UniProtKB - Q9NYV6 (RRN3_HUMAN)
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Protein
RNA polymerase I-specific transcription initiation factor RRN3
Gene
RRN3
Organism
Homo sapiens (Human)
Status
Functioni
Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent preinitiation complex (PIC). Dissociates from pol I as a consequence of transcription. In vitro, cannot activate transcription in a subsequent transcription reaction (By similarity).By similarity4 Publications
GO - Molecular functioni
- RNA polymerase I core binding Source: GO_Central
- RNA polymerase I CORE element sequence-specific DNA binding Source: UniProtKB
- transcription factor activity, core RNA polymerase I binding Source: GO_Central
GO - Biological processi
- cell proliferation Source: Ensembl
- cytoplasm organization Source: Ensembl
- homeostasis of number of cells Source: Ensembl
- in utero embryonic development Source: Ensembl
- negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator Source: Ensembl
- nucleolus organization Source: Ensembl
- positive regulation of neuron projection development Source: Ensembl
- positive regulation of transcription, DNA-templated Source: Ensembl
- regulation of DNA-templated transcription, initiation Source: Ensembl
- ribosome biogenesis Source: Ensembl
- transcription initiation from RNA polymerase I promoter Source: Reactome
Keywordsi
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-HSA-73762. RNA Polymerase I Transcription Initiation. R-HSA-73772. RNA Polymerase I Promoter Escape. |
SIGNORi | Q9NYV6. |
Names & Taxonomyi
Protein namesi | Recommended name: RNA polymerase I-specific transcription initiation factor RRN3Alternative name(s): Transcription initiation factor IA Short name: TIF-IA |
Gene namesi | Name:RRN3 Synonyms:TIFIA |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000085721.12. |
HGNCi | HGNC:30346. RRN3. |
MIMi | 605121. gene. |
neXtProti | NX_Q9NYV6. |
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 411 – 415 | Missing : Abolishes interaction with TAF1B and TAF1C. 1 Publication | 5 |
Organism-specific databases
DisGeNETi | 54700. |
OpenTargetsi | ENSG00000085721. |
PharmGKBi | PA134878601. |
Polymorphism and mutation databases
BioMutai | RRN3. |
DMDMi | 74719591. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000211426 | 1 – 651 | RNA polymerase I-specific transcription initiation factor RRN3Add BLAST | 651 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 170 | PhosphoserineCombined sources | 1 | |
Modified residuei | 172 | PhosphoserineCombined sources | 1 | |
Modified residuei | 200 | Phosphothreonine; by MAPK91 Publication | 1 | |
Modified residuei | 640 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Phosphorylation is required for participation in rDNA transcription (By similarity). Phosphorylated at Thr-200 by MAPK9/JNK2, which abrogates initiation complex formation.By similarity1 Publication
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9NYV6. |
MaxQBi | Q9NYV6. |
PaxDbi | Q9NYV6. |
PeptideAtlasi | Q9NYV6. |
PRIDEi | Q9NYV6. |
PTM databases
iPTMneti | Q9NYV6. |
PhosphoSitePlusi | Q9NYV6. |
Expressioni
Gene expression databases
Bgeei | ENSG00000085721. |
CleanExi | HS_RRN3. |
ExpressionAtlasi | Q9NYV6. baseline and differential. |
Genevisiblei | Q9NYV6. HS. |
Organism-specific databases
HPAi | HPA049837. |
Interactioni
Subunit structurei
Interacts with TWISTNB, EIF3L, TAF1B and TAF1C.2 Publications
GO - Molecular functioni
- RNA polymerase I core binding Source: GO_Central
Protein-protein interaction databases
BioGridi | 120102. 31 interactors. |
CORUMi | Q9NYV6. |
