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Protein

UDP-glucose:glycoprotein glucosyltransferase 2

Gene

UGGT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation (By similarity).By similarity

Cofactori

Pathwayi

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiREACT_25091. ER Quality Control Compartment (ERQC).
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT24. Glycosyltransferase Family 24.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucose:glycoprotein glucosyltransferase 2 (EC:2.4.1.-)
Short name:
UGT2
Short name:
hUGT2
Alternative name(s):
UDP--Glc:glycoprotein glucosyltransferase 2
UDP-glucose ceramide glucosyltransferase-like 1
Gene namesi
Name:UGGT2
Synonyms:UGCGL2, UGT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:15664. UGGT2.

Subcellular locationi

  • Endoplasmic reticulum lumen PROSITE-ProRule annotation1 Publication
  • Endoplasmic reticulum-Golgi intermediate compartment PROSITE-ProRule annotation1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38015.

Polymorphism and mutation databases

BioMutaiUGGT2.
DMDMi311033544.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence AnalysisAdd
BLAST
Chaini28 – 15161489UDP-glucose:glycoprotein glucosyltransferase 2PRO_0000012274Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi256 – 2561N-linked (GlcNAc...)Sequence Analysis
Glycosylationi286 – 2861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi920 – 9201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi950 – 9501N-linked (GlcNAc...)Sequence Analysis
Modified residuei1289 – 12891Phosphotyrosine1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9NYU1.
PaxDbiQ9NYU1.
PRIDEiQ9NYU1.

PTM databases

PhosphoSiteiQ9NYU1.

Expressioni

Tissue specificityi

Higher levels in kidney, pancreas, heart, and skeletal muscle.1 Publication

Gene expression databases

BgeeiQ9NYU1.
CleanExiHS_UGCGL2.
ExpressionAtlasiQ9NYU1. baseline and differential.
GenevestigatoriQ9NYU1.

Organism-specific databases

HPAiHPA047955.

Interactioni

Subunit structurei

Interacts with METTL23.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
APPBP2Q926243EBI-1054215,EBI-743771

Protein-protein interaction databases

BioGridi120875. 7 interactions.
IntActiQ9NYU1. 3 interactions.
STRINGi9606.ENSP00000365938.

