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Protein

WD repeat and SOCS box-containing protein 2

Gene

WSB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

SignaLinkiQ9NYS7.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat and SOCS box-containing protein 2
Short name:
WSB-2
Alternative name(s):
CS box-containing WD protein
Gene namesi
Name:WSB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:19222. WSB2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128395787.

Polymorphism and mutation databases

DMDMi20532294.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 404404WD repeat and SOCS box-containing protein 2PRO_0000051460Add
BLAST

Proteomic databases

PaxDbiQ9NYS7.
PRIDEiQ9NYS7.

PTM databases

PhosphoSiteiQ9NYS7.

Expressioni

Gene expression databases

BgeeiQ9NYS7.
CleanExiHS_WSB2.
ExpressionAtlasiQ9NYS7. baseline and differential.
GenevisibleiQ9NYS7. HS.

Organism-specific databases

HPAiHPA052606.

Interactioni

Protein-protein interaction databases

BioGridi120976. 23 interactions.
IntActiQ9NYS7. 21 interactions.
MINTiMINT-1379403.
STRINGi9606.ENSP00000319474.

Structurei

3D structure databases

ProteinModelPortaliQ9NYS7.
SMRiQ9NYS7. Positions 26-360.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati16 – 5540WD 1Add
BLAST
Repeati81 – 14060WD 2Add
BLAST
Repeati144 – 18340WD 3Add
BLAST
Repeati188 – 22639WD 4Add
BLAST
Repeati230 – 26839WD 5Add
BLAST
Repeati283 – 32240WD 6Add
BLAST
Repeati325 – 36238WD 7Add
BLAST
Domaini356 – 40449SOCS boxPROSITE-ProRule annotationAdd
BLAST

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.By similarity

Sequence similaritiesi

Contains 1 SOCS box domain.PROSITE-ProRule annotation
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0266. Eukaryota.
ENOG410XP3K. LUCA.
GeneTreeiENSGT00830000128308.
HOGENOMiHOG000063727.
HOVERGENiHBG034543.
InParanoidiQ9NYS7.
KOiK10342.
OMAiQVPDVSC.
OrthoDBiEOG7J17ZP.
PhylomeDBiQ9NYS7.
TreeFamiTF329216.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR001496. SOCS_box.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF07525. SOCS_box. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
SM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF50978. SSF50978. 1 hit.
PROSITEiPS50225. SOCS. 1 hit.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NYS7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAGEEPLLL AELKPGRPHQ FDWKSSCETW SVAFSPDGSW FAWSQGHCIV
60 70 80 90 100
KLIPWPLEEQ FIPKGFEAKS RSSKNETKGR GSPKEKTLDC GQIVWGLAFS
110 120 130 140 150
PWPSPPSRKL WARHHPQVPD VSCLVLATGL NDGQIKIWEV QTGLLLLNLS
160 170 180 190 200
GHQDVVRDLS FTPSGSLILV SASRDKTLRI WDLNKHGKQI QVLSGHLQWV
210 220 230 240 250
YCCSISPDCS MLCSAAGEKS VFLWSMRSYT LIRKLEGHQS SVVSCDFSPD
260 270 280 290 300
SALLVTASYD TNVIMWDPYT GERLRSLHHT QVDPAMDDSD VHISSLRSVC
310 320 330 340 350
FSPEGLYLAT VADDRLLRIW ALELKTPIAF APMTNGLCCT FFPHGGVIAT
360 370 380 390 400
GTRDGHVQFW TAPRVLSSLK HLCRKALRSF LTTYQVLALP IPKKMKEFLT

YRTF
Length:404
Mass (Da):45,286
Last modified:October 1, 2000 - v1
Checksum:i97EFC9CDE447E019
GO
Isoform 2 (identifier: Q9NYS7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: MEAG → MRVDRESRFLRGTGTGEAVAV

Note: No experimental confirmation available.
Show »
Length:421
Mass (Da):47,187
Checksum:iDEE4E3C72B2B33D7
GO
Isoform 3 (identifier: Q9NYS7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-210: Missing.

