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Q9NYS0

- KBRS1_HUMAN

UniProt

Q9NYS0 - KBRS1_HUMAN

Protein

NF-kappa-B inhibitor-interacting Ras-like protein 1

Gene

NKIRAS1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.3 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 188GTPBy similarity
    Nucleotide bindingi61 – 655GTPBy similarity
    Nucleotide bindingi120 – 1234GTPBy similarity

    GO - Molecular functioni

    1. GTPase activity Source: UniProtKB
    2. GTP binding Source: UniProtKB-KW

    GO - Biological processi

    1. I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
    2. small GTPase mediated signal transduction Source: InterPro

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiQ9NYS0.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NF-kappa-B inhibitor-interacting Ras-like protein 1
    Alternative name(s):
    I-kappa-B-interacting Ras-like protein 1
    Short name:
    Kappa B-Ras protein 1
    Short name:
    KappaB-Ras1
    Gene namesi
    Name:NKIRAS1
    Synonyms:KBRAS1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:17899. NKIRAS1.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. membrane Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi38 – 381T → A: Loss of function. 1 Publication

    Organism-specific databases

    PharmGKBiPA134958823.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 192192NF-kappa-B inhibitor-interacting Ras-like protein 1PRO_0000225675Add
    BLAST

    Proteomic databases

    MaxQBiQ9NYS0.
    PaxDbiQ9NYS0.
    PRIDEiQ9NYS0.

    PTM databases

    PhosphoSiteiQ9NYS0.

    Expressioni

    Tissue specificityi

    Widely expressed.1 Publication

    Gene expression databases

    ArrayExpressiQ9NYS0.
    BgeeiQ9NYS0.
    CleanExiHS_NKIRAS1.
    GenevestigatoriQ9NYS0.

    Interactioni

    Subunit structurei

    Interacts with both NF-kappa-B inhibitor alpha (NFKBIA) and beta (NFKBIB) in vitro. However, it probably only interacts with NFKBIB in vivo. Forms a complex with NFKBIB and NF-kappa-B heterodimer (p50/NFKB1 and p65/RELA). Also interacts with c-Rel (REL).3 Publications

    Protein-protein interaction databases

    BioGridi118389. 4 interactions.
    IntActiQ9NYS0. 1 interaction.
    STRINGi9606.ENSP00000373411.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NYS0.
    SMRiQ9NYS0. Positions 6-170.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni58 – 9336Interactions with NFKBIA and NFKBIBAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi35 – 439Effector region

    Domaini

    In contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the conserved Gly and Gln residues in positions 13 and 65, which are replaced by Leu residues, and are therefore similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family are clearly different from other small GTPases proteins.

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG302793.
    HOGENOMiHOG000230991.
    HOVERGENiHBG105089.
    InParanoidiQ9NYS0.
    KOiK17197.
    OMAiPKHYFSV.
    OrthoDBiEOG70KGQS.
    PhylomeDBiQ9NYS0.
    TreeFamiTF314483.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR020849. Small_GTPase_Ras.
    [Graphical view]
    PANTHERiPTHR24070. PTHR24070. 1 hit.
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NYS0-1 [UniParc]FASTAAdd to Basket

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    MGKGCKVVVC GLLSVGKTAI LEQLLYGNHT IGMEDCETME DVYMASVETD    50
    RGVKEQLHLY DTRGLQEGVE LPKHYFSFAD GFVLVYSVNN LESFQRVELL 100
    KKEIDKFKDK KEVAIVVLGN KIDLSEQRQV DAEVAQQWAK SEKVRLWEVT 150
    VTDRKTLIEP FTLLASKLSQ PQSKSSFPLP GRKNKGNSNS EN 192
    Length:192
    Mass (Da):21,643
    Last modified:October 1, 2000 - v1
    Checksum:i84948448BE0853B0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti95 – 951Q → R in BAB55341. (PubMed:14702039)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF229839 mRNA. Translation: AAF34998.1.
    AK027749 mRNA. Translation: BAB55341.1.
    DQ314881 Genomic DNA. Translation: ABC40740.1.
    BC066940 mRNA. Translation: AAH66940.1.
    BC012145 mRNA. Translation: AAH12145.1.
    CCDSiCCDS33717.1.
    RefSeqiNP_065078.1. NM_020345.3.
    XP_005265133.1. XM_005265076.1.
    XP_005265134.1. XM_005265077.2.
    XP_005265135.1. XM_005265078.1.
    UniGeneiHs.173202.