Structurei

3D structure databases

ProteinModelPortaliQ9NYU1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1220 – 1516297GlucosyltransferaseAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1513 – 15164Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the glycosyltransferase 8 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG320899.
GeneTreeiENSGT00390000004600.
HOGENOMiHOG000293330.
HOVERGENiHBG079469.
InParanoidiQ9NYU1.
KOiK11718.
OMAiFLIEGMD.
OrthoDBiEOG75J0M7.
PhylomeDBiQ9NYU1.
TreeFamiTF300320.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR002495. Glyco_trans_8.
IPR029044. Nucleotide-diphossugar_trans.
IPR009448. UDP-g_GGtrans.
[Graphical view]
PANTHERiPTHR11226. PTHR11226. 1 hit.
PfamiPF01501. Glyco_transf_8. 1 hit.
PF06427. UDP-g_GGTase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NYU1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPAKATNVV RLLLGSTALW LSQLGSGTVA ASKSVTAHLA AKWPETPLLL
60 70 80 90 100
EASEFMAEES NEKFWQFLET VQELAIYKQT ESDYSYYNLI LKKAGQFLDN
110 120 130 140 150
LHINLLKFAF SIRAYSPAIQ MFQQIAADEP PPDGCNAFVV IHKKHTCKIN
160 170 180 190 200
EIKKLLKKAA SRTRPYLFKG DHKFPTNKEN LPVVILYAEM GTRTFSAFHK
210 220 230 240 250
VLSEKAQNEE ILYVLRHYIQ KPSSRKMYLS GYGVELAIKS TEYKALDDTQ
260 270 280 290 300
VKTVTNTTVE DETETNEVQG FLFGKLKEIY SDLRDNLTAF QKYLIESNKQ
310 320 330 340 350
MMPLKVWELQ DLSFQAASQI MSAPVYDSIK LMKDISQNFP IKARSLTRIA
360 370 380 390 400
VNQHMREEIK ENQKDLQVRF KIQPGDARLF INGLRVDMDV YDAFSILDML
410 420 430 440 450
KLEGKMMNGL RNLGINGEDM SKFLKLNSHI WEYTYVLDIR HSSIMWINDL
460 470 480 490 500
ENDDLYITWP TSCQKLLKPV FPGSVPSIRR NFHNLVLFID PAQEYTLDFI
510 520 530 540 550
KLADVFYSHE VPLRIGFVFI LNTDDEVDGA NDAGVALWRA FNYIAEEFDI
560 570 580 590 600
SEAFISIVHM YQKVKKDQNI LTVDNVKSVL QNTFPHANIW DILGIHSKYD
610 620 630 640 650
EERKAGASFY KMTGLGPLPQ ALYNGEPFKH EEMNIKELKM AVLQRMMDAS
660 670 680 690 700
VYLQREVFLG TLNDRTNAID FLMDRNNVVP RINTLILRTN QQYLNLISTS
710 720 730 740 750
VTADVEDFST FFFLDSQDKS AVIAKNMYYL TQDDESIISA VTLWIIADFD
760 770 780 790 800
KPSGRKLLFN ALKHMKTSVH SRLGIIYNPT SKINEENTAI SRGILAAFLT
810 820 830 840 850
QKNMFLRSFL GQLAKEEIAT AIYSGDKIKT FLIEGMDKNA FEKKYNTVGV
860 870 880 890 900
NIFRTHQLFC QDVLKLRPGE MGIVSNGRFL GPLDEDFYAE DFYLLEKITF
910 920 930 940 950
SNLGEKIKGI VENMGINANN MSDFIMKVDA LMSSVPKRAS RYDVTFLREN
960 970 980 990 1000
HSVIKTNPQE NDMFFNVIAI VDPLTREAQK MAQLLVVLGK IINMKIKLFM
1010 1020 1030 1040 1050
NCRGRLSEAP LESFYRFVLE PELMSGANDV SSLGPVAKFL DIPESPLLIL
1060 1070 1080 1090 1100
NMITPEGWLV ETVHSNCDLD NIHLKDTEKT VTAEYELEYL LLEGQCFDKV
1110 1120 1130 1140 1150
TEQPPRGLQF TLGTKNKPAV VDTIVMAHHG YFQLKANPGA WILRLHQGKS
1160 1170 1180 1190 1200
EDIYQIVGHE GTDSQADLED IIVVLNSFKS KILKVKVKKE TDKIKEDILT
1210 1220 1230 1240 1250
DEDEKTKGLW DSIKSFTVSL HKENKKEKDV LNIFSVASGH LYERFLRIMM
1260 1270 1280 1290 1300
LSVLRNTKTP VKFWLLKNYL SPTFKEVIPH MAKEYGFRYE LVQYRWPRWL
1310 1320 1330 1340 1350
RQQTERQRII WGYKILFLDV LFPLAVDKII FVDADQIVRH DLKELRDFDL
1360 1370 1380 1390 1400
DGAPYGYTPF CDSRREMDGY RFWKTGYWAS HLLRRKYHIS ALYVVDLKKF
1410 1420 1430 1440 1450
RRIGAGDRLR SQYQALSQDP NSLSNLDQDL PNNMIYQVAI KSLPQDWLWC
1460 1470 1480 1490 1500
ETWCDDESKQ RAKTIDLCNN PKTKESKLKA AARIVPEWVE YDAEIRQLLD
1510
HLENKKQDTI LTHDEL
Length:1,516
Mass (Da):174,735
Last modified:November 2, 2010 - v4
Checksum:iBD216896ECA54E4F
GO
Isoform 2 (identifier: Q9NYU1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     278-278: E → S
     279-1516: Missing.

Note: No experimental confirmation available.

Show »
Length:278
Mass (Da):31,425
Checksum:i8B2126D4F7309389
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti323 – 3231A → T.1 Publication
Corresponds to variant rs12863903 [ dbSNP | Ensembl ].
VAR_030006
Natural varianti328 – 3281S → A.2 Publications
Corresponds to variant rs816142 [ dbSNP | Ensembl ].
VAR_030007
Natural varianti821 – 8211A → T.1 Publication
Corresponds to variant rs33949518 [ dbSNP | Ensembl ].
VAR_055849
Natural varianti865 – 8651K → R.
Corresponds to variant rs35060832 [ dbSNP | Ensembl ].
VAR_061196
Natural varianti924 – 9241F → I.
Corresponds to variant rs35780499 [ dbSNP | Ensembl ].
VAR_055850
Natural varianti994 – 9941M → L.2 Publications
Corresponds to variant rs12876018 [ dbSNP | Ensembl ].
VAR_030008
Natural varianti1274 – 12741F → L.
Corresponds to variant rs9525072 [ dbSNP | Ensembl ].
VAR_055851
Natural varianti1285 – 12851Y → F.
Corresponds to variant rs35123499 [ dbSNP | Ensembl ].
VAR_061197

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei278 – 2781E → S in isoform 2. 1 PublicationVSP_056319
Alternative sequencei279 – 15161238Missing in isoform 2. 1 PublicationVSP_056320Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF227906 mRNA. Translation: AAF66233.2.
AL136104
, AL158192, AL162500, AL607038 Genomic DNA. Translation: CAH72447.1.
AL158192
, AL136104, AL162500, AL607038 Genomic DNA. Translation: CAI13708.1.
AL607038
, AL136104, AL158192, AL162500 Genomic DNA. Translation: CAI39962.1.
AL162500
, AL136104, AL158192, AL607038 Genomic DNA. Translation: CAI40146.1.
BC032302 mRNA. Translation: AAH32302.1.
BC125233 mRNA. Translation: AAI25234.1.
AL133051 mRNA. Translation: CAB61378.1.
CCDSiCCDS9480.1. [Q9NYU1-1]
PIRiT42654.
RefSeqiNP_064506.3. NM_020121.3. [Q9NYU1-1]
UniGeneiHs.193226.
Hs.656444.

