Reviewed, UniProtKB/Swiss-Prot Q9NYQ7 (CELR3_HUMAN)

Names and origin

Protein names

Recommended name:
    Cadherin EGF LAG seven-pass G-type receptor 3
Alternative name(s):
    Flamingo homolog 1
      Short name=hFmi1
    Multiple epidermal growth factor-like domains 2
    Epidermal growth factor-like 1

Gene names

Name:	CELSR3
Synonyms:	CDHF11, EGFL1, FMI1, KIAA0812, MEGF2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	3312 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Receptor that may have an important role in cell/cell signaling during nervous system formation.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. Contains 9 cadherin domains. Contains 8 EGF-like domains. Contains 1 GPS domain. Contains 1 laminin EGF-like domain. Contains 2 laminin G-like domains.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	EGF-like domain Laminin EGF-like domain Repeat Signal Transmembrane
Ligand	Calcium
Molecular function	Developmental protein G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Hydroxylation
Gene Ontology (GO)
Biological process	homophilic cell adhesion Inferred from electronic annotation. Source: InterPro multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW neuropeptide signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Traceable author statement. Source: GDB plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	G-protein coupled receptor activity Traceable author statement. Source: GDB calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ABL1	P00519	1	EBI-308417,EBI-375543
FYN	P06241	1	EBI-308417,EBI-515315
GRB2	P62993	1	EBI-308417,EBI-401755
NCK1	P16333	1	EBI-308417,EBI-389883

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NYQ7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NYQ7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     2158-2158: G → GLRGAG

