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Q9NYQ7

- CELR3_HUMAN

UniProt

Q9NYQ7 - CELR3_HUMAN

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Protein

Cadherin EGF LAG seven-pass G-type receptor 3

Gene
CELSR3, CDHF11, EGFL1, FMI1, KIAA0812, MEGF2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor that may have an important role in cell/cell signaling during nervous system formation.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. G-protein coupled receptor activity Source: GDB
  3. protein binding Source: IntAct

GO - Biological processi

  1. axonal fasciculation Source: Ensembl
  2. cilium assembly Source: Ensembl
  3. G-protein coupled receptor signaling pathway Source: GDB
  4. homophilic cell adhesion Source: InterPro
  5. neuron migration Source: Ensembl
  6. neuropeptide signaling pathway Source: InterPro
  7. regulation of protein localization Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, G-protein coupled receptor, Receptor, Transducer

Keywords - Ligandi

Calcium

Enzyme and pathway databases

SignaLinkiQ9NYQ7.

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin EGF LAG seven-pass G-type receptor 3
Alternative name(s):
Cadherin family member 11
Epidermal growth factor-like protein 1
Short name:
EGF-like protein 1
Flamingo homolog 1
Short name:
hFmi1
Multiple epidermal growth factor-like domains protein 2
Short name:
Multiple EGF-like domains protein 2
Gene namesi
Name:CELSR3
Synonyms:CDHF11, EGFL1, FMI1, KIAA0812, MEGF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:3230. CELSR3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini33 – 25402508Extracellular Reviewed predictionAdd
BLAST
Transmembranei2541 – 256121Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini2562 – 257211Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei2573 – 259321Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini2594 – 26018Extracellular Reviewed prediction
Transmembranei2602 – 262221Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini2623 – 264321Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei2644 – 266421Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini2665 – 268117Extracellular Reviewed predictionAdd
BLAST
Transmembranei2682 – 270221Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini2703 – 272523Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei2726 – 274621Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini2747 – 27537Extracellular Reviewed prediction
Transmembranei2754 – 277421Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini2775 – 3312538Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: GDB
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26395.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232 Reviewed predictionAdd
BLAST
Chaini33 – 33123280Cadherin EGF LAG seven-pass G-type receptor 3PRO_0000012918Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi632 – 6321N-linked (GlcNAc...) Reviewed prediction
Glycosylationi847 – 8471N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1182 – 11821N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1222 – 12221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1317 – 13171N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1327 – 13271N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1379 ↔ 1390 By similarity
Disulfide bondi1384 ↔ 1421 By similarity
Disulfide bondi1423 ↔ 1432 By similarity
Disulfide bondi1439 ↔ 1450 By similarity
Disulfide bondi1444 ↔ 1459 By similarity
Disulfide bondi1461 ↔ 1470 By similarity
Disulfide bondi1479 ↔ 1490 By similarity
Disulfide bondi1484 ↔ 1500 By similarity
Disulfide bondi1502 ↔ 1513 By similarity
Glycosylationi1649 – 16491N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1693 ↔ 1719 By similarity
Glycosylationi1713 – 17131N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1726 ↔ 1737 By similarity
Disulfide bondi1731 ↔ 1746 By similarity
Disulfide bondi1748 ↔ 1757 By similarity
Glycosylationi1770 – 17701N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1915 ↔ 1944 By similarity
Disulfide bondi1950 ↔ 1961 By similarity
Disulfide bondi1955 ↔ 1970 By similarity
Modified residuei1963 – 19631(3R)-3-hydroxyaspartate Reviewed prediction
Disulfide bondi1972 ↔ 1981 By similarity
Disulfide bondi1985 ↔ 1996 By similarity
Disulfide bondi1990 ↔ 2008 By similarity
Disulfide bondi2010 ↔ 2019 By similarity
Disulfide bondi2027 ↔ 2040 By similarity
Disulfide bondi2042 ↔ 2052 By similarity
Glycosylationi2053 – 20531N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2059 ↔ 2074 By similarity
Disulfide bondi2061 ↔ 2077 By similarity
Disulfide bondi2079 ↔ 2089 By similarity
Disulfide bondi2098 ↔ 2107 By similarity
Disulfide bondi2110 ↔ 2122 By similarity
Modified residuei2126 – 21261Phosphotyrosine By similarity
Glycosylationi2177 – 21771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2196 – 21961N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2386 – 23861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2474 – 24741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2506 – 25061N-linked (GlcNAc...) Reviewed prediction
Modified residuei3051 – 30511Phosphotyrosine By similarity
Modified residuei3097 – 30971Phosphoserine By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation, Phosphoprotein

Proteomic databases

MaxQBiQ9NYQ7.
PaxDbiQ9NYQ7.
PRIDEiQ9NYQ7.

