UniProtKB - Q9NYU1 (UGGG2_HUMAN)
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Protein
UDP-glucose:glycoprotein glucosyltransferase 2
Gene
UGGT2
Organism
Homo sapiens (Human)
Status
Functioni
Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation (By similarity).By similarity
Cofactori
: protein glycosylation Pathwayi
This protein is involved in the pathway protein glycosylation, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.
GO - Molecular functioni
- UDP-glucose:glycoprotein glucosyltransferase activity Source: UniProtKB
- unfolded protein binding Source: GO_Central
GO - Biological processi
- 'de novo' posttranslational protein folding Source: GO_Central
- endoplasmic reticulum mannose trimming Source: Reactome
- endoplasmic reticulum unfolded protein response Source: GO_Central
- ER-associated misfolded protein catabolic process Source: GO_Central
- protein N-linked glycosylation via asparagine Source: GO_Central
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Enzyme and pathway databases
Reactomei | R-HSA-901032. ER Quality Control Compartment (ERQC). |
UniPathwayi | UPA00378. |
Protein family/group databases
CAZyi | GT24. Glycosyltransferase Family 24. |
Names & Taxonomyi
Protein namesi | Recommended name: UDP-glucose:glycoprotein glucosyltransferase 2 (EC:2.4.1.-)Short name: UGT2 Short name: hUGT2 Alternative name(s): UDP--Glc:glycoprotein glucosyltransferase 2 UDP-glucose ceramide glucosyltransferase-like 1 |
Gene namesi | Name:UGGT2 Synonyms:UGCGL2, UGT2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000102595.18. |
HGNCi | HGNC:15664. UGGT2. |
MIMi | 605898. gene. |
neXtProti | NX_Q9NYU1. |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 55757. |
OpenTargetsi | ENSG00000102595. |
PharmGKBi | PA38015. |
Polymorphism and mutation databases
BioMutai | UGGT2. |
DMDMi | 311033544. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 27 | Sequence analysisAdd BLAST | 27 | |
ChainiPRO_0000012274 | 28 – 1516 | UDP-glucose:glycoprotein glucosyltransferase 2Add BLAST | 1489 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 256 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 286 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 920 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 950 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 1289 | PhosphotyrosineCombined sources | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q9NYU1. |
MaxQBi | Q9NYU1. |
PaxDbi | Q9NYU1. |
PeptideAtlasi | Q9NYU1. |
PRIDEi | Q9NYU1. |
PTM databases
iPTMneti | Q9NYU1. |
PhosphoSitePlusi | Q9NYU1. |
Expressioni
Tissue specificityi
Higher levels in kidney, pancreas, heart, and skeletal muscle.1 Publication
Gene expression databases
Bgeei | ENSG00000102595. |
CleanExi | HS_UGCGL2. |
ExpressionAtlasi | Q9NYU1. baseline and differential. |
Genevisiblei | Q9NYU1. HS. |
Organism-specific databases
HPAi | HPA047955. |
Interactioni
Subunit structurei
Interacts with METTL23.1 Publication
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
APPBP2 | Q92624 | 3 | EBI-1054215,EBI-743771 |