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 32	32	Potential
	Chain	33 – 3312	3280	Cadherin EGF LAG seven-pass G-type receptor 3		PRO_0000012918
Regions
	Topological domain	33 – 2540	2508	Extracellular Potential
	Transmembrane	2541 – 2561	21	1 Potential
	Topological domain	2562 – 2572	11	Cytoplasmic Potential
	Transmembrane	2573 – 2593	21	2 Potential
	Topological domain	2594 – 2601	8	Extracellular Potential
	Transmembrane	2602 – 2622	21	3 Potential
	Topological domain	2623 – 2643	21	Cytoplasmic Potential
	Transmembrane	2644 – 2664	21	4 Potential
	Topological domain	2665 – 2681	17	Extracellular Potential
	Transmembrane	2682 – 2702	21	5 Potential
	Topological domain	2703 – 2725	23	Cytoplasmic Potential
	Transmembrane	2726 – 2746	21	6 Potential
	Topological domain	2747 – 2753	7	Extracellular Potential
	Transmembrane	2754 – 2774	21	7 Potential
	Topological domain	2775 – 3312	538	Cytoplasmic Potential
	Domain	326 – 433	108	Cadherin 1
	Domain	434 – 545	112	Cadherin 2
	Domain	546 – 651	106	Cadherin 3
	Domain	652 – 756	105	Cadherin 4
	Domain	757 – 858	102	Cadherin 5
	Domain	859 – 961	103	Cadherin 6
	Domain	962 – 1067	106	Cadherin 7
	Domain	1068 – 1169	102	Cadherin 8
	Domain	1170 – 1265	96	Cadherin 9
	Domain	1375 – 1433	59	EGF-like 1; calcium-binding
	Domain	1435 – 1471	37	EGF-like 2; calcium-binding
	Domain	1475 – 1514	40	EGF-like 3; calcium-binding
	Domain	1515 – 1719	205	Laminin G-like 1
	Domain	1722 – 1758	37	EGF-like 4; calcium-binding
	Domain	1764 – 1944	181	Laminin G-like 2
	Domain	1946 – 1982	37	EGF-like 5; calcium-binding
	Domain	1983 – 2020	38	EGF-like 6; calcium-binding
	Domain	2021 – 2053	33	EGF-like 7; calcium-binding
	Domain	2055 – 2090	36	EGF-like 8; calcium-binding
	Domain	2077 – 2124	48	Laminin EGF-like
	Domain	2477 – 2529	53	GPS
Amino acid modifications
	Modified residue	1963	1	(3R)-3-hydroxyaspartate Potential
	Glycosylation	632	1	N-linked (GlcNAc...) Potential
	Glycosylation	847	1	N-linked (GlcNAc...) Potential
	Glycosylation	1182	1	N-linked (GlcNAc...) Potential
	Glycosylation	1222	1	N-linked (GlcNAc...) Potential
	Glycosylation	1317	1	N-linked (GlcNAc...) Potential
	Glycosylation	1327	1	N-linked (GlcNAc...) Potential
	Glycosylation	1649	1	N-linked (GlcNAc...) Potential
	Glycosylation	1713	1	N-linked (GlcNAc...) Potential
	Glycosylation	1770	1	N-linked (GlcNAc...) Potential
	Glycosylation	2053	1	N-linked (GlcNAc...) Potential
	Glycosylation	2177	1	N-linked (GlcNAc...) Potential
