RNA polymerase I-specific transcription initiation factor RRN3

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• RNA polymerase I core binding Source: GO_Central
• RNA polymerase I CORE element sequence-specific DNA binding Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 22368283
• transcription factor activity, core RNA polymerase I binding Source: GO_Central

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• cell proliferation Source: Ensembl
• cytoplasm organization Source: Ensembl
• homeostasis of number of cells Source: Ensembl
• in utero embryonic development Source: Ensembl
• negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator Source: Ensembl
• nucleolus organization Source: Ensembl
• positive regulation of neuron projection development Source: Ensembl
• positive regulation of transcription, DNA-templated Source: Ensembl
• regulation of DNA-templated transcription, initiation Source: Ensembl
• ribosome biogenesis Source: Ensembl
• transcription initiation from RNA polymerase I promoter Source: Reactome
• transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section"><span class="caps">PTM</span>/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">‘Interaction’</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• RNA polymerase I core binding Source: GO_Central

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)ⁱ

<p>This subsection of the ‘Sequence’ section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsⁱ produced by alternative splicing. AlignAdd to basketAdded to basket

        10         20         30         40         50
MAAPLLHTRL PGDAAASSSA VKKLGASRTG ISNMRALEND FFNSPPRKTV 
        60         70         80         90        100
RFGGTVTEVL LKYKKGETND FELLKNQLLD PDIKDDQIIN WLLEFRSSIM 
       110        120        130        140        150
YLTKDFEQLI SIILRLPWLN RSQTVVEEYL AFLGNLVSAQ TVFLRPCLSM 
       160        170        180        190        200
IASHFVPPRV IIKEGDVDVS DSDDEDDNLP ANFDTCHRAL QIIARYVPST 
       210        220        230        240        250
PWFLMPILVE KFPFVRKSER TLECYVHNLL RISVYFPTLR HEILELIIEK 
       260        270        280        290        300
LLKLDVNASR QGIEDAEETA TQTCGGTDST EGLFNMDEDE ETEHETKAGP 
       310        320        330        340        350
ERLDQMVHPV AERLDILMSL VLSYMKDVCY VDGKVDNGKT KDLYRDLINI 
       360        370        380        390        400
FDKLLLPTHA SCHVQFFMFY LCSFKLGFAE AFLEHLWKKL QDPSNPAIIR 
       410        420        430        440        450
QAAGNYIGSF LARAKFIPLI TVKSCLDLLV NWLHIYLNNQ DSGTKAFCDV 
       460        470        480        490        500
ALHGPFYSAC QAVFYTFVFR HKQLLSGNLK EGLQYLQSLN FERIVMSQLN 
       510        520        530        540        550
PLKICLPSVV NFFAAITNKY QLVFCYTIIE RNNRQMLPVI RSTAGGDSVQ 
       560        570        580        590        600
ICTNPLDTFF PFDPCVLKRS KKFIDPIYQV WEDMSAEELQ EFKKPMKKDI 
       610        620        630        640        650
VEDEDDDFLK GEVPQNDTVI GITPSSFDTH FRSPSSSVGS PPVLYMQPSP 

L                                             

        10         20         30         40         50
MAAPLLHTRL PGDAAASSSA VKKLGASRTG ISNMRALEND FFNSPPRKTV 
        60         70         80         90        100
RFGGTVTEVL LKYKKGETND FELLKNQLLD PDIKDDQIIN WLLEFRSSIM 
       110        120        130        140        150
YLTKDFEQLI SIILRLPWLN RSQTVVEEYL AFLGNLVSAQ TVFLRPCLSM 
       160        170        180        190        200
IASHFVPPRV IIKEGDVDVS DSDDEDDNLP ANFDTCHRAL QIIARYVPST 
       210        220        230        240        250
PWFLMPILVE KFPFVRKSER TLECYVHNLL RISVYFPTLR HEILELIIEK 
       260        270        280        290        300
LLKLDVNASR QGIEDAEETA TQTCGGTDST EGLFNMVSSL LMKVEMKFII 

