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Q9NYV6

- RRN3_HUMAN

UniProt

Q9NYV6 - RRN3_HUMAN

Protein

RNA polymerase I-specific transcription initiation factor RRN3

Gene

RRN3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent preinitiation complex (PIC). Dissociates from pol I as a consequence of transcription. In vitro, cannot activate transcription in a subsequent transcription reaction By similarity.By similarity

    GO - Biological processi

    1. cell proliferation Source: Ensembl
    2. cytoplasm organization Source: Ensembl
    3. gene expression Source: Reactome
    4. homeostasis of number of cells Source: Ensembl
    5. in utero embryonic development Source: Ensembl
    6. negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator Source: Ensembl
    7. nucleolus organization Source: Ensembl
    8. positive regulation of transcription, DNA-templated Source: Ensembl
    9. regulation of DNA-templated transcription, initiation Source: Ensembl
    10. ribosome biogenesis Source: Ensembl
    11. transcription from RNA polymerase I promoter Source: Reactome
    12. transcription initiation from RNA polymerase I promoter Source: Reactome

    Keywords - Biological processi

    Transcription, Transcription regulation

    Enzyme and pathway databases

    ReactomeiREACT_1913. RNA Polymerase I Promoter Escape.
    REACT_953. RNA Polymerase I Transcription Initiation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA polymerase I-specific transcription initiation factor RRN3
    Alternative name(s):
    Transcription initiation factor IA
    Short name:
    TIF-IA
    Gene namesi
    Name:RRN3
    Synonyms:TIFIA
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:30346. RRN3.

    Subcellular locationi

    Nucleusnucleolus 1 Publication

    GO - Cellular componenti

    1. nucleolus Source: HPA
    2. nucleoplasm Source: Reactome
    3. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi411 – 4155Missing: Abolishes interaction with TAF1B and TAF1C. 1 Publication

    Organism-specific databases

    PharmGKBiPA134878601.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 651651RNA polymerase I-specific transcription initiation factor RRN3PRO_0000211426Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei170 – 1701Phosphoserine1 Publication
    Modified residuei172 – 1721Phosphoserine1 Publication
    Modified residuei200 – 2001Phosphothreonine; by MAPK91 Publication
    Modified residuei640 – 6401Phosphoserine2 Publications

    Post-translational modificationi

    Phosphorylation is required for participation in rDNA transcription By similarity. Phosphorylated at Thr-200 by MAPK9/JNK2, which abrogates initiation complex formation.By similarity3 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9NYV6.
    PaxDbiQ9NYV6.
    PRIDEiQ9NYV6.

    PTM databases

    PhosphoSiteiQ9NYV6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NYV6.
    BgeeiQ9NYV6.
    CleanExiHS_RRN3.
    GenevestigatoriQ9NYV6.

    Organism-specific databases

    HPAiHPA049837.

    Interactioni

    Subunit structurei

    Interacts with TWISTNB, EIF3L, TAF1B and TAF1C.2 Publications

    Protein-protein interaction databases

    BioGridi120102. 23 interactions.
    IntActiQ9NYV6. 4 interactions.
    MINTiMINT-249163.
    STRINGi9606.ENSP00000198767.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NYV6.
    SMRiQ9NYV6. Positions 179-585.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni500 – 651152Interaction with TWISTNBAdd
    BLAST
    Regioni557 – 65195Interaction with EIF3LAdd
    BLAST

    Sequence similaritiesi

    Belongs to the RRN3 family.Curated

    Phylogenomic databases

    eggNOGiNOG275643.
    HOGENOMiHOG000236344.
    HOVERGENiHBG056994.
    InParanoidiQ9NYV6.
    KOiK15216.
    OMAiFRWRDLT.
    OrthoDBiEOG7ZGX2R.
    PhylomeDBiQ9NYV6.
    TreeFamiTF312979.

