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Protein

Protocadherin Fat 2

Gene

FAT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the migration of epidermal cells. May modulate the extracellular space surronding parallel fibers of cerebellar during development (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • epithelial cell migration Source: UniProtKB
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000086570-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin Fat 2
Short name:
hFat2
Alternative name(s):
Cadherin family member 8
Multiple epidermal growth factor-like domains protein 1
Short name:
Multiple EGF-like domains protein 1
Gene namesi
Name:FAT2
Synonyms:CDHF8, KIAA0811, MEGF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:3596. FAT2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 4048ExtracellularSequence analysisAdd BLAST4030
Transmembranei4049 – 4069HelicalSequence analysisAdd BLAST21
Topological domaini4070 – 4349CytoplasmicSequence analysisAdd BLAST280

GO - Cellular componenti

  • cell-cell adherens junction Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • nucleus Source: UniProtKB-SubCell
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi2196.
OpenTargetsiENSG00000086570.
PharmGKBiPA28009.

Polymorphism and mutation databases

BioMutaiFAT2.
DMDMi296434503.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000000401819 – 4349Protocadherin Fat 2Add BLAST4331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi39N-linked (GlcNAc...)Sequence analysis1
Glycosylationi210N-linked (GlcNAc...)Sequence analysis1
Glycosylationi280N-linked (GlcNAc...)Sequence analysis1
Glycosylationi330N-linked (GlcNAc...)Sequence analysis1
Glycosylationi459N-linked (GlcNAc...)Sequence analysis1
Glycosylationi568N-linked (GlcNAc...)Sequence analysis1
Glycosylationi627N-linked (GlcNAc...)Sequence analysis1
Glycosylationi655N-linked (GlcNAc...)Sequence analysis1
Glycosylationi789N-linked (GlcNAc...)Sequence analysis1
Glycosylationi996N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1175N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1383N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1417N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1904N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1998N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2007N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2165N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2183N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2325N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2368N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2387N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2430N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2470N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2547N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2597N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2654N-linked (GlcNAc...)Sequence analysis1
Glycosylationi3125N-linked (GlcNAc...)Sequence analysis1
Glycosylationi3276N-linked (GlcNAc...)Sequence analysis1
Glycosylationi3310N-linked (GlcNAc...)Sequence analysis1
Glycosylationi3430N-linked (GlcNAc...)Sequence analysis1
Glycosylationi3471N-linked (GlcNAc...)Sequence analysis1
Glycosylationi3601N-linked (GlcNAc...)Sequence analysis1
Glycosylationi3772N-linked (GlcNAc...)Sequence analysis1
Glycosylationi3813N-linked (GlcNAc...)Sequence analysis1
Glycosylationi3840N-linked (GlcNAc...)Sequence analysis1
Glycosylationi3873N-linked (GlcNAc...)Sequence analysis1
Glycosylationi3904N-linked (GlcNAc...)1 Publication1
Disulfide bondi3912 ↔ 3944By similarity
Disulfide bondi3951 ↔ 3962By similarity
Disulfide bondi3956 ↔ 3972By similarity
Disulfide bondi3974 ↔ 3983By similarity
Glycosylationi3989N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi3990 ↔ 4001By similarity
Disulfide bondi3995 ↔ 4010By similarity
Disulfide bondi4012 ↔ 4021By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9NYQ8.
MaxQBiQ9NYQ8.
PaxDbiQ9NYQ8.
PeptideAtlasiQ9NYQ8.
PRIDEiQ9NYQ8.

PTM databases

iPTMnetiQ9NYQ8.
PhosphoSitePlusiQ9NYQ8.

Expressioni

Tissue specificityi

Expressed in epidermal keratinocytes, infant brain, cerebellum, and also in a variety of tumors, such as pancreatic cancer, diffuse type gastric cancer, ovarian cancer, esophageal cancer, skin squamous cell carcinoma, head and neck cancer. Not expressed in melanoma cell line A375 cells, normal epidermal melanocytes or normal dermal fibroblasts. Expressed in epidermal keratinocytes and squamous cell carcinoma (at protein level).2 Publications

Gene expression databases

BgeeiENSG00000086570.
CleanExiHS_FAT2.
ExpressionAtlasiQ9NYQ8. baseline and differential.
GenevisibleiQ9NYQ8. HS.

