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Protein

Hydroxyacid oxidase 2

Gene

Hao2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has 2-hydroxyacid oxidase activity. Most active on medium-chain substrates.

Caution

Was originally thought to originate from human.1 Publication

Catalytic activityi

(S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei106FMNPROSITE-ProRule annotation1
Binding sitei128FMNPROSITE-ProRule annotation1
Binding sitei130SubstratePROSITE-ProRule annotation1
Binding sitei156FMNPROSITE-ProRule annotation1
Binding sitei165SubstratePROSITE-ProRule annotation1
Binding sitei224FMNPROSITE-ProRule annotation1
Active sitei248Proton acceptorPROSITE-ProRule annotation1
Binding sitei251SubstratePROSITE-ProRule annotation1
Binding sitei303FMNPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi279 – 303FMNPROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFlavoprotein, FMN

Enzyme and pathway databases

ReactomeiR-MMU-390918 Peroxisomal lipid metabolism
R-MMU-9033241 Peroxisomal protein import

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyacid oxidase 2 (EC:1.1.3.15)
Short name:
HAOX2
Alternative name(s):
(S)-2-hydroxy-acid oxidase, peroxisomal
Medium chain alpha-hydroxy acid oxidase
Medium-chain L-2-hydroxy acid oxidase
Gene namesi
Name:Hao2
Synonyms:Hao3, Haox2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:96012 Hao2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002063211 – 353Hydroxyacid oxidase 2Add BLAST353

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei171PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9NYQ2
PaxDbiQ9NYQ2
PRIDEiQ9NYQ2

PTM databases

iPTMnetiQ9NYQ2
PhosphoSitePlusiQ9NYQ2

Expressioni

Tissue specificityi

Pancreas.

Gene expression databases

BgeeiENSMUSG00000027870
CleanExiMM_HAO3
GenevisibleiQ9NYQ2 MM

Interactioni

Subunit structurei

Homotetramer or homooctamer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029464

Structurei

3D structure databases

ProteinModelPortaliQ9NYQ2
SMRiQ9NYQ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 353FMN hydroxy acid dehydrogenasePROSITE-ProRule annotationAdd BLAST352

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi351 – 353Microbody targeting signalSequence analysis3

Sequence similaritiesi

Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0538 Eukaryota
COG1304 LUCA
GeneTreeiENSGT00390000018717
HOGENOMiHOG000217463
HOVERGENiHBG051881
InParanoidiQ9NYQ2
KOiK11517
OMAiNEFHTSM
OrthoDBiEOG091G0ADA
PhylomeDBiQ9NYQ2
TreeFamiTF313363

Family and domain databases

CDDicd02809 alpha_hydroxyacid_oxid_FMN, 1 hit
Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR012133 Alpha-hydoxy_acid_DH_FMN
IPR000262 FMN-dep_DH
IPR037396 FMN_HAD
IPR008259 FMN_hydac_DH_AS
PfamiView protein in Pfam
PF01070 FMN_dh, 1 hit
PIRSFiPIRSF000138 Al-hdrx_acd_dh, 1 hit
PROSITEiView protein in PROSITE
PS00557 FMN_HYDROXY_ACID_DH_1, 1 hit
PS51349 FMN_HYDROXY_ACID_DH_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NYQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLCLADFK AQAQKQLSKT SWDFIEGEAD DGITYNDNLA AFRRIRLRPR
60 70 80 90 100
YLRDVSKIDT RTTIQGQEIN APICISPTAF HSIAWADGEK STAKAAQKAN
110 120 130 140 150
ICYVISSYAS YTVEDIVAAA PGGLHWFQLY VQPDWDINKQ MVQRIEALGF
160 170 180 190 200
KALVVTVDAP VLGNRRGNKR SLLDLEANIK LKDLRSPGES KSGLPTPLSM
210 220 230 240 250
PSSSSCWNDL PLLQSMTRLP IILKGILTKE DAELAVKHNI RGIIVSNHGG
260 270 280 290 300
RQLDEVPASI DALREVVAAV NGKIEVYMDG GVRTGNDVLK ALALGARCIF
310 320 330 340 350
LGRPIIWGLA CKGEDGVKEV LDILKEELHT CMALSGCRSV AEISPDLIQF

SRL
Length:353
Mass (Da):38,700
Last modified:October 1, 2000 - v1
Checksum:i0604D529F69DE3C7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti164N → H in CAB96380 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF231918 mRNA Translation: AAF40201.1
AF272947 mRNA Translation: AAF81795.1
AJ251820 mRNA Translation: CAB96380.1
AK078908 mRNA Translation: BAC37452.1
CCDSiCCDS17671.1
RefSeqiNP_062418.3, NM_019545.4
XP_011238471.1, XM_011240169.2
UniGeneiMm.281874

Genome annotation databases

EnsembliENSMUST00000029464; ENSMUSP00000029464; ENSMUSG00000027870
GeneIDi56185
KEGGimmu:56185
UCSCiuc008qqj.2 mouse

Similar proteinsi

Entry informationi

Entry nameiHAOX2_MOUSE
AccessioniPrimary (citable) accession number: Q9NYQ2
Secondary accession number(s): Q9JHS7, Q9JI00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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