RRN3

Functionⁱ

Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent preinitiation complex (PIC). Dissociates from pol I as a consequence of transcription. In vitro, cannot activate transcription in a subsequent transcription reaction (By similarity).By similarity4 Publications

GO - Molecular functionⁱ

RNA polymerase I core binding Source: GO_Central
RNA polymerase I CORE element sequence-specific DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 22368283
transcription factor activity, core RNA polymerase I binding Source: GO_Central

Complete GO annotation...

GO - Biological processⁱ

cell proliferation Source: Ensembl
cytoplasm organization Source: Ensembl
homeostasis of number of cells Source: Ensembl
in utero embryonic development Source: Ensembl
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator Source: Ensembl
nucleolus organization Source: Ensembl
positive regulation of neuron projection development Source: Ensembl
positive regulation of transcription, DNA-templated Source: Ensembl
regulation of DNA-templated transcription, initiation Source: Ensembl
ribosome biogenesis Source: Ensembl
transcription initiation from RNA polymerase I promoter Source: Reactome
transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript Source: GO_Central

Complete GO annotation...

Keywordsⁱ

Biological process	Transcription, Transcription regulation

Biological process

Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-73762. RNA Polymerase I Transcription Initiation. R-HSA-73772. RNA Polymerase I Promoter Escape.
SIGNORⁱ	Q9NYV6.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: RNA polymerase I-specific transcription initiation factor RRN3 Alternative name(s): Transcription initiation factor IA Short name: TIF-IA
Gene namesⁱ	Name:RRN3 Synonyms:TIFIA
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30346. RRN3.

HGNCⁱ

HGNC:30346. RRN3.

Subcellular locationⁱ

Nucleus › nucleolus
1 Publication
Manual assertion based on experiment inⁱ
- Ref.7
  "hRRN3 is essential in the SL1-mediated recruitment of RNA polymerase I to rRNA gene promoters."
  Miller G., Panov K.I., Friedrich J.K., Trinkle-Mulcahy L., Lamond A.I., Zomerdijk J.C.B.M.
  EMBO J. 20:1373-1382(2001) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH TAF1B AND TAF1C.

GO - Cellular componentⁱ

nucleolus Source: HPA
nucleoplasm Source: Reactome
nucleus Source: HPA

Complete GO annotation...

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	411 – 415	Missing : Abolishes interaction with TAF1B and TAF1C. 1 Publication		5

Organism-specific databases

DisGeNET More...DisGeNETⁱ	54700.
Open Targets More...OpenTargetsⁱ	ENSG00000085721.
PharmGKBⁱ	PA134878601.

Polymorphism and mutation databases

BioMutaⁱ	RRN3.
DMDMⁱ	74719591.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000211426	1 – 651	RNA polymerase I-specific transcription initiation factor RRN3Add BLAST		651

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	170	PhosphoserineCombined sources	1
Modified residueⁱ	172	PhosphoserineCombined sources	1
Modified residueⁱ	200	Phosphothreonine; by MAPK91 Publication	1
Modified residueⁱ	640	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylation is required for participation in rDNA transcription (By similarity). Phosphorylated at Thr-200 by MAPK9/JNK2, which abrogates initiation complex formation.By similarity1 Publication

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9NYV6.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9NYV6.
PaxDbⁱ	Q9NYV6.
PeptideAtlas More...PeptideAtlasⁱ	Q9NYV6.
PRIDEⁱ	Q9NYV6.

PTM databases

iPTMnetⁱ	Q9NYV6.
PhosphoSitePlusⁱ	Q9NYV6.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000085721.
CleanExⁱ	HS_RRN3.
ExpressionAtlasⁱ	Q9NYV6. baseline and differential.
Genevisibleⁱ	Q9NYV6. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA049837.

HPAⁱ

HPA049837.