Organism-specific databases

HPAiCAB033680.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

MINTiMINT-2819753.
STRINGi9606.ENSP00000261800.

Structurei

3D structure databases

ProteinModelPortaliQ9NYQ8.
SMRiQ9NYQ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 148Cadherin 1PROSITE-ProRule annotationAdd BLAST115
Domaini149 – 256Cadherin 2PROSITE-ProRule annotationAdd BLAST108
Domaini363 – 458Cadherin 3PROSITE-ProRule annotationAdd BLAST96
Domaini459 – 564Cadherin 4PROSITE-ProRule annotationAdd BLAST106
Domaini565 – 669Cadherin 5PROSITE-ProRule annotationAdd BLAST105
Domaini716 – 820Cadherin 6PROSITE-ProRule annotationAdd BLAST105
Domaini821 – 925Cadherin 7PROSITE-ProRule annotationAdd BLAST105
Domaini926 – 1032Cadherin 8PROSITE-ProRule annotationAdd BLAST107
Domaini1033 – 1137Cadherin 9PROSITE-ProRule annotationAdd BLAST105
Domaini1138 – 1242Cadherin 10PROSITE-ProRule annotationAdd BLAST105
Domaini1243 – 1346Cadherin 11PROSITE-ProRule annotationAdd BLAST104
Domaini1350 – 1448Cadherin 12PROSITE-ProRule annotationAdd BLAST99
Domaini1449 – 1555Cadherin 13PROSITE-ProRule annotationAdd BLAST107
Domaini1556 – 1660Cadherin 14PROSITE-ProRule annotationAdd BLAST105
Domaini1661 – 1758Cadherin 15PROSITE-ProRule annotationAdd BLAST98
Domaini1759 – 1872Cadherin 16PROSITE-ProRule annotationAdd BLAST114
Domaini1969 – 2070Cadherin 17PROSITE-ProRule annotationAdd BLAST102
Domaini2071 – 2171Cadherin 18PROSITE-ProRule annotationAdd BLAST101
Domaini2172 – 2272Cadherin 19PROSITE-ProRule annotationAdd BLAST101
Domaini2273 – 2379Cadherin 20PROSITE-ProRule annotationAdd BLAST107
Domaini2380 – 2481Cadherin 21PROSITE-ProRule annotationAdd BLAST102
Domaini2482 – 2585Cadherin 22PROSITE-ProRule annotationAdd BLAST104
Domaini2586 – 2691Cadherin 23PROSITE-ProRule annotationAdd BLAST106
Domaini2692 – 2797Cadherin 24PROSITE-ProRule annotationAdd BLAST106
Domaini2798 – 2906Cadherin 25PROSITE-ProRule annotationAdd BLAST109
Domaini2907 – 3011Cadherin 26PROSITE-ProRule annotationAdd BLAST105
Domaini3012 – 3113Cadherin 27PROSITE-ProRule annotationAdd BLAST102
Domaini3114 – 3218Cadherin 28PROSITE-ProRule annotationAdd BLAST105
Domaini3219 – 3321Cadherin 29PROSITE-ProRule annotationAdd BLAST103
Domaini3322 – 3426Cadherin 30PROSITE-ProRule annotationAdd BLAST105
Domaini3427 – 3531Cadherin 31PROSITE-ProRule annotationAdd BLAST105
Domaini3532 – 3642Cadherin 32PROSITE-ProRule annotationAdd BLAST111
Domaini3773 – 3944Laminin G-likePROSITE-ProRule annotationAdd BLAST172
Domaini3947 – 3984EGF-like 1PROSITE-ProRule annotationAdd BLAST38
Domaini3986 – 4022EGF-like 2PROSITE-ProRule annotationAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3297 – 3302Poly-Ser6