GO - Molecular functioni
- unfolded protein binding Source: GO_Central
Protein-protein interaction databases
BioGridi | 120875. 12 interactors. |
IntActi | Q9NYU1. 9 interactors. |
MINTi | Q9NYU1. |
STRINGi | 9606.ENSP00000365938. |
Structurei
3D structure databases
ProteinModelPortali | Q9NYU1. |
SMRi | Q9NYU1. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1220 – 1516 | GlucosyltransferaseAdd BLAST | 297 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 1513 – 1516 | Prevents secretion from ERPROSITE-ProRule annotation | 4 |
Sequence similaritiesi
Belongs to the glycosyltransferase 8 family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG1879. Eukaryota. ENOG410XRK6. LUCA. |
GeneTreei | ENSGT00390000004600. |
HOGENOMi | HOG000293330. |
HOVERGENi | HBG079469. |
InParanoidi | Q9NYU1. |
KOi | K11718. |
OMAi | MITPEGW. |
OrthoDBi | EOG091G010F. |
PhylomeDBi | Q9NYU1. |
TreeFami | TF300320. |
Family and domain databases
Gene3Di | 3.90.550.10. 1 hit. |
InterProi | View protein in InterPro IPR002495. Glyco_trans_8. IPR029044. Nucleotide-diphossugar_trans. IPR009448. UDP-g_GGtrans. |
PANTHERi | PTHR11226. PTHR11226. 1 hit. |
Pfami | View protein in Pfam PF01501. Glyco_transf_8. 1 hit. PF06427. UDP-g_GGTase. 1 hit. |
SUPFAMi | SSF53448. SSF53448. 1 hit. |
PROSITEi | View protein in PROSITE PS00014. ER_TARGET. 1 hit. |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9NYU1-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MAPAKATNVV RLLLGSTALW LSQLGSGTVA ASKSVTAHLA AKWPETPLLL
60 70 80 90 100
EASEFMAEES NEKFWQFLET VQELAIYKQT ESDYSYYNLI LKKAGQFLDN
110 120 130 140 150
LHINLLKFAF SIRAYSPAIQ MFQQIAADEP PPDGCNAFVV IHKKHTCKIN
160 170 180 190 200
EIKKLLKKAA SRTRPYLFKG DHKFPTNKEN LPVVILYAEM GTRTFSAFHK
210 220 230 240 250
VLSEKAQNEE ILYVLRHYIQ KPSSRKMYLS GYGVELAIKS TEYKALDDTQ
260 270 280 290 300
VKTVTNTTVE DETETNEVQG FLFGKLKEIY SDLRDNLTAF QKYLIESNKQ
310 320 330 340 350
MMPLKVWELQ DLSFQAASQI MSAPVYDSIK LMKDISQNFP IKARSLTRIA
360 370 380 390 400
VNQHMREEIK ENQKDLQVRF KIQPGDARLF INGLRVDMDV YDAFSILDML
410 420 430 440 450
KLEGKMMNGL RNLGINGEDM SKFLKLNSHI WEYTYVLDIR HSSIMWINDL
460 470 480 490 500
ENDDLYITWP TSCQKLLKPV FPGSVPSIRR NFHNLVLFID PAQEYTLDFI
510 520 530 540 550
KLADVFYSHE VPLRIGFVFI LNTDDEVDGA NDAGVALWRA FNYIAEEFDI
560 570 580 590 600
SEAFISIVHM YQKVKKDQNI LTVDNVKSVL QNTFPHANIW DILGIHSKYD
610 620 630 640 650
EERKAGASFY KMTGLGPLPQ ALYNGEPFKH EEMNIKELKM AVLQRMMDAS
660 670 680 690 700
VYLQREVFLG TLNDRTNAID FLMDRNNVVP RINTLILRTN QQYLNLISTS
710 720 730 740 750
VTADVEDFST FFFLDSQDKS AVIAKNMYYL TQDDESIISA VTLWIIADFD
760 770 780 790 800
KPSGRKLLFN ALKHMKTSVH SRLGIIYNPT SKINEENTAI SRGILAAFLT
810 820 830 840 850
QKNMFLRSFL GQLAKEEIAT AIYSGDKIKT FLIEGMDKNA FEKKYNTVGV
860 870 880 890 900
NIFRTHQLFC QDVLKLRPGE MGIVSNGRFL GPLDEDFYAE DFYLLEKITF
910 920 930 940 950
SNLGEKIKGI VENMGINANN MSDFIMKVDA LMSSVPKRAS RYDVTFLREN
960 970 980 990 1000
HSVIKTNPQE NDMFFNVIAI VDPLTREAQK MAQLLVVLGK IINMKIKLFM
1010 1020 1030 1040 1050
NCRGRLSEAP LESFYRFVLE PELMSGANDV SSLGPVAKFL DIPESPLLIL
1060 1070 1080 1090 1100
NMITPEGWLV ETVHSNCDLD NIHLKDTEKT VTAEYELEYL LLEGQCFDKV