PTM databases

PhosphoSiteiQ9NYQ7.

Expressioni

Gene expression databases

ArrayExpressiQ9NYQ7.
BgeeiQ9NYQ7.
CleanExiHS_CELSR3.
GenevestigatoriQ9NYQ7.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NCK1P163332EBI-308417,EBI-389883

Protein-protein interaction databases

BioGridi108271. 4 interactions.
IntActiQ9NYQ7. 18 interactions.
MINTiMINT-1381104.
STRINGi9606.ENSP00000164024.

Structurei

3D structure databases

ProteinModelPortaliQ9NYQ7.
SMRiQ9NYQ7. Positions 318-1248, 1383-1853, 1949-2122.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini326 – 433108Cadherin 1Add
BLAST
Domaini434 – 545112Cadherin 2Add
BLAST
Domaini546 – 651106Cadherin 3Add
BLAST
Domaini652 – 756105Cadherin 4Add
BLAST
Domaini757 – 858102Cadherin 5Add
BLAST
Domaini859 – 961103Cadherin 6Add
BLAST
Domaini962 – 1067106Cadherin 7Add
BLAST
Domaini1068 – 1169102Cadherin 8Add
BLAST
Domaini1170 – 126596Cadherin 9Add
BLAST
Domaini1375 – 143359EGF-like 1; calcium-bindingAdd
BLAST
Domaini1435 – 147137EGF-like 2; calcium-bindingAdd
BLAST
Domaini1475 – 151440EGF-like 3; calcium-bindingAdd
BLAST
Domaini1515 – 1719205Laminin G-like 1Add
BLAST
Domaini1722 – 175837EGF-like 4; calcium-bindingAdd
BLAST
Domaini1764 – 1944181Laminin G-like 2Add
BLAST
Domaini1946 – 198237EGF-like 5; calcium-bindingAdd
BLAST
Domaini1983 – 202038EGF-like 6; calcium-bindingAdd
BLAST
Domaini2021 – 205333EGF-like 7; calcium-bindingAdd
BLAST
Domaini2055 – 209036EGF-like 8; calcium-bindingAdd
BLAST
Domaini2077 – 212448Laminin EGF-likeAdd
BLAST
Domaini2477 – 252953GPSAdd
BLAST

Sequence similaritiesi

Contains 9 cadherin domains.
Contains 8 EGF-like domains.
Contains 1 GPS domain.