    Family and domain databases

    InterProiIPR007991. RNA_pol_I_trans_ini_fac_RRN3.
    [Graphical view]
    PANTHERiPTHR12790. PTHR12790. 1 hit.
    PfamiPF05327. RRN3. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NYV6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAPLLHTRL PGDAAASSSA VKKLGASRTG ISNMRALEND FFNSPPRKTV    50
    RFGGTVTEVL LKYKKGETND FELLKNQLLD PDIKDDQIIN WLLEFRSSIM 100
    YLTKDFEQLI SIILRLPWLN RSQTVVEEYL AFLGNLVSAQ TVFLRPCLSM 150
    IASHFVPPRV IIKEGDVDVS DSDDEDDNLP ANFDTCHRAL QIIARYVPST 200
    PWFLMPILVE KFPFVRKSER TLECYVHNLL RISVYFPTLR HEILELIIEK 250
    LLKLDVNASR QGIEDAEETA TQTCGGTDST EGLFNMDEDE ETEHETKAGP 300
    ERLDQMVHPV AERLDILMSL VLSYMKDVCY VDGKVDNGKT KDLYRDLINI 350
    FDKLLLPTHA SCHVQFFMFY LCSFKLGFAE AFLEHLWKKL QDPSNPAIIR 400
    QAAGNYIGSF LARAKFIPLI TVKSCLDLLV NWLHIYLNNQ DSGTKAFCDV 450
    ALHGPFYSAC QAVFYTFVFR HKQLLSGNLK EGLQYLQSLN FERIVMSQLN 500
    PLKICLPSVV NFFAAITNKY QLVFCYTIIE RNNRQMLPVI RSTAGGDSVQ 550
    ICTNPLDTFF PFDPCVLKRS KKFIDPIYQV WEDMSAEELQ EFKKPMKKDI 600
    VEDEDDDFLK GEVPQNDTVI GITPSSFDTH FRSPSSSVGS PPVLYMQPSP 650
    L 651
    Length:651
    Mass (Da):74,107
    Last modified:October 1, 2000 - v1
    Checksum:iC646DC6677C49895
    GO
    Isoform 2 (identifier: Q9NYV6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         287-305: DEDEETEHETKAGPERLDQ → VSSLLMKVEMKFIIKGGNS
         306-651: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:305
    Mass (Da):34,472
    Checksum:i1745373E5CC8CE7B
    GO
    Isoform 3 (identifier: Q9NYV6-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-33: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:618
    Mass (Da):70,876
    Checksum:i1D119D4C3DADB659
    GO
    Isoform 4 (identifier: Q9NYV6-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-149: Missing.
         223-255: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:469
    Mass (Da):53,315
    Checksum:iFCAE200CD69B3663
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti348 – 3481I → M.
    Corresponds to variant rs2941256 [ dbSNP | Ensembl ].
    VAR_051886

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 149149Missing in isoform 4. 1 PublicationVSP_056519Add
    BLAST
    Alternative sequencei1 – 3333Missing in isoform 3. 1 PublicationVSP_056520Add
    BLAST
    Alternative sequencei223 – 25533Missing in isoform 4. 1 PublicationVSP_056521Add
    BLAST
    Alternative sequencei287 – 30519DEDEE…ERLDQ → VSSLLMKVEMKFIIKGGNS in isoform 2. 1 PublicationVSP_056338Add
    BLAST
    Alternative sequencei306 – 651346Missing in isoform 2. 1 PublicationVSP_056339Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ272050 mRNA. Translation: CAC07955.1.
    AF227156 mRNA. Translation: AAF66160.1.
    AK303405 mRNA. Translation: BAG64459.1.
    AK304856 mRNA. Translation: BAG65594.1.
    AK314769 mRNA. Translation: BAG37307.1.
    AC139256 Genomic DNA. No translation available.
    CH471301 Genomic DNA. Translation: EAW54754.1.
    BC071868 mRNA. Translation: AAH71868.1.
    BC104660 mRNA. Translation: AAI04661.1.
    BC132688 mRNA. Translation: AAI32689.1.
    BC132690 mRNA. Translation: AAI32691.1.
    CCDSiCCDS10559.1.
    RefSeqiNP_060897.3. NM_018427.3.
    UniGeneiHs.460078.

    Genome annotation databases

    EnsembliENST00000198767; ENSP00000198767; ENSG00000085721.
    ENST00000327307; ENSP00000318484; ENSG00000085721.
    ENST00000540462; ENSP00000437963; ENSG00000085721.
    ENST00000564131; ENSP00000454238; ENSG00000085721.
    GeneIDi54700.
    KEGGihsa:54700.
    UCSCiuc002dde.3. human.

    Polymorphism databases

    DMDMi74719591.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ272050 mRNA. Translation: CAC07955.1 .
    AF227156 mRNA. Translation: AAF66160.1 .
    AK303405 mRNA. Translation: BAG64459.1 .
    AK304856 mRNA. Translation: BAG65594.1 .
    AK314769 mRNA. Translation: BAG37307.1 .
    AC139256 Genomic DNA. No translation available.
    CH471301 Genomic DNA. Translation: EAW54754.1 .
    BC071868 mRNA. Translation: AAH71868.1 .
    BC104660 mRNA. Translation: AAI04661.1 .
    BC132688 mRNA. Translation: AAI32689.1 .
    BC132690 mRNA. Translation: AAI32691.1 .
    CCDSi CCDS10559.1.
    RefSeqi NP_060897.3. NM_018427.3.
    UniGenei Hs.460078.

