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Q9NYV6 - RRN3_HUMAN

UniProt

Q9NYV6 - RRN3_HUMAN

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Protein

RNA polymerase I-specific transcription initiation factor RRN3

Gene

RRN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent preinitiation complex (PIC). Dissociates from pol I as a consequence of transcription. In vitro, cannot activate transcription in a subsequent transcription reaction (By similarity).By similarity

GO - Biological processi

  1. cell proliferation Source: Ensembl
  2. cytoplasm organization Source: Ensembl
  3. gene expression Source: Reactome
  4. homeostasis of number of cells Source: Ensembl
  5. in utero embryonic development Source: Ensembl
  6. negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator Source: Ensembl
  7. nucleolus organization Source: Ensembl
  8. positive regulation of transcription, DNA-templated Source: Ensembl
  9. regulation of DNA-templated transcription, initiation Source: Ensembl
  10. ribosome biogenesis Source: Ensembl
  11. transcription from RNA polymerase I promoter Source: Reactome
  12. transcription initiation from RNA polymerase I promoter Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_1913. RNA Polymerase I Promoter Escape.
REACT_953. RNA Polymerase I Transcription Initiation.

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase I-specific transcription initiation factor RRN3
Alternative name(s):
Transcription initiation factor IA
Short name:
TIF-IA
Gene namesi
Name:RRN3
Synonyms:TIFIA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
ProteomesiUP000005640: Chromosome 16, UP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:30346. RRN3.

Subcellular locationi

Nucleus › nucleolus 1 Publication

GO - Cellular componenti

  1. nucleolus Source: HPA
  2. nucleoplasm Source: Reactome
  3. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi411 – 4155Missing: Abolishes interaction with TAF1B and TAF1C. 1 Publication

Organism-specific databases

PharmGKBiPA134878601.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 651651RNA polymerase I-specific transcription initiation factor RRN3PRO_0000211426Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei170 – 1701Phosphoserine1 Publication
Modified residuei172 – 1721Phosphoserine1 Publication
Modified residuei200 – 2001Phosphothreonine; by MAPK91 Publication
Modified residuei640 – 6401Phosphoserine2 Publications

Post-translational modificationi

Phosphorylation is required for participation in rDNA transcription (By similarity). Phosphorylated at Thr-200 by MAPK9/JNK2, which abrogates initiation complex formation.By similarity3 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9NYV6.
PaxDbiQ9NYV6.
PRIDEiQ9NYV6.

PTM databases

PhosphoSiteiQ9NYV6.

Expressioni

Gene expression databases

BgeeiQ9NYV6.
CleanExiHS_RRN3.
ExpressionAtlasiQ9NYV6. baseline and differential.
GenevestigatoriQ9NYV6.

Organism-specific databases

HPAiHPA049837.

Interactioni

Subunit structurei

Interacts with TWISTNB, EIF3L, TAF1B and TAF1C.2 Publications

Protein-protein interaction databases

BioGridi120102. 24 interactions.
IntActiQ9NYV6. 4 interactions.
MINTiMINT-249163.
STRINGi9606.ENSP00000198767.

Structurei

3D structure databases

ProteinModelPortaliQ9NYV6.
SMRiQ9NYV6. Positions 179-585.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni500 – 651152Interaction with TWISTNBAdd
BLAST
Regioni557 – 65195Interaction with EIF3LAdd
BLAST

Sequence similaritiesi

Belongs to the RRN3 family.Curated

Phylogenomic databases

eggNOGiNOG275643.
GeneTreeiENSGT00390000001488.
HOGENOMiHOG000236344.
HOVERGENiHBG056994.
InParanoidiQ9NYV6.
KOiK15216.
OMAiIQVDMED.
OrthoDBiEOG7ZGX2R.
PhylomeDBiQ9NYV6.
TreeFamiTF312979.