Keywords - Domaini

EGF-like domain, Laminin EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000231346.
HOVERGENiHBG050887.
KOiK04602.
OMAiYRFVGPP.
OrthoDBiEOG7BP81K.
PhylomeDBiQ9NYQ7.
TreeFamiTF323983.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
2.60.40.60. 9 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR022624. DUF3497.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR002049. EGF_laminin.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF00028. Cadherin. 8 hits.
PF12003. DUF3497. 1 hit.
PF00008. EGF. 2 hits.
PF01825. GPS. 1 hit.
PF02793. HRM. 1 hit.
PF00053. Laminin_EGF. 1 hit.
PF02210. Laminin_G_2. 2 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
PR00249. GPCRSECRETIN.
SMARTiSM00112. CA. 9 hits.
SM00181. EGF. 6 hits.
SM00180. EGF_Lam. 1 hit.
SM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00282. LamG. 2 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 9 hits.
SSF49899. SSF49899. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS00232. CADHERIN_1. 7 hits.
PS50268. CADHERIN_2. 8 hits.
PS00022. EGF_1. 6 hits.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 6 hits.
PS01248. EGF_LAM_1. 1 hit.
PS50027. EGF_LAM_2. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NYQ7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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MMARRPPWRG LGGRSTPILL LLLLSLFPLS QEELGGGGHQ GWDPGLAATT     50
GPRAHIGGGA LALCPESSGV REDGGPGLGV REPIFVGLRG RRQSARNSRG 100
PPEQPNEELG IEHGVQPLGS RERETGQGPG SVLYWRPEVS SCGRTGPLQR 150
GSLSPGALSS GVPGSGNSSP LPSDFLIRHH GPKPVSSQRN AGTGSRKRVG 200
TARCCGELWA TGSKGQGERA TTSGAERTAP RRNCLPGASG SGPELDSAPR 250
TARTAPASGS APRESRTAPE PAPKRMRSRG LFRCRFLPQR PGPRPPGLPA 300
RPEARKVTSA NRARFRRAAN RHPQFPQYNY QTLVPENEAA GTAVLRVVAQ 350
DPDAGEAGRL VYSLAALMNS RSLELFSIDP QSGLIRTAAA LDRESMERHY 400
LRVTAQDHGS PRLSATTMVA VTVADRNDHS PVFEQAQYRE TLRENVEEGY 450
PILQLRATDG DAPPNANLRY RFVGPPAARA AAAAAFEIDP RSGLISTSGR 500
VDREHMESYE LVVEASDQGQ EPGPRSATVR VHITVLDEND NAPQFSEKRY 550
VAQVREDVRP HTVVLRVTAT DRDKDANGLV HYNIISGNSR GHFAIDSLTG 600
EIQVVAPLDF EAEREYALRI RAQDAGRPPL SNNTGLASIQ VVDINDHIPI 650
FVSTPFQVSV LENAPLGHSV IHIQAVDADH GENARLEYSL TGVAPDTPFV 700
INSATGWVSV SGPLDRESVE HYFFGVEARD HGSPPLSASA SVTVTVLDVN 750
DNRPEFTMKE YHLRLNEDAA VGTSVVSVTA VDRDANSAIS YQITGGNTRN 800
RFAISTQGGV GLVTLALPLD YKQERYFKLV LTASDRALHD HCYVHINITD 850
ANTHRPVFQS AHYSVSVNED RPMGSTIVVI SASDDDVGEN ARITYLLEDN 900
LPQFRIDADS GAITLQAPLD YEDQVTYTLA ITARDNGIPQ KADTTYVEVM 950
VNDVNDNAPQ FVASHYTGLV SEDAPPFTSV LQISATDRDA HANGRVQYTF 1000
QNGEDGDGDF TIEPTSGIVR TVRRLDREAV SVYELTAYAV DRGVPPLRTP 1050
VSIQVMVQDV NDNAPVFPAE EFEVRVKENS IVGSVVAQIT AVDPDEGPNA 1100
HIMYQIVEGN IPELFQMDIF SGELTALIDL DYEARQEYVI VVQATSAPLV 1150
SRATVHVRLV DQNDNSPVLN NFQILFNNYV SNRSDTFPSG IIGRIPAYDP 1200
DVSDHLFYSF ERGNELQLLV VNQTSGELRL SRKLDNNRPL VASMLVTVTD 1250
GLHSVTAQCV LRVVIITEEL LANSLTVRLE NMWQERFLSP LLGRFLEGVA 1300
AVLATPAEDV FIFNIQNDTD VGGTVLNVSF SALAPRGAGA GAAGPWFSSE 1350
ELQEQLYVRR AALAARSLLD VLPFDDNVCL REPCENYMKC VSVLRFDSSA 1400
PFLASASTLF RPIQPIAGLR CRCPPGFTGD FCETELDLCY SNPCRNGGAC 1450
ARREGGYTCV CRPRFTGEDC ELDTEAGRCV PGVCRNGGTC TDAPNGGFRC 1500
QCPAGGAFEG PRCEVAARSF PPSSFVMFRG LRQRFHLTLS LSFATVQQSG 1550
LLFYNGRLNE KHDFLALELV AGQVRLTYST GESNTVVSPT VPGGLSDGQW 1600
HTVHLRYYNK PRTDALGGAQ GPSKDKVAVL SVDDCDVAVA LQFGAEIGNY 1650
SCAAAGVQTS SKKSLDLTGP LLLGGVPNLP ENFPVSHKDF IGCMRDLHID 1700
GRRVDMAAFV ANNGTMAGCQ AKLHFCDSGP CKNSGFCSER WGSFSCDCPV 1750
GFGGKDCQLT MAHPHHFRGN GTLSWNFGSD MAVSVPWYLG LAFRTRATQG 1800
VLMQVQAGPH STLLCQLDRG LLSVTVTRGS GRASHLLLDQ VTVSDGRWHD 1850
LRLELQEEPG GRRGHHVLMV SLDFSLFQDT MAVGSELQGL KVKQLHVGGL 1900
PPGSAEEAPQ GLVGCIQGVW LGSTPSGSPA LLPPSHRVNA EPGCVVTNAC 1950
ASGPCPPHAD CRDLWQTFSC TCQPGYYGPG CVDACLLNPC QNQGSCRHLP 2000
GAPHGYTCDC VGGYFGHHCE HRMDQQCPRG WWGSPTCGPC NCDVHKGFDP 2050
NCNKTNGQCH CKEFHYRPRG SDSCLPCDCY PVGSTSRSCA PHSGQCPCRP 2100
GALGRQCNSC DSPFAEVTAS GCRVLYDACP KSLRSGVWWP QTKFGVLATV 2150
PCPRGALGAA VRLCDEAQGW LEPDLFNCTS PAFRELSLLL DGLELNKTAL 2200
DTMEAKKLAQ RLREVTGHTD HYFSQDVRVT ARLLAHLLAF ESHQQGFGLT 2250
ATQDAHFNEN LLWAGSALLA PETGDLWAAL GQRAPGGSPG SAGLVRHLEE 2300
YAATLARNME LTYLNPMGLV TPNIMLSIDR MEHPSSPRGA RRYPRYHSNL 2350
FRGQDAWDPH THVLLPSQSP RPSPSEVLPT SSSIENSTTS SVVPPPAPPE 2400
PEPGISIIIL LVYRTLGGLL PAQFQAERRG ARLPQNPVMN SPVVSVAVFH 2450
GRNFLRGILE SPISLEFRLL QTANRSKAIC VQWDPPGLAE QHGVWTARDC 2500
ELVHRNGSHA RCRCSRTGTF GVLMDASPRE RLEGDLELLA VFTHVVVAVS 2550
VAALVLTAAI LLSLRSLKSN VRGIHANVAA ALGVAELLFL LGIHRTHNQL 2600
VCTAVAILLH YFFLSTFAWL FVQGLHLYRM QVEPRNVDRG AMRFYHALGW 2650
GVPAVLLGLA VGLDPEGYGN PDFCWISVHE PLIWSFAGPV VLVIVMNGTM 2700
FLLAARTSCS TGQREAKKTS ALTLRSSFLL LLLVSASWLF GLLAVNHSIL 2750
AFHYLHAGLC GLQGLAVLLL FCVLNADARA AWMPACLGRK AAPEEARPAP 2800
GLGPGAYNNT ALFEESGLIR ITLGASTVSS VSSARSGRTQ DQDSQRGRSY 2850
LRDNVLVRHG SAADHTDHSL QAHAGPTDLD VAMFHRDAGA DSDSDSDLSL 2900
EEERSLSIPS SESEDNGRTR GRFQRPLCRA AQSERLLTHP KDVDGNDLLS 2950
YWPALGECEA APCALQTWGS ERRLGLDTSK DAANNNQPDP ALTSGDETSL 3000
GRAQRQRKGI LKNRLQYPLV PQTRGAPELS WCRAATLGHR AVPAASYGRI 3050
YAGGGTGSLS QPASRYSSRE QLDLLLRRQL SRERLEEAPA PVLRPLSRPG 3100
SQECMDAAPG RLEPKDRGST LPRRQPPRDY PGAMAGRFGS RDALDLGAPR 3150
EWLSTLPPPR RTRDLDPQPP PLPLSPQRQL SRDPLLPSRP LDSLSRSSNS 3200
REQLDQVPSR HPSREALGPL PQLLRAREDS VSGPSHGPST EQLDILSSIL 3250
ASFNSSALSS VQSSSTPLGP HTTATPSATA SVLGPSTPRS ATSHSISELS 3300
PDSEVPRSEG HS 3312
Length:3,312
Mass (Da):358,185
Last modified:May 5, 2009 - v2
Checksum:i9E6B37787A9F0348
GO
Isoform 2 (identifier: Q9NYQ7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2158-2158: G → GLRGAG

