RRN3

Functionⁱ

Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent preinitiation complex (PIC). Dissociates from pol I as a consequence of transcription. In vitro, cannot activate transcription in a subsequent transcription reaction (By similarity).By similarity4 Publications

Enzyme and pathway databases

Reactomeⁱ	R-HSA-73762. RNA Polymerase I Transcription Initiation. R-HSA-73772. RNA Polymerase I Promoter Escape.
SIGNORⁱ	Q9NYV6.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: RNA polymerase I-specific transcription initiation factor RRN3 Alternative name(s): Transcription initiation factor IA Short name: TIF-IA
Gene namesⁱ	Name:RRN3 Synonyms:TIFIA
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

HGNCⁱ	HGNC:30346. RRN3.

HGNCⁱ

HGNC:30346. RRN3.

Subcellular locationⁱ

Nucleus › nucleolus
1 Publication
Manual assertion based on experiment inⁱ
- Ref.7
  "hRRN3 is essential in the SL1-mediated recruitment of RNA polymerase I to rRNA gene promoters."
  Miller G., Panov K.I., Friedrich J.K., Trinkle-Mulcahy L., Lamond A.I., Zomerdijk J.C.B.M.
  EMBO J. 20:1373-1382(2001) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH TAF1B AND TAF1C.

GO - Cellular componentⁱ

nucleolus Source: HPA
nucleoplasm Source: Reactome
nucleus Source: HPA

Complete GO annotation...

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Mutagenesisⁱ	411 – 415	5	Missing : Abolishes interaction with TAF1B and TAF1C. 1 Publication Manual assertion based on experiment inⁱ Ref.8 "Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter." Yuan X., Zhao J., Zentgraf H., Hoffmann-Rohrer U., Grummt I. EMBO Rep. 3:1082-1087(2002) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH TWISTNB; EIF3L; TAF1B AND TAF1C, MUTAGENESIS OF 411-LEU--LYS-415.

Organism-specific databases

PharmGKBⁱ	PA134878601.

PharmGKBⁱ

PA134878601.

Polymorphism and mutation databases

BioMutaⁱ	RRN3.
DMDMⁱ	74719591.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Chainⁱ	1 – 651	651	RNA polymerase I-specific transcription initiation factor RRN3		PRO_0000211426	Add BLAST

Amino acid modifications

Feature key	Position(s)	Length	Description
Modified residueⁱ	170 – 170	1	PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ Ref.10 "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-170; SER-172 AND SER-640, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Modified residueⁱ	172 – 172	1	PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ Ref.10 "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-170; SER-172 AND SER-640, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Modified residueⁱ	200 – 200	1	Phosphothreonine; by MAPK91 Publication Manual assertion based on experiment inⁱ Ref.9 "The nucleolus as a stress sensor: JNK2 inactivates the transcription factor TIF-IA and down-regulates rRNA synthesis." Mayer C., Bierhoff H., Grummt I. Genes Dev. 19:933-941(2005) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION AT THR-200 BY MAPK9/JNK2, FUNCTION.
Modified residueⁱ	640 – 640	1	PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ Ref.10 "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-170; SER-172 AND SER-640, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Ref.11 "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-640, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Post-translational modificationⁱ

Phosphorylation is required for participation in rDNA transcription (By similarity). Phosphorylated at Thr-200 by MAPK9/JNK2, which abrogates initiation complex formation.By similarity1 Publication

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9NYV6.
MaxQBⁱ	Q9NYV6.
PaxDbⁱ	Q9NYV6.
PeptideAtlasⁱ	Q9NYV6.
PRIDEⁱ	Q9NYV6.

PTM databases

iPTMnetⁱ	Q9NYV6.
PhosphoSiteⁱ	Q9NYV6.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000085721.
CleanExⁱ	HS_RRN3.
ExpressionAtlasⁱ	Q9NYV6. baseline and differential.
Genevisibleⁱ	Q9NYV6. HS.

Organism-specific databases

HPAⁱ	HPA049837.

