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Protein

Protocadherin Fat 2

Gene

FAT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the migration of epidermal cells. May modulate the extracellular space surronding parallel fibers of cerebellar during development (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • epithelial cell migration Source: UniProtKB
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin Fat 2
Short name:
hFat2
Alternative name(s):
Cadherin family member 8
Multiple epidermal growth factor-like domains protein 1
Short name:
Multiple EGF-like domains protein 1
Gene namesi
Name:FAT2
Synonyms:CDHF8, KIAA0811, MEGF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:3596. FAT2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 40484030ExtracellularSequence analysisAdd
BLAST
Transmembranei4049 – 406921HelicalSequence analysisAdd
BLAST
Topological domaini4070 – 4349280CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell-cell adherens junction Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • nucleus Source: UniProtKB-SubCell
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28009.

Polymorphism and mutation databases

BioMutaiFAT2.
DMDMi296434503.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 43494331Protocadherin Fat 2PRO_0000004018Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi39 – 391N-linked (GlcNAc...)Sequence analysis
Glycosylationi210 – 2101N-linked (GlcNAc...)Sequence analysis
Glycosylationi280 – 2801N-linked (GlcNAc...)Sequence analysis
Glycosylationi330 – 3301N-linked (GlcNAc...)Sequence analysis
Glycosylationi459 – 4591N-linked (GlcNAc...)Sequence analysis
Glycosylationi568 – 5681N-linked (GlcNAc...)Sequence analysis
Glycosylationi627 – 6271N-linked (GlcNAc...)Sequence analysis
Glycosylationi655 – 6551N-linked (GlcNAc...)Sequence analysis
Glycosylationi789 – 7891N-linked (GlcNAc...)Sequence analysis
Glycosylationi996 – 9961N-linked (GlcNAc...)Sequence analysis
Glycosylationi1175 – 11751N-linked (GlcNAc...)Sequence analysis
Glycosylationi1383 – 13831N-linked (GlcNAc...)Sequence analysis
Glycosylationi1417 – 14171N-linked (GlcNAc...)Sequence analysis
Glycosylationi1904 – 19041N-linked (GlcNAc...)Sequence analysis
Glycosylationi1998 – 19981N-linked (GlcNAc...)Sequence analysis
Glycosylationi2007 – 20071N-linked (GlcNAc...)Sequence analysis
Glycosylationi2165 – 21651N-linked (GlcNAc...)Sequence analysis
Glycosylationi2183 – 21831N-linked (GlcNAc...)Sequence analysis
Glycosylationi2325 – 23251N-linked (GlcNAc...)Sequence analysis
Glycosylationi2368 – 23681N-linked (GlcNAc...)Sequence analysis
Glycosylationi2387 – 23871N-linked (GlcNAc...)Sequence analysis
Glycosylationi2430 – 24301N-linked (GlcNAc...)Sequence analysis
Glycosylationi2470 – 24701N-linked (GlcNAc...)Sequence analysis
Glycosylationi2547 – 25471N-linked (GlcNAc...)Sequence analysis
Glycosylationi2597 – 25971N-linked (GlcNAc...)Sequence analysis
Glycosylationi2654 – 26541N-linked (GlcNAc...)Sequence analysis
Glycosylationi3125 – 31251N-linked (GlcNAc...)Sequence analysis
Glycosylationi3276 – 32761N-linked (GlcNAc...)Sequence analysis
Glycosylationi3310 – 33101N-linked (GlcNAc...)Sequence analysis
Glycosylationi3430 – 34301N-linked (GlcNAc...)Sequence analysis
Glycosylationi3471 – 34711N-linked (GlcNAc...)Sequence analysis
Glycosylationi3601 – 36011N-linked (GlcNAc...)Sequence analysis
Glycosylationi3772 – 37721N-linked (GlcNAc...)Sequence analysis
Glycosylationi3813 – 38131N-linked (GlcNAc...)Sequence analysis
Glycosylationi3840 – 38401N-linked (GlcNAc...)Sequence analysis
Glycosylationi3873 – 38731N-linked (GlcNAc...)Sequence analysis
Glycosylationi3904 – 39041N-linked (GlcNAc...)1 Publication
Disulfide bondi3912 ↔ 3944By similarity
Disulfide bondi3951 ↔ 3962By similarity
Disulfide bondi3956 ↔ 3972By similarity
Disulfide bondi3974 ↔ 3983By similarity
Glycosylationi3989 – 39891N-linked (GlcNAc...)Sequence analysis
Disulfide bondi3990 ↔ 4001By similarity
Disulfide bondi3995 ↔ 4010By similarity
Disulfide bondi4012 ↔ 4021By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9NYQ8.
MaxQBiQ9NYQ8.
PaxDbiQ9NYQ8.
PeptideAtlasiQ9NYQ8.
PRIDEiQ9NYQ8.