Interactionⁱ

Subunit structureⁱ

Interacts with TWISTNB, EIF3L, TAF1B and TAF1C.2 Publications

GO - Molecular functionⁱ

RNA polymerase I core binding Source: GO_Central

Complete GO annotation...

Protein-protein interaction databases

BioGridⁱ	120102. 27 interactors.
IntActⁱ	Q9NYV6. 4 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-249163.
STRINGⁱ	9606.ENSP00000198767.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9NYV6.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	500 – 651	Interaction with TWISTNB1 PublicationAdd BLAST		152
Regionⁱ	557 – 651	Interaction with EIF3L1 PublicationAdd BLAST		95

Sequence similaritiesⁱ

Belongs to the RRN3 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2434. Eukaryota. ENOG410XRJJ. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000001488.
HOGENOMⁱ	HOG000132846.
HOVERGENⁱ	HBG056994.
InParanoidⁱ	Q9NYV6.
KEGG Orthology (KO) More...KOⁱ	K15216.
OMAⁱ	PLKVCSP.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G089T.
PhylomeDBⁱ	Q9NYV6.
TreeFamⁱ	TF312979.

Family and domain databases

Gene3Dⁱ	1.25.10.10. 2 hits.
InterProⁱ	View protein in InterPro IPR011989. ARM-like. IPR007991. RNA_pol_I_trans_ini_fac_RRN3.
PANTHERⁱ	PTHR12790. PTHR12790. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05327. RRN3. 1 hit.

Sequences (4)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q9NYV6-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPLLHTRL PGDAAASSSA VKKLGASRTG ISNMRALEND FFNSPPRKTV 
        60         70         80         90        100
RFGGTVTEVL LKYKKGETND FELLKNQLLD PDIKDDQIIN WLLEFRSSIM 
       110        120        130        140        150
YLTKDFEQLI SIILRLPWLN RSQTVVEEYL AFLGNLVSAQ TVFLRPCLSM 
       160        170        180        190        200
IASHFVPPRV IIKEGDVDVS DSDDEDDNLP ANFDTCHRAL QIIARYVPST 
       210        220        230        240        250
PWFLMPILVE KFPFVRKSER TLECYVHNLL RISVYFPTLR HEILELIIEK 
       260        270        280        290        300
LLKLDVNASR QGIEDAEETA TQTCGGTDST EGLFNMDEDE ETEHETKAGP 
       310        320        330        340        350
ERLDQMVHPV AERLDILMSL VLSYMKDVCY VDGKVDNGKT KDLYRDLINI 
       360        370        380        390        400
FDKLLLPTHA SCHVQFFMFY LCSFKLGFAE AFLEHLWKKL QDPSNPAIIR 
       410        420        430        440        450
QAAGNYIGSF LARAKFIPLI TVKSCLDLLV NWLHIYLNNQ DSGTKAFCDV 
       460        470        480        490        500
ALHGPFYSAC QAVFYTFVFR HKQLLSGNLK EGLQYLQSLN FERIVMSQLN 
       510        520        530        540        550
PLKICLPSVV NFFAAITNKY QLVFCYTIIE RNNRQMLPVI RSTAGGDSVQ 
       560        570        580        590        600
ICTNPLDTFF PFDPCVLKRS KKFIDPIYQV WEDMSAEELQ EFKKPMKKDI 
       610        620        630        640        650
VEDEDDDFLK GEVPQNDTVI GITPSSFDTH FRSPSSSVGS PPVLYMQPSP 

L

Length:651

Mass (Da):74,107

Last modified:October 1, 2000 - v1

Checksum:ⁱC646DC6677C49895

GO

Isoform 2 (identifier: Q9NYV6-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
287-305: DEDEETEHETKAGPERLDQ → VSSLLMKVEMKFIIKGGNS
306-651: Missing.