Sequence similaritiesi

Contains 32 cadherin domains.PROSITE-ProRule annotation
Contains 2 EGF-like domains.PROSITE-ProRule annotation
Contains 1 laminin G-like domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1219. Eukaryota.
ENOG410XPEI. LUCA.
GeneTreeiENSGT00760000118805.
HOGENOMiHOG000046499.
HOVERGENiHBG005641.
InParanoidiQ9NYQ8.
KOiK16506.
OMAiEPLYTFS.
OrthoDBiEOG091G00A0.
PhylomeDBiQ9NYQ8.
TreeFamiTF316403.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
2.60.40.60. 33 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF00028. Cadherin. 29 hits.
PF00008. EGF. 2 hits.
PF02210. Laminin_G_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 33 hits.
SM00181. EGF. 2 hits.
SM00179. EGF_CA. 2 hits.
SM00282. LamG. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 33 hits.
SSF49899. SSF49899. 1 hit.
PROSITEiPS00232. CADHERIN_1. 14 hits.
PS50268. CADHERIN_2. 32 hits.
PS00022. EGF_1. 2 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS50025. LAM_G_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NYQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIALLGFAI FLLHCATCEK PLEGILSSSA WHFTHSHYNA TIYENSSPKT
60 70 80 90 100
YVESFEKMGI YLAEPQWAVR YRIISGDVAN VFKTEEYVVG NFCFLRIRTK
110 120 130 140 150
SSNTALLNRE VRDSYTLIIQ ATEKTLELEA LTRVVVHILD QNDLKPLFSP
160 170 180 190 200
PSYRVTISED MPLKSPICKV TATDADLGQN AEFYYAFNTR SEMFAIHPTS
210 220 230 240 250
GVVTVAGKLN VTWRGKHELQ VLAVDRMRKI SEGNGFGSLA ALVVHVEPAL
260 270 280 290 300
RKPPAIASVV VTPPDSNDGT TYATVLVDAN SSGAEVESVE VVGGDPGKHF
310 320 330 340 350
KAIKSYARSN EFSLVSVKDI NWMEYLHGFN LSLQARSGSG PYFYSQIRGF
360 370 380 390 400
HLPPSKLSSL KFEKAVYRVQ LSEFSPPGSR VVMVRVTPAF PNLQYVLKPS
410 420 430 440 450
SENVGFKLNA RTGLITTTKL MDFHDRAHYQ LHIRTSPGQA STVVVIDIVD
460 470 480 490 500
CNNHAPLFNR SSYDGTLDEN IPPGTSVLAV TATDRDHGEN GYVTYSIAGP
510 520 530 540 550
KALPFSIDPY LGIISTSKPM DYELMKRIYT FRVRASDWGS PFRREKEVSI
560 570 580 590 600
FLQLRNLNDN QPMFEEVNCT GSIRQDWPVG KSIMTMSAID VDELQNLKYE
610 620 630 640 650
IVSGNELEYF DLNHFSGVIS LKRPFINLTA GQPTSYSLKI TASDGKNYAS
660 670 680 690 700
PTTLNITVVK DPHFEVPVTC DKTGVLTQFT KTILHFIGLQ NQESSDEEFT
710 720 730 740 750
SLSTYQINHY TPQFEDHFPQ SIDVLESVPI NTPLARLAAT DPDAGFNGKL
760 770 780 790 800
VYVIADGNEE GCFDIELETG LLTVAAPLDY EATNFYILNV TVYDLGTPQK
810 820 830 840 850
SSWKLLTVNV KDWNDNAPRF PPGGYQLTIS EDTEVGTTIA ELTTKDADSE
860 870 880 890 900
DNGRVRYTLL SPTEKFSLHP LTGELVVTGH LDRESEPRYI LKVEARDQPS
910 920 930 940 950
KGHQLFSVTD LIITLEDVND NSPQCITEHN RLKVPEDLPP GTVLTFLDAS
960 970 980 990 1000
DPDLGPAGEV RYVLMDGAHG TFRVDLMTGA LILERELDFE RRAGYNLSLW
1010 1020 1030 1040 1050
ASDGGRPLAR RTLCHVEVIV LDVNENLHPP HFASFVHQGQ VQENSPSGTQ
1060 1070 1080 1090 1100
VIVVAAQDDD SGLDGELQYF LRAGTGLAAF SINQDTGMIQ TLAPLDREFA
1110 1120 1130 1140 1150
SYYWLTVLAV DRGSVPLSSV TEVYIEVTDA NDNPPQMSQA VFYPSIQEDA
1160 1170 1180 1190 1200
PVGTSVLQLD AWDPDSSSKG KLTFNITSGN YMGFFMIHPV TGLLSTAQQL
1210 1220 1230 1240 1250
DRENKDEHIL EVTVLDNGEP SLKSTSRVVV GILDVNDNPP IFSHKLFNVR
1260 1270 1280 1290 1300
LPERLSPVSP GPVYRLVASD LDEGLNGRVT YSIEDSDEEA FSIDLVTGVV
1310 1320 1330 1340 1350
SSSSTFTAGE YNILTIKATD SGQPPLSASV RLHIEWIPWP RPSSIPLAFD
1360 1370 1380 1390 1400
ETYYSFTVME TDPVNHMVGV ISVEGRPGLF WFNISGGDKD MDFDIEKTTG
1410 1420 1430 1440 1450
SIVIARPLDT RRRSNYNLTV EVTDGSRTIA TQVHIFMIAN INHHRPQFLE
1460 1470 1480 1490 1500
TRYEVRVPQD TVPGVELLRV QAIDQDKGKS LIYTIHGSQD PGSASLFQLD
1510 1520 1530 1540 1550
PSSGVLVTVG KLDLGSGPSQ HTLTVMVRDQ EIPIKRNFVW VTIHVEDGNL
1560 1570 1580 1590 1600
HPPRFTQLHY EASVPDTIAP GTELLQVRAM DADRGVNAEV HYSLLKGNSE
1610 1620 1630 1640 1650
GFFNINALLG IITLAQKLDQ ANHAPHTLTV KAEDQGSPQW HDLATVIIHV
1660 1670 1680 1690 1700
YPSDRSAPIF SKSEYFVEIP ESIPVGSPIL LVSAMSPSEV TYELREGNKD
1710 1720 1730 1740 1750
GVFSMNSYSG LISTQKKLDH EKISSYQLKI RGSNMAGAFT DVMVVVDIID
1760 1770 1780 1790 1800
ENDNAPMFLK STFVGQISEA APLYSMIMDK NNNPFVIHAS DSDKEANSLL
1810 1820 1830 1840 1850
VYKILEPEAL KFFKIDPSMG TLTIVSEMDY ESMPSFQFCV YVHDQGSPVL
1860 1870 1880 1890 1900
FAPRPAQVII HVRDVNDSPP RFSEQIYEVA IVGPIHPGME LLMVRASDED
1910 1920 1930 1940 1950
SEVNYSIKTG NADEAVTIHP VTGSISVLNP AFLGLSRKLT IRASDGLYQD
1960 1970 1980 1990 2000
TALVKISLTQ VLDKSLQFDQ DVYWAAVKEN LQDRKALVIL GAQGNHLNDT
2010 2020 2030 2040 2050
LSYFLLNGTD MFHMVQSAGV LQTRGVAFDR EQQDTHELAV EVRDNRTPQR
2060 2070 2080 2090 2100
VAQGLVRVSI EDVNDNPPKF KHLPYYTIIQ DGTEPGDVLF QVSATDEDLG
2110 2120 2130 2140 2150
TNGAVTYEFA EDYTYFRIDP YLGDISLKKP FDYQALNKYH LKVIARDGGT
2160 2170 2180 2190 2200
PSLQSEEEVL VTVRNKSNPL FQSPYYKVRV PENITLYTPI LHTQARSPEG
2210 2220 2230 2240 2250
LRLIYNIVEE EPLMLFTTDF KTGVLTVTGP LDYESKTKHV FTVRATDTAL
2260 2270 2280 2290 2300
GSFSEATVEV LVEDVNDNPP TFSQLVYTTS ISEGLPAQTP VIQLLASDQD
2310 2320 2330 2340 2350
SGRNRDVSYQ IVEDGSDVSK FFQINGSTGE MSTVQELDYE AQQHFHVKVR
2360 2370 2380 2390 2400
AMDKGDPPLT GETLVVVNVS DINDNPPEFR QPQYEANVSE LATCGHLVLK
2410 2420 2430 2440 2450
VQAIDPDSRD TSRLEYLILS GNQDRHFFIN SSSGIISMFN LCKKHLDSSY
2460 2470 2480 2490 2500
NLRVGASDGV FRATVPVYIN TTNANKYSPE FQQHLYEAEL AENAMVGTKV
2510 2520 2530 2540 2550
IDLLAIDKDS GPYGTIDYTI INKLASEKFS INPNGQIATL QKLDRENSTE
2560 2570 2580 2590 2600
RVIAIKVMAR DGGGRVAFCT VKIILTDEND NPPQFKASEY TVSIQSNVSK
2610 2620 2630 2640 2650
DSPVIQVLAY DADEGQNADV TYSVNPEDLV KDVIEINPVT GVVKVKDSLV
2660 2670 2680 2690 2700
GLENQTLDFF IKAQDGGPPH WNSLVPVRLQ VVPKKVSLPK FSEPLYTFSA
2710 2720 2730 2740 2750
PEDLPEGSEI GIVKAVAAQD PVIYSLVRGT TPESNKDGVF SLDPDTGVIK
2760 2770 2780 2790 2800
VRKPMDHEST KLYQIDVMAH CLQNTDVVSL VSVNIQVGDV NDNRPVFEAD
2810 2820 2830 2840 2850
PYKAVLTENM PVGTSVIQVT AIDKDTGRDG QVSYRLSADP GSNVHELFAI
2860 2870 2880 2890 2900
DSESGWITTL QELDCETCQT YHFHVVAYDH GQTIQLSSQA LVQVSITDEN
2910 2920 2930 2940 2950
DNAPRFASEE YRGSVVENSE PGELVATLKT LDADISEQNR QVTCYITEGD
2960 2970 2980 2990 3000
PLGQFGISQV GDEWRISSRK TLDREHTAKY LLRVTASDGK FQASVTVEIF
3010 3020 3030 3040 3050
VLDVNDNSPQ CSQLLYTGKV HEDVFPGHFI LKVSATDLDT DTNAQITYSL
3060 3070 3080 3090 3100
HGPGAHEFKL DPHTGELTTL TALDRERKDV FNLVAKATDG GGRSCQADIT
3110 3120 3130 3140 3150
LHVEDVNDNA PRFFPSHCAV AVFDNTTVKT PVAVVFARDP DQGANAQVVY
3160 3170 3180 3190 3200
SLPDSAEGHF SIDATTGVIR LEKPLQVRPQ APLELTVRAS DLGTPIPLST
3210 3220 3230 3240 3250
LGTVTVSVVG LEDYLPVFLN TEHSVQVPED APPGTEVLQL ATLTRPGAEK
3260 3270 3280 3290 3300
TGYRVVSGNE QGRFRLDART GILYVNASLD FETSPKYFLS IECSRKSSSS
3310 3320 3330 3340 3350
LSDVTTVMVN ITDVNEHRPQ FPQDPYSTRV LENALVGDVI LTVSATDEDG
3360 3370 3380 3390 3400
PLNSDITYSL IGGNQLGHFT IHPKKGELQV AKALDREQAS SYSLKLRATD
3410 3420 3430 3440 3450
SGQPPLHEDT DIAIQVADVN DNPPRFFQLN YSTTVQENSP IGSKVLQLIL
3460 3470 3480 3490 3500
SDPDSPENGP PYSFRITKGN NGSAFRVTPD GWLVTAEGLS RRAQEWYQLQ
3510 3520 3530 3540 3550
IQASDSGIPP LSSLTSVRVH VTEQSHYAPS ALPLEIFITV GEDEFQGGMV
3560 3570 3580 3590 3600
GKIHATDRDP QDTLTYSLAE EETLGRHFSV GAPDGKIIAA QGLPRGHYSF
3610 3620 3630 3640 3650
NVTVSDGTFT TTAGVHVYVW HVGQEALQQA MWMGFYQLTP EELVSDHWRN
3660 3670 3680 3690 3700
LQRFLSHKLD IKRANIHLAS LQPAEAVAGV DVLLVFEGHS GTFYEFQELA
3710 3720 3730 3740 3750
SIITHSAKEM EHSVGVQMRS AMPMVPCQGP TCQGQICHNT VHLDPKVGPT
3760 3770 3780 3790 3800
YSTARLSILT PRHHLQRSCS CNGTATRFSG QSYVRYRAPA ARNWHIHFYL
3810 3820 3830 3840 3850
KTLQPQAILL FTNETASVSL KLASGVPQLE YHCLGGFYGN LSSQRHVNDH
3860 3870 3880 3890 3900
EWHSILVEEM DASIRLMVDS MGNTSLVVPE NCRGLRPERH LLLGGLILLH
3910 3920 3930 3940 3950
SSSNVSQGFE GCLDAVVVNE EALDLLAPGK TVAGLLETQA LTQCCLHSDY
3960 3970 3980 3990 4000
CSQNTCLNGG KCSWTHGAGY VCKCPPQFSG KHCEQGRENC TFAPCLEGGT
4010 4020 4030 4040 4050
CILSPKGASC NCPHPYTGDR CEMEARGCSE GHCLVTPEIQ RGDWGQQELL
4060 4070 4080 4090 4100
IITVAVAFII ISTVGLLFYC RRCKSHKPVA MEDPDLLARS VGVDTQAMPA
4110 4120 4130 4140 4150
IELNPLSASS CNNLNQPEPS KASVPNELVT FGPNSKQRPV VCSVPPRLPP
4160 4170 4180 4190 4200
AAVPSHSDNE PVIKRTWSSE EMVYPGGAMV WPPTYSRNER WEYPHSEVTQ
4210 4220 4230 4240 4250
GPLPPSAHRH STPVVMPEPN GLYGGFPFPL EMENKRAPLP PRYSNQNLED
4260 4270 4280 4290 4300
LMPSRPPSPR ERLVAPCLNE YTAISYYHSQ FRQGGGGPCL ADGGYKGVGM
4310 4320 4330 4340
RLSRAGPSYA VCEVEGAPLA GQGQPRVPPN YEGSDMVESD YGSCEEVMF
Length:4,349
Mass (Da):479,317
Last modified:May 18, 2010 - v2
Checksum:iFCEDBB52E252A996