PTM databases

iPTMnetiQ9NYQ8.
PhosphoSiteiQ9NYQ8.

Expressioni

Tissue specificityi

Expressed in epidermal keratinocytes, infant brain, cerebellum, and also in a variety of tumors, such as pancreatic cancer, diffuse type gastric cancer, ovarian cancer, esophageal cancer, skin squamous cell carcinoma, head and neck cancer. Not expressed in melanoma cell line A375 cells, normal epidermal melanocytes or normal dermal fibroblasts. Expressed in epidermal keratinocytes and squamous cell carcinoma (at protein level).2 Publications

Gene expression databases

BgeeiQ9NYQ8.
CleanExiHS_FAT2.
ExpressionAtlasiQ9NYQ8. baseline and differential.
GenevisibleiQ9NYQ8. HS.

Organism-specific databases

HPAiCAB033680.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

MINTiMINT-2819753.
STRINGi9606.ENSP00000261800.

Structurei

3D structure databases

ProteinModelPortaliQ9NYQ8.
SMRiQ9NYQ8. Positions 41-248, 371-3622, 3790-4022.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 148115Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini149 – 256108Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini363 – 45896Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini459 – 564106Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini565 – 669105Cadherin 5PROSITE-ProRule annotationAdd
BLAST
Domaini716 – 820105Cadherin 6PROSITE-ProRule annotationAdd
BLAST
Domaini821 – 925105Cadherin 7PROSITE-ProRule annotationAdd
BLAST
Domaini926 – 1032107Cadherin 8PROSITE-ProRule annotationAdd
BLAST
Domaini1033 – 1137105Cadherin 9PROSITE-ProRule annotationAdd
BLAST
Domaini1138 – 1242105Cadherin 10PROSITE-ProRule annotationAdd
BLAST
Domaini1243 – 1346104Cadherin 11PROSITE-ProRule annotationAdd
BLAST
Domaini1350 – 144899Cadherin 12PROSITE-ProRule annotationAdd
BLAST
Domaini1449 – 1555107Cadherin 13PROSITE-ProRule annotationAdd
BLAST
Domaini1556 – 1660105Cadherin 14PROSITE-ProRule annotationAdd
BLAST
Domaini1661 – 175898Cadherin 15PROSITE-ProRule annotationAdd
BLAST
Domaini1759 – 1872114Cadherin 16PROSITE-ProRule annotationAdd
BLAST
Domaini1969 – 2070102Cadherin 17PROSITE-ProRule annotationAdd
BLAST
Domaini2071 – 2171101Cadherin 18PROSITE-ProRule annotationAdd
BLAST
Domaini2172 – 2272101Cadherin 19PROSITE-ProRule annotationAdd
BLAST
Domaini2273 – 2379107Cadherin 20PROSITE-ProRule annotationAdd
BLAST
Domaini2380 – 2481102Cadherin 21PROSITE-ProRule annotationAdd
BLAST
Domaini2482 – 2585104Cadherin 22PROSITE-ProRule annotationAdd
BLAST
Domaini2586 – 2691106Cadherin 23PROSITE-ProRule annotationAdd
BLAST
Domaini2692 – 2797106Cadherin 24PROSITE-ProRule annotationAdd
BLAST
Domaini2798 – 2906109Cadherin 25PROSITE-ProRule annotationAdd
BLAST
Domaini2907 – 3011105Cadherin 26PROSITE-ProRule annotationAdd
BLAST
Domaini3012 – 3113102Cadherin 27PROSITE-ProRule annotationAdd
BLAST
Domaini3114 – 3218105Cadherin 28PROSITE-ProRule annotationAdd
BLAST
Domaini3219 – 3321103Cadherin 29PROSITE-ProRule annotationAdd
BLAST
Domaini3322 – 3426105Cadherin 30PROSITE-ProRule annotationAdd
BLAST
Domaini3427 – 3531105Cadherin 31PROSITE-ProRule annotationAdd
BLAST
Domaini3532 – 3642111Cadherin 32PROSITE-ProRule annotationAdd
BLAST
Domaini3773 – 3944172Laminin G-likePROSITE-ProRule annotationAdd
BLAST
Domaini3947 – 398438EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini3986 – 402237EGF-like 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi3297 – 33026Poly-Ser

