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Protein

Cadherin EGF LAG seven-pass G-type receptor 3

Gene

CELSR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor that may have an important role in cell/cell signaling during nervous system formation.

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • G-protein coupled receptor activity Source: GDB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, G-protein coupled receptor, Receptor, Transducer

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000008300-MONOMER.
SignaLinkiQ9NYQ7.

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin EGF LAG seven-pass G-type receptor 3
Alternative name(s):
Cadherin family member 11
Epidermal growth factor-like protein 1
Short name:
EGF-like protein 1
Flamingo homolog 1
Short name:
hFmi1
Multiple epidermal growth factor-like domains protein 2
Short name:
Multiple EGF-like domains protein 2
Gene namesi
Name:CELSR3
Synonyms:CDHF11, EGFL1, FMI1, KIAA0812, MEGF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:3230. CELSR3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini33 – 2540ExtracellularSequence analysisAdd BLAST2508
Transmembranei2541 – 2561Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini2562 – 2572CytoplasmicSequence analysisAdd BLAST11
Transmembranei2573 – 2593Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini2594 – 2601ExtracellularSequence analysis8
Transmembranei2602 – 2622Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini2623 – 2643CytoplasmicSequence analysisAdd BLAST21
Transmembranei2644 – 2664Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini2665 – 2681ExtracellularSequence analysisAdd BLAST17
Transmembranei2682 – 2702Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini2703 – 2725CytoplasmicSequence analysisAdd BLAST23
Transmembranei2726 – 2746Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini2747 – 2753ExtracellularSequence analysis7
Transmembranei2754 – 2774Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini2775 – 3312CytoplasmicSequence analysisAdd BLAST538

GO - Cellular componenti

  • integral component of membrane Source: GDB
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1951.
OpenTargetsiENSG00000008300.
PharmGKBiPA26395.

Polymorphism and mutation databases

BioMutaiCELSR3.
DMDMi229462826.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_000001291833 – 3312Cadherin EGF LAG seven-pass G-type receptor 3Add BLAST3280

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi632N-linked (GlcNAc...)Sequence analysis1
Glycosylationi847N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1182N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1222N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1317N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1327N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1379 ↔ 1390By similarity
Disulfide bondi1384 ↔ 1421By similarity
Disulfide bondi1423 ↔ 1432By similarity
Disulfide bondi1439 ↔ 1450By similarity
Disulfide bondi1444 ↔ 1459By similarity
Disulfide bondi1461 ↔ 1470By similarity
Disulfide bondi1479 ↔ 1490By similarity
Disulfide bondi1484 ↔ 1500By similarity
Disulfide bondi1502 ↔ 1513By similarity
Glycosylationi1649N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1693 ↔ 1719By similarity
Glycosylationi1713N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1726 ↔ 1737By similarity
Disulfide bondi1731 ↔ 1746By similarity
Disulfide bondi1748 ↔ 1757By similarity
Glycosylationi1770N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1915 ↔ 1944By similarity
Disulfide bondi1950 ↔ 1961By similarity
Disulfide bondi1955 ↔ 1970By similarity
Modified residuei1963(3R)-3-hydroxyaspartateSequence analysis1
Disulfide bondi1972 ↔ 1981By similarity
Disulfide bondi1985 ↔ 1996By similarity
Disulfide bondi1990 ↔ 2008By similarity
Disulfide bondi2010 ↔ 2019By similarity
Disulfide bondi2027 ↔ 2040By similarity
Disulfide bondi2042 ↔ 2052By similarity
Glycosylationi2053N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi2059 ↔ 2074By similarity
Disulfide bondi2061 ↔ 2077By similarity
Disulfide bondi2079 ↔ 2089By similarity
Disulfide bondi2098 ↔ 2107By similarity
Disulfide bondi2110 ↔ 2122By similarity
Modified residuei2126PhosphotyrosineBy similarity1
Glycosylationi2177N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2196N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2386N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2474N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2506N-linked (GlcNAc...)Sequence analysis1
Modified residuei3051PhosphotyrosineBy similarity1
Modified residuei3097PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation, Phosphoprotein

Proteomic databases

EPDiQ9NYQ7.
MaxQBiQ9NYQ7.
PaxDbiQ9NYQ7.
PeptideAtlasiQ9NYQ7.
PRIDEiQ9NYQ7.