Genome annotation databases

EnsembliENST00000376714; ENSP00000365904; ENSG00000102595. [Q9NYU1-2]
ENST00000376747; ENSP00000365938; ENSG00000102595. [Q9NYU1-1]
GeneIDi55757.
KEGGihsa:55757.
UCSCiuc001vmt.3. human. [Q9NYU1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

GGDB

GlycoGene database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF227906 mRNA. Translation: AAF66233.2.
AL136104
, AL158192, AL162500, AL607038 Genomic DNA. Translation: CAH72447.1.
AL158192
, AL136104, AL162500, AL607038 Genomic DNA. Translation: CAI13708.1.
AL607038
, AL136104, AL158192, AL162500 Genomic DNA. Translation: CAI39962.1.
AL162500
, AL136104, AL158192, AL607038 Genomic DNA. Translation: CAI40146.1.
BC032302 mRNA. Translation: AAH32302.1.
BC125233 mRNA. Translation: AAI25234.1.
AL133051 mRNA. Translation: CAB61378.1.
CCDSiCCDS9480.1. [Q9NYU1-1]
PIRiT42654.
RefSeqiNP_064506.3. NM_020121.3. [Q9NYU1-1]
UniGeneiHs.193226.
Hs.656444.

3D structure databases

ProteinModelPortaliQ9NYU1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120875. 7 interactions.
IntActiQ9NYU1. 3 interactions.
STRINGi9606.ENSP00000365938.

Protein family/group databases

CAZyiGT24. Glycosyltransferase Family 24.

PTM databases

PhosphoSiteiQ9NYU1.

Polymorphism and mutation databases

BioMutaiUGGT2.
DMDMi311033544.

Proteomic databases

MaxQBiQ9NYU1.
PaxDbiQ9NYU1.
PRIDEiQ9NYU1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376714; ENSP00000365904; ENSG00000102595. [Q9NYU1-2]
ENST00000376747; ENSP00000365938; ENSG00000102595. [Q9NYU1-1]
GeneIDi55757.
KEGGihsa:55757.
UCSCiuc001vmt.3. human. [Q9NYU1-1]

Organism-specific databases

CTDi55757.
GeneCardsiGC13M096453.
H-InvDBHIX0011410.
HGNCiHGNC:15664. UGGT2.
HPAiHPA047955.
MIMi605898. gene.
neXtProtiNX_Q9NYU1.
PharmGKBiPA38015.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG320899.
GeneTreeiENSGT00390000004600.
HOGENOMiHOG000293330.
HOVERGENiHBG079469.
InParanoidiQ9NYU1.
KOiK11718.
OMAiFLIEGMD.
OrthoDBiEOG75J0M7.
PhylomeDBiQ9NYU1.
TreeFamiTF300320.

Enzyme and pathway databases

UniPathwayiUPA00378.
ReactomeiREACT_25091. ER Quality Control Compartment (ERQC).

Miscellaneous databases

ChiTaRSiUGGT2. human.
GenomeRNAii55757.
NextBioi60767.
PROiQ9NYU1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NYU1.
CleanExiHS_UGCGL2.
ExpressionAtlasiQ9NYU1. baseline and differential.
GenevestigatoriQ9NYU1.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR002495. Glyco_trans_8.
IPR029044. Nucleotide-diphossugar_trans.
IPR009448. UDP-g_GGtrans.
[Graphical view]
PANTHERiPTHR11226. PTHR11226. 1 hit.
PfamiPF01501. Glyco_transf_8. 1 hit.
PF06427. UDP-g_GGTase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Two homologues encoding human UDP-glucose:glycoprotein glucosyltransferase differ in mRNA expression and enzymatic activity."
    Arnold S.M., Fessler L.I., Fessler J.H., Kaufman R.J.
    Biochemistry 39:2149-2163(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANTS THR-323; ALA-328; THR-821 AND LEU-994.
    Tissue: Fetal liver.
  2. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS ALA-328 AND LEU-994.
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 151-1516 (ISOFORM 1).
    Tissue: Testis.
  5. "The noncatalytic portion of human UDP-glucose: glycoprotein glucosyltransferase I confers UDP-glucose binding and transferase function to the catalytic domain."
    Arnold S.M., Kaufman R.J.
    J. Biol. Chem. 278:43320-43328(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1289, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity."
    Cloutier P., Lavallee-Adam M., Faubert D., Blanchette M., Coulombe B.
    PLoS Genet. 9:E1003210-E1003210(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH METTL23.

Entry informationi

Entry nameiUGGG2_HUMAN
AccessioniPrimary (citable) accession number: Q9NYU1
Secondary accession number(s): A6NKL4
, Q08AD0, Q5JQR8, Q8N5K0, Q9UFC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: November 2, 2010
Last modified: April 29, 2015
This is version 125 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Has no enzymatic activity towards unfolded RNase B or thyroglobulin.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.