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Protein

UDP-glucose:glycoprotein glucosyltransferase 2

Gene

UGGT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation (By similarity).By similarity

Cofactori

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciZFISH:ENSG00000102595-MONOMER.
ReactomeiR-HSA-901032. ER Quality Control Compartment (ERQC).
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT24. Glycosyltransferase Family 24.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucose:glycoprotein glucosyltransferase 2 (EC:2.4.1.-)
Short name:
UGT2
Short name:
hUGT2
Alternative name(s):
UDP--Glc:glycoprotein glucosyltransferase 2
UDP-glucose ceramide glucosyltransferase-like 1
Gene namesi
Name:UGGT2
Synonyms:UGCGL2, UGT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:15664. UGGT2.

Subcellular locationi

  • Endoplasmic reticulum lumen PROSITE-ProRule annotation1 Publication
  • Endoplasmic reticulum-Golgi intermediate compartment PROSITE-ProRule annotation1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

DisGeNETi55757.
OpenTargetsiENSG00000102595.
PharmGKBiPA38015.

Polymorphism and mutation databases

BioMutaiUGGT2.
DMDMi311033544.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000001227428 – 1516UDP-glucose:glycoprotein glucosyltransferase 2Add BLAST1489

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi256N-linked (GlcNAc...)Sequence analysis1
Glycosylationi286N-linked (GlcNAc...)Sequence analysis1
Glycosylationi920N-linked (GlcNAc...)Sequence analysis1
Glycosylationi950N-linked (GlcNAc...)Sequence analysis1
Modified residuei1252PhosphoserineBy similarity1
Modified residuei1289PhosphotyrosineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9NYU1.
MaxQBiQ9NYU1.
PaxDbiQ9NYU1.
PeptideAtlasiQ9NYU1.
PRIDEiQ9NYU1.

PTM databases

iPTMnetiQ9NYU1.
PhosphoSitePlusiQ9NYU1.

Expressioni

Tissue specificityi

Higher levels in kidney, pancreas, heart, and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000102595.
CleanExiHS_UGCGL2.
ExpressionAtlasiQ9NYU1. baseline and differential.
GenevisibleiQ9NYU1. HS.

Organism-specific databases

HPAiHPA047955.

Interactioni

Subunit structurei

Interacts with METTL23.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
APPBP2Q926243EBI-1054215,EBI-743771

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120875. 11 interactors.
IntActiQ9NYU1. 6 interactors.
STRINGi9606.ENSP00000365938.

Structurei

3D structure databases

ProteinModelPortaliQ9NYU1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1220 – 1516GlucosyltransferaseAdd BLAST297

