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Q9NYR9

- KBRS2_HUMAN

UniProt

Q9NYR9 - KBRS2_HUMAN

Protein

NF-kappa-B inhibitor-interacting Ras-like protein 2

Gene

NKIRAS2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 188GTPBy similarity
    Nucleotide bindingi61 – 655GTPBy similarity
    Nucleotide bindingi120 – 1234GTPBy similarity

    GO - Molecular functioni

    1. GTPase activity Source: UniProtKB
    2. GTP binding Source: UniProtKB-KW

    GO - Biological processi

    1. I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
    2. small GTPase mediated signal transduction Source: InterPro

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NF-kappa-B inhibitor-interacting Ras-like protein 2
    Alternative name(s):
    I-kappa-B-interacting Ras-like protein 2
    Short name:
    Kappa B-Ras protein 2
    Short name:
    KappaB-Ras2
    Gene namesi
    Name:NKIRAS2
    Synonyms:KBRAS2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:17898. NKIRAS2.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. membrane Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134968907.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 191191NF-kappa-B inhibitor-interacting Ras-like protein 2PRO_0000225679Add
    BLAST

    Proteomic databases

    MaxQBiQ9NYR9.
    PaxDbiQ9NYR9.
    PRIDEiQ9NYR9.

    PTM databases

    PhosphoSiteiQ9NYR9.

    Expressioni

    Tissue specificityi

    Widely expressed.1 Publication

    Gene expression databases

    ArrayExpressiQ9NYR9.
    BgeeiQ9NYR9.
    CleanExiHS_NKIRAS2.
    GenevestigatoriQ9NYR9.

    Interactioni

    Subunit structurei

    Interacts with both NF-kappa-B inhibitor alpha (NFKBIA) and beta (NFKBIB) in vitro. However, it probably only interacts with NFKBIB in vivo.1 Publication

    Protein-protein interaction databases

    BioGridi118388. 4 interactions.
    IntActiQ9NYR9. 3 interactions.
    MINTiMINT-6945136.
    STRINGi9606.ENSP00000303580.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NYR9.
    SMRiQ9NYR9. Positions 6-155.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 191191Small GTPase-likeAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi35 – 439Effector region

    Domaini

    In contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the conserved Gly and Gln residues in positions 13 and 65, which are replaced by Ala and Leu residues, respectively, and are therefore similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family are clearly different from other small GTPases proteins.

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG302793.
    HOGENOMiHOG000230991.
    HOVERGENiHBG105089.
    KOiK17197.
    PhylomeDBiQ9NYR9.
    TreeFamiTF314483.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR020849. Small_GTPase_Ras.
    [Graphical view]
    PANTHERiPTHR24070. PTHR24070. 1 hit.
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NYR9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGKSCKVVVC GQASVGKTSI LEQLLYGNHV VGSEMIETQE DIYVGSIETD    50
    RGVREQVRFY DTRGLRDGAE LPRHCFSCTD GYVLVYSTDS RESFQRVELL 100
    KKEIDKSKDK KEVTIVVLGN KCDLQEQRRV DPDVAQHWAK SEKVKLWEVS 150
    VADRRSLLEP FVYLASKMTQ PQSKSAFPLS RKNKGSGSLD G 191
    Length:191
    Mass (Da):21,508
    Last modified:October 1, 2000 - v1
    Checksum:i27429230DA563342
    GO
    Isoform 2 (identifier: Q9NYR9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         33-34: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:189
    Mass (Da):21,292
    Checksum:i4857EEA02F788F38
    GO
    Isoform 3 (identifier: Q9NYR9-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         57-112: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:135
    Mass (Da):14,910
    Checksum:i8B874EC8C7EF28E4
    GO
    Isoform 4 (identifier: Q9NYR9-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         57-97: VRFYDTRGLR...TDSRESFQRV → IAESLFSVWS...TSVTYRSSGV
         98-191: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:97
    Mass (Da):10,770
    Checksum:i4049375BE44AF8A5
    GO

    Sequence cautioni

    The sequence BAB55006.1 differs from that shown. Reason: Absence of residues from position 133 within an exon that change the frame which is not the result of an alternative splicing.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei33 – 342Missing in isoform 2. 1 PublicationVSP_017412
    Alternative sequencei57 – 11256Missing in isoform 3. 1 PublicationVSP_043151Add
    BLAST
    Alternative sequencei57 – 9741VRFYD…SFQRV → IAESLFSVWSCSRRRLTNPR TRRRSPSWSLATSVTYRSSG V in isoform 4. 1 PublicationVSP_044873Add
    BLAST
    Alternative sequencei98 – 19194Missing in isoform 4. 1 PublicationVSP_044874Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF229840 mRNA. Translation: AAF34999.1.
    AK027265 mRNA. Translation: BAB55006.1. Sequence problems.
    AK054571 mRNA. Translation: BAG51392.1.
    AK297975 mRNA. Translation: BAG60285.1.
    DB126967 mRNA. No translation available.
    AL137682 mRNA. Translation: CAB70873.2.
    DQ314882 Genomic DNA. Translation: ABC40741.1.
    AC105024 Genomic DNA. No translation available.
    CH471152 Genomic DNA. Translation: EAW60791.1.
    BC007450 mRNA. Translation: AAH07450.1.
    BC063498 mRNA. Translation: AAH63498.1.
    CCDSiCCDS11415.1. [Q9NYR9-1]
    CCDS45679.1. [Q9NYR9-3]
    CCDS45680.1. [Q9NYR9-4]
    PIRiT46440.
    RefSeqiNP_001001349.1. NM_001001349.2. [Q9NYR9-1]
    NP_001138399.1. NM_001144927.1. [Q9NYR9-1]
    NP_001138400.1. NM_001144928.1. [Q9NYR9-3]
    NP_001138401.1. NM_001144929.1. [Q9NYR9-4]
    NP_060065.2. NM_017595.5. [Q9NYR9-1]
    XP_005257308.1. XM_005257251.1. [Q9NYR9-1]
    UniGeneiHs.632252.