PTM databases

iPTMnetiQ9NYQ7.
PhosphoSitePlusiQ9NYQ7.

Expressioni

Gene expression databases

BgeeiENSG00000008300.
CleanExiHS_CELSR3.
GenevisibleiQ9NYQ7. HS.

Organism-specific databases

HPAiHPA062866.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NCK1P163332EBI-308417,EBI-389883

Protein-protein interaction databases

BioGridi108271. 17 interactors.
IntActiQ9NYQ7. 18 interactors.
MINTiMINT-1381104.
STRINGi9606.ENSP00000164024.

Structurei

3D structure databases

ProteinModelPortaliQ9NYQ7.
SMRiQ9NYQ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini326 – 433Cadherin 1PROSITE-ProRule annotationAdd BLAST108
Domaini434 – 545Cadherin 2PROSITE-ProRule annotationAdd BLAST112
Domaini546 – 651Cadherin 3PROSITE-ProRule annotationAdd BLAST106
Domaini652 – 756Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini757 – 858Cadherin 5PROSITE-ProRule annotationAdd BLAST102
Domaini859 – 961Cadherin 6PROSITE-ProRule annotationAdd BLAST103
Domaini962 – 1067Cadherin 7PROSITE-ProRule annotationAdd BLAST106
Domaini1068 – 1169Cadherin 8PROSITE-ProRule annotationAdd BLAST102
Domaini1170 – 1265Cadherin 9PROSITE-ProRule annotationAdd BLAST96
Domaini1375 – 1433EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd BLAST59
Domaini1435 – 1471EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1475 – 1514EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini1515 – 1719Laminin G-like 1PROSITE-ProRule annotationAdd BLAST205
Domaini1722 – 1758EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1764 – 1944Laminin G-like 2PROSITE-ProRule annotationAdd BLAST181
Domaini1946 – 1982EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1983 – 2020EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST38
Domaini2021 – 2053EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST33
Domaini2055 – 2090EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Domaini2077 – 2124Laminin EGF-likePROSITE-ProRule annotationAdd BLAST48
Domaini2477 – 2529GPSPROSITE-ProRule annotationAdd BLAST53

Sequence similaritiesi

Contains 9 cadherin domains.PROSITE-ProRule annotation
Contains 8 EGF-like domains.PROSITE-ProRule annotation
Contains 1 GPS domain.PROSITE-ProRule annotation
Contains 1 laminin EGF-like domain.PROSITE-ProRule annotation
Contains 2 laminin G-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Laminin EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4289. Eukaryota.
ENOG410XTGH. LUCA.
GeneTreeiENSGT00760000118805.
HOGENOMiHOG000231346.
HOVERGENiHBG050887.
InParanoidiQ9NYQ7.
KOiK04602.
OMAiYRFVGPP.
OrthoDBiEOG091G0039.
PhylomeDBiQ9NYQ7.
TreeFamiTF323983.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
2.60.40.60. 9 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR032471. GAIN_dom_N.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR002049. Laminin_EGF.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF00028. Cadherin. 8 hits.
PF00008. EGF. 2 hits.
PF16489. GAIN. 1 hit.
PF01825. GPS. 1 hit.
PF00053. Laminin_EGF. 1 hit.
PF02210. Laminin_G_2. 2 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
PR00249. GPCRSECRETIN.
SMARTiSM00112. CA. 9 hits.
SM00181. EGF. 6 hits.
SM00179. EGF_CA. 5 hits.
SM00180. EGF_Lam. 1 hit.
SM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00282. LamG. 2 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 9 hits.
SSF49899. SSF49899. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS00232. CADHERIN_1. 7 hits.
PS50268. CADHERIN_2. 8 hits.
PS00022. EGF_1. 6 hits.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 6 hits.
PS01248. EGF_LAM_1. 1 hit.
PS50027. EGF_LAM_2. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NYQ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMARRPPWRG LGGRSTPILL LLLLSLFPLS QEELGGGGHQ GWDPGLAATT
60 70 80 90 100
GPRAHIGGGA LALCPESSGV REDGGPGLGV REPIFVGLRG RRQSARNSRG
110 120 130 140 150
PPEQPNEELG IEHGVQPLGS RERETGQGPG SVLYWRPEVS SCGRTGPLQR
160 170 180 190 200
GSLSPGALSS GVPGSGNSSP LPSDFLIRHH GPKPVSSQRN AGTGSRKRVG
210 220 230 240 250
TARCCGELWA TGSKGQGERA TTSGAERTAP RRNCLPGASG SGPELDSAPR
260 270 280 290 300
TARTAPASGS APRESRTAPE PAPKRMRSRG LFRCRFLPQR PGPRPPGLPA
310 320 330 340 350
RPEARKVTSA NRARFRRAAN RHPQFPQYNY QTLVPENEAA GTAVLRVVAQ
360 370 380 390 400
DPDAGEAGRL VYSLAALMNS RSLELFSIDP QSGLIRTAAA LDRESMERHY
410 420 430 440 450
LRVTAQDHGS PRLSATTMVA VTVADRNDHS PVFEQAQYRE TLRENVEEGY
460 470 480 490 500