IntActi | Q9NYV6. 4 interactors. |
MINTi | Q9NYV6. |
STRINGi | 9606.ENSP00000198767. |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 500 – 651 | Interaction with TWISTNB1 PublicationAdd BLAST | 152 | |
Regioni | 557 – 651 | Interaction with EIF3L1 PublicationAdd BLAST | 95 |
Sequence similaritiesi
Belongs to the RRN3 family.Curated
Phylogenomic databases
eggNOGi | KOG2434. Eukaryota. ENOG410XRJJ. LUCA. |
GeneTreei | ENSGT00390000001488. |
HOGENOMi | HOG000132846. |
HOVERGENi | HBG056994. |
InParanoidi | Q9NYV6. |
KOi | K15216. |
OMAi | PLKVCSP. |
OrthoDBi | EOG091G089T. |
PhylomeDBi | Q9NYV6. |
TreeFami | TF312979. |
Family and domain databases
InterProi | View protein in InterPro IPR007991. RNA_pol_I_trans_ini_fac_RRN3. |
PANTHERi | PTHR12790. PTHR12790. 1 hit. |
Pfami | View protein in Pfam PF05327. RRN3. 1 hit. |
s (4)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9NYV6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MAAPLLHTRL PGDAAASSSA VKKLGASRTG ISNMRALEND FFNSPPRKTV
60 70 80 90 100
RFGGTVTEVL LKYKKGETND FELLKNQLLD PDIKDDQIIN WLLEFRSSIM
110 120 130 140 150
YLTKDFEQLI SIILRLPWLN RSQTVVEEYL AFLGNLVSAQ TVFLRPCLSM
160 170 180 190 200
IASHFVPPRV IIKEGDVDVS DSDDEDDNLP ANFDTCHRAL QIIARYVPST
210 220 230 240 250
PWFLMPILVE KFPFVRKSER TLECYVHNLL RISVYFPTLR HEILELIIEK
260 270 280 290 300
LLKLDVNASR QGIEDAEETA TQTCGGTDST EGLFNMDEDE ETEHETKAGP
310 320 330 340 350
ERLDQMVHPV AERLDILMSL VLSYMKDVCY VDGKVDNGKT KDLYRDLINI
360 370 380 390 400
FDKLLLPTHA SCHVQFFMFY LCSFKLGFAE AFLEHLWKKL QDPSNPAIIR
410 420 430 440 450
QAAGNYIGSF LARAKFIPLI TVKSCLDLLV NWLHIYLNNQ DSGTKAFCDV
460 470 480 490 500
ALHGPFYSAC QAVFYTFVFR HKQLLSGNLK EGLQYLQSLN FERIVMSQLN
510 520 530 540 550
PLKICLPSVV NFFAAITNKY QLVFCYTIIE RNNRQMLPVI RSTAGGDSVQ
560 570 580 590 600
ICTNPLDTFF PFDPCVLKRS KKFIDPIYQV WEDMSAEELQ EFKKPMKKDI
610 620 630 640 650
VEDEDDDFLK GEVPQNDTVI GITPSSFDTH FRSPSSSVGS PPVLYMQPSP
L
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051886 | 348 | I → M. Corresponds to variant dbSNP:rs2941256Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056519 | 1 – 149 | Missing in isoform 4. 1 PublicationAdd BLAST | 149 | |
Alternative sequenceiVSP_056520 | 1 – 33 | Missing in isoform 3. 1 PublicationAdd BLAST | 33 | |
Alternative sequenceiVSP_056521 | 223 – 255 | Missing in isoform 4. 1 PublicationAdd BLAST | 33 | |
Alternative sequenceiVSP_056338 | 287 – 305 | DEDEE…ERLDQ → VSSLLMKVEMKFIIKGGNS in isoform 2. 1 PublicationAdd BLAST | 19 | |
Alternative sequenceiVSP_056339 | 306 – 651 | Missing in isoform 2. 1 PublicationAdd BLAST | 346 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ272050 mRNA. Translation: CAC07955.1. AF227156 mRNA. Translation: AAF66160.1. AK303405 mRNA. Translation: BAG64459.1. AK304856 mRNA. Translation: BAG65594.1. AK314769 mRNA. Translation: BAG37307.1. AC139256 Genomic DNA. No translation available. CH471301 Genomic DNA. Translation: EAW54754.1. BC071868 mRNA. Translation: AAH71868.1. BC104660 mRNA. Translation: AAI04661.1. BC132688 mRNA. Translation: AAI32689.1. BC132690 mRNA. Translation: AAI32691.1. |
CCDSi | CCDS10559.1. [Q9NYV6-1] |
RefSeqi | NP_060897.3. NM_018427.4. [Q9NYV6-1] |
UniGenei | Hs.460078. Hs.720348. |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Entry informationi
Entry namei | RRN3_HUMAN | |
Accessioni | Q9NYV6Primary (citable) accession number: Q9NYV6 Secondary accession number(s): A2RTY9 Q9H4F0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 24, 2006 |
Last sequence update: | October 1, 2000 | |
Last modified: | March 28, 2018 | |
This is version 121 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |