ID   CD2L7_HUMAN    STANDARD;      PRT;  1490 AA.
AC   Q9NYV4; O94978;
DT   16-OCT-2001 (Rel. 40, Created)
DT   16-OCT-2001 (Rel. 40, Last sequence update)
DT   01-MAY-2005 (Rel. 47, Last annotation update)
DE   Cell division cycle 2-related protein kinase 7 (EC 2.7.1.37) (CDC2-
DE   related protein kinase 7) (CrkRS).
GN   Name=CRK7; Synonyms=KIAA0904;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=21539573; PubMed=11683387;
RA   Ko T.K., Kelly E., Pines J.;
RT   "CrkRS: a novel conserved Cdc2-related protein kinase that colocalises
RT   with SC35 speckles.";
RL   J. Cell Sci. 114:2591-2603(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain;
RX   MEDLINE=99156230; PubMed=10048485;
RA   Nagase T., Ishikawa K.-I., Suyama M., Kikuno R., Hirosawa M.,
RA   Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. XII.
RT   The complete sequences of 100 new cDNA clones from brain which code
RT   for large proteins in vitro.";
RL   DNA Res. 5:355-364(1998).
RN   [3]
RP   SEQUENCE REVISION.
RX   MEDLINE=22158633; PubMed=12168954;
RA   Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.;
RT   "Construction of expression-ready cDNA clones for KIAA genes: manual
RT   curation of 330 KIAA cDNA clones.";
RL   DNA Res. 9:99-106(2002).
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- SUBCELLULAR LOCATION: Nuclear (Probable).
CC   -!- SIMILARITY: Belongs to the Ser/Thr protein kinase family.
CC       CDC2/CDKX subfamily.
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DR   EMBL; AF227198; AAF36401.1; -.
DR   EMBL; AB020711; BAA74927.2; ALT_INIT.
DR   HSSP; P24941; 1P2A.
DR   Ensembl; ENSG00000167258; Homo sapiens.
DR   H-InvDB; HIX0013777; -.
DR   InterPro; IPR011009; Kinase_like.
DR   InterPro; IPR000719; Prot_kinase.
DR   InterPro; IPR008271; Ser_thr_pkin_AS.
DR   Pfam; PF00069; Pkinase; 1.
DR   ProDom; PD000001; Prot_kinase; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
KW   ATP-binding; Kinase; Nuclear protein; Serine/threonine-protein kinase;
KW   Transferase.
FT   DOMAIN      727   1020       Protein kinase.
FT   NP_BIND     733    741       ATP (By similarity).
FT   BINDING     756    756       ATP (By similarity).
FT   ACT_SITE    859    859       Proton acceptor (By similarity).
FT   DOMAIN      407    413       Poly-Ala.
FT   DOMAIN      535    540       Poly-Pro.
FT   DOMAIN     1266   1280       Poly-Pro.
FT   CONFLICT    639    639       G -> D (in Ref. 2).
FT   CONFLICT    745    745       R -> K (in Ref. 2).
FT   CONFLICT   1254   1262       Missing (in Ref. 2).
SQ   SEQUENCE   1490 AA;  164155 MW;  851E18DF3BD2B1A1 CRC64;
     MPNSERHGGK KDGSGGASGT LQPSSGGGSS NSRERHRLVS KHKRHKSKHS KDMGLVTPEA
     ASLGTVIKPL VEYDDISSDS DTFSDDMAFK LDRRENDERR GSDRSDRLHK HRHHQHRRSR
     DLLKAKQTEK EKSQEVSSKS GSMKDRISGS SKRSNEETDD YGKAQVAKSS SKESRSSKLH
     KEKTRKEREL KSGHKDRSKS HRKRETPKSY KTVDSPKRRS RSPHRKWSDS SKQDDSPSGA
     SYGQDYDLSP SRSHTSSNYD SYKKSPGSTS RRQSVSPPYK EPSAYQSSTR SPSPYSRRQR
     SVSPYSRRRS SSYERSGSYS GRSPSPYGRR RSSSPFLSKR SLSRSPLPSR KSMKSRSRSP
     AYSRHSSSHS KKKRSSSRSR HSSISPVRLP LNSSLGAELS RKKKERAAAA AAAKMDGKES
     KGSPVFLPRK ENSSVEAKDS GLESKKLPRS VKLEKSAPDT ELVNVTHLNT EVKNSSDTGK
     VKLDENSEKH LVKDLKAQGT RDSKPIALKE EIVTPKETET SEKETPPPLP TIASPPPPLP
     TTTPPPQTPP LPPLPPIPAL PQQPPLPPSQ PAFSQVPASS TSTLPPSTHS KTSAVSSQAN
     SQPPVQVSVK TQVSVTAAIP HLKTSTLPPL PLPPLLPGGD DMDSPKETLP SKPVKKEKEQ
     RTRHLLTDLP LPPELPGGDL SPPDSPEPKA ITPPQQPYKK RPKICCPRYG ERRQTESDWG
     KRCVDKFDII GIIGEGTYGQ VYKARDKDTG ELVALKKVRL DNEKEGFPIT AIREIKILRQ
     LIHRSVVNMK EIVTDKQDAL DFKKDKGAFY LVFEYMDHDL MGLLESGLVH FSEDHIKSFM
     KQLMEGLEYC HKKNFLHRDI KCSNILLNNS GQIKLADFGL ARLYNSEESR PYTNKVITLW
     YRPPELLLGE ERYTPAIDVW SCGCILGELF TKKPIFQANL ELAQLELISR LCGSPCPAVW
     PDVIKLPYFN TMKPKKQYRR RLREEFSFIP SAALDLLDHM LTLDPSKRCT AEQTLQSDFL
     KDVELSKMAP PDLPHWQDCH ELWSKKRRRQ RQSGVVVEEP PPSKTSRKET TSGTSTEPVK
     NSSPAPPQPA PGKVESGAGD AIGLADITQQ LNQSELAVLL NLLQSQTDLS IPQMAQLLNI
     HSNPEMQQQL EALNQSISAL TEATSQQQDS ETMAPEESLK EAPSAPVILP SAEQMTLEAS
     STPADMQNIL AVLLSQLMKT QEPAGSLEEN NSDKNSGPQG PRRTPTMPQE EAAACPPHIL
     PPEKRPPEPP GPPPPPPPPP LVEGDLSSAP QELNPAVTAA LLQLLSQPEA EPPGHLPHEH
     QALRPMEYST RPRPNRTYGN TDGPETGFSA IDTDERNSGP ALTESLVQTL VKNRTFSGSL
     SHLGESSSYQ GTGSVQFPGD QDLRFARVPL ALHPVVGQPF LKAEGSSNSV VHAETKLQNY
     GELGPGTTGA SSSGAGLHWG GPTQSSAYGK LYRGPTRVPP RGGRGRGVPY
//