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Protein

Taste receptor type 2 member 16

Gene

TAS2R16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.2 Publications

GO - Molecular functioni

  • bitter taste receptor activity Source: UniProtKB

GO - Biological processi

  • detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProtKB
  • G-protein coupled receptor signaling pathway Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Enzyme and pathway databases

ReactomeiR-HSA-418594. G alpha (i) signalling events.
R-HSA-420499. Class C/3 (Metabotropic glutamate/pheromone receptors).

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 16
Short name:
T2R16
Gene namesi
Name:TAS2R16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:14921. TAS2R16.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 11ExtracellularSequence analysis
Transmembranei2 – 2221Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini23 – 4119CytoplasmicSequence analysisAdd
BLAST
Transmembranei42 – 6221Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini63 – 8422ExtracellularSequence analysisAdd
BLAST
Transmembranei85 – 10521Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini106 – 12520CytoplasmicSequence analysisAdd
BLAST
Transmembranei126 – 14621Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini147 – 18236ExtracellularSequence analysisAdd
BLAST
Transmembranei183 – 20321Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini204 – 22825CytoplasmicSequence analysisAdd
BLAST
Transmembranei229 – 24921Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini250 – 2578ExtracellularSequence analysis
Transmembranei258 – 27821Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini279 – 29113CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum Source: HGNC
  • external side of plasma membrane Source: HGNC
  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: Reactome
  • trans-Golgi network Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

MalaCardsiTAS2R16.
MIMi103780. phenotype.
PharmGKBiPA37931.

Chemistry

ChEMBLiCHEMBL3309106.

Polymorphism and mutation databases

BioMutaiTAS2R16.
DMDMi29839657.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 291291Taste receptor type 2 member 16PRO_0000082262Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi80 – 801N-linked (GlcNAc...)Sequence analysis
Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9NYV7.
PRIDEiQ9NYV7.

PTM databases

PhosphoSiteiQ9NYV7.

Expressioni

Tissue specificityi

Expressed in a subset of gustducin-positive taste receptor cells of the tongue. Expressed in circumvallate papillae and testis (PubMed:16720576).1 Publication

Gene expression databases

BgeeiQ9NYV7.
CleanExiHS_TAS2R16.
GenevisibleiQ9NYV7. HS.

Interactioni

Subunit structurei

Interacts with RTP3 and RTP4.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000249284.

Structurei

3D structure databases

ProteinModelPortaliQ9NYV7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKNW. Eukaryota.
ENOG41119UD. LUCA.
GeneTreeiENSGT00760000119096.
HOGENOMiHOG000234595.
HOVERGENiHBG098568.
InParanoidiQ9NYV7.
KOiK08474.
OMAiMITCVTI.
OrthoDBiEOG7JDQZC.
PhylomeDBiQ9NYV7.
TreeFamiTF335891.

Family and domain databases

InterProiIPR007960. T2R.
[Graphical view]
PANTHERiPTHR11394. PTHR11394. 1 hit.
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NYV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPIQLTVFF MIIYVLESLT IIVQSSLIVA VLGREWLQVR RLMPVDMILI
60 70 80 90 100
SLGISRFCLQ WASMLNNFCS YFNLNYVLCN LTITWEFFNI LTFWLNSLLT
110 120 130 140 150
VFYCIKVSSF THHIFLWLRW RILRLFPWIL LGSLMITCVT IIPSAIGNYI
160 170 180 190 200
QIQLLTMEHL PRNSTVTDKL ENFHQYQFQA HTVALVIPFI LFLASTIFLM
210 220 230 240 250
ASLTKQIQHH STGHCNPSMK ARFTALRSLA VLFIVFTSYF LTILITIIGT
260 270 280 290
LFDKRCWLWV WEAFVYAFIL MHSTSLMLSS PTLKRILKGK C
Length:291
Mass (Da):33,986
Last modified:October 1, 2000 - v1
Checksum:i0693085F23D57D73
GO

Polymorphismi

The Lys-172 polymorphism in TAS2R16 is associated with genetic susceptibility to alcoholism [MIMi:103780].