Interactionⁱ

Subunit structureⁱ

Interacts with TWISTNB, EIF3L, TAF1B and TAF1C.2 Publications

Protein-protein interaction databases

BioGridⁱ	120102. 27 interactions.
IntActⁱ	Q9NYV6. 4 interactions.
MINTⁱ	MINT-249163.
STRINGⁱ	9606.ENSP00000198767.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9NYV6.
SMRⁱ	Q9NYV6. Positions 179-585.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Regionⁱ	500 – 651	152	Interaction with TWISTNB			Add BLAST
Regionⁱ	557 – 651	95	Interaction with EIF3L			Add BLAST

Sequence similaritiesⁱ

Belongs to the RRN3 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2434. Eukaryota. ENOG410XRJJ. LUCA.
GeneTreeⁱ	ENSGT00390000001488.
HOGENOMⁱ	HOG000132846.
HOVERGENⁱ	HBG056994.
InParanoidⁱ	Q9NYV6.
KOⁱ	K15216.
OMAⁱ	IQVDMED.
OrthoDBⁱ	EOG091G089T.
PhylomeDBⁱ	Q9NYV6.
TreeFamⁱ	TF312979.

Family and domain databases

InterProⁱ	IPR007991. RNA_pol_I_trans_ini_fac_RRN3. [Graphical view]
PANTHERⁱ	PTHR12790. PTHR12790. 1 hit.
Pfamⁱ	PF05327. RRN3. 1 hit. [Graphical view]

Sequences (4)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q9NYV6-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPLLHTRL PGDAAASSSA VKKLGASRTG ISNMRALEND FFNSPPRKTV 
        60         70         80         90        100
RFGGTVTEVL LKYKKGETND FELLKNQLLD PDIKDDQIIN WLLEFRSSIM 
       110        120        130        140        150
YLTKDFEQLI SIILRLPWLN RSQTVVEEYL AFLGNLVSAQ TVFLRPCLSM 
       160        170        180        190        200
IASHFVPPRV IIKEGDVDVS DSDDEDDNLP ANFDTCHRAL QIIARYVPST 
       210        220        230        240        250
PWFLMPILVE KFPFVRKSER TLECYVHNLL RISVYFPTLR HEILELIIEK 
       260        270        280        290        300
LLKLDVNASR QGIEDAEETA TQTCGGTDST EGLFNMDEDE ETEHETKAGP 
       310        320        330        340        350
ERLDQMVHPV AERLDILMSL VLSYMKDVCY VDGKVDNGKT KDLYRDLINI 
       360        370        380        390        400
FDKLLLPTHA SCHVQFFMFY LCSFKLGFAE AFLEHLWKKL QDPSNPAIIR 
       410        420        430        440        450
QAAGNYIGSF LARAKFIPLI TVKSCLDLLV NWLHIYLNNQ DSGTKAFCDV 
       460        470        480        490        500
ALHGPFYSAC QAVFYTFVFR HKQLLSGNLK EGLQYLQSLN FERIVMSQLN 
       510        520        530        540        550
PLKICLPSVV NFFAAITNKY QLVFCYTIIE RNNRQMLPVI RSTAGGDSVQ 
       560        570        580        590        600
ICTNPLDTFF PFDPCVLKRS KKFIDPIYQV WEDMSAEELQ EFKKPMKKDI 
       610        620        630        640        650
VEDEDDDFLK GEVPQNDTVI GITPSSFDTH FRSPSSSVGS PPVLYMQPSP 

L

Length:651

Mass (Da):74,107

Last modified:October 1, 2000 - v1

Checksum:ⁱC646DC6677C49895

GO

Isoform 2 (identifier: Q9NYV6-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
287-305: DEDEETEHETKAGPERLDQ → VSSLLMKVEMKFIIKGGNS
306-651: Missing.

« Hide

        10         20         30         40         50
MAAPLLHTRL PGDAAASSSA VKKLGASRTG ISNMRALEND FFNSPPRKTV 
        60         70         80         90        100
RFGGTVTEVL LKYKKGETND FELLKNQLLD PDIKDDQIIN WLLEFRSSIM 
       110        120        130        140        150
YLTKDFEQLI SIILRLPWLN RSQTVVEEYL AFLGNLVSAQ TVFLRPCLSM 
       160        170        180        190        200
IASHFVPPRV IIKEGDVDVS DSDDEDDNLP ANFDTCHRAL QIIARYVPST 
       210        220        230        240        250
PWFLMPILVE KFPFVRKSER TLECYVHNLL RISVYFPTLR HEILELIIEK 
       260        270        280        290        300
LLKLDVNASR QGIEDAEETA TQTCGGTDST EGLFNMVSSL LMKVEMKFII 

KGGNS

Note: No experimental confirmation available.