Sequence similaritiesi

Contains 32 cadherin domains.PROSITE-ProRule annotation
Contains 2 EGF-like domains.PROSITE-ProRule annotation
Contains 1 laminin G-like domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1219. Eukaryota.
ENOG410XPEI. LUCA.
GeneTreeiENSGT00760000118805.
HOGENOMiHOG000046499.
HOVERGENiHBG005641.
InParanoidiQ9NYQ8.
KOiK16506.
OMAiEPLYTFS.
PhylomeDBiQ9NYQ8.
TreeFamiTF316403.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
2.60.40.60. 33 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF00028. Cadherin. 29 hits.
PF00008. EGF. 2 hits.
PF02210. Laminin_G_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 33 hits.
SM00181. EGF. 2 hits.
SM00179. EGF_CA. 2 hits.
SM00282. LamG. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 33 hits.
SSF49899. SSF49899. 1 hit.
PROSITEiPS00232. CADHERIN_1. 14 hits.
PS50268. CADHERIN_2. 32 hits.
PS00022. EGF_1. 2 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS50025. LAM_G_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NYQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIALLGFAI FLLHCATCEK PLEGILSSSA WHFTHSHYNA TIYENSSPKT
60 70 80 90 100
YVESFEKMGI YLAEPQWAVR YRIISGDVAN VFKTEEYVVG NFCFLRIRTK
110 120 130 140 150
SSNTALLNRE VRDSYTLIIQ ATEKTLELEA LTRVVVHILD QNDLKPLFSP
160 170 180 190 200
PSYRVTISED MPLKSPICKV TATDADLGQN AEFYYAFNTR SEMFAIHPTS
210 220 230 240 250
GVVTVAGKLN VTWRGKHELQ VLAVDRMRKI SEGNGFGSLA ALVVHVEPAL
260 270 280 290 300
RKPPAIASVV VTPPDSNDGT TYATVLVDAN SSGAEVESVE VVGGDPGKHF
310 320 330 340 350
KAIKSYARSN EFSLVSVKDI NWMEYLHGFN LSLQARSGSG PYFYSQIRGF
360 370 380 390 400
HLPPSKLSSL KFEKAVYRVQ LSEFSPPGSR VVMVRVTPAF PNLQYVLKPS
410 420 430 440 450
SENVGFKLNA RTGLITTTKL MDFHDRAHYQ LHIRTSPGQA STVVVIDIVD
460 470 480 490 500
CNNHAPLFNR SSYDGTLDEN IPPGTSVLAV TATDRDHGEN GYVTYSIAGP
510 520 530 540 550
KALPFSIDPY LGIISTSKPM DYELMKRIYT FRVRASDWGS PFRREKEVSI
560 570 580 590 600
FLQLRNLNDN QPMFEEVNCT GSIRQDWPVG KSIMTMSAID VDELQNLKYE
610 620 630 640 650
IVSGNELEYF DLNHFSGVIS LKRPFINLTA GQPTSYSLKI TASDGKNYAS
660 670 680 690 700
PTTLNITVVK DPHFEVPVTC DKTGVLTQFT KTILHFIGLQ NQESSDEEFT
710 720 730 740 750
SLSTYQINHY TPQFEDHFPQ SIDVLESVPI NTPLARLAAT DPDAGFNGKL
760 770 780 790 800
VYVIADGNEE GCFDIELETG LLTVAAPLDY EATNFYILNV TVYDLGTPQK
810 820 830 840 850
SSWKLLTVNV KDWNDNAPRF PPGGYQLTIS EDTEVGTTIA ELTTKDADSE
860 870 880 890 900
DNGRVRYTLL SPTEKFSLHP LTGELVVTGH LDRESEPRYI LKVEARDQPS
910 920 930 940 950
KGHQLFSVTD LIITLEDVND NSPQCITEHN RLKVPEDLPP GTVLTFLDAS
960 970 980 990 1000
DPDLGPAGEV RYVLMDGAHG TFRVDLMTGA LILERELDFE RRAGYNLSLW
1010 1020 1030 1040 1050
ASDGGRPLAR RTLCHVEVIV LDVNENLHPP HFASFVHQGQ VQENSPSGTQ
1060 1070 1080 1090 1100