1110 1120 1130 1140 1150
TEQPPRGLQF TLGTKNKPAV VDTIVMAHHG YFQLKANPGA WILRLHQGKS
1160 1170 1180 1190 1200
EDIYQIVGHE GTDSQADLED IIVVLNSFKS KILKVKVKKE TDKIKEDILT
1210 1220 1230 1240 1250
DEDEKTKGLW DSIKSFTVSL HKENKKEKDV LNIFSVASGH LYERFLRIMM
1260 1270 1280 1290 1300
LSVLRNTKTP VKFWLLKNYL SPTFKEVIPH MAKEYGFRYE LVQYRWPRWL
1310 1320 1330 1340 1350
RQQTERQRII WGYKILFLDV LFPLAVDKII FVDADQIVRH DLKELRDFDL
1360 1370 1380 1390 1400
DGAPYGYTPF CDSRREMDGY RFWKTGYWAS HLLRRKYHIS ALYVVDLKKF
1410 1420 1430 1440 1450
RRIGAGDRLR SQYQALSQDP NSLSNLDQDL PNNMIYQVAI KSLPQDWLWC
1460 1470 1480 1490 1500
ETWCDDESKQ RAKTIDLCNN PKTKESKLKA AARIVPEWVE YDAEIRQLLD
1510
HLENKKQDTI LTHDEL
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_030006 | 323 | A → T1 PublicationCorresponds to variant dbSNP:rs12863903Ensembl. | 1 | |
Natural variantiVAR_030007 | 328 | S → A3 PublicationsCorresponds to variant dbSNP:rs816142Ensembl. | 1 | |
Natural variantiVAR_055849 | 821 | A → T1 PublicationCorresponds to variant dbSNP:rs33949518Ensembl. | 1 | |
Natural variantiVAR_061196 | 865 | K → R. Corresponds to variant dbSNP:rs35060832Ensembl. | 1 | |
Natural variantiVAR_055850 | 924 | F → I. Corresponds to variant dbSNP:rs35780499Ensembl. | 1 | |
Natural variantiVAR_030008 | 994 | M → L2 PublicationsCorresponds to variant dbSNP:rs12876018Ensembl. | 1 | |
Natural variantiVAR_055851 | 1274 | F → L. Corresponds to variant dbSNP:rs9525072Ensembl. | 1 | |
Natural variantiVAR_061197 | 1285 | Y → F. Corresponds to variant dbSNP:rs35123499Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056319 | 278 | E → S in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_056320 | 279 – 1516 | Missing in isoform 2. 1 PublicationAdd BLAST | 1238 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF227906 mRNA. Translation: AAF66233.2. AL136104 Genomic DNA. No translation available. AL158192 Genomic DNA. No translation available. AL607038 Genomic DNA. No translation available. AL162500 Genomic DNA. No translation available. BC032302 mRNA. Translation: AAH32302.1. BC125233 mRNA. Translation: AAI25234.1. AL133051 mRNA. Translation: CAB61378.1. |
CCDSi | CCDS9480.1. [Q9NYU1-1] |
PIRi | T42654. |
RefSeqi | NP_064506.3. NM_020121.3. [Q9NYU1-1] |
UniGenei | Hs.193226. Hs.656444. |
Genome annotation databases
Ensembli | ENST00000376714; ENSP00000365904; ENSG00000102595. [Q9NYU1-2] ENST00000376747; ENSP00000365938; ENSG00000102595. [Q9NYU1-1] ENST00000621375; ENSP00000482021; ENSG00000102595. [Q9NYU1-2] |
GeneIDi | 55757. |
KEGGi | hsa:55757. |
UCSCi | uc001vmt.5. human. [Q9NYU1-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Entry informationi
Entry namei | UGGG2_HUMAN | |
Accessioni | Q9NYU1Primary (citable) accession number: Q9NYU1 Secondary accession number(s): A6NKL4 Q9UFC4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 12, 2003 |
Last sequence update: | November 2, 2010 | |
Last modified: | March 28, 2018 | |
This is version 155 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Caution
Has no enzymatic activity towards unfolded RNase B or thyroglobulin.1 Publication