Note: No experimental confirmation available.

Show »
Length:3,317
Mass (Da):358,640
Checksum:i2E19853A04982607
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti157 – 1571A → P.
Corresponds to variant rs3733085 [ dbSNP | Ensembl ].
VAR_020022
Natural varianti805 – 8051S → T.
Corresponds to variant rs3821875 [ dbSNP | Ensembl ].
VAR_020023
Natural varianti1758 – 17581Q → R.
Corresponds to variant rs12107252 [ dbSNP | Ensembl ].
VAR_055101

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei2158 – 21581G → GLRGAG in isoform 2. VSP_037125

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 131G → E in AAF61929. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF231023 mRNA. Translation: AAF61929.1.
AC121252 Genomic DNA. No translation available.
AB011536 mRNA. Translation: BAA32464.1.
CCDSiCCDS2775.1. [Q9NYQ7-1]
PIRiT00250.
RefSeqiNP_001398.2. NM_001407.2. [Q9NYQ7-1]
UniGeneiHs.631926.

Genome annotation databases

EnsembliENST00000164024; ENSP00000164024; ENSG00000008300. [Q9NYQ7-1]
ENST00000544264; ENSP00000445694; ENSG00000008300. [Q9NYQ7-2]
GeneIDi1951.
KEGGihsa:1951.
UCSCiuc003cul.3. human. [Q9NYQ7-1]

Polymorphism databases

DMDMi229462826.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF231023 mRNA. Translation: AAF61929.1 .
AC121252 Genomic DNA. No translation available.
AB011536 mRNA. Translation: BAA32464.1 .
CCDSi CCDS2775.1. [Q9NYQ7-1 ]
PIRi T00250.
RefSeqi NP_001398.2. NM_001407.2. [Q9NYQ7-1 ]
UniGenei Hs.631926.

3D structure databases

ProteinModelPortali Q9NYQ7.
SMRi Q9NYQ7. Positions 318-1248, 1383-1853, 1949-2122.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108271. 4 interactions.
IntActi Q9NYQ7. 18 interactions.
MINTi MINT-1381104.
STRINGi 9606.ENSP00000164024.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q9NYQ7.

Polymorphism databases

DMDMi 229462826.

Proteomic databases

MaxQBi Q9NYQ7.
PaxDbi Q9NYQ7.
PRIDEi Q9NYQ7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000164024 ; ENSP00000164024 ; ENSG00000008300 . [Q9NYQ7-1 ]
ENST00000544264 ; ENSP00000445694 ; ENSG00000008300 . [Q9NYQ7-2 ]
GeneIDi 1951.
KEGGi hsa:1951.
UCSCi uc003cul.3. human. [Q9NYQ7-1 ]

Organism-specific databases

CTDi 1951.
GeneCardsi GC03M048673.
H-InvDB HIX0200467.
HGNCi HGNC:3230. CELSR3.
MIMi 604264. gene.
neXtProti NX_Q9NYQ7.
PharmGKBi PA26395.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000231346.
HOVERGENi HBG050887.
KOi K04602.
OMAi YRFVGPP.
OrthoDBi EOG7BP81K.
PhylomeDBi Q9NYQ7.
TreeFami TF323983.

Enzyme and pathway databases

SignaLinki Q9NYQ7.

Miscellaneous databases

ChiTaRSi CELSR3. human.
GeneWikii CELSR3.
GenomeRNAii 1951.
NextBioi 7907.
PROi Q9NYQ7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9NYQ7.
Bgeei Q9NYQ7.
CleanExi HS_CELSR3.
Genevestigatori Q9NYQ7.

Family and domain databases

Gene3Di 2.60.120.200. 2 hits.
2.60.40.60. 9 hits.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR022624. DUF3497.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR002049. EGF_laminin.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR001791. Laminin_G.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF00028. Cadherin. 8 hits.
PF12003. DUF3497. 1 hit.
PF00008. EGF. 2 hits.
PF01825. GPS. 1 hit.
PF02793. HRM. 1 hit.
PF00053. Laminin_EGF. 1 hit.
PF02210. Laminin_G_2. 2 hits.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
PR00249. GPCRSECRETIN.
SMARTi SM00112. CA. 9 hits.
SM00181. EGF. 6 hits.
SM00180. EGF_Lam. 1 hit.
SM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00282. LamG. 2 hits.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 9 hits.
SSF49899. SSF49899. 2 hits.
PROSITEi PS00010. ASX_HYDROXYL. 1 hit.
PS00232. CADHERIN_1. 7 hits.
PS50268. CADHERIN_2. 8 hits.
PS00022. EGF_1. 6 hits.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 6 hits.
PS01248. EGF_LAM_1. 1 hit.
PS50027. EGF_LAM_2. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view ]
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Publicationsi

« Hide 'large scale' publications
  1. "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes."
    Wu Q., Maniatis T.
    Proc. Natl. Acad. Sci. U.S.A. 97:3124-3129(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening."
    Nakayama M., Nakajima D., Nagase T., Nomura N., Seki N., Ohara O.
    Genomics 51:27-34(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1954-3312 (ISOFORM 2).
    Tissue: Brain.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiCELR3_HUMAN
AccessioniPrimary (citable) accession number: Q9NYQ7
Secondary accession number(s): O75092
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: May 5, 2009
Last modified: July 9, 2014
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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