Q9NYT0 (PLEK2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pleckstrin-2

Gene names

Name:

PLEK2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	353 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May help orchestrate cytoskeletal arrangement. Contribute to lamellipodia formation.
Subcellular location	Cell projection › lamellipodium membrane; Peripheral membrane protein. Cytoplasm › cytoskeleton.
Sequence similarities	Contains 1 DEP domain. Contains 2 PH domains.

Ontologies

Keywords
Cellular component	Cell membrane Cell projection Cytoplasm Cytoskeleton Membrane
Coding sequence diversity	Polymorphism
Domain	Repeat
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	actin cytoskeleton organization Traceable author statement PubMed 10419454. Source: ProtInc intracellular signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell lamellipodium membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	phospholipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 353

353

Pleckstrin-2

PRO_0000053862

Regions

Domain

4 – 104

101

PH 1

Domain

139 – 225

87

DEP

Domain

247 – 353

107

PH 2

Natural variations

Natural variant

80

1

T → M.
Corresponds to variant rs34300264 [ dbSNP | Ensembl ].

VAR_050504

Secondary structure

1

.

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.

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353

Helix Strand Turn

Details...

Beta strand

246 – 257

12

Beta strand

259 – 275

17

Beta strand

277 – 281

5

Beta strand

283 – 285

3

Beta strand

294 – 296

3

Beta strand

306 – 309

4

Beta strand

322 – 324

3

Beta strand

332 – 334

3

Helix

339 – 352

14

Sequences

	Sequence		Length	Mass (Da)
	Q9NYT0 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: CE355BF917F2385E	FASTA	353	39,971
	10 20 30 40 50 60 MEDGVLKEGF LVKRGHIVHN WKARWFILRQ NTLVYYKLEG GRRVTPPKGR ILLDGCTITC 70 80 90 100 110 120 PCLEYENRPL LIKLKTQTST EYFLEACSRE ERDAWAFEIT GAIHAGQPGK VQQLHSLRNS 130 140 150 160 170 180 FKLPPHISLH RIVDKMHDSN TGIRSSPNME QGSTYKKTFL GSSLVDWLIS NSFTASRLEA 190 200 210 220 230 240 VTLASMLMEE NFLRPVGVRS MGAIRSGDLA EQFLDDSTAL YTFAESYKKK ISPKEEISLS 250 260 270 280 290 300 TVELSGTVVK QGYLAKQGHK RKNWKVRRFV LRKDPAFLHY YDPSKEENRP VGGFSLRGSL 310 320 330 340 350 VSALEDNGVP TGVKGNVQGN LFKVITKDDT HYYIQASSKA ERAEWIEAIK KLT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Homo sapiens pleckstrin 2: cloning and characterization." Inazu T. Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Cervix and Ovary.
[3]	"Solution structure of the C-terminal PH domain of human pleckstrin 2." RIKEN structural genomics initiative (RSGI) Submitted (OCT-2005) to the PDB data bank Cited for: STRUCTURE BY NMR OF 238-353.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF228603 mRNA. Translation: AAF34791.1.
BC001226 mRNA. Translation: AAH01226.1.
BC008056 mRNA. Translation: AAH08056.2.

IPI

IPI00009302.

RefSeq

NP_057529.1. NM_016445.1.

UniGene

Hs.170473.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1X1G	NMR	-	A	238-353	[»]

ProteinModelPortal

Q9NYT0.

ModBase

Search...

PTM databases

PhosphoSite

Q9NYT0.

Polymorphism databases

DMDM

20532216.

Proteomic databases

PaxDb

Q9NYT0.

PRIDE

Q9NYT0.

Protocols and materials databases

DNASU

26499.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000216446; ENSP00000216446; ENSG00000100558.

GeneID

26499.

KEGG

hsa:26499.

UCSC

uc001xjh.1. human.

Organism-specific databases

CTD

26499.

GeneCards

GC14M067853.

HGNC

HGNC:19238. PLEK2.

HPA

HPA001208.

MIM

608007. gene.

neXtProt

NX_Q9NYT0.

PharmGKB

PA134963543.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG44162.

HOGENOM

HOG000294078.

HOVERGEN

HBG001361.

InParanoid

Q9NYT0.

OMA

TEYFLEA.

OrthoDB

EOG4F1X3C.

PhylomeDB

Q9NYT0.

Gene expression databases

ArrayExpress

Q9NYT0.

Bgee

Q9NYT0.

CleanEx

HS_PLEK2.

Genevestigator

Q9NYT0.

GermOnline

ENSG00000100558. Homo sapiens.

Family and domain databases

Gene3D

1.10.10.10. 1 hit.
2.30.29.30. 2 hits.

InterPro

IPR000591. DEP_dom.
IPR011993. PH_like_dom.
IPR001849. Pleckstrin_homology.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]

Pfam

PF00610. DEP. 1 hit.
PF00169. PH. 2 hits.
[Graphical view]

SMART

SM00049. DEP. 1 hit.
SM00233. PH. 2 hits.
[Graphical view]

PROSITE

PS50186. DEP. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q9NYT0.

GenomeRNAi

26499.

NextBio

48764.

SOURCE

Search...

Entry information

Entry name

PLEK2_HUMAN

Accession

Primary (citable) accession number: Q9NYT0
Secondary accession number(s): Q96JT0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2002
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 102 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.