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Q9NYV8 (T2R14_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Taste receptor type 2 member 14

Short name=T2R14
Alternative name(s):
Taste receptor family B member 1
Short name=TRB1
Gene names
Name:TAS2R14
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length317 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

Sequence similarities

Belongs to the G-protein coupled receptor T2R family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 317317Taste receptor type 2 member 14
PRO_0000082255

Regions

Topological domain1 – 77Extracellular Potential
Transmembrane8 – 2821Helical; Name=1; Potential
Topological domain29 – 5527Cytoplasmic Potential
Transmembrane56 – 7621Helical; Name=2; Potential
Topological domain77 – 8711Extracellular Potential
Transmembrane88 – 10821Helical; Name=3; Potential
Topological domain109 – 12921Cytoplasmic Potential
Transmembrane130 – 15021Helical; Name=4; Potential
Topological domain151 – 18434Extracellular Potential
Transmembrane185 – 20521Helical; Name=5; Potential
Topological domain206 – 23227Cytoplasmic Potential
Transmembrane233 – 25321Helical; Name=6; Potential
Topological domain254 – 2618Extracellular Potential
Transmembrane262 – 28221Helical; Name=7; Potential
Topological domain283 – 31735Cytoplasmic Potential

Amino acid modifications

Glycosylation1531N-linked (GlcNAc...) Ref.8
Glycosylation1621N-linked (GlcNAc...) Potential
Glycosylation1711N-linked (GlcNAc...) Potential

Natural variations

Natural variant861T → A.
Corresponds to variant rs16925868 [ dbSNP | Ensembl ].
VAR_053347
Natural variant2011L → F.
Corresponds to variant rs35804287 [ dbSNP | Ensembl ].
VAR_062085

Sequences

Sequence LengthMass (Da)Tools
Q9NYV8 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: C79184343D679BE5

FASTA31736,160
        10         20         30         40         50         60 
MGGVIKSIFT FVLIVEFIIG NLGNSFIALV NCIDWVKGRK ISSVDRILTA LAISRISLVW 

        70         80         90        100        110        120 
LIFGSWCVSV FFPALFATEK MFRMLTNIWT VINHFSVWLA TGLGTFYFLK IANFSNSIFL 

       130        140        150        160        170        180 
YLKWRVKKVV LVLLLVTSVF LFLNIALINI HINASINGYR RNKTCSSDSS NFTRFSSLIV 

       190        200        210        220        230        240 
LTSTVFIFIP FTLSLAMFLL LIFSMWKHRK KMQHTVKISG DASTKAHRGV KSVITFFLLY 

       250        260        270        280        290        300 
AIFSLSFFIS VWTSERLEEN LIILSQVMGM AYPSCHSCVL ILGNKKLRQA SLSVLLWLRY 

       310 
MFKDGEPSGH KEFRESS 

« Hide

References

« Hide 'large scale' references
[1]"A novel family of mammalian taste receptors."
Adler E., Hoon M.A., Mueller K.L., Chandrashekar J., Ryba N.J.P., Zuker C.S.
Cell 100:693-702(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TOPOLOGY.
[2]"Evolution of bitter taste receptors in humans and apes."
Fischer A., Gilad Y., Man O., Paeaebo S.
Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"T2Rs function as bitter taste receptors."
Chandrashekar J., Mueller K.L., Hoon M.A., Adler E., Feng L., Guo W., Zuker C.S., Ryba N.J.P.
Cell 100:703-711(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[5]"Receptors for bitter and sweet taste."
Montmayeur J.-P., Matsunami H.
Curr. Opin. Neurobiol. 12:366-371(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[6]"Molecular mechanisms of bitter and sweet taste transduction."
Margolskee R.F.
J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[7]"Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[8]"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-153.
Tissue: Plasma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF227138 Genomic DNA. Translation: AAF43911.1.
AY724944 Genomic DNA. Translation: AAU21146.1.
BC069148 mRNA. Translation: AAH69148.1.
BC101993 mRNA. Translation: AAI01994.1.
BC101994 mRNA. Translation: AAI01995.1.
BC103699 mRNA. Translation: AAI03700.1.
CCDSCCDS8637.1.
RefSeqNP_076411.1. NM_023922.1.
UniGeneHs.679406.
Hs.731575.

3D structure databases

ProteinModelPortalQ9NYV8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000375094.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ9NYV8.

Polymorphism databases

DMDM29839658.

Proteomic databases

PaxDbQ9NYV8.
PRIDEQ9NYV8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000537503; ENSP00000441949; ENSG00000212127.
ENST00000574901; ENSP00000460620; ENSG00000262103.
ENST00000575008; ENSP00000458544; ENSG00000261984.
GeneID50840.
KEGGhsa:50840.
UCSCuc010shi.2. human.

Organism-specific databases

CTD50840.
GeneCardsGC12M011090.
HGNCHGNC:14920. TAS2R14.
MIM604790. gene.
neXtProtNX_Q9NYV8.
PharmGKBPA37930.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG46292.
HOGENOMHOG000234595.
HOVERGENHBG060698.
InParanoidQ9NYV8.
KOK08474.
OMALINIHIN.
OrthoDBEOG70CR7B.
PhylomeDBQ9NYV8.
TreeFamTF335891.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressQ9NYV8.
BgeeQ9NYV8.
CleanExHS_TAS2R14.
GenevestigatorQ9NYV8.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR017452. GPCR_Rhodpsn_7TM.
IPR007960. TAS2_rcpt.
[Graphical view]
PfamPF05296. TAS2R. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiTAS2R14.
GenomeRNAi50840.
NextBio53309.
PROQ9NYV8.
SOURCESearch...

Entry information

Entry nameT2R14_HUMAN
AccessionPrimary (citable) accession number: Q9NYV8
Secondary accession number(s): Q645X3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries