Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 226

Gene

ZNF226

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri252 – 274C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 302C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri307 – 329C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 357C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri363 – 385C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri391 – 413C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri419 – 441C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri447 – 469C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri475 – 497C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri503 – 525C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri531 – 553C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri559 – 581C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri587 – 609C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri615 – 637C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri643 – 665C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri671 – 693C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri699 – 721C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri727 – 749C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri755 – 777C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167380-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 226
Gene namesi
Name:ZNF226
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:13019. ZNF226.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167380.
PharmGKBiPA37598.

Polymorphism and mutation databases

BioMutaiZNF226.
DMDMi20178347.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474671 – 803Zinc finger protein 226Add BLAST803

Proteomic databases

EPDiQ9NYT6.
MaxQBiQ9NYT6.
PaxDbiQ9NYT6.
PeptideAtlasiQ9NYT6.
PRIDEiQ9NYT6.

PTM databases

iPTMnetiQ9NYT6.
PhosphoSitePlusiQ9NYT6.

Expressioni

Gene expression databases

BgeeiENSG00000167380.
CleanExiHS_ZNF226.
ExpressionAtlasiQ9NYT6. baseline and differential.
GenevisibleiQ9NYT6. HS.

Organism-specific databases

HPAiCAB034353.
HPA006145.

Interactioni

Protein-protein interaction databases

BioGridi113552. 3 interactors.
STRINGi9606.ENSP00000336719.

Structurei

3D structure databases

ProteinModelPortaliQ9NYT6.
SMRiQ9NYT6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 78KRABPROSITE-ProRule annotationAdd BLAST71

Sequence similaritiesi

Contains 19 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri252 – 274C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 302C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri307 – 329C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 357C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri363 – 385C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri391 – 413C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri419 – 441C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri447 – 469C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri475 – 497C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri503 – 525C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri531 – 553C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri559 – 581C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri587 – 609C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri615 – 637C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri643 – 665C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri671 – 693C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri699 – 721C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri727 – 749C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri755 – 777C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129740.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9NYT6.
KOiK09228.
OMAiHRVHKSE.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9NYT6.
TreeFamiTF350845.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 19 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 8 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 19 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 17 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NYT6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNMFKEAVTF KDVAVAFTEE ELGLLGPAQR KLYRDVMVEN FRNLLSVGHP
60 70 80 90 100
PFKQDVSPIE RNEQLWIMTT ATRRQGNLGE KNQSKLITVQ DRESEEELSC
110 120 130 140 150
WQIWQQIAND LTRCQDSMIN NSQCHKQGDF PYQVGTELSI QISEDENYIV
160 170 180 190 200
NKADGPNNTG NPEFPILRTQ DSWRKTFLTE SQRLNRDQQI SIKNKLCQCK
210 220 230 240 250
KGVDPIGWIS HHDGHRVHKS EKSYRPNDYE KDNMKILTFD HNSMIHTGQK
260 270 280 290 300
SYQCNECKKP FSDLSSFDLH QQLQSGEKSL TCVERGKGFC YSPVLPVHQK
310 320 330 340 350
VHVGEKLKCD ECGKEFSQGA HLQTHQKVHV IEKPYKCKQC GKGFSRRSAL
360 370 380 390 400
NVHCKVHTAE KPYNCEECGR AFSQASHLQD HQRLHTGEKP FKCDACGKSF
410 420 430 440 450
SRNSHLQSHQ RVHTGEKPYK CEECGKGFIC SSNLYIHQRV HTGEKPYKCE
460 470 480 490 500
ECGKGFSRPS SLQAHQGVHT GEKSYICTVC GKGFTLSSNL QAHQRVHTGE
510 520 530 540 550
KPYKCNECGK SFRRNSHYQV HLVVHTGEKP YKCEICGKGF SQSSYLQIHQ
560 570 580 590 600
KAHSIEKPFK CEECGQGFNQ SSRLQIHQLI HTGEKPYKCE ECGKGFSRRA
610 620 630 640 650
DLKIHCRIHT GEKPYNCEEC GKVFRQASNL LAHQRVHSGE KPFKCEECGK
660 670 680 690 700
SFGRSAHLQA HQKVHTGDKP YKCDECGKGF KWSLNLDMHQ RVHTGEKPYK
710 720 730 740 750
CGECGKYFSQ ASSLQLHQSV HTGEKPYKCD VCGKVFSRSS QLQSHQRVHT
760 770 780 790 800
GEKPYKCEIC GKSFSWRSNL TVHHRIHVGD KSYKSNRGGK NIRESTQEKK

SIK
Length:803
Mass (Da):91,921
Last modified:April 16, 2002 - v2
Checksum:i256DE75551A932A8
GO
Isoform 2 (identifier: Q9NYT6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     79-94: GEKNQSKLITVQDRES → DTLLVKALLLYDLAQT
     95-803: Missing.