VIVVAAQDDD SGLDGELQYF LRAGTGLAAF SINQDTGMIQ TLAPLDREFA
1110 1120 1130 1140 1150
SYYWLTVLAV DRGSVPLSSV TEVYIEVTDA NDNPPQMSQA VFYPSIQEDA
1160 1170 1180 1190 1200
PVGTSVLQLD AWDPDSSSKG KLTFNITSGN YMGFFMIHPV TGLLSTAQQL
1210 1220 1230 1240 1250
DRENKDEHIL EVTVLDNGEP SLKSTSRVVV GILDVNDNPP IFSHKLFNVR
1260 1270 1280 1290 1300
LPERLSPVSP GPVYRLVASD LDEGLNGRVT YSIEDSDEEA FSIDLVTGVV
1310 1320 1330 1340 1350
SSSSTFTAGE YNILTIKATD SGQPPLSASV RLHIEWIPWP RPSSIPLAFD
1360 1370 1380 1390 1400
ETYYSFTVME TDPVNHMVGV ISVEGRPGLF WFNISGGDKD MDFDIEKTTG
1410 1420 1430 1440 1450
SIVIARPLDT RRRSNYNLTV EVTDGSRTIA TQVHIFMIAN INHHRPQFLE
1460 1470 1480 1490 1500
TRYEVRVPQD TVPGVELLRV QAIDQDKGKS LIYTIHGSQD PGSASLFQLD
1510 1520 1530 1540 1550
PSSGVLVTVG KLDLGSGPSQ HTLTVMVRDQ EIPIKRNFVW VTIHVEDGNL
1560 1570 1580 1590 1600
HPPRFTQLHY EASVPDTIAP GTELLQVRAM DADRGVNAEV HYSLLKGNSE
1610 1620 1630 1640 1650
GFFNINALLG IITLAQKLDQ ANHAPHTLTV KAEDQGSPQW HDLATVIIHV
1660 1670 1680 1690 1700
YPSDRSAPIF SKSEYFVEIP ESIPVGSPIL LVSAMSPSEV TYELREGNKD
1710 1720 1730 1740 1750
GVFSMNSYSG LISTQKKLDH EKISSYQLKI RGSNMAGAFT DVMVVVDIID
1760 1770 1780 1790 1800
ENDNAPMFLK STFVGQISEA APLYSMIMDK NNNPFVIHAS DSDKEANSLL
1810 1820 1830 1840 1850
VYKILEPEAL KFFKIDPSMG TLTIVSEMDY ESMPSFQFCV YVHDQGSPVL
1860 1870 1880 1890 1900
FAPRPAQVII HVRDVNDSPP RFSEQIYEVA IVGPIHPGME LLMVRASDED
1910 1920 1930 1940 1950
SEVNYSIKTG NADEAVTIHP VTGSISVLNP AFLGLSRKLT IRASDGLYQD
1960 1970 1980 1990 2000
TALVKISLTQ VLDKSLQFDQ DVYWAAVKEN LQDRKALVIL GAQGNHLNDT
2010 2020 2030 2040 2050
LSYFLLNGTD MFHMVQSAGV LQTRGVAFDR EQQDTHELAV EVRDNRTPQR
2060 2070 2080 2090 2100
VAQGLVRVSI EDVNDNPPKF KHLPYYTIIQ DGTEPGDVLF QVSATDEDLG
2110 2120 2130 2140 2150
TNGAVTYEFA EDYTYFRIDP YLGDISLKKP FDYQALNKYH LKVIARDGGT
2160 2170 2180 2190 2200
PSLQSEEEVL VTVRNKSNPL FQSPYYKVRV PENITLYTPI LHTQARSPEG
2210 2220 2230 2240 2250
LRLIYNIVEE EPLMLFTTDF KTGVLTVTGP LDYESKTKHV FTVRATDTAL
2260 2270 2280 2290 2300
GSFSEATVEV LVEDVNDNPP TFSQLVYTTS ISEGLPAQTP VIQLLASDQD
2310 2320 2330 2340 2350
SGRNRDVSYQ IVEDGSDVSK FFQINGSTGE MSTVQELDYE AQQHFHVKVR
2360 2370 2380 2390 2400
AMDKGDPPLT GETLVVVNVS DINDNPPEFR QPQYEANVSE LATCGHLVLK
2410 2420 2430 2440 2450
VQAIDPDSRD TSRLEYLILS GNQDRHFFIN SSSGIISMFN LCKKHLDSSY
2460 2470 2480 2490 2500
NLRVGASDGV FRATVPVYIN TTNANKYSPE FQQHLYEAEL AENAMVGTKV
2510 2520 2530 2540 2550
IDLLAIDKDS GPYGTIDYTI INKLASEKFS INPNGQIATL QKLDRENSTE
2560 2570 2580 2590 2600
RVIAIKVMAR DGGGRVAFCT VKIILTDEND NPPQFKASEY TVSIQSNVSK
2610 2620 2630 2640 2650
DSPVIQVLAY DADEGQNADV TYSVNPEDLV KDVIEINPVT GVVKVKDSLV
2660 2670 2680 2690 2700
GLENQTLDFF IKAQDGGPPH WNSLVPVRLQ VVPKKVSLPK FSEPLYTFSA
2710 2720 2730 2740 2750