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1513 – 1516Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the glycosyltransferase 8 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1879. Eukaryota.
ENOG410XRK6. LUCA.
GeneTreeiENSGT00390000004600.
HOGENOMiHOG000293330.
HOVERGENiHBG079469.
InParanoidiQ9NYU1.
KOiK11718.
OMAiTRPYLFK.
OrthoDBiEOG091G010F.
PhylomeDBiQ9NYU1.
TreeFamiTF300320.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR002495. Glyco_trans_8.
IPR029044. Nucleotide-diphossugar_trans.
IPR009448. UDP-g_GGtrans.
[Graphical view]
PANTHERiPTHR11226. PTHR11226. 1 hit.
PfamiPF01501. Glyco_transf_8. 1 hit.
PF06427. UDP-g_GGTase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NYU1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPAKATNVV RLLLGSTALW LSQLGSGTVA ASKSVTAHLA AKWPETPLLL
60 70 80 90 100
EASEFMAEES NEKFWQFLET VQELAIYKQT ESDYSYYNLI LKKAGQFLDN
110 120 130 140 150
LHINLLKFAF SIRAYSPAIQ MFQQIAADEP PPDGCNAFVV IHKKHTCKIN
160 170 180 190 200
EIKKLLKKAA SRTRPYLFKG DHKFPTNKEN LPVVILYAEM GTRTFSAFHK
210 220 230 240 250
VLSEKAQNEE ILYVLRHYIQ KPSSRKMYLS GYGVELAIKS TEYKALDDTQ
260 270 280 290 300
VKTVTNTTVE DETETNEVQG FLFGKLKEIY SDLRDNLTAF QKYLIESNKQ
310 320 330 340 350
MMPLKVWELQ DLSFQAASQI MSAPVYDSIK LMKDISQNFP IKARSLTRIA
360 370 380 390 400
VNQHMREEIK ENQKDLQVRF KIQPGDARLF INGLRVDMDV YDAFSILDML
410 420 430 440 450
KLEGKMMNGL RNLGINGEDM SKFLKLNSHI WEYTYVLDIR HSSIMWINDL
460 470 480 490 500
ENDDLYITWP TSCQKLLKPV FPGSVPSIRR NFHNLVLFID PAQEYTLDFI
510 520 530 540 550
KLADVFYSHE VPLRIGFVFI LNTDDEVDGA NDAGVALWRA FNYIAEEFDI
560 570 580 590 600
SEAFISIVHM YQKVKKDQNI LTVDNVKSVL QNTFPHANIW DILGIHSKYD
610 620 630 640 650
EERKAGASFY KMTGLGPLPQ ALYNGEPFKH EEMNIKELKM AVLQRMMDAS
660 670 680 690 700
VYLQREVFLG TLNDRTNAID FLMDRNNVVP RINTLILRTN QQYLNLISTS
710 720 730 740 750
VTADVEDFST FFFLDSQDKS AVIAKNMYYL TQDDESIISA VTLWIIADFD
760 770 780 790 800
KPSGRKLLFN ALKHMKTSVH SRLGIIYNPT SKINEENTAI SRGILAAFLT
810 820 830 840 850
QKNMFLRSFL GQLAKEEIAT AIYSGDKIKT FLIEGMDKNA FEKKYNTVGV
860 870 880 890 900
NIFRTHQLFC QDVLKLRPGE MGIVSNGRFL GPLDEDFYAE DFYLLEKITF
910 920 930 940 950
SNLGEKIKGI VENMGINANN MSDFIMKVDA LMSSVPKRAS RYDVTFLREN
960 970 980 990 1000
HSVIKTNPQE NDMFFNVIAI VDPLTREAQK MAQLLVVLGK IINMKIKLFM
1010 1020 1030 1040 1050
NCRGRLSEAP LESFYRFVLE PELMSGANDV SSLGPVAKFL DIPESPLLIL
1060 1070 1080 1090 1100
NMITPEGWLV ETVHSNCDLD NIHLKDTEKT VTAEYELEYL LLEGQCFDKV
1110 1120 1130 1140 1150
TEQPPRGLQF TLGTKNKPAV VDTIVMAHHG YFQLKANPGA WILRLHQGKS
1160 1170 1180 1190 1200
EDIYQIVGHE GTDSQADLED IIVVLNSFKS KILKVKVKKE TDKIKEDILT
1210 1220 1230 1240 1250
DEDEKTKGLW DSIKSFTVSL HKENKKEKDV LNIFSVASGH LYERFLRIMM
1260 1270 1280 1290 1300
LSVLRNTKTP VKFWLLKNYL SPTFKEVIPH MAKEYGFRYE LVQYRWPRWL
1310 1320 1330 1340 1350
RQQTERQRII WGYKILFLDV LFPLAVDKII FVDADQIVRH DLKELRDFDL
1360 1370 1380 1390 1400
DGAPYGYTPF CDSRREMDGY RFWKTGYWAS HLLRRKYHIS ALYVVDLKKF
1410 1420 1430 1440 1450
RRIGAGDRLR SQYQALSQDP NSLSNLDQDL PNNMIYQVAI KSLPQDWLWC
1460 1470 1480 1490 1500
ETWCDDESKQ RAKTIDLCNN PKTKESKLKA AARIVPEWVE YDAEIRQLLD
1510
HLENKKQDTI LTHDEL
Length:1,516
Mass (Da):174,735
Last modified:November 2, 2010 - v4
Checksum:iBD216896ECA54E4F
GO
Isoform 2 (identifier: Q9NYU1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     278-278: E → S
     279-1516: Missing.

Note: No experimental confirmation available.
Show »
Length:278
Mass (Da):31,425
Checksum:i8B2126D4F7309389
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030006323A → T.1 PublicationCorresponds to variant rs12863903dbSNPEnsembl.1
Natural variantiVAR_030007328S → A.2 PublicationsCorresponds to variant rs816142dbSNPEnsembl.1
Natural variantiVAR_055849821A → T.1 PublicationCorresponds to variant rs33949518dbSNPEnsembl.1
Natural variantiVAR_061196865K → R.Corresponds to variant rs35060832dbSNPEnsembl.1
Natural variantiVAR_055850924F → I.Corresponds to variant rs35780499dbSNPEnsembl.1
Natural variantiVAR_030008994M → L.2 PublicationsCorresponds to variant rs12876018dbSNPEnsembl.1
Natural variantiVAR_0558511274F → L.Corresponds to variant rs9525072dbSNPEnsembl.1
Natural variantiVAR_0611971285Y → F.Corresponds to variant rs35123499dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056319278E → S in isoform 2. 1 Publication1
Alternative sequenceiVSP_056320279 – 1516Missing in isoform 2. 1 PublicationAdd BLAST1238

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF227906 mRNA. Translation: AAF66233.2.
AL136104
, AL158192, AL162500, AL607038 Genomic DNA. Translation: CAH72447.1.
AL158192
, AL136104, AL162500, AL607038 Genomic DNA. Translation: CAI13708.1.
AL607038
, AL136104, AL158192, AL162500 Genomic DNA. Translation: CAI39962.1.
AL162500
, AL136104, AL158192, AL607038 Genomic DNA. Translation: CAI40146.1.
BC032302 mRNA. Translation: AAH32302.1.
BC125233 mRNA. Translation: AAI25234.1.
AL133051 mRNA. Translation: CAB61378.1.
CCDSiCCDS9480.1. [Q9NYU1-1]
PIRiT42654.
RefSeqiNP_064506.3. NM_020121.3. [Q9NYU1-1]
UniGeneiHs.193226.
Hs.656444.

Genome annotation databases

EnsembliENST00000376714; ENSP00000365904; ENSG00000102595. [Q9NYU1-2]
ENST00000376747; ENSP00000365938; ENSG00000102595. [Q9NYU1-1]
GeneIDi55757.
KEGGihsa:55757.
UCSCiuc001vmt.5. human. [Q9NYU1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF227906 mRNA. Translation: AAF66233.2.
AL136104
, AL158192, AL162500, AL607038 Genomic DNA. Translation: CAH72447.1.
AL158192
, AL136104, AL162500, AL607038 Genomic DNA. Translation: CAI13708.1.
AL607038
, AL136104, AL158192, AL162500 Genomic DNA. Translation: CAI39962.1.
AL162500
, AL136104, AL158192, AL607038 Genomic DNA. Translation: CAI40146.1.
BC032302 mRNA. Translation: AAH32302.1.
BC125233 mRNA. Translation: AAI25234.1.
AL133051 mRNA. Translation: CAB61378.1.
CCDSiCCDS9480.1. [Q9NYU1-1]
PIRiT42654.
RefSeqiNP_064506.3. NM_020121.3. [Q9NYU1-1]
UniGeneiHs.193226.
Hs.656444.

3D structure databases

ProteinModelPortaliQ9NYU1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120875. 11 interactors.
IntActiQ9NYU1. 6 interactors.
STRINGi9606.ENSP00000365938.

Protein family/group databases

CAZyiGT24. Glycosyltransferase Family 24.

PTM databases

iPTMnetiQ9NYU1.
PhosphoSitePlusiQ9NYU1.

Polymorphism and mutation databases

BioMutaiUGGT2.
DMDMi311033544.

Proteomic databases

EPDiQ9NYU1.
MaxQBiQ9NYU1.
PaxDbiQ9NYU1.
PeptideAtlasiQ9NYU1.
PRIDEiQ9NYU1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376714; ENSP00000365904; ENSG00000102595. [Q9NYU1-2]
ENST00000376747; ENSP00000365938; ENSG00000102595. [Q9NYU1-1]
GeneIDi55757.
KEGGihsa:55757.
UCSCiuc001vmt.5. human. [Q9NYU1-1]

Organism-specific databases

CTDi55757.
DisGeNETi55757.
GeneCardsiUGGT2.
H-InvDBHIX0011410.
HGNCiHGNC:15664. UGGT2.
HPAiHPA047955.
MIMi605898. gene.
neXtProtiNX_Q9NYU1.
OpenTargetsiENSG00000102595.
PharmGKBiPA38015.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1879. Eukaryota.
ENOG410XRK6. LUCA.
GeneTreeiENSGT00390000004600.
HOGENOMiHOG000293330.
HOVERGENiHBG079469.
InParanoidiQ9NYU1.
KOiK11718.
OMAiTRPYLFK.
OrthoDBiEOG091G010F.
PhylomeDBiQ9NYU1.
TreeFamiTF300320.

Enzyme and pathway databases

UniPathwayiUPA00378.
BioCyciZFISH:ENSG00000102595-MONOMER.
ReactomeiR-HSA-901032. ER Quality Control Compartment (ERQC).

Miscellaneous databases

ChiTaRSiUGGT2. human.
GenomeRNAii55757.
PROiQ9NYU1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102595.
CleanExiHS_UGCGL2.
ExpressionAtlasiQ9NYU1. baseline and differential.
GenevisibleiQ9NYU1. HS.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR002495. Glyco_trans_8.
IPR029044. Nucleotide-diphossugar_trans.
IPR009448. UDP-g_GGtrans.
[Graphical view]
PANTHERiPTHR11226. PTHR11226. 1 hit.
PfamiPF01501. Glyco_transf_8. 1 hit.
PF06427. UDP-g_GGTase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUGGG2_HUMAN
AccessioniPrimary (citable) accession number: Q9NYU1
Secondary accession number(s): A6NKL4
, Q08AD0, Q5JQR8, Q8N5K0, Q9UFC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: November 2, 2010
Last modified: November 2, 2016
This is version 141 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Has no enzymatic activity towards unfolded RNase B or thyroglobulin.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.