Family and domain databases

InterProiIPR007991. RNA_pol_I_trans_ini_fac_RRN3.
[Graphical view]
PANTHERiPTHR12790. PTHR12790. 1 hit.
PfamiPF05327. RRN3. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NYV6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPLLHTRL PGDAAASSSA VKKLGASRTG ISNMRALEND FFNSPPRKTV 
        60         70         80         90        100
RFGGTVTEVL LKYKKGETND FELLKNQLLD PDIKDDQIIN WLLEFRSSIM 
       110        120        130        140        150
YLTKDFEQLI SIILRLPWLN RSQTVVEEYL AFLGNLVSAQ TVFLRPCLSM 
       160        170        180        190        200
IASHFVPPRV IIKEGDVDVS DSDDEDDNLP ANFDTCHRAL QIIARYVPST 
       210        220        230        240        250
PWFLMPILVE KFPFVRKSER TLECYVHNLL RISVYFPTLR HEILELIIEK 
       260        270        280        290        300
LLKLDVNASR QGIEDAEETA TQTCGGTDST EGLFNMDEDE ETEHETKAGP 
       310        320        330        340        350
ERLDQMVHPV AERLDILMSL VLSYMKDVCY VDGKVDNGKT KDLYRDLINI 
       360        370        380        390        400
FDKLLLPTHA SCHVQFFMFY LCSFKLGFAE AFLEHLWKKL QDPSNPAIIR 
       410        420        430        440        450
QAAGNYIGSF LARAKFIPLI TVKSCLDLLV NWLHIYLNNQ DSGTKAFCDV 
       460        470        480        490        500
ALHGPFYSAC QAVFYTFVFR HKQLLSGNLK EGLQYLQSLN FERIVMSQLN 
       510        520        530        540        550
PLKICLPSVV NFFAAITNKY QLVFCYTIIE RNNRQMLPVI RSTAGGDSVQ 
       560        570        580        590        600
ICTNPLDTFF PFDPCVLKRS KKFIDPIYQV WEDMSAEELQ EFKKPMKKDI 
       610        620        630        640        650
VEDEDDDFLK GEVPQNDTVI GITPSSFDTH FRSPSSSVGS PPVLYMQPSP 

L
Length:651
Mass (Da):74,107
Last modified:October 1, 2000 - v1
Checksum:iC646DC6677C49895
GO
Isoform 2 (identifier: Q9NYV6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     287-305: DEDEETEHETKAGPERLDQ → VSSLLMKVEMKFIIKGGNS
     306-651: Missing.

Note: No experimental confirmation available.

Show »
Length:305
Mass (Da):34,472
Checksum:i1745373E5CC8CE7B
GO
Isoform 3 (identifier: Q9NYV6-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.

Note: No experimental confirmation available.

Show »
Length:618
Mass (Da):70,876
Checksum:i1D119D4C3DADB659
GO
Isoform 4 (identifier: Q9NYV6-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-149: Missing.
     223-255: Missing.

Note: No experimental confirmation available.

Show »
Length:469
Mass (Da):53,315
Checksum:iFCAE200CD69B3663
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti348 – 3481I → M.
Corresponds to variant rs2941256 [ dbSNP | Ensembl ].		VAR_051886

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 149149Missing in isoform 4. 1 PublicationVSP_056519Add
BLAST
Alternative sequencei1 – 3333Missing in isoform 3. 1 PublicationVSP_056520Add
BLAST
Alternative sequencei223 – 25533Missing in isoform 4. 1 PublicationVSP_056521Add
BLAST
Alternative sequencei287 – 30519DEDEE…ERLDQ → VSSLLMKVEMKFIIKGGNS in isoform 2. 1 PublicationVSP_056338Add
BLAST
Alternative sequencei306 – 651346Missing in isoform 2. 1 PublicationVSP_056339Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ272050 mRNA. Translation: CAC07955.1.
AF227156 mRNA. Translation: AAF66160.1.
AK303405 mRNA. Translation: BAG64459.1.
AK304856 mRNA. Translation: BAG65594.1.
AK314769 mRNA. Translation: BAG37307.1.
AC139256 Genomic DNA. No translation available.
CH471301 Genomic DNA. Translation: EAW54754.1.
BC071868 mRNA. Translation: AAH71868.1.
BC104660 mRNA. Translation: AAI04661.1.
BC132688 mRNA. Translation: AAI32689.1.
BC132690 mRNA. Translation: AAI32691.1.
CCDSiCCDS10559.1. [Q9NYV6-1]
RefSeqiNP_060897.3. NM_018427.4. [Q9NYV6-1]
UniGeneiHs.460078.
Hs.720348.

Genome annotation databases

EnsembliENST00000198767; ENSP00000198767; ENSG00000085721. [Q9NYV6-1]
ENST00000327307; ENSP00000318484; ENSG00000085721. [Q9NYV6-3]
ENST00000564131; ENSP00000454238; ENSG00000085721. [Q9NYV6-2]
ENST00000616334; ENSP00000480743; ENSG00000278494. [Q9NYV6-1]
GeneIDi54700.
KEGGihsa:54700.
UCSCiuc002dde.3. human. [Q9NYV6-1]
uc002ddf.1. human.

Polymorphism databases

DMDMi74719591.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ272050 mRNA. Translation: CAC07955.1.
AF227156 mRNA. Translation: AAF66160.1.
AK303405 mRNA. Translation: BAG64459.1.
AK304856 mRNA. Translation: BAG65594.1.
AK314769 mRNA. Translation: BAG37307.1.
AC139256 Genomic DNA. No translation available.
CH471301 Genomic DNA. Translation: EAW54754.1.
BC071868 mRNA. Translation: AAH71868.1.
BC104660 mRNA. Translation: AAI04661.1.
BC132688 mRNA. Translation: AAI32689.1.
BC132690 mRNA. Translation: AAI32691.1.
CCDSiCCDS10559.1. [Q9NYV6-1]
RefSeqiNP_060897.3. NM_018427.4. [Q9NYV6-1]
UniGeneiHs.460078.
Hs.720348.

