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Protein

Pleckstrin-2

Gene

PLEK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May help orchestrate cytoskeletal arrangement. Contribute to lamellipodia formation.

GO - Biological processi

  • actin cytoskeleton organization Source: ProtInc
  • intracellular signal transduction Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin-2
Gene namesi
Name:PLEK2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:19238. PLEK2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134963543.

Polymorphism and mutation databases

BioMutaiPLEK2.
DMDMi20532216.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 353353Pleckstrin-2PRO_0000053862Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9NYT0.
MaxQBiQ9NYT0.
PaxDbiQ9NYT0.
PRIDEiQ9NYT0.

PTM databases

iPTMnetiQ9NYT0.
PhosphoSiteiQ9NYT0.

Expressioni

Gene expression databases

BgeeiQ9NYT0.
CleanExiHS_PLEK2.
ExpressionAtlasiQ9NYT0. baseline and differential.
GenevisibleiQ9NYT0. HS.

Organism-specific databases

HPAiHPA001208.

Interactioni

Protein-protein interaction databases

BioGridi117708. 4 interactions.
STRINGi9606.ENSP00000216446.

Structurei

Secondary structure

1
353
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi246 – 25712Combined sources
Beta strandi259 – 27517Combined sources
Beta strandi277 – 2815Combined sources
Beta strandi283 – 2853Combined sources
Beta strandi294 – 2963Combined sources
Beta strandi306 – 3094Combined sources
Beta strandi322 – 3243Combined sources
Beta strandi332 – 3343Combined sources
Helixi339 – 35214Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1X1GNMR-A238-353[»]
ProteinModelPortaliQ9NYT0.
SMRiQ9NYT0. Positions 4-95, 129-235, 241-353.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NYT0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 104101PH 1PROSITE-ProRule annotationAdd
BLAST
Domaini139 – 22587DEPPROSITE-ProRule annotationAdd
BLAST
Domaini247 – 353107PH 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 DEP domain.PROSITE-ProRule annotation
Contains 2 PH domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IGI2. Eukaryota.
ENOG410ZHY3. LUCA.
GeneTreeiENSGT00390000006543.
HOGENOMiHOG000294078.
HOVERGENiHBG001361.
InParanoidiQ9NYT0.
KOiK19993.
OMAiHNWKVRW.
OrthoDBiEOG74XS6R.
PhylomeDBiQ9NYT0.
TreeFamiTF332246.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.30.29.30. 2 hits.
InterProiIPR000591. DEP_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00610. DEP. 1 hit.
PF00169. PH. 2 hits.
[Graphical view]
SMARTiSM00049. DEP. 1 hit.
SM00233. PH. 2 hits.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiPS50186. DEP. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NYT0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDGVLKEGF LVKRGHIVHN WKARWFILRQ NTLVYYKLEG GRRVTPPKGR
60 70 80 90 100
ILLDGCTITC PCLEYENRPL LIKLKTQTST EYFLEACSRE ERDAWAFEIT
110 120 130 140 150
GAIHAGQPGK VQQLHSLRNS FKLPPHISLH RIVDKMHDSN TGIRSSPNME
160 170 180 190 200
QGSTYKKTFL GSSLVDWLIS NSFTASRLEA VTLASMLMEE NFLRPVGVRS
210 220 230 240 250
MGAIRSGDLA EQFLDDSTAL YTFAESYKKK ISPKEEISLS TVELSGTVVK
260 270 280 290 300
QGYLAKQGHK RKNWKVRRFV LRKDPAFLHY YDPSKEENRP VGGFSLRGSL
310 320 330 340 350
VSALEDNGVP TGVKGNVQGN LFKVITKDDT HYYIQASSKA ERAEWIEAIK

KLT
Length:353
Mass (Da):39,971
Last modified:October 1, 2000 - v1
Checksum:iCE355BF917F2385E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti80 – 801T → M.
Corresponds to variant rs34300264 [ dbSNP | Ensembl ].
VAR_050504

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF228603 mRNA. Translation: AAF34791.1.
BC001226 mRNA. Translation: AAH01226.1.
BC008056 mRNA. Translation: AAH08056.2.
CCDSiCCDS9782.1.
RefSeqiNP_057529.1. NM_016445.2.
UniGeneiHs.170473.

Genome annotation databases

EnsembliENST00000216446; ENSP00000216446; ENSG00000100558.
GeneIDi26499.
KEGGihsa:26499.
UCSCiuc001xjh.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF228603 mRNA. Translation: AAF34791.1.
BC001226 mRNA. Translation: AAH01226.1.
BC008056 mRNA. Translation: AAH08056.2.
CCDSiCCDS9782.1.
RefSeqiNP_057529.1. NM_016445.2.
UniGeneiHs.170473.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1X1GNMR-A238-353[»]
ProteinModelPortaliQ9NYT0.
SMRiQ9NYT0. Positions 4-95, 129-235, 241-353.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117708. 4 interactions.
STRINGi9606.ENSP00000216446.

PTM databases

iPTMnetiQ9NYT0.
PhosphoSiteiQ9NYT0.

Polymorphism and mutation databases

BioMutaiPLEK2.
DMDMi20532216.

Proteomic databases

EPDiQ9NYT0.
MaxQBiQ9NYT0.
PaxDbiQ9NYT0.
PRIDEiQ9NYT0.

Protocols and materials databases

DNASUi26499.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216446; ENSP00000216446; ENSG00000100558.
GeneIDi26499.
KEGGihsa:26499.
UCSCiuc001xjh.2. human.

Organism-specific databases

CTDi26499.
GeneCardsiPLEK2.
HGNCiHGNC:19238. PLEK2.
HPAiHPA001208.
MIMi608007. gene.
neXtProtiNX_Q9NYT0.
PharmGKBiPA134963543.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGI2. Eukaryota.
ENOG410ZHY3. LUCA.
GeneTreeiENSGT00390000006543.
HOGENOMiHOG000294078.
HOVERGENiHBG001361.
InParanoidiQ9NYT0.
KOiK19993.
OMAiHNWKVRW.
OrthoDBiEOG74XS6R.
PhylomeDBiQ9NYT0.
TreeFamiTF332246.

Miscellaneous databases

ChiTaRSiPLEK2. human.
EvolutionaryTraceiQ9NYT0.
GeneWikiiPLEK2.
GenomeRNAii26499.
NextBioi48764.
PROiQ9NYT0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NYT0.
CleanExiHS_PLEK2.
ExpressionAtlasiQ9NYT0. baseline and differential.
GenevisibleiQ9NYT0. HS.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.30.29.30. 2 hits.
InterProiIPR000591. DEP_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00610. DEP. 1 hit.
PF00169. PH. 2 hits.
[Graphical view]
SMARTiSM00049. DEP. 1 hit.
SM00233. PH. 2 hits.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiPS50186. DEP. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Homo sapiens pleckstrin 2: cloning and characterization."
    Inazu T.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cervix and Ovary.
  3. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. "Solution structure of the C-terminal PH domain of human pleckstrin 2."
    RIKEN structural genomics initiative (RSGI)
    Submitted (OCT-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 238-353.

Entry informationi

Entry nameiPLEK2_HUMAN
AccessioniPrimary (citable) accession number: Q9NYT0
Secondary accession number(s): Q96JT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: October 1, 2000
Last modified: May 11, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.