« Hide

        10         20         30         40         50
MAAPLLHTRL PGDAAASSSA VKKLGASRTG ISNMRALEND FFNSPPRKTV 
        60         70         80         90        100
RFGGTVTEVL LKYKKGETND FELLKNQLLD PDIKDDQIIN WLLEFRSSIM 
       110        120        130        140        150
YLTKDFEQLI SIILRLPWLN RSQTVVEEYL AFLGNLVSAQ TVFLRPCLSM 
       160        170        180        190        200
IASHFVPPRV IIKEGDVDVS DSDDEDDNLP ANFDTCHRAL QIIARYVPST 
       210        220        230        240        250
PWFLMPILVE KFPFVRKSER TLECYVHNLL RISVYFPTLR HEILELIIEK 
       260        270        280        290        300
LLKLDVNASR QGIEDAEETA TQTCGGTDST EGLFNMVSSL LMKVEMKFII 

KGGNS

Note: No experimental confirmation available.

Show »

Length:305

Mass (Da):34,472

Checksum:ⁱ1745373E5CC8CE7B

GO

Isoform 3 (identifier: Q9NYV6-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-33: Missing.

« Hide

        10         20         30         40         50
MRALENDFFN SPPRKTVRFG GTVTEVLLKY KKGETNDFEL LKNQLLDPDI 
        60         70         80         90        100
KDDQIINWLL EFRSSIMYLT KDFEQLISII LRLPWLNRSQ TVVEEYLAFL 
       110        120        130        140        150
GNLVSAQTVF LRPCLSMIAS HFVPPRVIIK EGDVDVSDSD DEDDNLPANF 
       160        170        180        190        200
DTCHRALQII ARYVPSTPWF LMPILVEKFP FVRKSERTLE CYVHNLLRIS 
       210        220        230        240        250
VYFPTLRHEI LELIIEKLLK LDVNASRQGI EDAEETATQT CGGTDSTEGL 
       260        270        280        290        300
FNMDEDEETE HETKAGPERL DQMVHPVAER LDILMSLVLS YMKDVCYVDG 
       310        320        330        340        350
KVDNGKTKDL YRDLINIFDK LLLPTHASCH VQFFMFYLCS FKLGFAEAFL 
       360        370        380        390        400
EHLWKKLQDP SNPAIIRQAA GNYIGSFLAR AKFIPLITVK SCLDLLVNWL 
       410        420        430        440        450
HIYLNNQDSG TKAFCDVALH GPFYSACQAV FYTFVFRHKQ LLSGNLKEGL 
       460        470        480        490        500
QYLQSLNFER IVMSQLNPLK ICLPSVVNFF AAITNKYQLV FCYTIIERNN 
       510        520        530        540        550
RQMLPVIRST AGGDSVQICT NPLDTFFPFD PCVLKRSKKF IDPIYQVWED 
       560        570        580        590        600
MSAEELQEFK KPMKKDIVED EDDDFLKGEV PQNDTVIGIT PSSFDTHFRS 
       610 
PSSSVGSPPV LYMQPSPL

Note: No experimental confirmation available.

Show »

Length:618

Mass (Da):70,876

Checksum:ⁱ1D119D4C3DADB659

GO

Isoform 4 (identifier: Q9NYV6-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-149: Missing.
223-255: Missing.

« Hide

        10         20         30         40         50
MIASHFVPPR VIIKEGDVDV SDSDDEDDNL PANFDTCHRA LQIIARYVPS 
        60         70         80         90        100
TPWFLMPILV EKFPFVRKSE RTLVNASRQG IEDAEETATQ TCGGTDSTEG 
       110        120        130        140        150
LFNMDEDEET EHETKAGPER LDQMVHPVAE RLDILMSLVL SYMKDVCYVD 
       160        170        180        190        200
GKVDNGKTKD LYRDLINIFD KLLLPTHASC HVQFFMFYLC SFKLGFAEAF 
       210        220        230        240        250
LEHLWKKLQD PSNPAIIRQA AGNYIGSFLA RAKFIPLITV KSCLDLLVNW 
       260        270        280        290        300
LHIYLNNQDS GTKAFCDVAL HGPFYSACQA VFYTFVFRHK QLLSGNLKEG 
       310        320        330        340        350
LQYLQSLNFE RIVMSQLNPL KICLPSVVNF FAAITNKYQL VFCYTIIERN 
       360        370        380        390        400
NRQMLPVIRS TAGGDSVQIC TNPLDTFFPF DPCVLKRSKK FIDPIYQVWE 
       410        420        430        440        450
DMSAEELQEF KKPMKKDIVE DEDDDFLKGE VPQNDTVIGI TPSSFDTHFR 
       460 
SPSSSVGSPP VLYMQPSPL

