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Q9NYV8

- T2R14_HUMAN

UniProt

Q9NYV8 - T2R14_HUMAN

Protein

Taste receptor type 2 member 14

Gene

TAS2R14

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 By similarity.By similarity

    GO - Molecular functioni

    1. bitter taste receptor activity Source: HGNC
    2. taste receptor activity Source: UniProtKB

    GO - Biological processi

    1. detection of chemical stimulus involved in sensory perception of bitter taste Source: HGNC
    2. G-protein coupled receptor signaling pathway Source: HGNC

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Sensory transduction, Taste

    Enzyme and pathway databases

    ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Taste receptor type 2 member 14
    Short name:
    T2R14
    Alternative name(s):
    Taste receptor family B member 1
    Short name:
    TRB1
    Gene namesi
    Name:TAS2R14
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:14920. TAS2R14.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: HGNC
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37930.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 317317Taste receptor type 2 member 14PRO_0000082255Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi153 – 1531N-linked (GlcNAc...)1 Publication
    Glycosylationi162 – 1621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi171 – 1711N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9NYV8.
    PRIDEiQ9NYV8.

    PTM databases

    PhosphoSiteiQ9NYV8.

    Expressioni

    Tissue specificityi

    Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.

    Gene expression databases

    ArrayExpressiQ9NYV8.
    BgeeiQ9NYV8.
    CleanExiHS_TAS2R14.
    GenevestigatoriQ9NYV8.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000375094.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NYV8.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 77ExtracellularSequence Analysis
    Topological domaini29 – 5527CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini77 – 8711ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini109 – 12921CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini151 – 18434ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini206 – 23227CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini254 – 2618ExtracellularSequence Analysis
    Topological domaini283 – 31735CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8 – 2821Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei56 – 7621Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei88 – 10821Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei130 – 15021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei185 – 20521Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei233 – 25321Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei262 – 28221Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46292.
    HOGENOMiHOG000234595.
    HOVERGENiHBG060698.
    InParanoidiQ9NYV8.
    KOiK08474.
    OMAiLINIHIN.
    OrthoDBiEOG70CR7B.
    PhylomeDBiQ9NYV8.
    TreeFamiTF335891.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR017452. GPCR_Rhodpsn_7TM.
    IPR007960. TAS2_rcpt.
    [Graphical view]
    PfamiPF05296. TAS2R. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NYV8-1 [UniParc]FASTAAdd to Basket

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    MGGVIKSIFT FVLIVEFIIG NLGNSFIALV NCIDWVKGRK ISSVDRILTA    50
    LAISRISLVW LIFGSWCVSV FFPALFATEK MFRMLTNIWT VINHFSVWLA 100
    TGLGTFYFLK IANFSNSIFL YLKWRVKKVV LVLLLVTSVF LFLNIALINI 150
    HINASINGYR RNKTCSSDSS NFTRFSSLIV LTSTVFIFIP FTLSLAMFLL 200
    LIFSMWKHRK KMQHTVKISG DASTKAHRGV KSVITFFLLY AIFSLSFFIS 250
    VWTSERLEEN LIILSQVMGM AYPSCHSCVL ILGNKKLRQA SLSVLLWLRY 300
    MFKDGEPSGH KEFRESS 317
    Length:317
    Mass (Da):36,160
    Last modified:October 1, 2000 - v1
    Checksum:iC79184343D679BE5
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti86 – 861T → A.
    Corresponds to variant rs16925868 [ dbSNP | Ensembl ].
    VAR_053347
    Natural varianti201 – 2011L → F.
    Corresponds to variant rs35804287 [ dbSNP | Ensembl ].
    VAR_062085

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF227138 Genomic DNA. Translation: AAF43911.1.
    AY724944 Genomic DNA. Translation: AAU21146.1.
    BC069148 mRNA. Translation: AAH69148.1.
    BC101993 mRNA. Translation: AAI01994.1.
    BC101994 mRNA. Translation: AAI01995.1.
    BC103699 mRNA. Translation: AAI03700.1.
    CCDSiCCDS8637.1.
    RefSeqiNP_076411.1. NM_023922.1.
    UniGeneiHs.679406.
    Hs.731575.

    Genome annotation databases

    EnsembliENST00000537503; ENSP00000441949; ENSG00000212127.
    ENST00000575008; ENSP00000458544; ENSG00000261984.
    GeneIDi50840.
    KEGGihsa:50840.
    UCSCiuc010shi.2. human.

    Polymorphism databases

    DMDMi29839658.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF227138 Genomic DNA. Translation: AAF43911.1 .
    AY724944 Genomic DNA. Translation: AAU21146.1 .
    BC069148 mRNA. Translation: AAH69148.1 .
    BC101993 mRNA. Translation: AAI01994.1 .
    BC101994 mRNA. Translation: AAI01995.1 .
    BC103699 mRNA. Translation: AAI03700.1 .
    CCDSi CCDS8637.1.
    RefSeqi NP_076411.1. NM_023922.1.
    UniGenei Hs.679406.
    Hs.731575.

    3D structure databases

    ProteinModelPortali Q9NYV8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000375094.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9NYV8.

    Polymorphism databases

    DMDMi 29839658.

    Proteomic databases

    PaxDbi Q9NYV8.
    PRIDEi Q9NYV8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000537503 ; ENSP00000441949 ; ENSG00000212127 .
    ENST00000575008 ; ENSP00000458544 ; ENSG00000261984 .
    GeneIDi 50840.
    KEGGi hsa:50840.
    UCSCi uc010shi.2. human.

    Organism-specific databases

    CTDi 50840.
    GeneCardsi GC12M011090.
    HGNCi HGNC:14920. TAS2R14.
    MIMi 604790. gene.
    neXtProti NX_Q9NYV8.
    PharmGKBi PA37930.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46292.
    HOGENOMi HOG000234595.
    HOVERGENi HBG060698.
    InParanoidi Q9NYV8.
    KOi K08474.
    OMAi LINIHIN.
    OrthoDBi EOG70CR7B.
    PhylomeDBi Q9NYV8.
    TreeFami TF335891.

    Enzyme and pathway databases

    Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii TAS2R14.
    GenomeRNAii 50840.
    NextBioi 53309.
    PROi Q9NYV8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NYV8.
    Bgeei Q9NYV8.
    CleanExi HS_TAS2R14.
    Genevestigatori Q9NYV8.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR017452. GPCR_Rhodpsn_7TM.
    IPR007960. TAS2_rcpt.
    [Graphical view ]
    Pfami PF05296. TAS2R. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TOPOLOGY.
    2. "Evolution of bitter taste receptors in humans and apes."
      Fischer A., Gilad Y., Man O., Paeaebo S.
      Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Cited for: CHARACTERIZATION.
    5. Cited for: REVIEW.
    6. "Molecular mechanisms of bitter and sweet taste transduction."
      Margolskee R.F.
      J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    7. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
      Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
      Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    8. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-153.
      Tissue: Plasma.

    Entry informationi

    Entry nameiT2R14_HUMAN
    AccessioniPrimary (citable) accession number: Q9NYV8
    Secondary accession number(s): Q645X3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 11, 2003
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3