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Protein

Taste receptor type 2 member 14

Gene

TAS2R14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).By similarity

GO - Molecular functioni

  • bitter taste receptor activity Source: UniProtKB
  • taste receptor activity Source: UniProtKB

GO - Biological processi

  • detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProtKB
  • G-protein coupled receptor signaling pathway Source: HGNC
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Enzyme and pathway databases

ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 14
Short name:
T2R14
Alternative name(s):
Taste receptor family B member 1
Short name:
TRB1
Gene namesi
Name:TAS2R14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componentsi: Chromosome 12, Unplaced

Organism-specific databases

HGNCiHGNC:14920. TAS2R14.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77ExtracellularSequence Analysis
Transmembranei8 – 2821Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini29 – 5527CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei56 – 7621Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini77 – 8711ExtracellularSequence AnalysisAdd
BLAST
Transmembranei88 – 10821Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini109 – 12921CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei130 – 15021Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini151 – 18434ExtracellularSequence AnalysisAdd
BLAST
Transmembranei185 – 20521Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini206 – 23227CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei233 – 25321Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini254 – 2618ExtracellularSequence Analysis
Transmembranei262 – 28221Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini283 – 31735CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37930.

Polymorphism and mutation databases

BioMutaiTAS2R14.
DMDMi29839658.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 317317Taste receptor type 2 member 14PRO_0000082255Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi153 – 1531N-linked (GlcNAc...)1 Publication
Glycosylationi162 – 1621N-linked (GlcNAc...)Sequence Analysis
Glycosylationi171 – 1711N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9NYV8.
PRIDEiQ9NYV8.

PTM databases

PhosphoSiteiQ9NYV8.

Expressioni

Tissue specificityi

Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.

Gene expression databases

BgeeiQ9NYV8.
CleanExiHS_TAS2R14.
GenevestigatoriQ9NYV8.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000375094.

Structurei

3D structure databases

ProteinModelPortaliQ9NYV8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46292.
GeneTreeiENSGT00760000119096.
HOGENOMiHOG000234595.
HOVERGENiHBG060698.
InParanoidiQ9NYV8.
KOiK08474.
OMAiLINIHIN.
OrthoDBiEOG70CR7B.
PhylomeDBiQ9NYV8.
TreeFamiTF335891.

Family and domain databases

InterProiIPR007960. T2R.
[Graphical view]
PANTHERiPTHR11394. PTHR11394. 1 hit.
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NYV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGVIKSIFT FVLIVEFIIG NLGNSFIALV NCIDWVKGRK ISSVDRILTA
60 70 80 90 100
LAISRISLVW LIFGSWCVSV FFPALFATEK MFRMLTNIWT VINHFSVWLA
110 120 130 140 150
TGLGTFYFLK IANFSNSIFL YLKWRVKKVV LVLLLVTSVF LFLNIALINI
160 170 180 190 200
HINASINGYR RNKTCSSDSS NFTRFSSLIV LTSTVFIFIP FTLSLAMFLL
210 220 230 240 250
LIFSMWKHRK KMQHTVKISG DASTKAHRGV KSVITFFLLY AIFSLSFFIS
260 270 280 290 300
VWTSERLEEN LIILSQVMGM AYPSCHSCVL ILGNKKLRQA SLSVLLWLRY
310
MFKDGEPSGH KEFRESS
Length:317
Mass (Da):36,160
Last modified:October 1, 2000 - v1
Checksum:iC79184343D679BE5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti86 – 861T → A.
Corresponds to variant rs16925868 [ dbSNP | Ensembl ].
VAR_053347
Natural varianti201 – 2011L → F.
Corresponds to variant rs35804287 [ dbSNP | Ensembl ].
VAR_062085

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF227138 Genomic DNA. Translation: AAF43911.1.
AY724944 Genomic DNA. Translation: AAU21146.1.
BC069148 mRNA. Translation: AAH69148.1.
BC101993 mRNA. Translation: AAI01994.1.
BC101994 mRNA. Translation: AAI01995.1.
BC103699 mRNA. Translation: AAI03700.1.
CCDSiCCDS8637.1.
RefSeqiNP_076411.1. NM_023922.1.
UniGeneiHs.679406.
Hs.731575.

Genome annotation databases

EnsembliENST00000537503; ENSP00000441949; ENSG00000212127.
ENST00000575008; ENSP00000458544; ENSG00000261984.
ENST00000614274; ENSP00000484251; ENSG00000276541.
GeneIDi50840.
KEGGihsa:50840.
UCSCiuc010shi.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF227138 Genomic DNA. Translation: AAF43911.1.
AY724944 Genomic DNA. Translation: AAU21146.1.
BC069148 mRNA. Translation: AAH69148.1.
BC101993 mRNA. Translation: AAI01994.1.
BC101994 mRNA. Translation: AAI01995.1.
BC103699 mRNA. Translation: AAI03700.1.
CCDSiCCDS8637.1.
RefSeqiNP_076411.1. NM_023922.1.
UniGeneiHs.679406.
Hs.731575.

3D structure databases

ProteinModelPortaliQ9NYV8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000375094.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ9NYV8.

Polymorphism and mutation databases

BioMutaiTAS2R14.
DMDMi29839658.

Proteomic databases

PaxDbiQ9NYV8.
PRIDEiQ9NYV8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000537503; ENSP00000441949; ENSG00000212127.
ENST00000575008; ENSP00000458544; ENSG00000261984.
ENST00000614274; ENSP00000484251; ENSG00000276541.
GeneIDi50840.
KEGGihsa:50840.
UCSCiuc010shi.2. human.

Organism-specific databases

CTDi50840.
GeneCardsiGC12M011090.
HGNCiHGNC:14920. TAS2R14.
MIMi604790. gene.
neXtProtiNX_Q9NYV8.
PharmGKBiPA37930.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG46292.
GeneTreeiENSGT00760000119096.
HOGENOMiHOG000234595.
HOVERGENiHBG060698.
InParanoidiQ9NYV8.
KOiK08474.
OMAiLINIHIN.
OrthoDBiEOG70CR7B.
PhylomeDBiQ9NYV8.
TreeFamiTF335891.

Enzyme and pathway databases

ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikiiTAS2R14.
GenomeRNAii50840.
NextBioi53309.
PROiQ9NYV8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NYV8.
CleanExiHS_TAS2R14.
GenevestigatoriQ9NYV8.

Family and domain databases

InterProiIPR007960. T2R.
[Graphical view]
PANTHERiPTHR11394. PTHR11394. 1 hit.
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TOPOLOGY.
  2. "Evolution of bitter taste receptors in humans and apes."
    Fischer A., Gilad Y., Man O., Paeaebo S.
    Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: CHARACTERIZATION.
  5. Cited for: REVIEW.
  6. "Molecular mechanisms of bitter and sweet taste transduction."
    Margolskee R.F.
    J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  7. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
    Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
    Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  8. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-153.
    Tissue: Plasma.

Entry informationi

Entry nameiT2R14_HUMAN
AccessioniPrimary (citable) accession number: Q9NYV8
Secondary accession number(s): Q645X3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: October 1, 2000
Last modified: May 27, 2015
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.