	Glycosylation	2196	1	N-linked (GlcNAc...) Potential
	Glycosylation	2386	1	N-linked (GlcNAc...) Potential
	Glycosylation	2474	1	N-linked (GlcNAc...) Potential
	Glycosylation	2506	1	N-linked (GlcNAc...) Potential
	Disulfide bond	1379 ↔ 1390		By similarity
	Disulfide bond	1384 ↔ 1421		By similarity
	Disulfide bond	1423 ↔ 1432		By similarity
	Disulfide bond	1439 ↔ 1450		By similarity
	Disulfide bond	1444 ↔ 1459		By similarity
	Disulfide bond	1461 ↔ 1470		By similarity
	Disulfide bond	1479 ↔ 1490		By similarity
	Disulfide bond	1484 ↔ 1500		By similarity
	Disulfide bond	1502 ↔ 1513		By similarity
	Disulfide bond	1693 ↔ 1719		By similarity
	Disulfide bond	1726 ↔ 1737		By similarity
	Disulfide bond	1731 ↔ 1746		By similarity
	Disulfide bond	1748 ↔ 1757		By similarity
	Disulfide bond	1915 ↔ 1944		By similarity
	Disulfide bond	1950 ↔ 1961		By similarity
	Disulfide bond	1955 ↔ 1970		By similarity
	Disulfide bond	1972 ↔ 1981		By similarity
	Disulfide bond	1985 ↔ 1996		By similarity
	Disulfide bond	1990 ↔ 2008		By similarity
	Disulfide bond	2010 ↔ 2019		By similarity
	Disulfide bond	2027 ↔ 2040		By similarity
	Disulfide bond	2042 ↔ 2052		By similarity
	Disulfide bond	2059 ↔ 2074		By similarity
	Disulfide bond	2061 ↔ 2077		By similarity
	Disulfide bond	2079 ↔ 2089		By similarity
	Disulfide bond	2098 ↔ 2107		By similarity
	Disulfide bond	2110 ↔ 2122		By similarity
Natural variations
	Alternative sequence	2158	1	G → GLRGAG in isoform 2.		VSP_037125
	Natural variant	157	1	A → P: dbSNP rs3733085.		VAR_020022
	Natural variant	805	1	S → T: dbSNP rs3821875.		VAR_020023
	Natural variant	1758	1	Q → R: dbSNP rs12107252.		VAR_055101
Experimental info
	Sequence conflict	13	1	G → E in AAF61929. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 5, 2009. Version 2. Checksum: 9E6B37787A9F0348	FASTA	3,312	358,185
	10 20 30 40 50 60 MMARRPPWRG LGGRSTPILL LLLLSLFPLS QEELGGGGHQ GWDPGLAATT GPRAHIGGGA 70 80 90 100 110 120 LALCPESSGV REDGGPGLGV REPIFVGLRG RRQSARNSRG PPEQPNEELG IEHGVQPLGS 130 140 150 160 170 180 RERETGQGPG SVLYWRPEVS SCGRTGPLQR GSLSPGALSS GVPGSGNSSP LPSDFLIRHH 190 200 210 220 230 240 GPKPVSSQRN AGTGSRKRVG TARCCGELWA TGSKGQGERA TTSGAERTAP RRNCLPGASG 250 260 270 280 290 300 SGPELDSAPR TARTAPASGS APRESRTAPE PAPKRMRSRG LFRCRFLPQR PGPRPPGLPA 310 320 330 340 350 360 RPEARKVTSA NRARFRRAAN RHPQFPQYNY QTLVPENEAA GTAVLRVVAQ DPDAGEAGRL 370 380 390 400 410 420 VYSLAALMNS RSLELFSIDP QSGLIRTAAA LDRESMERHY LRVTAQDHGS PRLSATTMVA 430 440 450 460 470 480 VTVADRNDHS PVFEQAQYRE TLRENVEEGY PILQLRATDG DAPPNANLRY RFVGPPAARA 490 500 510 520 530 540 AAAAAFEIDP RSGLISTSGR VDREHMESYE LVVEASDQGQ EPGPRSATVR VHITVLDEND 550 560 570 580 590 600 NAPQFSEKRY VAQVREDVRP HTVVLRVTAT DRDKDANGLV HYNIISGNSR GHFAIDSLTG 610 620 630 640 650 660 EIQVVAPLDF EAEREYALRI RAQDAGRPPL SNNTGLASIQ VVDINDHIPI FVSTPFQVSV 670 680 690 700 710 720 LENAPLGHSV IHIQAVDADH GENARLEYSL TGVAPDTPFV INSATGWVSV SGPLDRESVE 730 740 750 760 770 780 HYFFGVEARD HGSPPLSASA SVTVTVLDVN DNRPEFTMKE YHLRLNEDAA VGTSVVSVTA 790 800 810 820 830 840 VDRDANSAIS YQITGGNTRN RFAISTQGGV GLVTLALPLD YKQERYFKLV LTASDRALHD 850 860 870 880 890 900 HCYVHINITD ANTHRPVFQS AHYSVSVNED RPMGSTIVVI SASDDDVGEN ARITYLLEDN 910 920 930 940 950 960 LPQFRIDADS GAITLQAPLD YEDQVTYTLA ITARDNGIPQ KADTTYVEVM VNDVNDNAPQ 970 980 990 1000 1010 1020 FVASHYTGLV SEDAPPFTSV LQISATDRDA HANGRVQYTF QNGEDGDGDF TIEPTSGIVR 1030 1040 1050 1060 1070 1080 TVRRLDREAV SVYELTAYAV DRGVPPLRTP VSIQVMVQDV NDNAPVFPAE EFEVRVKENS 1090 1100 1110 1120 1130 1140 IVGSVVAQIT AVDPDEGPNA HIMYQIVEGN IPELFQMDIF SGELTALIDL DYEARQEYVI 1150 1160 1170 1180 1190 1200 VVQATSAPLV SRATVHVRLV DQNDNSPVLN NFQILFNNYV SNRSDTFPSG IIGRIPAYDP 1210 1220 1230 1240 1250 1260 DVSDHLFYSF ERGNELQLLV VNQTSGELRL SRKLDNNRPL VASMLVTVTD GLHSVTAQCV 1270 1280 1290 1300 1310 1320 LRVVIITEEL LANSLTVRLE NMWQERFLSP LLGRFLEGVA AVLATPAEDV FIFNIQNDTD 1330 1340 1350 1360 1370 1380 VGGTVLNVSF SALAPRGAGA GAAGPWFSSE ELQEQLYVRR AALAARSLLD VLPFDDNVCL 1390 1400 1410 1420 1430 1440 REPCENYMKC VSVLRFDSSA PFLASASTLF RPIQPIAGLR CRCPPGFTGD FCETELDLCY 1450 1460 1470 1480 1490 1500 SNPCRNGGAC ARREGGYTCV CRPRFTGEDC ELDTEAGRCV PGVCRNGGTC TDAPNGGFRC 1510 1520 1530 1540 1550 1560 QCPAGGAFEG PRCEVAARSF PPSSFVMFRG LRQRFHLTLS LSFATVQQSG LLFYNGRLNE 1570 1580 1590 1600 1610 1620 KHDFLALELV AGQVRLTYST GESNTVVSPT VPGGLSDGQW HTVHLRYYNK PRTDALGGAQ 1630 1640 1650 1660 1670 1680 GPSKDKVAVL SVDDCDVAVA LQFGAEIGNY SCAAAGVQTS SKKSLDLTGP LLLGGVPNLP 1690 1700 1710 1720 1730 1740 ENFPVSHKDF IGCMRDLHID GRRVDMAAFV ANNGTMAGCQ AKLHFCDSGP CKNSGFCSER 1750 1760 1770 1780 1790 1800 WGSFSCDCPV GFGGKDCQLT MAHPHHFRGN GTLSWNFGSD MAVSVPWYLG LAFRTRATQG 1810 1820 1830 1840 1850 1860 VLMQVQAGPH STLLCQLDRG LLSVTVTRGS GRASHLLLDQ VTVSDGRWHD LRLELQEEPG 1870 1880 1890 1900 1910 1920 GRRGHHVLMV SLDFSLFQDT MAVGSELQGL KVKQLHVGGL PPGSAEEAPQ GLVGCIQGVW 1930 1940 1950 1960 1970 1980 LGSTPSGSPA LLPPSHRVNA EPGCVVTNAC ASGPCPPHAD CRDLWQTFSC TCQPGYYGPG 1990 2000 2010 2020 2030 2040 CVDACLLNPC QNQGSCRHLP GAPHGYTCDC VGGYFGHHCE HRMDQQCPRG WWGSPTCGPC 2050 2060 2070 2080 2090 2100 NCDVHKGFDP NCNKTNGQCH CKEFHYRPRG SDSCLPCDCY PVGSTSRSCA PHSGQCPCRP 2110 2120 2130 2140 2150 2160 GALGRQCNSC DSPFAEVTAS GCRVLYDACP KSLRSGVWWP QTKFGVLATV PCPRGALGAA 2170 2180 2190 2200 2210 2220 VRLCDEAQGW LEPDLFNCTS PAFRELSLLL DGLELNKTAL DTMEAKKLAQ RLREVTGHTD 2230 2240 2250 2260 2270 2280 HYFSQDVRVT ARLLAHLLAF ESHQQGFGLT ATQDAHFNEN LLWAGSALLA PETGDLWAAL 2290 2300 2310 2320 2330 2340 GQRAPGGSPG SAGLVRHLEE YAATLARNME LTYLNPMGLV TPNIMLSIDR MEHPSSPRGA 2350 2360 2370 2380 2390 2400 RRYPRYHSNL FRGQDAWDPH THVLLPSQSP RPSPSEVLPT SSSIENSTTS SVVPPPAPPE 2410 2420 2430 2440 2450 2460 PEPGISIIIL LVYRTLGGLL PAQFQAERRG ARLPQNPVMN SPVVSVAVFH GRNFLRGILE 2470 2480 2490 2500 2510 2520 SPISLEFRLL QTANRSKAIC VQWDPPGLAE QHGVWTARDC ELVHRNGSHA RCRCSRTGTF 2530 2540 2550 2560 2570 2580 GVLMDASPRE RLEGDLELLA VFTHVVVAVS VAALVLTAAI LLSLRSLKSN VRGIHANVAA 2590 2600 2610 2620 2630 2640 ALGVAELLFL LGIHRTHNQL VCTAVAILLH YFFLSTFAWL FVQGLHLYRM QVEPRNVDRG 2650 2660 2670 2680 2690 2700 AMRFYHALGW GVPAVLLGLA VGLDPEGYGN PDFCWISVHE PLIWSFAGPV VLVIVMNGTM 2710 2720 2730 2740 2750 2760 FLLAARTSCS TGQREAKKTS ALTLRSSFLL LLLVSASWLF GLLAVNHSIL AFHYLHAGLC 2770 2780 2790 2800 2810 2820 GLQGLAVLLL FCVLNADARA AWMPACLGRK AAPEEARPAP GLGPGAYNNT ALFEESGLIR 2830 2840 2850 2860 2870 2880 ITLGASTVSS VSSARSGRTQ DQDSQRGRSY LRDNVLVRHG SAADHTDHSL QAHAGPTDLD 2890 2900 2910 2920 2930 2940 VAMFHRDAGA DSDSDSDLSL EEERSLSIPS SESEDNGRTR GRFQRPLCRA AQSERLLTHP 2950 2960 2970 2980 2990 3000 KDVDGNDLLS YWPALGECEA APCALQTWGS ERRLGLDTSK DAANNNQPDP ALTSGDETSL 3010 3020 3030 3040 3050 3060 GRAQRQRKGI LKNRLQYPLV PQTRGAPELS WCRAATLGHR AVPAASYGRI YAGGGTGSLS 3070 3080 3090 3100 3110 3120 QPASRYSSRE QLDLLLRRQL SRERLEEAPA PVLRPLSRPG SQECMDAAPG RLEPKDRGST 3130 3140 3150 3160 3170 3180 LPRRQPPRDY PGAMAGRFGS RDALDLGAPR EWLSTLPPPR RTRDLDPQPP PLPLSPQRQL 3190 3200 3210 3220 3230 3240 SRDPLLPSRP LDSLSRSSNS REQLDQVPSR HPSREALGPL PQLLRAREDS VSGPSHGPST 3250 3260 3270 3280 3290 3300 EQLDILSSIL ASFNSSALSS VQSSSTPLGP HTTATPSATA SVLGPSTPRS ATSHSISELS 3310 PDSEVPRSEG HS
	Isoform 2. Checksum: 2E19853A04982607	FASTA	3,317	358,640
	10 20 30 40 50 60 MMARRPPWRG LGGRSTPILL LLLLSLFPLS QEELGGGGHQ GWDPGLAATT GPRAHIGGGA 70 80 90 100 110 120 LALCPESSGV REDGGPGLGV REPIFVGLRG RRQSARNSRG PPEQPNEELG IEHGVQPLGS 130 140 150 160 170 180 RERETGQGPG SVLYWRPEVS SCGRTGPLQR GSLSPGALSS GVPGSGNSSP LPSDFLIRHH 190 200 210 220 230 240 GPKPVSSQRN AGTGSRKRVG TARCCGELWA TGSKGQGERA TTSGAERTAP RRNCLPGASG 250 260 270 280 290 300 SGPELDSAPR TARTAPASGS APRESRTAPE PAPKRMRSRG LFRCRFLPQR PGPRPPGLPA 310 320 330 340 350 360 RPEARKVTSA NRARFRRAAN RHPQFPQYNY QTLVPENEAA GTAVLRVVAQ DPDAGEAGRL 370 380 390 400 410 420 VYSLAALMNS RSLELFSIDP QSGLIRTAAA LDRESMERHY LRVTAQDHGS PRLSATTMVA 430 440 450 460 470 480 VTVADRNDHS PVFEQAQYRE TLRENVEEGY PILQLRATDG DAPPNANLRY RFVGPPAARA 490 500 510 520 530 540 AAAAAFEIDP RSGLISTSGR VDREHMESYE LVVEASDQGQ EPGPRSATVR VHITVLDEND 550 560 570 580 590 600 NAPQFSEKRY VAQVREDVRP HTVVLRVTAT DRDKDANGLV HYNIISGNSR GHFAIDSLTG 610 620 630 640 650 660 EIQVVAPLDF EAEREYALRI RAQDAGRPPL SNNTGLASIQ VVDINDHIPI FVSTPFQVSV 670 680 690 700 710 720 LENAPLGHSV IHIQAVDADH GENARLEYSL TGVAPDTPFV INSATGWVSV SGPLDRESVE 730 740 750 760 770 780 HYFFGVEARD HGSPPLSASA SVTVTVLDVN DNRPEFTMKE YHLRLNEDAA VGTSVVSVTA 790 800 810 820 830 840 VDRDANSAIS YQITGGNTRN RFAISTQGGV GLVTLALPLD YKQERYFKLV LTASDRALHD 850 860 870 880 890 900 HCYVHINITD ANTHRPVFQS AHYSVSVNED RPMGSTIVVI SASDDDVGEN ARITYLLEDN 910 920 930 940 950 960 LPQFRIDADS GAITLQAPLD YEDQVTYTLA ITARDNGIPQ KADTTYVEVM VNDVNDNAPQ 970 980 990 1000 1010 1020 FVASHYTGLV SEDAPPFTSV LQISATDRDA HANGRVQYTF QNGEDGDGDF TIEPTSGIVR 1030 1040 1050 1060 1070 1080 TVRRLDREAV SVYELTAYAV DRGVPPLRTP VSIQVMVQDV NDNAPVFPAE EFEVRVKENS 1090 1100 1110 1120 1130 1140 IVGSVVAQIT AVDPDEGPNA HIMYQIVEGN IPELFQMDIF SGELTALIDL DYEARQEYVI 1150 1160 1170 1180 1190 1200 VVQATSAPLV SRATVHVRLV DQNDNSPVLN NFQILFNNYV SNRSDTFPSG IIGRIPAYDP 1210 1220 1230 1240 1250 1260 DVSDHLFYSF ERGNELQLLV VNQTSGELRL SRKLDNNRPL VASMLVTVTD GLHSVTAQCV 1270 1280 1290 1300 1310 1320 LRVVIITEEL LANSLTVRLE NMWQERFLSP LLGRFLEGVA AVLATPAEDV FIFNIQNDTD 1330 1340 1350 1360 1370 1380 VGGTVLNVSF SALAPRGAGA GAAGPWFSSE ELQEQLYVRR AALAARSLLD VLPFDDNVCL 1390 1400 1410 1420 1430 1440 REPCENYMKC VSVLRFDSSA PFLASASTLF RPIQPIAGLR CRCPPGFTGD FCETELDLCY 1450 1460 1470 1480 1490 1500 SNPCRNGGAC ARREGGYTCV CRPRFTGEDC ELDTEAGRCV PGVCRNGGTC TDAPNGGFRC 1510 1520 1530 1540 1550 1560 QCPAGGAFEG PRCEVAARSF PPSSFVMFRG LRQRFHLTLS LSFATVQQSG LLFYNGRLNE 1570 1580 1590 1600 1610 1620 KHDFLALELV AGQVRLTYST GESNTVVSPT VPGGLSDGQW HTVHLRYYNK PRTDALGGAQ 1630 1640 1650 1660 1670 1680 GPSKDKVAVL SVDDCDVAVA LQFGAEIGNY SCAAAGVQTS SKKSLDLTGP LLLGGVPNLP 1690 1700 1710 1720 1730 1740 ENFPVSHKDF IGCMRDLHID GRRVDMAAFV ANNGTMAGCQ AKLHFCDSGP CKNSGFCSER 1750 1760 1770 1780 1790 1800 WGSFSCDCPV GFGGKDCQLT MAHPHHFRGN GTLSWNFGSD MAVSVPWYLG LAFRTRATQG 1810 1820 1830 1840 1850 1860 VLMQVQAGPH STLLCQLDRG LLSVTVTRGS GRASHLLLDQ VTVSDGRWHD LRLELQEEPG 1870 1880 1890 1900 1910 1920 GRRGHHVLMV SLDFSLFQDT MAVGSELQGL KVKQLHVGGL PPGSAEEAPQ GLVGCIQGVW 1930 1940 1950 1960 1970 1980 LGSTPSGSPA LLPPSHRVNA EPGCVVTNAC ASGPCPPHAD CRDLWQTFSC TCQPGYYGPG 1990 2000 2010 2020 2030 2040 CVDACLLNPC QNQGSCRHLP GAPHGYTCDC VGGYFGHHCE HRMDQQCPRG WWGSPTCGPC 2050 2060 2070 2080 2090 2100 NCDVHKGFDP NCNKTNGQCH CKEFHYRPRG SDSCLPCDCY PVGSTSRSCA PHSGQCPCRP 2110 2120 2130 2140 2150 2160 GALGRQCNSC DSPFAEVTAS GCRVLYDACP KSLRSGVWWP QTKFGVLATV PCPRGALGLR 2170 2180 2190 2200 2210 2220 GAGAAVRLCD EAQGWLEPDL FNCTSPAFRE LSLLLDGLEL NKTALDTMEA KKLAQRLREV 2230 2240 2250 2260 2270 2280 TGHTDHYFSQ DVRVTARLLA HLLAFESHQQ GFGLTATQDA HFNENLLWAG SALLAPETGD 2290 2300 2310 2320 2330 2340 LWAALGQRAP GGSPGSAGLV RHLEEYAATL ARNMELTYLN PMGLVTPNIM LSIDRMEHPS 2350 2360 2370 2380 2390 2400 SPRGARRYPR YHSNLFRGQD AWDPHTHVLL PSQSPRPSPS EVLPTSSSIE NSTTSSVVPP 2410 2420 2430 2440 2450 2460 PAPPEPEPGI SIIILLVYRT LGGLLPAQFQ AERRGARLPQ NPVMNSPVVS VAVFHGRNFL 2470 2480 2490 2500 2510 2520 RGILESPISL EFRLLQTANR SKAICVQWDP PGLAEQHGVW TARDCELVHR NGSHARCRCS 2530 2540 2550 2560 2570 2580 RTGTFGVLMD ASPRERLEGD LELLAVFTHV VVAVSVAALV LTAAILLSLR SLKSNVRGIH 2590 2600 2610 2620 2630 2640 ANVAAALGVA ELLFLLGIHR THNQLVCTAV AILLHYFFLS TFAWLFVQGL HLYRMQVEPR 2650 2660 2670 2680 2690 2700 NVDRGAMRFY HALGWGVPAV LLGLAVGLDP EGYGNPDFCW ISVHEPLIWS FAGPVVLVIV 2710 2720 2730 2740 2750 2760 MNGTMFLLAA RTSCSTGQRE AKKTSALTLR SSFLLLLLVS ASWLFGLLAV NHSILAFHYL 2770 2780 2790 2800 2810 2820 HAGLCGLQGL AVLLLFCVLN ADARAAWMPA CLGRKAAPEE ARPAPGLGPG AYNNTALFEE 2830 2840 2850 2860 2870 2880 SGLIRITLGA STVSSVSSAR SGRTQDQDSQ RGRSYLRDNV LVRHGSAADH TDHSLQAHAG 2890 2900 2910 2920 2930 2940 PTDLDVAMFH RDAGADSDSD SDLSLEEERS LSIPSSESED NGRTRGRFQR PLCRAAQSER 2950 2960 2970 2980 2990 3000 LLTHPKDVDG NDLLSYWPAL GECEAAPCAL QTWGSERRLG LDTSKDAANN NQPDPALTSG 3010 3020 3030 3040 3050 3060 DETSLGRAQR QRKGILKNRL QYPLVPQTRG APELSWCRAA TLGHRAVPAA SYGRIYAGGG 3070 3080 3090 3100 3110 3120 TGSLSQPASR YSSREQLDLL LRRQLSRERL EEAPAPVLRP LSRPGSQECM DAAPGRLEPK 3130 3140 3150 3160 3170 3180 DRGSTLPRRQ PPRDYPGAMA GRFGSRDALD LGAPREWLST LPPPRRTRDL DPQPPPLPLS 3190 3200 3210 3220 3230 3240 PQRQLSRDPL LPSRPLDSLS RSSNSREQLD QVPSRHPSRE ALGPLPQLLR AREDSVSGPS 3250 3260 3270 3280 3290 3300 HGPSTEQLDI LSSILASFNS SALSSVQSSS TPLGPHTTAT PSATASVLGP STPRSATSHS 3310 ISELSPDSEV PRSEGHS

References

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[1]	"Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes." Wu Q., Maniatis T. Proc. Natl. Acad. Sci. U.S.A. 97:3124-3129(2000) [PubMed: 10716726] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed: 16641997] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening." Nakayama M., Nakajima D., Nagase T., Nomura N., Seki N., Ohara O. Genomics 51:27-34(1998) [PubMed: 9693030] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1954-3312 (ISOFORM 2). Tissue: Brain.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF231023 mRNA. Translation: AAF61929.1. AC121252 Genomic DNA. No translation available. AB011536 mRNA. Translation: BAA32464.1.
IPI	IPI00015345.
PIR	T00250.
RefSeq	NP_001398.2.
UniGene	Hs.631926
3D structure databases
HSSP	HSSP built from PDB template 1GK5 based on UniProtKB P01132.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NYQ7. 18 interactions.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q9NYQ7.
Proteomic databases
PRIDE	Q9NYQ7.
Genome annotation databases
Ensembl	ENSG00000008300. Homo sapiens. [Contig view]
GeneID	1951.
KEGG	hsa:1951.
Organism-specific databases
GeneCards	GC03M048638.
H-InvDB	HIX0003291.
HGNC	HGNC:3230. CELSR3.
MIM	604264. gene.
PharmGKB	PA26395.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q9NYQ7.
Gene expression databases
ArrayExpress	Q9NYQ7.
Bgee	Q9NYQ7.
CleanEx	HS_CELSR3.
GermOnline	ENSG00000008300. Homo sapiens.
Family and domain databases
InterPro	IPR002126. Cadherin. IPR013320. ConA-like_subgrp. IPR006209. EGF. IPR006210. EGF-like. IPR013032. EGF-like_reg_CS. IPR000152. EGF-type_Asp/Asn_hydroxyl_CS. IPR000742. EGF_3. IPR002049. EGF_laminin. IPR017981. GPCR_2-like. IPR001879. GPCR_2_extracellular. IPR000832. GPCR_2_secretin-like. IPR017983. GPCR_2_secretin-like_CS. IPR001791. Laminin_G. IPR012680. Laminin_G_2. IPR000203. PKD_cys_rich. [Graphical view]
Gene3D	G3DSA:2.60.40.60. Cadherin. 8 hits. G3DSA:2.60.120.200. ConA_like_subgrp. 2 hits.
Pfam	PF00002. 7tm_2. 1 hit. PF00028. Cadherin. 9 hits. PF00008. EGF. 6 hits. PF01825. GPS. 1 hit. PF02793. HRM. 1 hit. PF00053. Laminin_EGF. 1 hit. PF02210. Laminin_G_2. 2 hits. [Graphical view]
PRINTS	PR00205. CADHERIN.
SMART	SM00112. CA. 9 hits. SM00181. EGF. 6 hits. SM00180. EGF_Lam. 1 hit. SM00303. GPS. 1 hit. SM00008. HormR. 1 hit. SM00282. LamG. 2 hits. [Graphical view]
PROSITE	PS00010. ASX_HYDROXYL. 1 hit. PS00232. CADHERIN_1. 7 hits. PS50268. CADHERIN_2. 8 hits. PS00022. EGF_1. 6 hits. PS01186. EGF_2. 4 hits. PS50026. EGF_3. 6 hits. PS01248. EGF_LAM_1. 1 hit. PS50027. EGF_LAM_2. 1 hit. PS00649. G_PROTEIN_RECEP_F2_1. False negative. PS00650. G_PROTEIN_RECEP_F2_2. 1 hit. PS50227. G_PROTEIN_RECEP_F2_3. 1 hit. PS50261. G_PROTEIN_RECEP_F2_4. 1 hit. PS50221. GPS. 1 hit. PS50025. LAM_G_DOMAIN. 2 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	7907.
SOURCE	Search...

Entry information

Entry name

CELR3_HUMAN

Accession

Primary (citable) accession number: Q9NYQ7
Secondary accession number(s): O75092

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 2, 2002
Last sequence update:	May 5, 2009
Last modified:	June 16, 2009
This is version 86 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)