    Genome annotation databases

    EnsembliENST00000388759; ENSP00000373411; ENSG00000197885.
    ENST00000416026; ENSP00000394214; ENSG00000197885.
    ENST00000421515; ENSP00000392307; ENSG00000197885.
    ENST00000425478; ENSP00000400385; ENSG00000197885.
    ENST00000443659; ENSP00000393785; ENSG00000197885.
    GeneIDi28512.
    KEGGihsa:28512.
    UCSCiuc003ccj.3. human.

    Polymorphism databases

    DMDMi74753075.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF229839 mRNA. Translation: AAF34998.1 .
    AK027749 mRNA. Translation: BAB55341.1 .
    DQ314881 Genomic DNA. Translation: ABC40740.1 .
    BC066940 mRNA. Translation: AAH66940.1 .
    BC012145 mRNA. Translation: AAH12145.1 .
    CCDSi CCDS33717.1.
    RefSeqi NP_065078.1. NM_020345.3.
    XP_005265133.1. XM_005265076.1.
    XP_005265134.1. XM_005265077.2.
    XP_005265135.1. XM_005265078.1.
    UniGenei Hs.173202.

    3D structure databases

    ProteinModelPortali Q9NYS0.
    SMRi Q9NYS0. Positions 6-170.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118389. 4 interactions.
    IntActi Q9NYS0. 1 interaction.
    STRINGi 9606.ENSP00000373411.

    PTM databases

    PhosphoSitei Q9NYS0.

    Polymorphism databases

    DMDMi 74753075.

    Proteomic databases

    MaxQBi Q9NYS0.
    PaxDbi Q9NYS0.
    PRIDEi Q9NYS0.

    Protocols and materials databases

    DNASUi 28512.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000388759 ; ENSP00000373411 ; ENSG00000197885 .
    ENST00000416026 ; ENSP00000394214 ; ENSG00000197885 .
    ENST00000421515 ; ENSP00000392307 ; ENSG00000197885 .
    ENST00000425478 ; ENSP00000400385 ; ENSG00000197885 .
    ENST00000443659 ; ENSP00000393785 ; ENSG00000197885 .
    GeneIDi 28512.
    KEGGi hsa:28512.
    UCSCi uc003ccj.3. human.

    Organism-specific databases

    CTDi 28512.
    GeneCardsi GC03M023933.
    HGNCi HGNC:17899. NKIRAS1.
    MIMi 604496. gene.
    neXtProti NX_Q9NYS0.
    PharmGKBi PA134958823.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG302793.
    HOGENOMi HOG000230991.
    HOVERGENi HBG105089.
    InParanoidi Q9NYS0.
    KOi K17197.
    OMAi PKHYFSV.
    OrthoDBi EOG70KGQS.
    PhylomeDBi Q9NYS0.
    TreeFami TF314483.

    Enzyme and pathway databases

    SignaLinki Q9NYS0.

    Miscellaneous databases

    ChiTaRSi NKIRAS1. human.
    GenomeRNAii 28512.
    NextBioi 50976.
    PROi Q9NYS0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NYS0.
    Bgeei Q9NYS0.
    CleanExi HS_NKIRAS1.
    Genevestigatori Q9NYS0.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR020849. Small_GTPase_Ras.
    [Graphical view ]
    PANTHERi PTHR24070. PTHR24070. 1 hit.
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A subclass of Ras proteins that regulate the degradation of IkappaB."
      Fenwick C., Na S.-Y., Voll R.E., Zhong H., Im S.-Y., Lee J.W., Ghosh S.
      Science 287:869-873(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, GTP-BINDING, INTERACTION WITH NFKBIA AND NFKBIB.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    3. NHLBI resequencing and genotyping service (RS&G)
      Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Lung.
    5. "KappaB-Ras binds to the unique insert within the ankyrin repeat domain of IkappaBbeta and regulates cytoplasmic retention of IkappaBbeta.NF-kappaB complexes."
      Chen Y., Wu J., Ghosh G.
      J. Biol. Chem. 278:23101-23106(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH NFKBIB.
    6. "Inhibition of NF-kappaB activity by IkappaBbeta in association with kappaB-Ras."
      Chen Y., Vallee S., Wu J., Vu D., Sondek J., Ghosh G.
      Mol. Cell. Biol. 24:3048-3056(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH REL, MUTAGENESIS OF THR-38.

    Entry informationi

    Entry nameiKBRS1_HUMAN
    AccessioniPrimary (citable) accession number: Q9NYS0
    Secondary accession number(s): Q96K18
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3