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1287D → Y in AAF61928 (PubMed:10716726).Curated1
Sequence conflicti1303S → N in AAF61928 (PubMed:10716726).Curated1
Sequence conflicti4160E → G in BAA32463 (PubMed:9693030).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055595201G → A.Corresponds to variant rs11739693dbSNPEnsembl.1
Natural variantiVAR_055596248P → S.Corresponds to variant rs3734061dbSNPEnsembl.1
Natural variantiVAR_055597574R → C.Corresponds to variant rs1432862dbSNPEnsembl.1
Natural variantiVAR_055598686F → S.Corresponds to variant rs9324700dbSNPEnsembl.1
Natural variantiVAR_055599992R → Q.Corresponds to variant rs3734056dbSNPEnsembl.1
Natural variantiVAR_0556001004G → S.Corresponds to variant rs3734055dbSNPEnsembl.1
Natural variantiVAR_0556011164P → L.Corresponds to variant rs2304053dbSNPEnsembl.1
Natural variantiVAR_0610761181Y → H.Corresponds to variant rs6872614dbSNPEnsembl.1
Natural variantiVAR_0582861295L → P.Corresponds to variant rs35640822dbSNPEnsembl.1
Natural variantiVAR_0556021462V → M.Corresponds to variant rs2278371dbSNPEnsembl.1
Natural variantiVAR_0556031515G → S.Corresponds to variant rs2278370dbSNPEnsembl.1
Natural variantiVAR_0556041571G → S.Corresponds to variant rs10044879dbSNPEnsembl.1
Natural variantiVAR_0556051895R → W.Corresponds to variant rs34464977dbSNPEnsembl.1
Natural variantiVAR_0556062054G → A.Corresponds to variant rs34493925dbSNPEnsembl.1
Natural variantiVAR_0610772428F → S.Corresponds to variant rs6892335dbSNPEnsembl.1
Natural variantiVAR_0556072907A → T.Corresponds to variant rs3734053dbSNPEnsembl.1
Natural variantiVAR_0556083318R → Q.Corresponds to variant rs7718054dbSNPEnsembl.1
Natural variantiVAR_0556093318R → W.Corresponds to variant rs2304024dbSNPEnsembl.1
Natural variantiVAR_0556103514L → S.Corresponds to variant rs2053028dbSNPEnsembl.1
Natural variantiVAR_0556113631M → I.Corresponds to variant rs6650971dbSNPEnsembl.1
Natural variantiVAR_0556123664A → G.Corresponds to variant rs35963695dbSNPEnsembl.1
Natural variantiVAR_0556133953Q → H.Corresponds to variant rs2304029dbSNPEnsembl.1
Natural variantiVAR_0556144117P → L.1 PublicationCorresponds to variant rs1105168dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF231022 mRNA. Translation: AAF61928.1.
AB011535 mRNA. Translation: BAA32463.1.
AL157443 mRNA. Translation: CAB75663.1.
AC011337 Genomic DNA. No translation available.
AC011374 Genomic DNA. No translation available.
AC034205 Genomic DNA. No translation available.
CCDSiCCDS4317.1.
PIRiT46927.
RefSeqiNP_001438.1. NM_001447.2.
XP_006714824.1. XM_006714761.3.
XP_011535902.1. XM_011537600.2.
XP_011535905.1. XM_011537603.2.
XP_016864713.1. XM_017009224.1.
XP_016864714.1. XM_017009225.1.
UniGeneiHs.591255.