Show »

Length:305

Mass (Da):34,472

Checksum:ⁱ1745373E5CC8CE7B

GO

Isoform 3 (identifier: Q9NYV6-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-33: Missing.

« Hide

        10         20         30         40         50
MRALENDFFN SPPRKTVRFG GTVTEVLLKY KKGETNDFEL LKNQLLDPDI 
        60         70         80         90        100
KDDQIINWLL EFRSSIMYLT KDFEQLISII LRLPWLNRSQ TVVEEYLAFL 
       110        120        130        140        150
GNLVSAQTVF LRPCLSMIAS HFVPPRVIIK EGDVDVSDSD DEDDNLPANF 
       160        170        180        190        200
DTCHRALQII ARYVPSTPWF LMPILVEKFP FVRKSERTLE CYVHNLLRIS 
       210        220        230        240        250
VYFPTLRHEI LELIIEKLLK LDVNASRQGI EDAEETATQT CGGTDSTEGL 
       260        270        280        290        300
FNMDEDEETE HETKAGPERL DQMVHPVAER LDILMSLVLS YMKDVCYVDG 
       310        320        330        340        350
KVDNGKTKDL YRDLINIFDK LLLPTHASCH VQFFMFYLCS FKLGFAEAFL 
       360        370        380        390        400
EHLWKKLQDP SNPAIIRQAA GNYIGSFLAR AKFIPLITVK SCLDLLVNWL 
       410        420        430        440        450
HIYLNNQDSG TKAFCDVALH GPFYSACQAV FYTFVFRHKQ LLSGNLKEGL 
       460        470        480        490        500
QYLQSLNFER IVMSQLNPLK ICLPSVVNFF AAITNKYQLV FCYTIIERNN 
       510        520        530        540        550
RQMLPVIRST AGGDSVQICT NPLDTFFPFD PCVLKRSKKF IDPIYQVWED 
       560        570        580        590        600
MSAEELQEFK KPMKKDIVED EDDDFLKGEV PQNDTVIGIT PSSFDTHFRS 
       610 
PSSSVGSPPV LYMQPSPL

Note: No experimental confirmation available.

Show »

Length:618

Mass (Da):70,876

Checksum:ⁱ1D119D4C3DADB659

GO

Isoform 4 (identifier: Q9NYV6-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-149: Missing.
223-255: Missing.

« Hide

        10         20         30         40         50
MIASHFVPPR VIIKEGDVDV SDSDDEDDNL PANFDTCHRA LQIIARYVPS 
        60         70         80         90        100
TPWFLMPILV EKFPFVRKSE RTLVNASRQG IEDAEETATQ TCGGTDSTEG 
       110        120        130        140        150
LFNMDEDEET EHETKAGPER LDQMVHPVAE RLDILMSLVL SYMKDVCYVD 
       160        170        180        190        200
GKVDNGKTKD LYRDLINIFD KLLLPTHASC HVQFFMFYLC SFKLGFAEAF 
       210        220        230        240        250
LEHLWKKLQD PSNPAIIRQA AGNYIGSFLA RAKFIPLITV KSCLDLLVNW 
       260        270        280        290        300
LHIYLNNQDS GTKAFCDVAL HGPFYSACQA VFYTFVFRHK QLLSGNLKEG 
       310        320        330        340        350
LQYLQSLNFE RIVMSQLNPL KICLPSVVNF FAAITNKYQL VFCYTIIERN 
       360        370        380        390        400
NRQMLPVIRS TAGGDSVQIC TNPLDTFFPF DPCVLKRSKK FIDPIYQVWE 
       410        420        430        440        450
DMSAEELQEF KKPMKKDIVE DEDDDFLKGE VPQNDTVIGI TPSSFDTHFR 
       460 
SPSSSVGSPP VLYMQPSPL

Note: No experimental confirmation available.