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti172 – 1721N → K Associated with susceptibility to alcoholism. 1 Publication
Corresponds to variant rs846664 [ dbSNP | Ensembl ].
VAR_034539
Natural varianti222 – 2221R → H.3 Publications
Corresponds to variant rs860170 [ dbSNP | Ensembl ].
VAR_020205

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF227139 Genomic DNA. Translation: AAF43912.1.
AY724962 Genomic DNA. Translation: AAU21158.1.
AC004838 Genomic DNA. Translation: AAP21892.1.
CH236947 Genomic DNA. Translation: EAL24338.1.
BC095524 mRNA. Translation: AAH95524.1.
CCDSiCCDS5785.1.
RefSeqiNP_058641.1. NM_016945.2.
UniGeneiHs.272395.

Genome annotation databases

EnsembliENST00000249284; ENSP00000249284; ENSG00000128519.
GeneIDi50833.
KEGGihsa:50833.
UCSCiuc003vkl.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF227139 Genomic DNA. Translation: AAF43912.1.
AY724962 Genomic DNA. Translation: AAU21158.1.
AC004838 Genomic DNA. Translation: AAP21892.1.
CH236947 Genomic DNA. Translation: EAL24338.1.
BC095524 mRNA. Translation: AAH95524.1.
CCDSiCCDS5785.1.
RefSeqiNP_058641.1. NM_016945.2.
UniGeneiHs.272395.

3D structure databases

ProteinModelPortaliQ9NYV7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000249284.

Chemistry

ChEMBLiCHEMBL3309106.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ9NYV7.

Polymorphism and mutation databases

BioMutaiTAS2R16.
DMDMi29839657.

Proteomic databases

PaxDbiQ9NYV7.
PRIDEiQ9NYV7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000249284; ENSP00000249284; ENSG00000128519.
GeneIDi50833.
KEGGihsa:50833.
UCSCiuc003vkl.2. human.

Organism-specific databases

CTDi50833.
GeneCardsiTAS2R16.
HGNCiHGNC:14921. TAS2R16.
MalaCardsiTAS2R16.
MIMi103780. phenotype.
604867. gene.
neXtProtiNX_Q9NYV7.
PharmGKBiPA37931.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKNW. Eukaryota.
ENOG41119UD. LUCA.
GeneTreeiENSGT00760000119096.
HOGENOMiHOG000234595.
HOVERGENiHBG098568.
InParanoidiQ9NYV7.
KOiK08474.
OMAiMITCVTI.
OrthoDBiEOG7JDQZC.
PhylomeDBiQ9NYV7.
TreeFamiTF335891.

Enzyme and pathway databases

ReactomeiR-HSA-418594. G alpha (i) signalling events.
R-HSA-420499. Class C/3 (Metabotropic glutamate/pheromone receptors).

Miscellaneous databases

GeneWikiiTAS2R16.
GenomeRNAii50833.
NextBioi53281.
PROiQ9NYV7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NYV7.
CleanExiHS_TAS2R16.
GenevisibleiQ9NYV7. HS.

Family and domain databases

InterProiIPR007960. T2R.
[Graphical view]
PANTHERiPTHR11394. PTHR11394. 1 hit.
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TOPOLOGY.
  2. "Evolution of bitter taste receptors in humans and apes."
    Fischer A., Gilad Y., Man O., Paeaebo S.
    Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT HIS-222.
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT HIS-222.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT HIS-222.
  6. Cited for: CHARACTERIZATION.
  7. "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides."
    Bufe B., Hofmann T., Krautwurst D., Raguse J.-D., Meyerhof W.
    Nat. Genet. 32:397-401(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. Cited for: FUNCTION.
  9. Cited for: REVIEW.
  10. "Molecular mechanisms of bitter and sweet taste transduction."
    Margolskee R.F.
    J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  11. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
    Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
    Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  12. "Members of RTP and REEP gene families influence functional bitter taste receptor expression."
    Behrens M., Bartelt J., Reichling C., Winnig M., Kuhn C., Meyerhof W.
    J. Biol. Chem. 281:20650-20659(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RTP3 AND RTP4, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  13. Cited for: VARIANT LYS-172, ASSOCIATION WITH SUSCEPTIBILITY TO ALCOHOLISM.

Entry informationi

Entry nameiT2R16_HUMAN
AccessioniPrimary (citable) accession number: Q9NYV7
Secondary accession number(s): A4D0X2
, Q502V3, Q549U8, Q645W1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: October 1, 2000
Last modified: May 11, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Several bitter taste receptors are expressed in a single taste receptor cell.
Confers bitter perception of salicin to non-taster mice.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.