Note: No experimental confirmation available.

Show »

Length:469

Mass (Da):53,315

Checksum:ⁱFCAE200CD69B3663

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_051886	348	I → M. Corresponds to variant dbSNP:rs2941256Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_056519	1 – 149	Missing in isoform 4. 1 PublicationAdd BLAST	149
Alternative sequenceⁱVSP_056520	1 – 33	Missing in isoform 3. 1 PublicationAdd BLAST	33
Alternative sequenceⁱVSP_056521	223 – 255	Missing in isoform 4. 1 PublicationAdd BLAST	33
Alternative sequenceⁱVSP_056338	287 – 305	DEDEE…ERLDQ → VSSLLMKVEMKFIIKGGNS in isoform 2. 1 PublicationAdd BLAST	19
Alternative sequenceⁱVSP_056339	306 – 651	Missing in isoform 2. 1 PublicationAdd BLAST	346

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ272050 mRNA. Translation: CAC07955.1. AF227156 mRNA. Translation: AAF66160.1. AK303405 mRNA. Translation: BAG64459.1. AK304856 mRNA. Translation: BAG65594.1. AK314769 mRNA. Translation: BAG37307.1. AC139256 Genomic DNA. No translation available. CH471301 Genomic DNA. Translation: EAW54754.1. BC071868 mRNA. Translation: AAH71868.1. BC104660 mRNA. Translation: AAI04661.1. BC132688 mRNA. Translation: AAI32689.1. BC132690 mRNA. Translation: AAI32691.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10559.1. [Q9NYV6-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_060897.3. NM_018427.4. [Q9NYV6-1]
UniGeneⁱ	Hs.460078. Hs.720348.

Genome annotation databases

Ensemblⁱ	ENST00000198767; ENSP00000198767; ENSG00000085721. [Q9NYV6-1] ENST00000327307; ENSP00000318484; ENSG00000085721. [Q9NYV6-3] ENST00000564131; ENSP00000454238; ENSG00000085721. [Q9NYV6-2] ENST00000616334; ENSP00000480743; ENSG00000278494. [Q9NYV6-1] ENST00000632541; ENSP00000488651; ENSG00000278494. [Q9NYV6-3] ENST00000634151; ENSP00000487821; ENSG00000278494. [Q9NYV6-2]
GeneIDⁱ	54700.
KEGGⁱ	hsa:54700.
UCSC genome browser More...UCSCⁱ	uc002dde.4. human. [Q9NYV6-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ272050 mRNA. Translation: CAC07955.1. AF227156 mRNA. Translation: AAF66160.1. AK303405 mRNA. Translation: BAG64459.1. AK304856 mRNA. Translation: BAG65594.1. AK314769 mRNA. Translation: BAG37307.1. AC139256 Genomic DNA. No translation available. CH471301 Genomic DNA. Translation: EAW54754.1. BC071868 mRNA. Translation: AAH71868.1. BC104660 mRNA. Translation: AAI04661.1. BC132688 mRNA. Translation: AAI32689.1. BC132690 mRNA. Translation: AAI32691.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10559.1. [Q9NYV6-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_060897.3. NM_018427.4. [Q9NYV6-1]
UniGeneⁱ	Hs.460078. Hs.720348.

3D structure databases

ProteinModelPortalⁱ	Q9NYV6.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	120102. 27 interactors.
IntActⁱ	Q9NYV6. 4 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-249163.
STRINGⁱ	9606.ENSP00000198767.

PTM databases

iPTMnetⁱ	Q9NYV6.
PhosphoSitePlusⁱ	Q9NYV6.

Polymorphism and mutation databases

BioMutaⁱ	RRN3.
DMDMⁱ	74719591.

Proteomic databases

EPDⁱ	Q9NYV6.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9NYV6.
PaxDbⁱ	Q9NYV6.
PeptideAtlas More...PeptideAtlasⁱ	Q9NYV6.
PRIDEⁱ	Q9NYV6.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	54700.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000198767; ENSP00000198767; ENSG00000085721. [Q9NYV6-1] ENST00000327307; ENSP00000318484; ENSG00000085721. [Q9NYV6-3] ENST00000564131; ENSP00000454238; ENSG00000085721. [Q9NYV6-2] ENST00000616334; ENSP00000480743; ENSG00000278494. [Q9NYV6-1] ENST00000632541; ENSP00000488651; ENSG00000278494. [Q9NYV6-3] ENST00000634151; ENSP00000487821; ENSG00000278494. [Q9NYV6-2]
GeneIDⁱ	54700.
KEGGⁱ	hsa:54700.
UCSC genome browser More...UCSCⁱ	uc002dde.4. human. [Q9NYV6-1]

Organism-specific databases

CTDⁱ	54700.
DisGeNET More...DisGeNETⁱ	54700.
GeneCardsⁱ	RRN3.
H-InvDBⁱ	HIX0012886. HIX0038660. HIX0038739.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30346. RRN3.
Human Protein Atlas More...HPAⁱ	HPA049837.
MIMⁱ	605121. gene.
neXtProtⁱ	NX_Q9NYV6.
Open Targets More...OpenTargetsⁱ	ENSG00000085721.
PharmGKBⁱ	PA134878601.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2434. Eukaryota. ENOG410XRJJ. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000001488.
HOGENOMⁱ	HOG000132846.
HOVERGENⁱ	HBG056994.
InParanoidⁱ	Q9NYV6.
KEGG Orthology (KO) More...KOⁱ	K15216.
OMAⁱ	PLKVCSP.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G089T.
PhylomeDBⁱ	Q9NYV6.
TreeFamⁱ	TF312979.

Enzyme and pathway databases

Reactomeⁱ	R-HSA-73762. RNA Polymerase I Transcription Initiation. R-HSA-73772. RNA Polymerase I Promoter Escape.
SIGNORⁱ	Q9NYV6.

Miscellaneous databases

GeneWikiⁱ	RRN3.
GenomeRNAiⁱ	54700.
Protein Ontology More...PROⁱ	PR:Q9NYV6.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000085721.
CleanExⁱ	HS_RRN3.
ExpressionAtlasⁱ	Q9NYV6. baseline and differential.
Genevisibleⁱ	Q9NYV6. HS.

Family and domain databases

Gene3Dⁱ	1.25.10.10. 2 hits.
InterProⁱ	View protein in InterPro IPR011989. ARM-like. IPR007991. RNA_pol_I_trans_ini_fac_RRN3.
PANTHERⁱ	PTHR12790. PTHR12790. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05327. RRN3. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RRN3_HUMAN
Accessionⁱ	Q9NYV6Primary (citable) accession number: Q9NYV6 Secondary accession number(s): A2RTY9 , B4E0J7, B4E3T2, Q3MHU9, Q6IPL4, Q9H4F0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 24, 2006
	Last sequence update:	October 1, 2000
	Last modified:	June 7, 2017
	This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9NYV6 (RRN3_HUMAN)

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RNA polymerase I-specific transcription initiation factor RRN3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequences (4)ⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