3D structure databases

ProteinModelPortaliQ9NYV6.
SMRiQ9NYV6. Positions 179-585.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120102. 24 interactions.
IntActiQ9NYV6. 4 interactions.
MINTiMINT-249163.
STRINGi9606.ENSP00000198767.

PTM databases

PhosphoSiteiQ9NYV6.

Polymorphism databases

DMDMi74719591.

Proteomic databases

MaxQBiQ9NYV6.
PaxDbiQ9NYV6.
PRIDEiQ9NYV6.

Protocols and materials databases

DNASUi54700.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000198767; ENSP00000198767; ENSG00000085721. [Q9NYV6-1]
ENST00000327307; ENSP00000318484; ENSG00000085721. [Q9NYV6-3]
ENST00000564131; ENSP00000454238; ENSG00000085721. [Q9NYV6-2]
ENST00000616334; ENSP00000480743; ENSG00000278494. [Q9NYV6-1]
GeneIDi54700.
KEGGihsa:54700.
UCSCiuc002dde.3. human. [Q9NYV6-1]
uc002ddf.1. human.

Organism-specific databases

CTDi54700.
GeneCardsiGC16M015153.
H-InvDBHIX0012886.
HIX0038660.
HIX0038739.
HGNCiHGNC:30346. RRN3.
HPAiHPA049837.
MIMi605121. gene.
neXtProtiNX_Q9NYV6.
PharmGKBiPA134878601.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG275643.
GeneTreeiENSGT00390000001488.
HOGENOMiHOG000236344.
HOVERGENiHBG056994.
InParanoidiQ9NYV6.
KOiK15216.
OMAiIQVDMED.
OrthoDBiEOG7ZGX2R.
PhylomeDBiQ9NYV6.
TreeFamiTF312979.

Enzyme and pathway databases

ReactomeiREACT_1913. RNA Polymerase I Promoter Escape.
REACT_953. RNA Polymerase I Transcription Initiation.

Miscellaneous databases

GeneWikiiRRN3.
GenomeRNAii54700.
NextBioi35476776.
PROiQ9NYV6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NYV6.
CleanExiHS_RRN3.
ExpressionAtlasiQ9NYV6. baseline and differential.
GenevestigatoriQ9NYV6.

Family and domain databases

InterProiIPR007991. RNA_pol_I_trans_ini_fac_RRN3.
[Graphical view]
PANTHERiPTHR12790. PTHR12790. 1 hit.
PfamiPF05327. RRN3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "TIF-IA, the factor mediating growth-dependent control of ribosomal RNA synthesis, is the mammalian homolog of yeast Rrn3p."
    Bodem J., Dobreva G., Hoffmann-Rohrer U., Iben S., Zentgraf H., Delius H., Vingron M., Grummt I.
    EMBO Rep. 1:171-175(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
  2. "RNA polymerase I transcription factor Rrn3 is functionally conserved between yeast and human."
    Moorefield B., Greene E.A., Reeder R.H.
    Proc. Natl. Acad. Sci. U.S.A. 97:4724-4729(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).
    Tissue: Hippocampus, Thymus and Uterus.
  4. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Kidney and Spleen.
  7. "hRRN3 is essential in the SL1-mediated recruitment of RNA polymerase I to rRNA gene promoters."
    Miller G., Panov K.I., Friedrich J.K., Trinkle-Mulcahy L., Lamond A.I., Zomerdijk J.C.B.M.
    EMBO J. 20:1373-1382(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH TAF1B AND TAF1C.
  8. "Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter."
    Yuan X., Zhao J., Zentgraf H., Hoffmann-Rohrer U., Grummt I.
    EMBO Rep. 3:1082-1087(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TWISTNB; EIF3L; TAF1B AND TAF1C, MUTAGENESIS OF 411-LEU--LYS-415.
  9. "The nucleolus as a stress sensor: JNK2 inactivates the transcription factor TIF-IA and down-regulates rRNA synthesis."
    Mayer C., Bierhoff H., Grummt I.
    Genes Dev. 19:933-941(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT THR-200 BY MAPK9/JNK2, FUNCTION.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-170; SER-172 AND SER-640, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-640, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Entry informationi

Entry nameiRRN3_HUMAN
AccessioniPrimary (citable) accession number: Q9NYV6
Secondary accession number(s): A2RTY9
, B4E0J7, B4E3T2, Q3MHU9, Q6IPL4, Q9H4F0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: October 1, 2000
Last modified: January 7, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.