Genome annotation databases

EnsembliENST00000261800; ENSP00000261800; ENSG00000086570.
GeneIDi2196.
KEGGihsa:2196.
UCSCiuc003lue.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF231022 mRNA. Translation: AAF61928.1.
AB011535 mRNA. Translation: BAA32463.1.
AL157443 mRNA. Translation: CAB75663.1.
AC011337 Genomic DNA. No translation available.
AC011374 Genomic DNA. No translation available.
AC034205 Genomic DNA. No translation available.
CCDSiCCDS4317.1.
PIRiT46927.
RefSeqiNP_001438.1. NM_001447.2.
XP_006714824.1. XM_006714761.3.
XP_011535902.1. XM_011537600.2.
XP_011535905.1. XM_011537603.2.
XP_016864713.1. XM_017009224.1.
XP_016864714.1. XM_017009225.1.
UniGeneiHs.591255.

3D structure databases

ProteinModelPortaliQ9NYQ8.
SMRiQ9NYQ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-2819753.
STRINGi9606.ENSP00000261800.

PTM databases

iPTMnetiQ9NYQ8.
PhosphoSitePlusiQ9NYQ8.

Polymorphism and mutation databases

BioMutaiFAT2.
DMDMi296434503.

Proteomic databases

EPDiQ9NYQ8.
MaxQBiQ9NYQ8.
PaxDbiQ9NYQ8.
PeptideAtlasiQ9NYQ8.
PRIDEiQ9NYQ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261800; ENSP00000261800; ENSG00000086570.
GeneIDi2196.
KEGGihsa:2196.
UCSCiuc003lue.5. human.

Organism-specific databases

CTDi2196.
DisGeNETi2196.
GeneCardsiFAT2.
H-InvDBHIX0005330.
HGNCiHGNC:3596. FAT2.
HPAiCAB033680.
MIMi604269. gene.
neXtProtiNX_Q9NYQ8.
OpenTargetsiENSG00000086570.
PharmGKBiPA28009.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1219. Eukaryota.
ENOG410XPEI. LUCA.
GeneTreeiENSGT00760000118805.
HOGENOMiHOG000046499.
HOVERGENiHBG005641.
InParanoidiQ9NYQ8.
KOiK16506.
OMAiEPLYTFS.
OrthoDBiEOG091G00A0.
PhylomeDBiQ9NYQ8.
TreeFamiTF316403.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000086570-MONOMER.

Miscellaneous databases

GenomeRNAii2196.
PROiQ9NYQ8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000086570.
CleanExiHS_FAT2.
ExpressionAtlasiQ9NYQ8. baseline and differential.
GenevisibleiQ9NYQ8. HS.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
2.60.40.60. 33 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF00028. Cadherin. 29 hits.
PF00008. EGF. 2 hits.
PF02210. Laminin_G_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 33 hits.
SM00181. EGF. 2 hits.
SM00179. EGF_CA. 2 hits.
SM00282. LamG. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 33 hits.
SSF49899. SSF49899. 1 hit.
PROSITEiPS00232. CADHERIN_1. 14 hits.
PS50268. CADHERIN_2. 32 hits.
PS00022. EGF_1. 2 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS50025. LAM_G_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFAT2_HUMAN
AccessioniPrimary (citable) accession number: Q9NYQ8
Secondary accession number(s): O75091, Q9NSR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 155 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.