Note: No experimental confirmation available.
Show »
Length:194
Mass (Da):21,809
Checksum:iEC5F4E31349F94C7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51E → K in AAF80478 (Ref. 2) Curated
Sequence conflicti101 – 1033PWP → LCL in AAF80478 (Ref. 2) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 210210Missing in isoform 3. 1 PublicationVSP_054576Add
BLAST
Alternative sequencei1 – 44MEAG → MRVDRESRFLRGTGTGEAVA V in isoform 2. 1 PublicationVSP_054016

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF229181 mRNA. Translation: AAF71302.1.
AF163324 mRNA. Translation: AAF80478.1.
AK295555 mRNA. Translation: BAG58458.1.
AK298513 mRNA. Translation: BAG60718.1.
AC131159 Genomic DNA. No translation available.
AC131238 Genomic DNA. No translation available.
BC015887 mRNA. Translation: AAH15887.1.
CCDSiCCDS61251.1. [Q9NYS7-3]
CCDS61252.1. [Q9NYS7-2]
CCDS9186.1. [Q9NYS7-1]
RefSeqiNP_001265486.1. NM_001278557.1. [Q9NYS7-2]
NP_001265487.1. NM_001278558.1. [Q9NYS7-3]
NP_061109.1. NM_018639.4. [Q9NYS7-1]
UniGeneiHs.506985.

Genome annotation databases

EnsembliENST00000315436; ENSP00000319474; ENSG00000176871. [Q9NYS7-1]
ENST00000441406; ENSP00000409131; ENSG00000176871. [Q9NYS7-2]
ENST00000544233; ENSP00000444431; ENSG00000176871. [Q9NYS7-3]
GeneIDi55884.
KEGGihsa:55884.
UCSCiuc001twr.4. human. [Q9NYS7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF229181 mRNA. Translation: AAF71302.1.
AF163324 mRNA. Translation: AAF80478.1.
AK295555 mRNA. Translation: BAG58458.1.
AK298513 mRNA. Translation: BAG60718.1.
AC131159 Genomic DNA. No translation available.
AC131238 Genomic DNA. No translation available.
BC015887 mRNA. Translation: AAH15887.1.
CCDSiCCDS61251.1. [Q9NYS7-3]
CCDS61252.1. [Q9NYS7-2]
CCDS9186.1. [Q9NYS7-1]
RefSeqiNP_001265486.1. NM_001278557.1. [Q9NYS7-2]
NP_001265487.1. NM_001278558.1. [Q9NYS7-3]
NP_061109.1. NM_018639.4. [Q9NYS7-1]
UniGeneiHs.506985.

3D structure databases

ProteinModelPortaliQ9NYS7.
SMRiQ9NYS7. Positions 26-360.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120976. 23 interactions.
IntActiQ9NYS7. 21 interactions.
MINTiMINT-1379403.
STRINGi9606.ENSP00000319474.

PTM databases

PhosphoSiteiQ9NYS7.

Polymorphism and mutation databases

DMDMi20532294.

Proteomic databases

PaxDbiQ9NYS7.
PRIDEiQ9NYS7.

Protocols and materials databases

DNASUi55884.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315436; ENSP00000319474; ENSG00000176871. [Q9NYS7-1]
ENST00000441406; ENSP00000409131; ENSG00000176871. [Q9NYS7-2]
ENST00000544233; ENSP00000444431; ENSG00000176871. [Q9NYS7-3]
GeneIDi55884.
KEGGihsa:55884.
UCSCiuc001twr.4. human. [Q9NYS7-1]

Organism-specific databases

CTDi55884.
GeneCardsiWSB2.
HGNCiHGNC:19222. WSB2.
HPAiHPA052606.
neXtProtiNX_Q9NYS7.
PharmGKBiPA128395787.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0266. Eukaryota.
ENOG410XP3K. LUCA.
GeneTreeiENSGT00830000128308.
HOGENOMiHOG000063727.
HOVERGENiHBG034543.
InParanoidiQ9NYS7.
KOiK10342.
OMAiQVPDVSC.
OrthoDBiEOG7J17ZP.
PhylomeDBiQ9NYS7.
TreeFamiTF329216.

Enzyme and pathway databases

UniPathwayiUPA00143.
SignaLinkiQ9NYS7.

Miscellaneous databases

ChiTaRSiWSB2. human.
GenomeRNAii55884.
PROiQ9NYS7.

Gene expression databases

BgeeiQ9NYS7.
CleanExiHS_WSB2.
ExpressionAtlasiQ9NYS7. baseline and differential.
GenevisibleiQ9NYS7. HS.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR001496. SOCS_box.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF07525. SOCS_box. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
SM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF50978. SSF50978. 1 hit.
PROSITEiPS50225. SOCS. 1 hit.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning of a up-regulated SOCS box-containing WD protein in human colonic cancer cells induced by sodium butyrate."
    Li F., Song J.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Colon carcinoma.
  2. "Human full-length cDNA cloned from NB4 cell line induced from all trans retinoid acid."
    Zhang J.W., Liu T.X., Tao J.
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Hippocampus.
  4. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Uterus.

Entry informationi

Entry nameiWSB2_HUMAN
AccessioniPrimary (citable) accession number: Q9NYS7
Secondary accession number(s): B4DIE6, B4DPV6, Q9NRX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: October 1, 2000
Last modified: June 8, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.