PEDLPEGSEI GIVKAVAAQD PVIYSLVRGT TPESNKDGVF SLDPDTGVIK
2760 2770 2780 2790 2800
VRKPMDHEST KLYQIDVMAH CLQNTDVVSL VSVNIQVGDV NDNRPVFEAD
2810 2820 2830 2840 2850
PYKAVLTENM PVGTSVIQVT AIDKDTGRDG QVSYRLSADP GSNVHELFAI
2860 2870 2880 2890 2900
DSESGWITTL QELDCETCQT YHFHVVAYDH GQTIQLSSQA LVQVSITDEN
2910 2920 2930 2940 2950
DNAPRFASEE YRGSVVENSE PGELVATLKT LDADISEQNR QVTCYITEGD
2960 2970 2980 2990 3000
PLGQFGISQV GDEWRISSRK TLDREHTAKY LLRVTASDGK FQASVTVEIF
3010 3020 3030 3040 3050
VLDVNDNSPQ CSQLLYTGKV HEDVFPGHFI LKVSATDLDT DTNAQITYSL
3060 3070 3080 3090 3100
HGPGAHEFKL DPHTGELTTL TALDRERKDV FNLVAKATDG GGRSCQADIT
3110 3120 3130 3140 3150
LHVEDVNDNA PRFFPSHCAV AVFDNTTVKT PVAVVFARDP DQGANAQVVY
3160 3170 3180 3190 3200
SLPDSAEGHF SIDATTGVIR LEKPLQVRPQ APLELTVRAS DLGTPIPLST
3210 3220 3230 3240 3250
LGTVTVSVVG LEDYLPVFLN TEHSVQVPED APPGTEVLQL ATLTRPGAEK
3260 3270 3280 3290 3300
TGYRVVSGNE QGRFRLDART GILYVNASLD FETSPKYFLS IECSRKSSSS
3310 3320 3330 3340 3350
LSDVTTVMVN ITDVNEHRPQ FPQDPYSTRV LENALVGDVI LTVSATDEDG
3360 3370 3380 3390 3400
PLNSDITYSL IGGNQLGHFT IHPKKGELQV AKALDREQAS SYSLKLRATD
3410 3420 3430 3440 3450
SGQPPLHEDT DIAIQVADVN DNPPRFFQLN YSTTVQENSP IGSKVLQLIL
3460 3470 3480 3490 3500
SDPDSPENGP PYSFRITKGN NGSAFRVTPD GWLVTAEGLS RRAQEWYQLQ
3510 3520 3530 3540 3550
IQASDSGIPP LSSLTSVRVH VTEQSHYAPS ALPLEIFITV GEDEFQGGMV
3560 3570 3580 3590 3600
GKIHATDRDP QDTLTYSLAE EETLGRHFSV GAPDGKIIAA QGLPRGHYSF
3610 3620 3630 3640 3650
NVTVSDGTFT TTAGVHVYVW HVGQEALQQA MWMGFYQLTP EELVSDHWRN
3660 3670 3680 3690 3700
LQRFLSHKLD IKRANIHLAS LQPAEAVAGV DVLLVFEGHS GTFYEFQELA
3710 3720 3730 3740 3750
SIITHSAKEM EHSVGVQMRS AMPMVPCQGP TCQGQICHNT VHLDPKVGPT
3760 3770 3780 3790 3800
YSTARLSILT PRHHLQRSCS CNGTATRFSG QSYVRYRAPA ARNWHIHFYL
3810 3820 3830 3840 3850
KTLQPQAILL FTNETASVSL KLASGVPQLE YHCLGGFYGN LSSQRHVNDH
3860 3870 3880 3890 3900
EWHSILVEEM DASIRLMVDS MGNTSLVVPE NCRGLRPERH LLLGGLILLH
3910 3920 3930 3940 3950
SSSNVSQGFE GCLDAVVVNE EALDLLAPGK TVAGLLETQA LTQCCLHSDY
3960 3970 3980 3990 4000
CSQNTCLNGG KCSWTHGAGY VCKCPPQFSG KHCEQGRENC TFAPCLEGGT
4010 4020 4030 4040 4050
CILSPKGASC NCPHPYTGDR CEMEARGCSE GHCLVTPEIQ RGDWGQQELL
4060 4070 4080 4090 4100
IITVAVAFII ISTVGLLFYC RRCKSHKPVA MEDPDLLARS VGVDTQAMPA
4110 4120 4130 4140 4150
IELNPLSASS CNNLNQPEPS KASVPNELVT FGPNSKQRPV VCSVPPRLPP
4160 4170 4180 4190 4200
AAVPSHSDNE PVIKRTWSSE EMVYPGGAMV WPPTYSRNER WEYPHSEVTQ
4210 4220 4230 4240 4250
GPLPPSAHRH STPVVMPEPN GLYGGFPFPL EMENKRAPLP PRYSNQNLED
4260 4270 4280 4290 4300
LMPSRPPSPR ERLVAPCLNE YTAISYYHSQ FRQGGGGPCL ADGGYKGVGM
4310 4320 4330 4340
RLSRAGPSYA VCEVEGAPLA GQGQPRVPPN YEGSDMVESD YGSCEEVMF
Length:4,349
Mass (Da):479,317
