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Protein

Pleckstrin-2

Gene

PLEK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May help orchestrate cytoskeletal arrangement. Contribute to lamellipodia formation.

GO - Biological processi

  • actin cytoskeleton organization Source: ProtInc
  • intracellular signal transduction Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100558-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin-2
Gene namesi
Name:PLEK2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:19238. PLEK2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi26499.
OpenTargetsiENSG00000100558.
PharmGKBiPA134963543.

Polymorphism and mutation databases

BioMutaiPLEK2.
DMDMi20532216.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000538621 – 353Pleckstrin-2Add BLAST353

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei120PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9NYT0.
MaxQBiQ9NYT0.
PaxDbiQ9NYT0.
PeptideAtlasiQ9NYT0.
PRIDEiQ9NYT0.

PTM databases

iPTMnetiQ9NYT0.
PhosphoSitePlusiQ9NYT0.

Expressioni

Gene expression databases

BgeeiENSG00000100558.
CleanExiHS_PLEK2.
ExpressionAtlasiQ9NYT0. baseline and differential.
GenevisibleiQ9NYT0. HS.

Organism-specific databases

HPAiHPA001208.

Interactioni

Protein-protein interaction databases

BioGridi117708. 4 interactors.
STRINGi9606.ENSP00000216446.

Structurei

Secondary structure

1353
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi246 – 257Combined sources12
Beta strandi259 – 275Combined sources17
Beta strandi277 – 281Combined sources5
Beta strandi283 – 285Combined sources3
Beta strandi294 – 296Combined sources3
Beta strandi306 – 309Combined sources4
Beta strandi322 – 324Combined sources3
Beta strandi332 – 334Combined sources3
Helixi339 – 352Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X1GNMR-A238-353[»]
ProteinModelPortaliQ9NYT0.
SMRiQ9NYT0.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NYT0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 104PH 1PROSITE-ProRule annotationAdd BLAST101
Domaini139 – 225DEPPROSITE-ProRule annotationAdd BLAST87
Domaini247 – 353PH 2PROSITE-ProRule annotationAdd BLAST107

Sequence similaritiesi

Contains 1 DEP domain.PROSITE-ProRule annotation
Contains 2 PH domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IGI2. Eukaryota.
ENOG410ZHY3. LUCA.
GeneTreeiENSGT00390000006543.
HOGENOMiHOG000294078.
HOVERGENiHBG001361.
InParanoidiQ9NYT0.
KOiK19993.
OMAiHNWKVRW.
OrthoDBiEOG091G09EY.
PhylomeDBiQ9NYT0.
TreeFamiTF332246.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.30.29.30. 2 hits.
InterProiIPR000591. DEP_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00610. DEP. 1 hit.
PF00169. PH. 2 hits.
[Graphical view]
SMARTiSM00049. DEP. 1 hit.
SM00233. PH. 2 hits.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiPS50186. DEP. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NYT0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDGVLKEGF LVKRGHIVHN WKARWFILRQ NTLVYYKLEG GRRVTPPKGR
60 70 80 90 100
ILLDGCTITC PCLEYENRPL LIKLKTQTST EYFLEACSRE ERDAWAFEIT
110 120 130 140 150
GAIHAGQPGK VQQLHSLRNS FKLPPHISLH RIVDKMHDSN TGIRSSPNME
160 170 180 190 200
QGSTYKKTFL GSSLVDWLIS NSFTASRLEA VTLASMLMEE NFLRPVGVRS
210 220 230 240 250
MGAIRSGDLA EQFLDDSTAL YTFAESYKKK ISPKEEISLS TVELSGTVVK
260 270 280 290 300
QGYLAKQGHK RKNWKVRRFV LRKDPAFLHY YDPSKEENRP VGGFSLRGSL
310 320 330 340 350
VSALEDNGVP TGVKGNVQGN LFKVITKDDT HYYIQASSKA ERAEWIEAIK

KLT
Length:353
Mass (Da):39,971
Last modified:October 1, 2000 - v1
Checksum:iCE355BF917F2385E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05050480T → M.Corresponds to variant rs34300264dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF228603 mRNA. Translation: AAF34791.1.
BC001226 mRNA. Translation: AAH01226.1.
BC008056 mRNA. Translation: AAH08056.2.
CCDSiCCDS9782.1.
RefSeqiNP_057529.1. NM_016445.2.
UniGeneiHs.170473.

Genome annotation databases

EnsembliENST00000216446; ENSP00000216446; ENSG00000100558.
GeneIDi26499.
KEGGihsa:26499.
UCSCiuc001xjh.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF228603 mRNA. Translation: AAF34791.1.
BC001226 mRNA. Translation: AAH01226.1.
BC008056 mRNA. Translation: AAH08056.2.
CCDSiCCDS9782.1.
RefSeqiNP_057529.1. NM_016445.2.
UniGeneiHs.170473.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X1GNMR-A238-353[»]
ProteinModelPortaliQ9NYT0.
SMRiQ9NYT0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117708. 4 interactors.
STRINGi9606.ENSP00000216446.

PTM databases

iPTMnetiQ9NYT0.
PhosphoSitePlusiQ9NYT0.

Polymorphism and mutation databases

BioMutaiPLEK2.
DMDMi20532216.

Proteomic databases

EPDiQ9NYT0.
MaxQBiQ9NYT0.
PaxDbiQ9NYT0.
PeptideAtlasiQ9NYT0.
PRIDEiQ9NYT0.

Protocols and materials databases

DNASUi26499.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216446; ENSP00000216446; ENSG00000100558.
GeneIDi26499.
KEGGihsa:26499.
UCSCiuc001xjh.2. human.

Organism-specific databases

CTDi26499.
DisGeNETi26499.
GeneCardsiPLEK2.
HGNCiHGNC:19238. PLEK2.
HPAiHPA001208.
MIMi608007. gene.
neXtProtiNX_Q9NYT0.
OpenTargetsiENSG00000100558.
PharmGKBiPA134963543.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGI2. Eukaryota.
ENOG410ZHY3. LUCA.
GeneTreeiENSGT00390000006543.
HOGENOMiHOG000294078.
HOVERGENiHBG001361.
InParanoidiQ9NYT0.
KOiK19993.
OMAiHNWKVRW.
OrthoDBiEOG091G09EY.
PhylomeDBiQ9NYT0.
TreeFamiTF332246.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100558-MONOMER.

Miscellaneous databases

ChiTaRSiPLEK2. human.
EvolutionaryTraceiQ9NYT0.
GeneWikiiPLEK2.
GenomeRNAii26499.
PROiQ9NYT0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100558.
CleanExiHS_PLEK2.
ExpressionAtlasiQ9NYT0. baseline and differential.
GenevisibleiQ9NYT0. HS.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.30.29.30. 2 hits.
InterProiIPR000591. DEP_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00610. DEP. 1 hit.
PF00169. PH. 2 hits.
[Graphical view]
SMARTiSM00049. DEP. 1 hit.
SM00233. PH. 2 hits.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiPS50186. DEP. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLEK2_HUMAN
AccessioniPrimary (citable) accession number: Q9NYT0
Secondary accession number(s): Q96JT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.