Note: No experimental confirmation available.
Show »
Length:94
Mass (Da):10,797
Checksum:i8CEB536281389870
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti195K → E in AAF34786 (PubMed:12743021).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04685379 – 94GEKNQ…QDRES → DTLLVKALLLYDLAQT in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_04685495 – 803Missing in isoform 2. 1 PublicationAdd BLAST709

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF228418 mRNA. Translation: AAF34786.1.
AK023091 mRNA. Translation: BAB14398.1.
AC074331 Genomic DNA. Translation: AAF88103.1.
AC138470 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57259.1.
BC017786 mRNA. Translation: AAH17786.1.
BC024197 mRNA. Translation: AAH24197.1.
CCDSiCCDS46102.1. [Q9NYT6-1]
CCDS46103.1. [Q9NYT6-2]
RefSeqiNP_001027544.1. NM_001032372.1. [Q9NYT6-1]
NP_001027545.1. NM_001032373.1. [Q9NYT6-1]
NP_001027546.1. NM_001032374.1. [Q9NYT6-2]
NP_001139692.1. NM_001146220.2. [Q9NYT6-2]
NP_001306017.1. NM_001319088.1. [Q9NYT6-1]
NP_001306018.1. NM_001319089.1. [Q9NYT6-1]
NP_001306019.1. NM_001319090.1. [Q9NYT6-1]
NP_057003.2. NM_015919.3. [Q9NYT6-2]
NP_057528.2. NM_016444.2. [Q9NYT6-1]
XP_005259284.1. XM_005259227.2. [Q9NYT6-1]
XP_006723430.1. XM_006723367.3. [Q9NYT6-1]
XP_006723431.1. XM_006723368.3. [Q9NYT6-1]
XP_006723432.1. XM_006723369.2. [Q9NYT6-1]
XP_016882751.1. XM_017027262.1. [Q9NYT6-1]
XP_016882754.1. XM_017027265.1. [Q9NYT6-2]
UniGeneiHs.145956.

Genome annotation databases

EnsembliENST00000300823; ENSP00000300823; ENSG00000167380. [Q9NYT6-2]
ENST00000337433; ENSP00000336719; ENSG00000167380. [Q9NYT6-1]
ENST00000413984; ENSP00000407474; ENSG00000167380. [Q9NYT6-2]
ENST00000454662; ENSP00000393265; ENSG00000167380. [Q9NYT6-1]
ENST00000588742; ENSP00000467003; ENSG00000167380. [Q9NYT6-2]
ENST00000590089; ENSP00000465121; ENSG00000167380. [Q9NYT6-1]
GeneIDi7769.
KEGGihsa:7769.
UCSCiuc002oyn.4. human. [Q9NYT6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF228418 mRNA. Translation: AAF34786.1.
AK023091 mRNA. Translation: BAB14398.1.
AC074331 Genomic DNA. Translation: AAF88103.1.
AC138470 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57259.1.
BC017786 mRNA. Translation: AAH17786.1.
BC024197 mRNA. Translation: AAH24197.1.
CCDSiCCDS46102.1. [Q9NYT6-1]
CCDS46103.1. [Q9NYT6-2]
RefSeqiNP_001027544.1. NM_001032372.1. [Q9NYT6-1]
NP_001027545.1. NM_001032373.1. [Q9NYT6-1]
NP_001027546.1. NM_001032374.1. [Q9NYT6-2]
NP_001139692.1. NM_001146220.2. [Q9NYT6-2]
NP_001306017.1. NM_001319088.1. [Q9NYT6-1]
NP_001306018.1. NM_001319089.1. [Q9NYT6-1]
NP_001306019.1. NM_001319090.1. [Q9NYT6-1]
NP_057003.2. NM_015919.3. [Q9NYT6-2]
NP_057528.2. NM_016444.2. [Q9NYT6-1]
XP_005259284.1. XM_005259227.2. [Q9NYT6-1]
XP_006723430.1. XM_006723367.3. [Q9NYT6-1]
XP_006723431.1. XM_006723368.3. [Q9NYT6-1]
XP_006723432.1. XM_006723369.2. [Q9NYT6-1]
XP_016882751.1. XM_017027262.1. [Q9NYT6-1]
XP_016882754.1. XM_017027265.1. [Q9NYT6-2]
UniGeneiHs.145956.

3D structure databases

ProteinModelPortaliQ9NYT6.
SMRiQ9NYT6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113552. 3 interactors.
STRINGi9606.ENSP00000336719.

PTM databases

iPTMnetiQ9NYT6.
PhosphoSitePlusiQ9NYT6.

Polymorphism and mutation databases

BioMutaiZNF226.
DMDMi20178347.

Proteomic databases

EPDiQ9NYT6.
MaxQBiQ9NYT6.
PaxDbiQ9NYT6.
PeptideAtlasiQ9NYT6.
PRIDEiQ9NYT6.

Protocols and materials databases

DNASUi7769.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300823; ENSP00000300823; ENSG00000167380. [Q9NYT6-2]
ENST00000337433; ENSP00000336719; ENSG00000167380. [Q9NYT6-1]
ENST00000413984; ENSP00000407474; ENSG00000167380. [Q9NYT6-2]
ENST00000454662; ENSP00000393265; ENSG00000167380. [Q9NYT6-1]
ENST00000588742; ENSP00000467003; ENSG00000167380. [Q9NYT6-2]
ENST00000590089; ENSP00000465121; ENSG00000167380. [Q9NYT6-1]
GeneIDi7769.
KEGGihsa:7769.
UCSCiuc002oyn.4. human. [Q9NYT6-1]

Organism-specific databases

CTDi7769.
GeneCardsiZNF226.
HGNCiHGNC:13019. ZNF226.
HPAiCAB034353.
HPA006145.
neXtProtiNX_Q9NYT6.
OpenTargetsiENSG00000167380.
PharmGKBiPA37598.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129740.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9NYT6.
KOiK09228.
OMAiHRVHKSE.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9NYT6.
TreeFamiTF350845.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167380-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF226. human.
GenomeRNAii7769.
PROiQ9NYT6.

Gene expression databases

BgeeiENSG00000167380.
CleanExiHS_ZNF226.
ExpressionAtlasiQ9NYT6. baseline and differential.
GenevisibleiQ9NYT6. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 19 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 8 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 19 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 17 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN226_HUMAN
AccessioniPrimary (citable) accession number: Q9NYT6
Secondary accession number(s): Q8WWE6, Q96TE6, Q9NS44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: April 16, 2002
Last modified: November 30, 2016
This is version 154 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.