Last modified:May 18, 2010 - v2
Checksum:iFCEDBB52E252A996
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1287 – 12871D → Y in AAF61928 (PubMed:10716726).Curated
Sequence conflicti1303 – 13031S → N in AAF61928 (PubMed:10716726).Curated
Sequence conflicti4160 – 41601E → G in BAA32463 (PubMed:9693030).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti201 – 2011G → A.
Corresponds to variant rs11739693 [ dbSNP | Ensembl ].
VAR_055595
Natural varianti248 – 2481P → S.
Corresponds to variant rs3734061 [ dbSNP | Ensembl ].
VAR_055596
Natural varianti574 – 5741R → C.
Corresponds to variant rs1432862 [ dbSNP | Ensembl ].
VAR_055597
Natural varianti686 – 6861F → S.
Corresponds to variant rs9324700 [ dbSNP | Ensembl ].
VAR_055598
Natural varianti992 – 9921R → Q.
Corresponds to variant rs3734056 [ dbSNP | Ensembl ].
VAR_055599
Natural varianti1004 – 10041G → S.
Corresponds to variant rs3734055 [ dbSNP | Ensembl ].
VAR_055600
Natural varianti1164 – 11641P → L.
Corresponds to variant rs2304053 [ dbSNP | Ensembl ].
VAR_055601
Natural varianti1181 – 11811Y → H.
Corresponds to variant rs6872614 [ dbSNP | Ensembl ].
VAR_061076
Natural varianti1295 – 12951L → P.
Corresponds to variant rs35640822 [ dbSNP | Ensembl ].
VAR_058286
Natural varianti1462 – 14621V → M.
Corresponds to variant rs2278371 [ dbSNP | Ensembl ].
VAR_055602
Natural varianti1515 – 15151G → S.
Corresponds to variant rs2278370 [ dbSNP | Ensembl ].
VAR_055603
Natural varianti1571 – 15711G → S.
Corresponds to variant rs10044879 [ dbSNP | Ensembl ].
VAR_055604
Natural varianti1895 – 18951R → W.
Corresponds to variant rs34464977 [ dbSNP | Ensembl ].
VAR_055605
Natural varianti2054 – 20541G → A.
Corresponds to variant rs34493925 [ dbSNP | Ensembl ].
VAR_055606
Natural varianti2428 – 24281F → S.
Corresponds to variant rs6892335 [ dbSNP | Ensembl ].
VAR_061077
Natural varianti2907 – 29071A → T.
Corresponds to variant rs3734053 [ dbSNP | Ensembl ].
VAR_055607
Natural varianti3318 – 33181R → Q.
Corresponds to variant rs7718054 [ dbSNP | Ensembl ].
VAR_055608
Natural varianti3318 – 33181R → W.
Corresponds to variant rs2304024 [ dbSNP | Ensembl ].
VAR_055609
Natural varianti3514 – 35141L → S.
Corresponds to variant rs2053028 [ dbSNP | Ensembl ].
VAR_055610
Natural varianti3631 – 36311M → I.
Corresponds to variant rs6650971 [ dbSNP | Ensembl ].
VAR_055611
Natural varianti3664 – 36641A → G.
Corresponds to variant rs35963695 [ dbSNP | Ensembl ].
VAR_055612
Natural varianti3953 – 39531Q → H.
Corresponds to variant rs2304029 [ dbSNP | Ensembl ].
VAR_055613
Natural varianti4117 – 41171P → L.1 Publication
Corresponds to variant rs1105168 [ dbSNP | Ensembl ].
VAR_055614