PILQLRATDG DAPPNANLRY RFVGPPAARA AAAAAFEIDP RSGLISTSGR
510 520 530 540 550
VDREHMESYE LVVEASDQGQ EPGPRSATVR VHITVLDEND NAPQFSEKRY
560 570 580 590 600
VAQVREDVRP HTVVLRVTAT DRDKDANGLV HYNIISGNSR GHFAIDSLTG
610 620 630 640 650
EIQVVAPLDF EAEREYALRI RAQDAGRPPL SNNTGLASIQ VVDINDHIPI
660 670 680 690 700
FVSTPFQVSV LENAPLGHSV IHIQAVDADH GENARLEYSL TGVAPDTPFV
710 720 730 740 750
INSATGWVSV SGPLDRESVE HYFFGVEARD HGSPPLSASA SVTVTVLDVN
760 770 780 790 800
DNRPEFTMKE YHLRLNEDAA VGTSVVSVTA VDRDANSAIS YQITGGNTRN
810 820 830 840 850
RFAISTQGGV GLVTLALPLD YKQERYFKLV LTASDRALHD HCYVHINITD
860 870 880 890 900
ANTHRPVFQS AHYSVSVNED RPMGSTIVVI SASDDDVGEN ARITYLLEDN
910 920 930 940 950
LPQFRIDADS GAITLQAPLD YEDQVTYTLA ITARDNGIPQ KADTTYVEVM
960 970 980 990 1000
VNDVNDNAPQ FVASHYTGLV SEDAPPFTSV LQISATDRDA HANGRVQYTF
1010 1020 1030 1040 1050
QNGEDGDGDF TIEPTSGIVR TVRRLDREAV SVYELTAYAV DRGVPPLRTP
1060 1070 1080 1090 1100
VSIQVMVQDV NDNAPVFPAE EFEVRVKENS IVGSVVAQIT AVDPDEGPNA
1110 1120 1130 1140 1150
HIMYQIVEGN IPELFQMDIF SGELTALIDL DYEARQEYVI VVQATSAPLV
1160 1170 1180 1190 1200
SRATVHVRLV DQNDNSPVLN NFQILFNNYV SNRSDTFPSG IIGRIPAYDP
1210 1220 1230 1240 1250
DVSDHLFYSF ERGNELQLLV VNQTSGELRL SRKLDNNRPL VASMLVTVTD
1260 1270 1280 1290 1300
GLHSVTAQCV LRVVIITEEL LANSLTVRLE NMWQERFLSP LLGRFLEGVA
1310 1320 1330 1340 1350
AVLATPAEDV FIFNIQNDTD VGGTVLNVSF SALAPRGAGA GAAGPWFSSE
1360 1370 1380 1390 1400
ELQEQLYVRR AALAARSLLD VLPFDDNVCL REPCENYMKC VSVLRFDSSA
1410 1420 1430 1440 1450
PFLASASTLF RPIQPIAGLR CRCPPGFTGD FCETELDLCY SNPCRNGGAC
1460 1470 1480 1490 1500
ARREGGYTCV CRPRFTGEDC ELDTEAGRCV PGVCRNGGTC TDAPNGGFRC
1510 1520 1530 1540 1550
QCPAGGAFEG PRCEVAARSF PPSSFVMFRG LRQRFHLTLS LSFATVQQSG
1560 1570 1580 1590 1600
LLFYNGRLNE KHDFLALELV AGQVRLTYST GESNTVVSPT VPGGLSDGQW
1610 1620 1630 1640 1650
HTVHLRYYNK PRTDALGGAQ GPSKDKVAVL SVDDCDVAVA LQFGAEIGNY
1660 1670 1680 1690 1700
SCAAAGVQTS SKKSLDLTGP LLLGGVPNLP ENFPVSHKDF IGCMRDLHID
1710 1720 1730 1740 1750
GRRVDMAAFV ANNGTMAGCQ AKLHFCDSGP CKNSGFCSER WGSFSCDCPV
1760 1770 1780 1790 1800
GFGGKDCQLT MAHPHHFRGN GTLSWNFGSD MAVSVPWYLG LAFRTRATQG
1810 1820 1830 1840 1850
VLMQVQAGPH STLLCQLDRG LLSVTVTRGS GRASHLLLDQ VTVSDGRWHD
1860 1870 1880 1890 1900
LRLELQEEPG GRRGHHVLMV SLDFSLFQDT MAVGSELQGL KVKQLHVGGL
1910 1920 1930 1940 1950
PPGSAEEAPQ GLVGCIQGVW LGSTPSGSPA LLPPSHRVNA EPGCVVTNAC
1960 1970 1980 1990 2000
ASGPCPPHAD CRDLWQTFSC TCQPGYYGPG CVDACLLNPC QNQGSCRHLP
2010 2020 2030 2040 2050
GAPHGYTCDC VGGYFGHHCE HRMDQQCPRG WWGSPTCGPC NCDVHKGFDP
2060 2070 2080 2090 2100
NCNKTNGQCH CKEFHYRPRG SDSCLPCDCY PVGSTSRSCA PHSGQCPCRP
2110 2120 2130 2140 2150
GALGRQCNSC DSPFAEVTAS GCRVLYDACP KSLRSGVWWP QTKFGVLATV
2160 2170 2180 2190 2200
PCPRGALGAA VRLCDEAQGW LEPDLFNCTS PAFRELSLLL DGLELNKTAL
2210 2220 2230 2240 2250
DTMEAKKLAQ RLREVTGHTD HYFSQDVRVT ARLLAHLLAF ESHQQGFGLT
2260 2270 2280 2290 2300
ATQDAHFNEN LLWAGSALLA PETGDLWAAL GQRAPGGSPG SAGLVRHLEE
2310 2320 2330 2340 2350
YAATLARNME LTYLNPMGLV TPNIMLSIDR MEHPSSPRGA RRYPRYHSNL
2360 2370 2380 2390 2400
FRGQDAWDPH THVLLPSQSP RPSPSEVLPT SSSIENSTTS SVVPPPAPPE
2410 2420 2430 2440 2450
PEPGISIIIL LVYRTLGGLL PAQFQAERRG ARLPQNPVMN SPVVSVAVFH
2460 2470 2480 2490 2500
GRNFLRGILE SPISLEFRLL QTANRSKAIC VQWDPPGLAE QHGVWTARDC
2510 2520 2530 2540 2550
ELVHRNGSHA RCRCSRTGTF GVLMDASPRE RLEGDLELLA VFTHVVVAVS
2560 2570 2580 2590 2600
VAALVLTAAI LLSLRSLKSN VRGIHANVAA ALGVAELLFL LGIHRTHNQL
2610 2620 2630 2640 2650
VCTAVAILLH YFFLSTFAWL FVQGLHLYRM QVEPRNVDRG AMRFYHALGW
2660 2670 2680 2690 2700
GVPAVLLGLA VGLDPEGYGN PDFCWISVHE PLIWSFAGPV VLVIVMNGTM
2710 2720 2730 2740 2750
FLLAARTSCS TGQREAKKTS ALTLRSSFLL LLLVSASWLF GLLAVNHSIL
2760 2770 2780 2790 2800
AFHYLHAGLC GLQGLAVLLL FCVLNADARA AWMPACLGRK AAPEEARPAP
2810 2820 2830 2840 2850
GLGPGAYNNT ALFEESGLIR ITLGASTVSS VSSARSGRTQ DQDSQRGRSY
2860 2870 2880 2890 2900
LRDNVLVRHG SAADHTDHSL QAHAGPTDLD VAMFHRDAGA DSDSDSDLSL
2910 2920 2930 2940 2950
EEERSLSIPS SESEDNGRTR GRFQRPLCRA AQSERLLTHP KDVDGNDLLS
2960 2970 2980 2990 3000
YWPALGECEA APCALQTWGS ERRLGLDTSK DAANNNQPDP ALTSGDETSL
3010 3020 3030 3040 3050
GRAQRQRKGI LKNRLQYPLV PQTRGAPELS WCRAATLGHR AVPAASYGRI
3060 3070 3080 3090 3100
YAGGGTGSLS QPASRYSSRE QLDLLLRRQL SRERLEEAPA PVLRPLSRPG
3110 3120 3130 3140 3150
SQECMDAAPG RLEPKDRGST LPRRQPPRDY PGAMAGRFGS RDALDLGAPR
3160 3170 3180 3190 3200
EWLSTLPPPR RTRDLDPQPP PLPLSPQRQL SRDPLLPSRP LDSLSRSSNS
3210 3220 3230 3240 3250
REQLDQVPSR HPSREALGPL PQLLRAREDS VSGPSHGPST EQLDILSSIL
3260 3270 3280 3290 3300
ASFNSSALSS VQSSSTPLGP HTTATPSATA SVLGPSTPRS ATSHSISELS
3310
PDSEVPRSEG HS
Length:3,312
Mass (Da):358,185
Last modified:May 5, 2009 - v2
Checksum:i9E6B37787A9F0348
GO
Isoform 2 (identifier: Q9NYQ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2158-2158: G → GLRGAG

Note: No experimental confirmation available.
Show »
Length:3,317
Mass (Da):358,640
Checksum:i2E19853A04982607
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13G → E in AAF61929 (PubMed:10716726).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020022157A → P.Corresponds to variant rs3733085dbSNPEnsembl.1
Natural variantiVAR_020023805S → T.Corresponds to variant rs3821875dbSNPEnsembl.1
Natural variantiVAR_0551011758Q → R.Corresponds to variant rs12107252dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0371252158G → GLRGAG in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF231023 mRNA. Translation: AAF61929.1.
AC121252 Genomic DNA. No translation available.
AB011536 mRNA. Translation: BAA32464.1.
CCDSiCCDS2775.1. [Q9NYQ7-1]
PIRiT00250.
RefSeqiNP_001398.2. NM_001407.2. [Q9NYQ7-1]
UniGeneiHs.631926.

Genome annotation databases

EnsembliENST00000164024; ENSP00000164024; ENSG00000008300. [Q9NYQ7-1]
GeneIDi1951.
KEGGihsa:1951.
UCSCiuc003cul.4. human. [Q9NYQ7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF231023 mRNA. Translation: AAF61929.1.
AC121252 Genomic DNA. No translation available.
AB011536 mRNA. Translation: BAA32464.1.
CCDSiCCDS2775.1. [Q9NYQ7-1]
PIRiT00250.
RefSeqiNP_001398.2. NM_001407.2. [Q9NYQ7-1]
UniGeneiHs.631926.

3D structure databases

ProteinModelPortaliQ9NYQ7.
SMRiQ9NYQ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108271. 17 interactors.
IntActiQ9NYQ7. 18 interactors.
MINTiMINT-1381104.
STRINGi9606.ENSP00000164024.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9NYQ7.
PhosphoSitePlusiQ9NYQ7.

Polymorphism and mutation databases

BioMutaiCELSR3.
DMDMi229462826.

Proteomic databases

EPDiQ9NYQ7.
MaxQBiQ9NYQ7.
PaxDbiQ9NYQ7.
PeptideAtlasiQ9NYQ7.
PRIDEiQ9NYQ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000164024; ENSP00000164024; ENSG00000008300. [Q9NYQ7-1]
GeneIDi1951.
KEGGihsa:1951.
UCSCiuc003cul.4. human. [Q9NYQ7-1]

Organism-specific databases

CTDi1951.
DisGeNETi1951.
GeneCardsiCELSR3.
H-InvDBHIX0200467.
HGNCiHGNC:3230. CELSR3.
HPAiHPA062866.
MIMi604264. gene.
neXtProtiNX_Q9NYQ7.
OpenTargetsiENSG00000008300.
PharmGKBiPA26395.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4289. Eukaryota.
ENOG410XTGH. LUCA.
GeneTreeiENSGT00760000118805.
HOGENOMiHOG000231346.
HOVERGENiHBG050887.
InParanoidiQ9NYQ7.
KOiK04602.
OMAiYRFVGPP.
OrthoDBiEOG091G0039.
PhylomeDBiQ9NYQ7.
TreeFamiTF323983.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000008300-MONOMER.
SignaLinkiQ9NYQ7.

Miscellaneous databases

ChiTaRSiCELSR3. human.
GeneWikiiCELSR3.
GenomeRNAii1951.
PROiQ9NYQ7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000008300.
CleanExiHS_CELSR3.
GenevisibleiQ9NYQ7. HS.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
2.60.40.60. 9 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR032471. GAIN_dom_N.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR002049. Laminin_EGF.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF00028. Cadherin. 8 hits.
PF00008. EGF. 2 hits.
PF16489. GAIN. 1 hit.
PF01825. GPS. 1 hit.
PF00053. Laminin_EGF. 1 hit.
PF02210. Laminin_G_2. 2 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
PR00249. GPCRSECRETIN.
SMARTiSM00112. CA. 9 hits.
SM00181. EGF. 6 hits.
SM00179. EGF_CA. 5 hits.
SM00180. EGF_Lam. 1 hit.
SM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00282. LamG. 2 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 9 hits.
SSF49899. SSF49899. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS00232. CADHERIN_1. 7 hits.
PS50268. CADHERIN_2. 8 hits.
PS00022. EGF_1. 6 hits.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 6 hits.
PS01248. EGF_LAM_1. 1 hit.
PS50027. EGF_LAM_2. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCELR3_HUMAN
AccessioniPrimary (citable) accession number: Q9NYQ7
Secondary accession number(s): O75092
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: May 5, 2009
Last modified: November 2, 2016
This is version 158 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.