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Q9NYQ7

- CELR3_HUMAN

UniProt

Q9NYQ7 - CELR3_HUMAN

Protein

Cadherin EGF LAG seven-pass G-type receptor 3

Gene

CELSR3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 138 (01 Oct 2014)
      Sequence version 2 (05 May 2009)
      Previous versions | rss
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    Functioni

    Receptor that may have an important role in cell/cell signaling during nervous system formation.

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. G-protein coupled receptor activity Source: GDB
    3. protein binding Source: IntAct

    GO - Biological processi

    1. axonal fasciculation Source: Ensembl
    2. cilium assembly Source: Ensembl
    3. G-protein coupled receptor signaling pathway Source: GDB
    4. homophilic cell adhesion Source: InterPro
    5. neuron migration Source: Ensembl
    6. neuropeptide signaling pathway Source: InterPro
    7. regulation of protein localization Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein, G-protein coupled receptor, Receptor, Transducer

    Keywords - Ligandi

    Calcium

    Enzyme and pathway databases

    SignaLinkiQ9NYQ7.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cadherin EGF LAG seven-pass G-type receptor 3
    Alternative name(s):
    Cadherin family member 11
    Epidermal growth factor-like protein 1
    Short name:
    EGF-like protein 1
    Flamingo homolog 1
    Short name:
    hFmi1
    Multiple epidermal growth factor-like domains protein 2
    Short name:
    Multiple EGF-like domains protein 2
    Gene namesi
    Name:CELSR3
    Synonyms:CDHF11, EGFL1, FMI1, KIAA0812, MEGF2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:3230. CELSR3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: GDB
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26395.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3232Sequence AnalysisAdd
    BLAST
    Chaini33 – 33123280Cadherin EGF LAG seven-pass G-type receptor 3PRO_0000012918Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi632 – 6321N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi847 – 8471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1182 – 11821N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1222 – 12221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1317 – 13171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1327 – 13271N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1379 ↔ 1390By similarity
    Disulfide bondi1384 ↔ 1421By similarity
    Disulfide bondi1423 ↔ 1432By similarity
    Disulfide bondi1439 ↔ 1450By similarity
    Disulfide bondi1444 ↔ 1459By similarity
    Disulfide bondi1461 ↔ 1470By similarity
    Disulfide bondi1479 ↔ 1490By similarity
    Disulfide bondi1484 ↔ 1500By similarity
    Disulfide bondi1502 ↔ 1513By similarity
    Glycosylationi1649 – 16491N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1693 ↔ 1719By similarity
    Glycosylationi1713 – 17131N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1726 ↔ 1737By similarity
    Disulfide bondi1731 ↔ 1746By similarity
    Disulfide bondi1748 ↔ 1757By similarity
    Glycosylationi1770 – 17701N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1915 ↔ 1944By similarity
    Disulfide bondi1950 ↔ 1961By similarity
    Disulfide bondi1955 ↔ 1970By similarity
    Modified residuei1963 – 19631(3R)-3-hydroxyaspartateSequence Analysis
    Disulfide bondi1972 ↔ 1981By similarity
    Disulfide bondi1985 ↔ 1996By similarity
    Disulfide bondi1990 ↔ 2008By similarity
    Disulfide bondi2010 ↔ 2019By similarity
    Disulfide bondi2027 ↔ 2040By similarity
    Disulfide bondi2042 ↔ 2052By similarity
    Glycosylationi2053 – 20531N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi2059 ↔ 2074By similarity
    Disulfide bondi2061 ↔ 2077By similarity
    Disulfide bondi2079 ↔ 2089By similarity
    Disulfide bondi2098 ↔ 2107By similarity
    Disulfide bondi2110 ↔ 2122By similarity
    Modified residuei2126 – 21261PhosphotyrosineBy similarity
    Glycosylationi2177 – 21771N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2196 – 21961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2386 – 23861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2474 – 24741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2506 – 25061N-linked (GlcNAc...)Sequence Analysis
    Modified residuei3051 – 30511PhosphotyrosineBy similarity
    Modified residuei3097 – 30971PhosphoserineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Hydroxylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9NYQ7.
    PaxDbiQ9NYQ7.
    PRIDEiQ9NYQ7.

    PTM databases

    PhosphoSiteiQ9NYQ7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NYQ7.
    BgeeiQ9NYQ7.
    CleanExiHS_CELSR3.
    GenevestigatoriQ9NYQ7.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    NCK1P163332EBI-308417,EBI-389883

    Protein-protein interaction databases

    BioGridi108271. 4 interactions.
    IntActiQ9NYQ7. 18 interactions.
    MINTiMINT-1381104.
    STRINGi9606.ENSP00000164024.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NYQ7.
    SMRiQ9NYQ7. Positions 318-1248, 1383-1853, 1949-2122.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini33 – 25402508ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini2562 – 257211CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini2594 – 26018ExtracellularSequence Analysis
    Topological domaini2623 – 264321CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini2665 – 268117ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini2703 – 272523CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini2747 – 27537ExtracellularSequence Analysis
    Topological domaini2775 – 3312538CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei2541 – 256121Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei2573 – 259321Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei2602 – 262221Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei2644 – 266421Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei2682 – 270221Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei2726 – 274621Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei2754 – 277421Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini326 – 433108Cadherin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini434 – 545112Cadherin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini546 – 651106Cadherin 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini652 – 756105Cadherin 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini757 – 858102Cadherin 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini859 – 961103Cadherin 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini962 – 1067106Cadherin 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini1068 – 1169102Cadherin 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini1170 – 126596Cadherin 9PROSITE-ProRule annotationAdd
    BLAST
    Domaini1375 – 143359EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini1435 – 147137EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini1475 – 151440EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini1515 – 1719205Laminin G-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1722 – 175837EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini1764 – 1944181Laminin G-like 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1946 – 198237EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini1983 – 202038EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini2021 – 205333EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini2055 – 209036EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini2077 – 212448Laminin EGF-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini2477 – 252953GPSPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 9 cadherin domains.PROSITE-ProRule annotation
    Contains 8 EGF-like domains.PROSITE-ProRule annotation
    Contains 1 GPS domain.PROSITE-ProRule annotation
    Contains 1 laminin EGF-like domain.PROSITE-ProRule annotation
    Contains 2 laminin G-like domains.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Laminin EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG12793.
    HOGENOMiHOG000231346.
    HOVERGENiHBG050887.
    KOiK04602.
    OMAiYRFVGPP.
    OrthoDBiEOG7BP81K.
    PhylomeDBiQ9NYQ7.
    TreeFamiTF323983.

    Family and domain databases

    Gene3Di2.60.120.200. 2 hits.
    2.60.40.60. 9 hits.
    InterProiIPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR022624. DUF3497.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR002049. EGF_laminin.
    IPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    IPR000203. GPS.
    IPR001791. Laminin_G.
    [Graphical view]
    PfamiPF00002. 7tm_2. 1 hit.
    PF00028. Cadherin. 8 hits.
    PF12003. DUF3497. 1 hit.
    PF00008. EGF. 2 hits.
    PF01825. GPS. 1 hit.
    PF02793. HRM. 1 hit.
    PF00053. Laminin_EGF. 1 hit.
    PF02210. Laminin_G_2. 2 hits.
    [Graphical view]
    PRINTSiPR00205. CADHERIN.
    PR00249. GPCRSECRETIN.
    SMARTiSM00112. CA. 9 hits.
    SM00181. EGF. 6 hits.
    SM00180. EGF_Lam. 1 hit.
    SM00303. GPS. 1 hit.
    SM00008. HormR. 1 hit.
    SM00282. LamG. 2 hits.
    [Graphical view]
    SUPFAMiSSF49313. SSF49313. 9 hits.
    SSF49899. SSF49899. 2 hits.
    PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
    PS00232. CADHERIN_1. 7 hits.
    PS50268. CADHERIN_2. 8 hits.
    PS00022. EGF_1. 6 hits.
    PS01186. EGF_2. 4 hits.
    PS50026. EGF_3. 6 hits.
    PS01248. EGF_LAM_1. 1 hit.
    PS50027. EGF_LAM_2. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    PS50025. LAM_G_DOMAIN. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NYQ7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMARRPPWRG LGGRSTPILL LLLLSLFPLS QEELGGGGHQ GWDPGLAATT     50
    GPRAHIGGGA LALCPESSGV REDGGPGLGV REPIFVGLRG RRQSARNSRG 100
    PPEQPNEELG IEHGVQPLGS RERETGQGPG SVLYWRPEVS SCGRTGPLQR 150
    GSLSPGALSS GVPGSGNSSP LPSDFLIRHH GPKPVSSQRN AGTGSRKRVG 200
    TARCCGELWA TGSKGQGERA TTSGAERTAP RRNCLPGASG SGPELDSAPR 250
    TARTAPASGS APRESRTAPE PAPKRMRSRG LFRCRFLPQR PGPRPPGLPA 300
    RPEARKVTSA NRARFRRAAN RHPQFPQYNY QTLVPENEAA GTAVLRVVAQ 350
    DPDAGEAGRL VYSLAALMNS RSLELFSIDP QSGLIRTAAA LDRESMERHY 400
    LRVTAQDHGS PRLSATTMVA VTVADRNDHS PVFEQAQYRE TLRENVEEGY 450
    PILQLRATDG DAPPNANLRY RFVGPPAARA AAAAAFEIDP RSGLISTSGR 500
    VDREHMESYE LVVEASDQGQ EPGPRSATVR VHITVLDEND NAPQFSEKRY 550
    VAQVREDVRP HTVVLRVTAT DRDKDANGLV HYNIISGNSR GHFAIDSLTG 600
    EIQVVAPLDF EAEREYALRI RAQDAGRPPL SNNTGLASIQ VVDINDHIPI 650
    FVSTPFQVSV LENAPLGHSV IHIQAVDADH GENARLEYSL TGVAPDTPFV 700
    INSATGWVSV SGPLDRESVE HYFFGVEARD HGSPPLSASA SVTVTVLDVN 750
    DNRPEFTMKE YHLRLNEDAA VGTSVVSVTA VDRDANSAIS YQITGGNTRN 800
    RFAISTQGGV GLVTLALPLD YKQERYFKLV LTASDRALHD HCYVHINITD 850
    ANTHRPVFQS AHYSVSVNED RPMGSTIVVI SASDDDVGEN ARITYLLEDN 900
    LPQFRIDADS GAITLQAPLD YEDQVTYTLA ITARDNGIPQ KADTTYVEVM 950
    VNDVNDNAPQ FVASHYTGLV SEDAPPFTSV LQISATDRDA HANGRVQYTF 1000
    QNGEDGDGDF TIEPTSGIVR TVRRLDREAV SVYELTAYAV DRGVPPLRTP 1050
    VSIQVMVQDV NDNAPVFPAE EFEVRVKENS IVGSVVAQIT AVDPDEGPNA 1100
    HIMYQIVEGN IPELFQMDIF SGELTALIDL DYEARQEYVI VVQATSAPLV 1150
    SRATVHVRLV DQNDNSPVLN NFQILFNNYV SNRSDTFPSG IIGRIPAYDP 1200
    DVSDHLFYSF ERGNELQLLV VNQTSGELRL SRKLDNNRPL VASMLVTVTD 1250
    GLHSVTAQCV LRVVIITEEL LANSLTVRLE NMWQERFLSP LLGRFLEGVA 1300
    AVLATPAEDV FIFNIQNDTD VGGTVLNVSF SALAPRGAGA GAAGPWFSSE 1350
    ELQEQLYVRR AALAARSLLD VLPFDDNVCL REPCENYMKC VSVLRFDSSA 1400
    PFLASASTLF RPIQPIAGLR CRCPPGFTGD FCETELDLCY SNPCRNGGAC 1450
    ARREGGYTCV CRPRFTGEDC ELDTEAGRCV PGVCRNGGTC TDAPNGGFRC 1500
    QCPAGGAFEG PRCEVAARSF PPSSFVMFRG LRQRFHLTLS LSFATVQQSG 1550
    LLFYNGRLNE KHDFLALELV AGQVRLTYST GESNTVVSPT VPGGLSDGQW 1600
    HTVHLRYYNK PRTDALGGAQ GPSKDKVAVL SVDDCDVAVA LQFGAEIGNY 1650
    SCAAAGVQTS SKKSLDLTGP LLLGGVPNLP ENFPVSHKDF IGCMRDLHID 1700
    GRRVDMAAFV ANNGTMAGCQ AKLHFCDSGP CKNSGFCSER WGSFSCDCPV 1750
    GFGGKDCQLT MAHPHHFRGN GTLSWNFGSD MAVSVPWYLG LAFRTRATQG 1800
    VLMQVQAGPH STLLCQLDRG LLSVTVTRGS GRASHLLLDQ VTVSDGRWHD 1850
    LRLELQEEPG GRRGHHVLMV SLDFSLFQDT MAVGSELQGL KVKQLHVGGL 1900
    PPGSAEEAPQ GLVGCIQGVW LGSTPSGSPA LLPPSHRVNA EPGCVVTNAC 1950
    ASGPCPPHAD CRDLWQTFSC TCQPGYYGPG CVDACLLNPC QNQGSCRHLP 2000
    GAPHGYTCDC VGGYFGHHCE HRMDQQCPRG WWGSPTCGPC NCDVHKGFDP 2050
    NCNKTNGQCH CKEFHYRPRG SDSCLPCDCY PVGSTSRSCA PHSGQCPCRP 2100
    GALGRQCNSC DSPFAEVTAS GCRVLYDACP KSLRSGVWWP QTKFGVLATV 2150
    PCPRGALGAA VRLCDEAQGW LEPDLFNCTS PAFRELSLLL DGLELNKTAL 2200
    DTMEAKKLAQ RLREVTGHTD HYFSQDVRVT ARLLAHLLAF ESHQQGFGLT 2250
    ATQDAHFNEN LLWAGSALLA PETGDLWAAL GQRAPGGSPG SAGLVRHLEE 2300
    YAATLARNME LTYLNPMGLV TPNIMLSIDR MEHPSSPRGA RRYPRYHSNL 2350
    FRGQDAWDPH THVLLPSQSP RPSPSEVLPT SSSIENSTTS SVVPPPAPPE 2400
    PEPGISIIIL LVYRTLGGLL PAQFQAERRG ARLPQNPVMN SPVVSVAVFH 2450
    GRNFLRGILE SPISLEFRLL QTANRSKAIC VQWDPPGLAE QHGVWTARDC 2500
    ELVHRNGSHA RCRCSRTGTF GVLMDASPRE RLEGDLELLA VFTHVVVAVS 2550
    VAALVLTAAI LLSLRSLKSN VRGIHANVAA ALGVAELLFL LGIHRTHNQL 2600
    VCTAVAILLH YFFLSTFAWL FVQGLHLYRM QVEPRNVDRG AMRFYHALGW 2650
    GVPAVLLGLA VGLDPEGYGN PDFCWISVHE PLIWSFAGPV VLVIVMNGTM 2700
    FLLAARTSCS TGQREAKKTS ALTLRSSFLL LLLVSASWLF GLLAVNHSIL 2750
    AFHYLHAGLC GLQGLAVLLL FCVLNADARA AWMPACLGRK AAPEEARPAP 2800
    GLGPGAYNNT ALFEESGLIR ITLGASTVSS VSSARSGRTQ DQDSQRGRSY 2850
    LRDNVLVRHG SAADHTDHSL QAHAGPTDLD VAMFHRDAGA DSDSDSDLSL 2900
    EEERSLSIPS SESEDNGRTR GRFQRPLCRA AQSERLLTHP KDVDGNDLLS 2950
    YWPALGECEA APCALQTWGS ERRLGLDTSK DAANNNQPDP ALTSGDETSL 3000
    GRAQRQRKGI LKNRLQYPLV PQTRGAPELS WCRAATLGHR AVPAASYGRI 3050
    YAGGGTGSLS QPASRYSSRE QLDLLLRRQL SRERLEEAPA PVLRPLSRPG 3100
    SQECMDAAPG RLEPKDRGST LPRRQPPRDY PGAMAGRFGS RDALDLGAPR 3150
    EWLSTLPPPR RTRDLDPQPP PLPLSPQRQL SRDPLLPSRP LDSLSRSSNS 3200
    REQLDQVPSR HPSREALGPL PQLLRAREDS VSGPSHGPST EQLDILSSIL 3250
    ASFNSSALSS VQSSSTPLGP HTTATPSATA SVLGPSTPRS ATSHSISELS 3300
    PDSEVPRSEG HS 3312
    Length:3,312
    Mass (Da):358,185
    Last modified:May 5, 2009 - v2
    Checksum:i9E6B37787A9F0348
    GO
    Isoform 2 (identifier: Q9NYQ7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         2158-2158: G → GLRGAG

    Note: No experimental confirmation available.

    Show »
    Length:3,317
    Mass (Da):358,640
    Checksum:i2E19853A04982607
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti13 – 131G → E in AAF61929. (PubMed:10716726)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti157 – 1571A → P.
    Corresponds to variant rs3733085 [ dbSNP | Ensembl ].
    VAR_020022
    Natural varianti805 – 8051S → T.
    Corresponds to variant rs3821875 [ dbSNP | Ensembl ].
    VAR_020023
    Natural varianti1758 – 17581Q → R.
    Corresponds to variant rs12107252 [ dbSNP | Ensembl ].
    VAR_055101

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei2158 – 21581G → GLRGAG in isoform 2. 1 PublicationVSP_037125

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF231023 mRNA. Translation: AAF61929.1.
    AC121252 Genomic DNA. No translation available.
    AB011536 mRNA. Translation: BAA32464.1.
    CCDSiCCDS2775.1. [Q9NYQ7-1]
    PIRiT00250.
    RefSeqiNP_001398.2. NM_001407.2. [Q9NYQ7-1]
    UniGeneiHs.631926.

    Genome annotation databases

    EnsembliENST00000164024; ENSP00000164024; ENSG00000008300. [Q9NYQ7-1]
    GeneIDi1951.
    KEGGihsa:1951.
    UCSCiuc003cul.3. human. [Q9NYQ7-1]

    Polymorphism databases

    DMDMi229462826.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF231023 mRNA. Translation: AAF61929.1 .
    AC121252 Genomic DNA. No translation available.
    AB011536 mRNA. Translation: BAA32464.1 .
    CCDSi CCDS2775.1. [Q9NYQ7-1 ]
    PIRi T00250.
    RefSeqi NP_001398.2. NM_001407.2. [Q9NYQ7-1 ]
    UniGenei Hs.631926.

    3D structure databases

    ProteinModelPortali Q9NYQ7.
    SMRi Q9NYQ7. Positions 318-1248, 1383-1853, 1949-2122.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108271. 4 interactions.
    IntActi Q9NYQ7. 18 interactions.
    MINTi MINT-1381104.
    STRINGi 9606.ENSP00000164024.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9NYQ7.

    Polymorphism databases

    DMDMi 229462826.

    Proteomic databases

    MaxQBi Q9NYQ7.
    PaxDbi Q9NYQ7.
    PRIDEi Q9NYQ7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000164024 ; ENSP00000164024 ; ENSG00000008300 . [Q9NYQ7-1 ]
    GeneIDi 1951.
    KEGGi hsa:1951.
    UCSCi uc003cul.3. human. [Q9NYQ7-1 ]

    Organism-specific databases

    CTDi 1951.
    GeneCardsi GC03M048673.
    H-InvDB HIX0200467.
    HGNCi HGNC:3230. CELSR3.
    MIMi 604264. gene.
    neXtProti NX_Q9NYQ7.
    PharmGKBi PA26395.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG12793.
    HOGENOMi HOG000231346.
    HOVERGENi HBG050887.
    KOi K04602.
    OMAi YRFVGPP.
    OrthoDBi EOG7BP81K.
    PhylomeDBi Q9NYQ7.
    TreeFami TF323983.

    Enzyme and pathway databases

    SignaLinki Q9NYQ7.

    Miscellaneous databases

    ChiTaRSi CELSR3. human.
    GeneWikii CELSR3.
    GenomeRNAii 1951.
    NextBioi 7907.
    PROi Q9NYQ7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NYQ7.
    Bgeei Q9NYQ7.
    CleanExi HS_CELSR3.
    Genevestigatori Q9NYQ7.

    Family and domain databases

    Gene3Di 2.60.120.200. 2 hits.
    2.60.40.60. 9 hits.
    InterProi IPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR022624. DUF3497.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR002049. EGF_laminin.
    IPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    IPR000203. GPS.
    IPR001791. Laminin_G.
    [Graphical view ]
    Pfami PF00002. 7tm_2. 1 hit.
    PF00028. Cadherin. 8 hits.
    PF12003. DUF3497. 1 hit.
    PF00008. EGF. 2 hits.
    PF01825. GPS. 1 hit.
    PF02793. HRM. 1 hit.
    PF00053. Laminin_EGF. 1 hit.
    PF02210. Laminin_G_2. 2 hits.
    [Graphical view ]
    PRINTSi PR00205. CADHERIN.
    PR00249. GPCRSECRETIN.
    SMARTi SM00112. CA. 9 hits.
    SM00181. EGF. 6 hits.
    SM00180. EGF_Lam. 1 hit.
    SM00303. GPS. 1 hit.
    SM00008. HormR. 1 hit.
    SM00282. LamG. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49313. SSF49313. 9 hits.
    SSF49899. SSF49899. 2 hits.
    PROSITEi PS00010. ASX_HYDROXYL. 1 hit.
    PS00232. CADHERIN_1. 7 hits.
    PS50268. CADHERIN_2. 8 hits.
    PS00022. EGF_1. 6 hits.
    PS01186. EGF_2. 4 hits.
    PS50026. EGF_3. 6 hits.
    PS01248. EGF_LAM_1. 1 hit.
    PS50027. EGF_LAM_2. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    PS50025. LAM_G_DOMAIN. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes."
      Wu Q., Maniatis T.
      Proc. Natl. Acad. Sci. U.S.A. 97:3124-3129(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening."
      Nakayama M., Nakajima D., Nagase T., Nomura N., Seki N., Ohara O.
      Genomics 51:27-34(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1954-3312 (ISOFORM 2).
      Tissue: Brain.
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiCELR3_HUMAN
    AccessioniPrimary (citable) accession number: Q9NYQ7
    Secondary accession number(s): O75092
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 2, 2002
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 138 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3