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF231022 mRNA. Translation: AAF61928.1.
AB011535 mRNA. Translation: BAA32463.1.
AL157443 mRNA. Translation: CAB75663.1.
AC011337 Genomic DNA. No translation available.
AC011374 Genomic DNA. No translation available.
AC034205 Genomic DNA. No translation available.
CCDSiCCDS4317.1.
PIRiT46927.
RefSeqiNP_001438.1. NM_001447.2.
XP_006714824.1. XM_006714761.2.
XP_011535900.1. XM_011537598.1.
XP_011535901.1. XM_011537599.1.
XP_011535902.1. XM_011537600.1.
XP_011535903.1. XM_011537601.1.
XP_011535904.1. XM_011537602.1.
XP_011535905.1. XM_011537603.1.
UniGeneiHs.591255.

Genome annotation databases

EnsembliENST00000261800; ENSP00000261800; ENSG00000086570.
GeneIDi2196.
KEGGihsa:2196.
UCSCiuc003lue.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF231022 mRNA. Translation: AAF61928.1.
AB011535 mRNA. Translation: BAA32463.1.
AL157443 mRNA. Translation: CAB75663.1.
AC011337 Genomic DNA. No translation available.
AC011374 Genomic DNA. No translation available.
AC034205 Genomic DNA. No translation available.
CCDSiCCDS4317.1.
PIRiT46927.
RefSeqiNP_001438.1. NM_001447.2.
XP_006714824.1. XM_006714761.2.
XP_011535900.1. XM_011537598.1.
XP_011535901.1. XM_011537599.1.
XP_011535902.1. XM_011537600.1.
XP_011535903.1. XM_011537601.1.
XP_011535904.1. XM_011537602.1.
XP_011535905.1. XM_011537603.1.
UniGeneiHs.591255.