Show »

Length:469

Mass (Da):53,315

Checksum:ⁱFCAE200CD69B3663

GO

Natural variant

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Natural variantⁱ	348 – 348	1	I → M. Corresponds to variant rs2941256 [ dbSNP \| Ensembl ].		VAR_051886

Alternative sequence

Feature key	Position(s)	Length	Description	Feature identifier	Actions
Alternative sequenceⁱ	1 – 149	149	Missing in isoform 4. 1 Publication Manual assertion based on opinion inⁱ Ref.3 "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).	VSP_056519	Add BLAST
Alternative sequenceⁱ	1 – 33	33	Missing in isoform 3. 1 Publication Manual assertion based on opinion inⁱ Ref.3 "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).	VSP_056520	Add BLAST
Alternative sequenceⁱ	223 – 255	33	Missing in isoform 4. 1 Publication Manual assertion based on opinion inⁱ Ref.3 "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).	VSP_056521	Add BLAST
Alternative sequenceⁱ	287 – 305	19	DEDEE…ERLDQ → VSSLLMKVEMKFIIKGGNS in isoform 2. 1 Publication Manual assertion based on opinion inⁱ Ref.6 "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).	VSP_056338	Add BLAST
Alternative sequenceⁱ	306 – 651	346	Missing in isoform 2. 1 Publication Manual assertion based on opinion inⁱ Ref.6 "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).	VSP_056339	Add BLAST

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ272050 mRNA. Translation: CAC07955.1. AF227156 mRNA. Translation: AAF66160.1. AK303405 mRNA. Translation: BAG64459.1. AK304856 mRNA. Translation: BAG65594.1. AK314769 mRNA. Translation: BAG37307.1. AC139256 Genomic DNA. No translation available. CH471301 Genomic DNA. Translation: EAW54754.1. BC071868 mRNA. Translation: AAH71868.1. BC104660 mRNA. Translation: AAI04661.1. BC132688 mRNA. Translation: AAI32689.1. BC132690 mRNA. Translation: AAI32691.1.
CCDSⁱ	CCDS10559.1. [Q9NYV6-1]
RefSeqⁱ	NP_060897.3. NM_018427.4. [Q9NYV6-1]
UniGeneⁱ	Hs.460078. Hs.720348.

Genome annotation databases

Ensemblⁱ	ENST00000198767; ENSP00000198767; ENSG00000085721. [Q9NYV6-1] ENST00000327307; ENSP00000318484; ENSG00000085721. [Q9NYV6-3] ENST00000564131; ENSP00000454238; ENSG00000085721. [Q9NYV6-2] ENST00000616334; ENSP00000480743; ENSG00000278494. [Q9NYV6-1] ENST00000632541; ENSP00000488651; ENSG00000278494. [Q9NYV6-3] ENST00000634151; ENSP00000487821; ENSG00000278494. [Q9NYV6-2]
GeneIDⁱ	54700.
KEGGⁱ	hsa:54700.
UCSCⁱ	uc002dde.4. human. [Q9NYV6-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ272050 mRNA. Translation: CAC07955.1. AF227156 mRNA. Translation: AAF66160.1. AK303405 mRNA. Translation: BAG64459.1. AK304856 mRNA. Translation: BAG65594.1. AK314769 mRNA. Translation: BAG37307.1. AC139256 Genomic DNA. No translation available. CH471301 Genomic DNA. Translation: EAW54754.1. BC071868 mRNA. Translation: AAH71868.1. BC104660 mRNA. Translation: AAI04661.1. BC132688 mRNA. Translation: AAI32689.1. BC132690 mRNA. Translation: AAI32691.1.
CCDSⁱ	CCDS10559.1. [Q9NYV6-1]
RefSeqⁱ	NP_060897.3. NM_018427.4. [Q9NYV6-1]
UniGeneⁱ	Hs.460078. Hs.720348.

3D structure databases

ProteinModelPortalⁱ	Q9NYV6.
SMRⁱ	Q9NYV6. Positions 179-585.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	120102. 27 interactions.
IntActⁱ	Q9NYV6. 4 interactions.
MINTⁱ	MINT-249163.
STRINGⁱ	9606.ENSP00000198767.

PTM databases

iPTMnetⁱ	Q9NYV6.
PhosphoSiteⁱ	Q9NYV6.

Polymorphism and mutation databases

BioMutaⁱ	RRN3.
DMDMⁱ	74719591.