KGGNS                                             

        10         20         30         40         50
MRALENDFFN SPPRKTVRFG GTVTEVLLKY KKGETNDFEL LKNQLLDPDI 
        60         70         80         90        100
KDDQIINWLL EFRSSIMYLT KDFEQLISII LRLPWLNRSQ TVVEEYLAFL 
       110        120        130        140        150
GNLVSAQTVF LRPCLSMIAS HFVPPRVIIK EGDVDVSDSD DEDDNLPANF 
       160        170        180        190        200
DTCHRALQII ARYVPSTPWF LMPILVEKFP FVRKSERTLE CYVHNLLRIS 
       210        220        230        240        250
VYFPTLRHEI LELIIEKLLK LDVNASRQGI EDAEETATQT CGGTDSTEGL 
       260        270        280        290        300
FNMDEDEETE HETKAGPERL DQMVHPVAER LDILMSLVLS YMKDVCYVDG 
       310        320        330        340        350
KVDNGKTKDL YRDLINIFDK LLLPTHASCH VQFFMFYLCS FKLGFAEAFL 
       360        370        380        390        400
EHLWKKLQDP SNPAIIRQAA GNYIGSFLAR AKFIPLITVK SCLDLLVNWL 
       410        420        430        440        450
HIYLNNQDSG TKAFCDVALH GPFYSACQAV FYTFVFRHKQ LLSGNLKEGL 
       460        470        480        490        500
QYLQSLNFER IVMSQLNPLK ICLPSVVNFF AAITNKYQLV FCYTIIERNN 
       510        520        530        540        550
RQMLPVIRST AGGDSVQICT NPLDTFFPFD PCVLKRSKKF IDPIYQVWED 
       560        570        580        590        600
MSAEELQEFK KPMKKDIVED EDDDFLKGEV PQNDTVIGIT PSSFDTHFRS 
       610 
PSSSVGSPPV LYMQPSPL                                  

        10         20         30         40         50
MIASHFVPPR VIIKEGDVDV SDSDDEDDNL PANFDTCHRA LQIIARYVPS 
        60         70         80         90        100
TPWFLMPILV EKFPFVRKSE RTLVNASRQG IEDAEETATQ TCGGTDSTEG 
       110        120        130        140        150
LFNMDEDEET EHETKAGPER LDQMVHPVAE RLDILMSLVL SYMKDVCYVD 
       160        170        180        190        200
GKVDNGKTKD LYRDLINIFD KLLLPTHASC HVQFFMFYLC SFKLGFAEAF 
       210        220        230        240        250
LEHLWKKLQD PSNPAIIRQA AGNYIGSFLA RAKFIPLITV KSCLDLLVNW 
       260        270        280        290        300
LHIYLNNQDS GTKAFCDVAL HGPFYSACQA VFYTFVFRHK QLLSGNLKEG 
       310        320        330        340        350
LQYLQSLNFE RIVMSQLNPL KICLPSVVNF FAAITNKYQL VFCYTIIERN 
       360        370        380        390        400
NRQMLPVIRS TAGGDSVQIC TNPLDTFFPF DPCVLKRSKK FIDPIYQVWE 
       410        420        430        440        450
DMSAEELQEF KKPMKKDIVE DEDDDFLKGE VPQNDTVIGI TPSSFDTHFR 
       460 
SPSSSVGSPP VLYMQPSPL                                  

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ

Documents

1. Human chromosome 16
   Human chromosome 16: entries, gene names and cross-references to MIM
2. Human entries with polymorphisms or disease mutations
   List of human entries with polymorphisms or disease mutations
3. Human polymorphisms and disease mutations
   Index of human polymorphisms and disease mutations
4. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
5. SIMILARITY comments
   Index of protein domains and families