    3D structure databases

    ProteinModelPortali Q9NYV6.
    SMRi Q9NYV6. Positions 179-585.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120102. 23 interactions.
    IntActi Q9NYV6. 4 interactions.
    MINTi MINT-249163.
    STRINGi 9606.ENSP00000198767.

    PTM databases

    PhosphoSitei Q9NYV6.

    Polymorphism databases

    DMDMi 74719591.

    Proteomic databases

    MaxQBi Q9NYV6.
    PaxDbi Q9NYV6.
    PRIDEi Q9NYV6.

    Protocols and materials databases

    DNASUi 54700.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000198767 ; ENSP00000198767 ; ENSG00000085721 .
    ENST00000327307 ; ENSP00000318484 ; ENSG00000085721 .
    ENST00000540462 ; ENSP00000437963 ; ENSG00000085721 .
    ENST00000564131 ; ENSP00000454238 ; ENSG00000085721 .
    GeneIDi 54700.
    KEGGi hsa:54700.
    UCSCi uc002dde.3. human.

    Organism-specific databases

    CTDi 54700.
    GeneCardsi GC16M015153.
    H-InvDB HIX0012886.
    HIX0038660.
    HIX0038739.
    HGNCi HGNC:30346. RRN3.
    HPAi HPA049837.
    MIMi 605121. gene.
    neXtProti NX_Q9NYV6.
    PharmGKBi PA134878601.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG275643.
    HOGENOMi HOG000236344.
    HOVERGENi HBG056994.
    InParanoidi Q9NYV6.
    KOi K15216.
    OMAi FRWRDLT.
    OrthoDBi EOG7ZGX2R.
    PhylomeDBi Q9NYV6.
    TreeFami TF312979.

    Enzyme and pathway databases

    Reactomei REACT_1913. RNA Polymerase I Promoter Escape.
    REACT_953. RNA Polymerase I Transcription Initiation.

    Miscellaneous databases

    GeneWikii RRN3.
    GenomeRNAii 54700.
    NextBioi 57257.
    PROi Q9NYV6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NYV6.
    Bgeei Q9NYV6.
    CleanExi HS_RRN3.
    Genevestigatori Q9NYV6.

    Family and domain databases

    InterProi IPR007991. RNA_pol_I_trans_ini_fac_RRN3.
    [Graphical view ]
    PANTHERi PTHR12790. PTHR12790. 1 hit.
    Pfami PF05327. RRN3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "TIF-IA, the factor mediating growth-dependent control of ribosomal RNA synthesis, is the mammalian homolog of yeast Rrn3p."
      Bodem J., Dobreva G., Hoffmann-Rohrer U., Iben S., Zentgraf H., Delius H., Vingron M., Grummt I.
      EMBO Rep. 1:171-175(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
    2. "RNA polymerase I transcription factor Rrn3 is functionally conserved between yeast and human."
      Moorefield B., Greene E.A., Reeder R.H.
      Proc. Natl. Acad. Sci. U.S.A. 97:4724-4729(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).
      Tissue: Hippocampus, Thymus and Uterus.
    4. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Kidney and Spleen.
    7. "hRRN3 is essential in the SL1-mediated recruitment of RNA polymerase I to rRNA gene promoters."
      Miller G., Panov K.I., Friedrich J.K., Trinkle-Mulcahy L., Lamond A.I., Zomerdijk J.C.B.M.
      EMBO J. 20:1373-1382(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH TAF1B AND TAF1C.
    8. "Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter."
      Yuan X., Zhao J., Zentgraf H., Hoffmann-Rohrer U., Grummt I.
      EMBO Rep. 3:1082-1087(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TWISTNB; EIF3L; TAF1B AND TAF1C, MUTAGENESIS OF 411-LEU--LYS-415.
    9. "The nucleolus as a stress sensor: JNK2 inactivates the transcription factor TIF-IA and down-regulates rRNA synthesis."
      Mayer C., Bierhoff H., Grummt I.
      Genes Dev. 19:933-941(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT THR-200 BY MAPK9/JNK2, FUNCTION.
    10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-170; SER-172 AND SER-640, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-640, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRRN3_HUMAN
    AccessioniPrimary (citable) accession number: Q9NYV6
    Secondary accession number(s): A2RTY9
    , B4E0J7, B4E3T2, Q3MHU9, Q6IPL4, Q9H4F0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2006
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3