Proteomic databases

EPDⁱ	Q9NYV6.
MaxQBⁱ	Q9NYV6.
PaxDbⁱ	Q9NYV6.
PeptideAtlasⁱ	Q9NYV6.
PRIDEⁱ	Q9NYV6.

Protocols and materials databases

DNASUⁱ	54700.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000198767; ENSP00000198767; ENSG00000085721. [Q9NYV6-1] ENST00000327307; ENSP00000318484; ENSG00000085721. [Q9NYV6-3] ENST00000564131; ENSP00000454238; ENSG00000085721. [Q9NYV6-2] ENST00000616334; ENSP00000480743; ENSG00000278494. [Q9NYV6-1] ENST00000632541; ENSP00000488651; ENSG00000278494. [Q9NYV6-3] ENST00000634151; ENSP00000487821; ENSG00000278494. [Q9NYV6-2]
GeneIDⁱ	54700.
KEGGⁱ	hsa:54700.
UCSCⁱ	uc002dde.4. human. [Q9NYV6-1]

Organism-specific databases

CTDⁱ	54700.
GeneCardsⁱ	RRN3.
H-InvDB	HIX0012886. HIX0038660. HIX0038739.
HGNCⁱ	HGNC:30346. RRN3.
HPAⁱ	HPA049837.
MIMⁱ	605121. gene.
neXtProtⁱ	NX_Q9NYV6.
PharmGKBⁱ	PA134878601.
GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2434. Eukaryota. ENOG410XRJJ. LUCA.
GeneTreeⁱ	ENSGT00390000001488.
HOGENOMⁱ	HOG000132846.
HOVERGENⁱ	HBG056994.
InParanoidⁱ	Q9NYV6.
KOⁱ	K15216.
OMAⁱ	IQVDMED.
OrthoDBⁱ	EOG091G089T.
PhylomeDBⁱ	Q9NYV6.
TreeFamⁱ	TF312979.

Enzyme and pathway databases

Reactomeⁱ	R-HSA-73762. RNA Polymerase I Transcription Initiation. R-HSA-73772. RNA Polymerase I Promoter Escape.
SIGNORⁱ	Q9NYV6.

Miscellaneous databases

GeneWikiⁱ	RRN3.
GenomeRNAiⁱ	54700.
PROⁱ	Q9NYV6.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000085721.
CleanExⁱ	HS_RRN3.
ExpressionAtlasⁱ	Q9NYV6. baseline and differential.
Genevisibleⁱ	Q9NYV6. HS.

Family and domain databases

InterProⁱ	IPR007991. RNA_pol_I_trans_ini_fac_RRN3. [Graphical view]
PANTHERⁱ	PTHR12790. PTHR12790. 1 hit.
Pfamⁱ	PF05327. RRN3. 1 hit. [Graphical view]
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ

RRN3_HUMAN

Accessionⁱ

Primary (citable) accession number: Q9NYV6
Secondary accession number(s): A2RTY9

Q9H4F0

Entry historyⁱ

Integrated into UniProtKB/Swiss-Prot:	January 24, 2006
Last sequence update:	October 1, 2000
Last modified:	September 7, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]

Entry statusⁱ

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9NYV6 (RRN3_HUMAN)

UniProt

Q9NYV6 - RRN3_HUMAN

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RNA polymerase I-specific transcription initiation factor RRN3

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<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>Provides information on the location and the topology of the mature protein in the cell.</p><p><a href='../manual/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>Provides information on the disease(s) and phenotype(s) associated with a protein.</p><p><a href='../manual/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>Describes post-translational modifications (PTMs) and/or processing events.</p><p><a href='../manual/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>Provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.</p><p><a href='../manual/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>Provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.</p><p><a href='../manual/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>Provides information on the tertiary and secondary structure of a protein.</p><p><a href='../manual/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>Provides information about the sequence similarity with other proteins.</p><p><a href='../manual/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>Displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.</p><p><a href='../manual/sequences_section' target='_top'>More...</a></p>Sequences (4)i

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>Provides general information on the entry.</p><p><a href='../manual/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>Contains any relevant information that doesn’t fit in any other defined sections</p><p><a href='../manual/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequences (4)ⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