFSSPAFL 

       130        140        150        160        170        180 
YLKWRVNKVI LMILLGTLVF LFLNLIQINM HIKDWLDRYE RNTTWNFSMS DFETFSVSVK 

       190        200        210        220        230        240 
FTMTMFSLTP FTVAFISFLL LIFSLQKHLQ KMQLNYKGHR DPRTKVHTNA LKIVISFLLF 

       250        260        270        280        290        300 
YASFFLCVLI SWISELYQNT VIYMLCETIG VFSPSSHSFL LILGNAKLRQ AFLLVAAKVW 


AKR 

« Hide

References

« Hide 'large scale' references
[1]"A novel family of mammalian taste receptors."
Adler E., Hoon M.A., Mueller K.L., Chandrashekar J., Ryba N.J.P., Zuker C.S.
Cell 100:693-702(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TOPOLOGY.
[2]"Evolution of bitter taste receptors in humans and apes."
Fischer A., Gilad Y., Man O., Paeaebo S.
Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-259.
[4]"T2Rs function as bitter taste receptors."
Chandrashekar J., Mueller K.L., Hoon M.A., Adler E., Feng L., Guo W., Zuker C.S., Ryba N.J.P.
Cell 100:703-711(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[5]"Receptors for bitter and sweet taste."
Montmayeur J.-P., Matsunami H.
Curr. Opin. Neurobiol. 12:366-371(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[6]"Molecular mechanisms of bitter and sweet taste transduction."
Margolskee R.F.
J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[7]"Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[8]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-149.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF227137 Genomic DNA. Translation: AAF43910.1.
AY724945 Genomic DNA. Translation: AAU21147.1.
BC069376 mRNA. Translation: AAH69376.1.
BC095518 mRNA. Translation: AAH95518.1.
RefSeqNP_076409.1. NM_023920.2.
UniGeneHs.679407.

3D structure databases

ProteinModelPortalQ9NYV9.
SMRQ9NYV9. Positions 277-303.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119148. 3 interactions.
STRING9606.ENSP00000375095.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM29839659.

Proteomic databases

PaxDbQ9NYV9.
PRIDEQ9NYV9.

Protocols and materials databases

DNASU50838.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000390677; ENSP00000375095; ENSG00000212128.
ENST00000574870; ENSP00000461365; ENSG00000273457.
ENST00000575183; ENSP00000460588; ENSG00000273105.
GeneID50838.
KEGGhsa:50838.
UCSCuc001qzg.1. human.

Organism-specific databases

CTD50838.
GeneCardsGC12M011060.
HGNCHGNC:14919. TAS2R13.
MIM604792. gene.
neXtProtNX_Q9NYV9.
PharmGKBPA37929.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG42620.
HOGENOMHOG000234595.
HOVERGENHBG060698.
InParanoidQ9NYV9.
KOK08474.
OMALNLIQIN.
OrthoDBEOG741Z3C.
PhylomeDBQ9NYV9.
TreeFamTF335891.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressQ9NYV9.
CleanExHS_TAS2R13.
GenevestigatorQ9NYV9.

Family and domain databases

InterProIPR007960. TAS2_rcpt.
[Graphical view]
PfamPF05296. TAS2R. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiTAS2R13.
GenomeRNAi50838.
NextBio53301.
PROQ9NYV9.
SOURCESearch...

Entry information

Entry nameT2R13_HUMAN
AccessionPrimary (citable) accession number: Q9NYV9
Secondary accession number(s): Q4G0I5, Q502V8, Q645X2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries