SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9NYV8

- T2R14_HUMAN

UniProt

Q9NYV8 - T2R14_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Taste receptor type 2 member 14

Gene
TAS2R14
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 By similarity.

GO - Molecular functioni

  1. bitter taste receptor activity Source: HGNC
  2. taste receptor activity Source: UniProtKB

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception of bitter taste Source: HGNC
  2. G-protein coupled receptor signaling pathway Source: HGNC
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Enzyme and pathway databases

ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 14
Short name:
T2R14
Alternative name(s):
Taste receptor family B member 1
Short name:
TRB1
Gene namesi
Name:TAS2R14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:14920. TAS2R14.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77Extracellular Reviewed prediction
Transmembranei8 – 2821Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini29 – 5527Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei56 – 7621Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini77 – 8711Extracellular Reviewed predictionAdd
BLAST
Transmembranei88 – 10821Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini109 – 12921Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei130 – 15021Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini151 – 18434Extracellular Reviewed predictionAdd
BLAST
Transmembranei185 – 20521Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini206 – 23227Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei233 – 25321Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini254 – 2618Extracellular Reviewed prediction
Transmembranei262 – 28221Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini283 – 31735Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: HGNC
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37930.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 317317Taste receptor type 2 member 14PRO_0000082255Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi153 – 1531N-linked (GlcNAc...)1 Publication
Glycosylationi162 – 1621N-linked (GlcNAc...) Reviewed prediction
Glycosylationi171 – 1711N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9NYV8.
PRIDEiQ9NYV8.

PTM databases

PhosphoSiteiQ9NYV8.

Expressioni

Tissue specificityi

Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.

Gene expression databases

ArrayExpressiQ9NYV8.
BgeeiQ9NYV8.
CleanExiHS_TAS2R14.
GenevestigatoriQ9NYV8.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000375094.

Structurei

3D structure databases

ProteinModelPortaliQ9NYV8.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46292.
HOGENOMiHOG000234595.
HOVERGENiHBG060698.
InParanoidiQ9NYV8.
KOiK08474.
OMAiLINIHIN.
OrthoDBiEOG70CR7B.
PhylomeDBiQ9NYV8.
TreeFamiTF335891.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR007960. TAS2_rcpt.
[Graphical view]
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NYV8-1 [UniParc]FASTAAdd to Basket

« Hide

MGGVIKSIFT FVLIVEFIIG NLGNSFIALV NCIDWVKGRK ISSVDRILTA    50
LAISRISLVW LIFGSWCVSV FFPALFATEK MFRMLTNIWT VINHFSVWLA 100
TGLGTFYFLK IANFSNSIFL YLKWRVKKVV LVLLLVTSVF LFLNIALINI 150
HINASINGYR RNKTCSSDSS NFTRFSSLIV LTSTVFIFIP FTLSLAMFLL 200
LIFSMWKHRK KMQHTVKISG DASTKAHRGV KSVITFFLLY AIFSLSFFIS 250
VWTSERLEEN LIILSQVMGM AYPSCHSCVL ILGNKKLRQA SLSVLLWLRY 300
MFKDGEPSGH KEFRESS 317
Length:317
Mass (Da):36,160
Last modified:October 1, 2000 - v1
Checksum:iC79184343D679BE5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti86 – 861T → A.
Corresponds to variant rs16925868 [ dbSNP | Ensembl ].
VAR_053347
Natural varianti201 – 2011L → F.
Corresponds to variant rs35804287 [ dbSNP | Ensembl ].
VAR_062085

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF227138 Genomic DNA. Translation: AAF43911.1.
AY724944 Genomic DNA. Translation: AAU21146.1.
BC069148 mRNA. Translation: AAH69148.1.
BC101993 mRNA. Translation: AAI01994.1.
BC101994 mRNA. Translation: AAI01995.1.
BC103699 mRNA. Translation: AAI03700.1.
CCDSiCCDS8637.1.
RefSeqiNP_076411.1. NM_023922.1.
UniGeneiHs.679406.
Hs.731575.

Genome annotation databases

EnsembliENST00000537503; ENSP00000441949; ENSG00000212127.
ENST00000574901; ENSP00000460620; ENSG00000262103.
ENST00000575008; ENSP00000458544; ENSG00000261984.
GeneIDi50840.
KEGGihsa:50840.
UCSCiuc010shi.2. human.

Polymorphism databases

DMDMi29839658.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF227138 Genomic DNA. Translation: AAF43911.1 .
AY724944 Genomic DNA. Translation: AAU21146.1 .
BC069148 mRNA. Translation: AAH69148.1 .
BC101993 mRNA. Translation: AAI01994.1 .
BC101994 mRNA. Translation: AAI01995.1 .
BC103699 mRNA. Translation: AAI03700.1 .
CCDSi CCDS8637.1.
RefSeqi NP_076411.1. NM_023922.1.
UniGenei Hs.679406.
Hs.731575.

3D structure databases

ProteinModelPortali Q9NYV8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000375094.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q9NYV8.

Polymorphism databases

DMDMi 29839658.

Proteomic databases

PaxDbi Q9NYV8.
PRIDEi Q9NYV8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000537503 ; ENSP00000441949 ; ENSG00000212127 .
ENST00000574901 ; ENSP00000460620 ; ENSG00000262103 .
ENST00000575008 ; ENSP00000458544 ; ENSG00000261984 .
GeneIDi 50840.
KEGGi hsa:50840.
UCSCi uc010shi.2. human.

Organism-specific databases

CTDi 50840.
GeneCardsi GC12M011090.
HGNCi HGNC:14920. TAS2R14.
MIMi 604790. gene.
neXtProti NX_Q9NYV8.
PharmGKBi PA37930.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46292.
HOGENOMi HOG000234595.
HOVERGENi HBG060698.
InParanoidi Q9NYV8.
KOi K08474.
OMAi LINIHIN.
OrthoDBi EOG70CR7B.
PhylomeDBi Q9NYV8.
TreeFami TF335891.

Enzyme and pathway databases

Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii TAS2R14.
GenomeRNAii 50840.
NextBioi 53309.
PROi Q9NYV8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9NYV8.
Bgeei Q9NYV8.
CleanExi HS_TAS2R14.
Genevestigatori Q9NYV8.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR017452. GPCR_Rhodpsn_7TM.
IPR007960. TAS2_rcpt.
[Graphical view ]
Pfami PF05296. TAS2R. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TOPOLOGY.
  2. "Evolution of bitter taste receptors in humans and apes."
    Fischer A., Gilad Y., Man O., Paeaebo S.
    Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: CHARACTERIZATION.
  5. Cited for: REVIEW.
  6. "Molecular mechanisms of bitter and sweet taste transduction."
    Margolskee R.F.
    J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  7. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
    Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
    Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  8. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-153.
    Tissue: Plasma.

Entry informationi

Entry nameiT2R14_HUMAN
AccessioniPrimary (citable) accession number: Q9NYV8
Secondary accession number(s): Q645X3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi