ID   CRK7_HUMAN     STANDARD;      PRT;  1490 AA.
AC   Q9NYV4; O94978;
DT   16-OCT-2001 (Rel. 40, Created)
DT   16-OCT-2001 (Rel. 40, Last sequence update)
DT   16-OCT-2001 (Rel. 40, Last annotation update)
DE   Cell division cycle 2-related protein kinase 7 (EC 2.7.1.-) (CDC2-
DE   related protein kinase 7) (CrkRS).
GN   CRK7 OR KIAA0904.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A.
RA   Pines J.N., Kelly E.;
RT   "CRK7: a novel CDC2-related protein kinase that colocalizes with
RT   interchromatin granule clusters.";
RL   Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   SEQUENCE OF 266-1262 FROM N.A.
RC   TISSUE=Brain;
RX   MEDLINE=99156230; PubMed=10048485;
RA   Nagase T., Ishikawa K.-I., Suyama M., Kikuno R., Hirosawa M.,
RA   Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. XII.
RT   The complete sequences of 100 new cDNA clones from brain which code
RT   for large proteins in vitro.";
RL   DNA Res. 5:355-364(1998).
CC   -!- SUBCELLULAR LOCATION: Nuclear (Probable).
CC   -!- SIMILARITY: BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES.
CC       CDC2/CDKX SUBFAMILY.
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DR   EMBL; AF227198; AAF36401.1; -.
DR   EMBL; AB020711; BAA74927.1; -.
DR   HSSP; P24941; 1BUH.
DR   InterPro; IPR000719; Euk_pkinase.
DR   InterPro; IPR002290; Ser_thr_pkinase.
DR   Pfam; PF00069; pkinase; 1.
DR   ProDom; PD000001; Euk_pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
KW   Transferase; Serine/threonine-protein kinase; ATP-binding;
KW   Nuclear protein.
FT   DOMAIN      727   1020       PROTEIN KINASE.
FT   NP_BIND     733    741       ATP (BY SIMILARITY).
FT   BINDING     756    756       ATP (BY SIMILARITY).
FT   ACT_SITE    859    859       BY SIMILARITY.
FT   DOMAIN      407    413       POLY-ALA.
FT   DOMAIN      535    540       POLY-PRO.
FT   DOMAIN     1266   1280       POLY-PRO.
FT   CONFLICT    266    310       PGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYS
FT                                RRRS -> SSSRSRHSSISPVRLPLNSSLGAELSRKKKERA
FT                                AAAAAAKMDGKE (IN REF. 2).
FT   CONFLICT    639    639       G -> D (IN REF. 2).
FT   CONFLICT    745    745       R -> K (IN REF. 2).
FT   CONFLICT   1195   1195       M -> T (IN REF. 2).
FT   CONFLICT   1254   1262       ACPPHILPP -> GRSNGGNAL (IN REF. 2).
SQ   SEQUENCE   1490 AA;  164154 MW;  851E18DF3BD2B1A1 CRC64;
     MPNSERHGGK KDGSGGASGT LQPSSGGGSS NSRERHRLVS KHKRHKSKHS KDMGLVTPEA
     ASLGTVIKPL VEYDDISSDS DTFSDDMAFK LDRRENDERR GSDRSDRLHK HRHHQHRRSR
     DLLKAKQTEK EKSQEVSSKS GSMKDRISGS SKRSNEETDD YGKAQVAKSS SKESRSSKLH
     KEKTRKEREL KSGHKDRSKS HRKRETPKSY KTVDSPKRRS RSPHRKWSDS SKQDDSPSGA
     SYGQDYDLSP SRSHTSSNYD SYKKSPGSTS RRQSVSPPYK EPSAYQSSTR SPSPYSRRQR
     SVSPYSRRRS SSYERSGSYS GRSPSPYGRR RSSSPFLSKR SLSRSPLPSR KSMKSRSRSP
     AYSRHSSSHS KKKRSSSRSR HSSISPVRLP LNSSLGAELS RKKKERAAAA AAAKMDGKES
     KGSPVFLPRK ENSSVEAKDS GLESKKLPRS VKLEKSAPDT ELVNVTHLNT EVKNSSDTGK
     VKLDENSEKH LVKDLKAQGT RDSKPIALKE EIVTPKETET SEKETPPPLP TIASPPPPLP
     TTTPPPQTPP LPPLPPIPAL PQQPPLPPSQ PAFSQVPASS TSTLPPSTHS KTSAVSSQAN
     SQPPVQVSVK TQVSVTAAIP HLKTSTLPPL PLPPLLPGGD DMDSPKETLP SKPVKKEKEQ
     RTRHLLTDLP LPPELPGGDL SPPDSPEPKA ITPPQQPYKK RPKICCPRYG ERRQTESDWG
     KRCVDKFDII GIIGEGTYGQ VYKARDKDTG ELVALKKVRL DNEKEGFPIT AIREIKILRQ
     LIHRSVVNMK EIVTDKQDAL DFKKDKGAFY LVFEYMDHDL MGLLESGLVH FSEDHIKSFM
     KQLMEGLEYC HKKNFLHRDI KCSNILLNNS GQIKLADFGL ARLYNSEESR PYTNKVITLW
     YRPPELLLGE ERYTPAIDVW SCGCILGELF TKKPIFQANL ELAQLELISR LCGSPCPAVW
     PDVIKLPYFN TMKPKKQYRR RLREEFSFIP SAALDLLDHM LTLDPSKRCT AEQTLQSDFL
     KDVELSKMAP PDLPHWQDCH ELWSKKRRRQ RQSGVVVEEP PPSKTSRKET TSGTSTEPVK
     NSSPAPPQPA PGKVESGAGD AIGLADITQQ LNQSELAVLL NLLQSQTDLS IPQMAQLLNI
     HSNPEMQQQL EALNQSISAL TEATSQQQDS ETMAPEESLK EAPSAPVILP SAEQMTLEAS
     STPADMQNIL AVLLSQLMKT QEPAGSLEEN NSDKNSGPQG PRRTPTMPQE EAAACPPHIL
     PPEKRPPEPP GPPPPPPPPP LVEGDLSSAP QELNPAVTAA LLQLLSQPEA EPPGHLPHEH
     QALRPMEYST RPRPNRTYGN TDGPETGFSA IDTDERNSGP ALTESLVQTL VKNRTFSGSL
     SHLGESSSYQ GTGSVQFPGD QDLRFARVPL ALHPVVGQPF LKAEGSSNSV VHAETKLQNY
     GELGPGTTGA SSSGAGLHWG GPTQSSAYGK LYRGPTRVPP RGGRGRGVPY
//