    Genome annotation databases

    EnsembliENST00000307641; ENSP00000303580; ENSG00000168256. [Q9NYR9-1]
    ENST00000393880; ENSP00000377458; ENSG00000168256. [Q9NYR9-1]
    ENST00000393881; ENSP00000377459; ENSG00000168256. [Q9NYR9-1]
    ENST00000393885; ENSP00000377463; ENSG00000168256. [Q9NYR9-1]
    ENST00000449471; ENSP00000401976; ENSG00000168256. [Q9NYR9-3]
    ENST00000479407; ENSP00000465633; ENSG00000168256. [Q9NYR9-4]
    GeneIDi28511.
    KEGGihsa:28511.
    UCSCiuc002hyq.3. human. [Q9NYR9-1]
    uc010wge.2. human. [Q9NYR9-3]

    Polymorphism databases

    DMDMi74734716.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF229840 mRNA. Translation: AAF34999.1 .
    AK027265 mRNA. Translation: BAB55006.1 . Sequence problems.
    AK054571 mRNA. Translation: BAG51392.1 .
    AK297975 mRNA. Translation: BAG60285.1 .
    DB126967 mRNA. No translation available.
    AL137682 mRNA. Translation: CAB70873.2 .
    DQ314882 Genomic DNA. Translation: ABC40741.1 .
    AC105024 Genomic DNA. No translation available.
    CH471152 Genomic DNA. Translation: EAW60791.1 .
    BC007450 mRNA. Translation: AAH07450.1 .
    BC063498 mRNA. Translation: AAH63498.1 .
    CCDSi CCDS11415.1. [Q9NYR9-1 ]
    CCDS45679.1. [Q9NYR9-3 ]
    CCDS45680.1. [Q9NYR9-4 ]
    PIRi T46440.
    RefSeqi NP_001001349.1. NM_001001349.2. [Q9NYR9-1 ]
    NP_001138399.1. NM_001144927.1. [Q9NYR9-1 ]
    NP_001138400.1. NM_001144928.1. [Q9NYR9-3 ]
    NP_001138401.1. NM_001144929.1. [Q9NYR9-4 ]
    NP_060065.2. NM_017595.5. [Q9NYR9-1 ]
    XP_005257308.1. XM_005257251.1. [Q9NYR9-1 ]
    UniGenei Hs.632252.

    3D structure databases

    ProteinModelPortali Q9NYR9.
    SMRi Q9NYR9. Positions 6-155.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118388. 4 interactions.
    IntActi Q9NYR9. 3 interactions.
    MINTi MINT-6945136.
    STRINGi 9606.ENSP00000303580.

    PTM databases

    PhosphoSitei Q9NYR9.

    Polymorphism databases

    DMDMi 74734716.

    Proteomic databases

    MaxQBi Q9NYR9.
    PaxDbi Q9NYR9.
    PRIDEi Q9NYR9.

    Protocols and materials databases

    DNASUi 28511.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000307641 ; ENSP00000303580 ; ENSG00000168256 . [Q9NYR9-1 ]
    ENST00000393880 ; ENSP00000377458 ; ENSG00000168256 . [Q9NYR9-1 ]
    ENST00000393881 ; ENSP00000377459 ; ENSG00000168256 . [Q9NYR9-1 ]
    ENST00000393885 ; ENSP00000377463 ; ENSG00000168256 . [Q9NYR9-1 ]
    ENST00000449471 ; ENSP00000401976 ; ENSG00000168256 . [Q9NYR9-3 ]
    ENST00000479407 ; ENSP00000465633 ; ENSG00000168256 . [Q9NYR9-4 ]
    GeneIDi 28511.
    KEGGi hsa:28511.
    UCSCi uc002hyq.3. human. [Q9NYR9-1 ]
    uc010wge.2. human. [Q9NYR9-3 ]

    Organism-specific databases

    CTDi 28511.
    GeneCardsi GC17P040170.
    HGNCi HGNC:17898. NKIRAS2.
    MIMi 604497. gene.
    neXtProti NX_Q9NYR9.
    PharmGKBi PA134968907.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG302793.
    HOGENOMi HOG000230991.
    HOVERGENi HBG105089.
    KOi K17197.
    PhylomeDBi Q9NYR9.
    TreeFami TF314483.

    Miscellaneous databases

    ChiTaRSi NKIRAS2. human.
    GeneWikii NKIRAS2.
    GenomeRNAii 28511.
    NextBioi 50970.
    PROi Q9NYR9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NYR9.
    Bgeei Q9NYR9.
    CleanExi HS_NKIRAS2.
    Genevestigatori Q9NYR9.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR020849. Small_GTPase_Ras.
    [Graphical view ]
    PANTHERi PTHR24070. PTHR24070. 1 hit.
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A subclass of Ras proteins that regulate the degradation of IkappaB."
      Fenwick C., Na S.-Y., Voll R.E., Zhong H., Im S.-Y., Lee J.W., Ghosh S.
      Science 287:869-873(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INTERACTION WITH NFKBIA AND NFKBIB.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).
      Tissue: Embryo and Thymus.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.
    4. NHLBI resequencing and genotyping service (RS&G)
      Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain and Muscle.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiKBRS2_HUMAN
    AccessioniPrimary (citable) accession number: Q9NYR9
    Secondary accession number(s): A6NCZ5
    , B3KNN0, B4DNM3, Q6PK52, Q96KC7, Q9NSX1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3