3D structure databases

ProteinModelPortaliQ9NYQ8.
SMRiQ9NYQ8. Positions 41-248, 371-3622, 3790-4022.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-2819753.
STRINGi9606.ENSP00000261800.

PTM databases

iPTMnetiQ9NYQ8.
PhosphoSiteiQ9NYQ8.

Polymorphism and mutation databases

BioMutaiFAT2.
DMDMi296434503.

Proteomic databases

EPDiQ9NYQ8.
MaxQBiQ9NYQ8.
PaxDbiQ9NYQ8.
PeptideAtlasiQ9NYQ8.
PRIDEiQ9NYQ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261800; ENSP00000261800; ENSG00000086570.
GeneIDi2196.
KEGGihsa:2196.
UCSCiuc003lue.5. human.

Organism-specific databases

CTDi2196.
GeneCardsiFAT2.
H-InvDBHIX0005330.
HGNCiHGNC:3596. FAT2.
HPAiCAB033680.
MIMi604269. gene.
neXtProtiNX_Q9NYQ8.
PharmGKBiPA28009.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1219. Eukaryota.
ENOG410XPEI. LUCA.
GeneTreeiENSGT00760000118805.
HOGENOMiHOG000046499.
HOVERGENiHBG005641.
InParanoidiQ9NYQ8.
KOiK16506.
OMAiEPLYTFS.
PhylomeDBiQ9NYQ8.
TreeFamiTF316403.

Miscellaneous databases

GenomeRNAii2196.
PROiQ9NYQ8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NYQ8.
CleanExiHS_FAT2.
ExpressionAtlasiQ9NYQ8. baseline and differential.
GenevisibleiQ9NYQ8. HS.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
2.60.40.60. 33 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF00028. Cadherin. 29 hits.
PF00008. EGF. 2 hits.
PF02210. Laminin_G_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 33 hits.
SM00181. EGF. 2 hits.
SM00179. EGF_CA. 2 hits.
SM00282. LamG. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 33 hits.
SSF49899. SSF49899. 1 hit.
PROSITEiPS00232. CADHERIN_1. 14 hits.
PS50268. CADHERIN_2. 32 hits.
PS00022. EGF_1. 2 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS50025. LAM_G_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes."
    Wu Q., Maniatis T.
    Proc. Natl. Acad. Sci. U.S.A. 97:3124-3129(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening."
    Nakayama M., Nakajima D., Nagase T., Nomura N., Seki N., Ohara O.
    Genomics 51:27-34(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3777-4349, VARIANT LEU-4117.
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4142-4349.
    Tissue: Testis.
  4. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-3904.
    Tissue: Plasma.
  6. "Comparative integromics on FAT1, FAT2, FAT3 and FAT4."
    Katoh Y., Katoh M.
    Int. J. Mol. Med. 18:523-528(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  7. "Human Fat2 is localized at immature adherens junctions in epidermal keratinocytes."
    Matsui S., Utani A., Takahashi K., Mukoyama Y., Miyachi Y., Matsuyoshi N.
    J. Dermatol. Sci. 48:233-236(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  8. "Knockdown of Fat2 by siRNA inhibits the migration of human squamous carcinoma cells."
    Matsui S., Utani A., Takahashi K., Mukoyama Y., Miyachi Y., Matsuyoshi N.
    J. Dermatol. Sci. 51:207-210(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFAT2_HUMAN
AccessioniPrimary (citable) accession number: Q9NYQ8
Secondary accession number(s): O75091, Q9NSR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: May 18, 2010
Last modified: July 6, 2016
This is version 152 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.