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Q9NYQ2

- HAOX2_MOUSE

UniProt

Q9NYQ2 - HAOX2_MOUSE

Protein

Hydroxyacid oxidase 2

Gene

Hao2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Has 2-hydroxyacid oxidase activity. Most active on medium-chain substrates.

    Catalytic activityi

    (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2.

    Cofactori

    FMN.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei106 – 1061FMNPROSITE-ProRule annotation
    Binding sitei128 – 1281FMNPROSITE-ProRule annotation
    Binding sitei130 – 1301SubstratePROSITE-ProRule annotation
    Binding sitei156 – 1561FMNPROSITE-ProRule annotation
    Binding sitei165 – 1651SubstratePROSITE-ProRule annotation
    Binding sitei224 – 2241FMNPROSITE-ProRule annotation
    Active sitei248 – 2481Proton acceptorPROSITE-ProRule annotation
    Binding sitei251 – 2511SubstratePROSITE-ProRule annotation
    Binding sitei303 – 3031FMNPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi279 – 30325FMNPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. FMN binding Source: Ensembl
    2. long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity Source: UniProtKB-EC
    3. medium-chain-(S)-2-hydroxy-acid oxidase activity Source: UniProtKB-EC
    4. very-long-chain-(S)-2-hydroxy-acid oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. fatty acid oxidation Source: Ensembl
    2. mandelate metabolic process Source: Ensembl
    3. protein homooligomerization Source: Ensembl

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Flavoprotein, FMN

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hydroxyacid oxidase 2 (EC:1.1.3.15)
    Short name:
    HAOX2
    Alternative name(s):
    (S)-2-hydroxy-acid oxidase, peroxisomal
    Medium chain alpha-hydroxy acid oxidase
    Medium-chain L-2-hydroxy acid oxidase
    Gene namesi
    Name:Hao2
    Synonyms:Hao3, Haox2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:96012. Hao2.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: MGI
    2. peroxisome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 353352Hydroxyacid oxidase 2PRO_0000206321Add
    BLAST

    Proteomic databases

    MaxQBiQ9NYQ2.
    PaxDbiQ9NYQ2.
    PRIDEiQ9NYQ2.

    PTM databases

    PhosphoSiteiQ9NYQ2.

    Expressioni

    Tissue specificityi

    Pancreas.

    Gene expression databases

    BgeeiQ9NYQ2.
    CleanExiMM_HAO3.
    GenevestigatoriQ9NYQ2.

    Interactioni

    Subunit structurei

    Homotetramer or homooctamer.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000029464.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NYQ2.
    SMRiQ9NYQ2. Positions 3-352.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 353352FMN hydroxy acid dehydrogenasePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi351 – 3533Microbody targeting signalSequence Analysis

    Sequence similaritiesi

    Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.PROSITE-ProRule annotation
    Contains 1 FMN hydroxy acid dehydrogenase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1304.
    GeneTreeiENSGT00390000018717.
    HOGENOMiHOG000217463.
    HOVERGENiHBG051881.
    InParanoidiQ9NYQ2.
    KOiK11517.
    OMAiTAFHSIA.
    OrthoDBiEOG7B5WW0.
    PhylomeDBiQ9NYQ2.
    TreeFamiTF313363.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR012133. Alpha-hydoxy_acid_DH_FMN.
    IPR000262. FMN-dep_DH.
    IPR008259. FMN_hydac_DH_AS.
    [Graphical view]
    PfamiPF01070. FMN_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000138. Al-hdrx_acd_dh. 1 hit.
    PROSITEiPS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
    PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9NYQ2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLLCLADFK AQAQKQLSKT SWDFIEGEAD DGITYNDNLA AFRRIRLRPR    50
    YLRDVSKIDT RTTIQGQEIN APICISPTAF HSIAWADGEK STAKAAQKAN 100
    ICYVISSYAS YTVEDIVAAA PGGLHWFQLY VQPDWDINKQ MVQRIEALGF 150
    KALVVTVDAP VLGNRRGNKR SLLDLEANIK LKDLRSPGES KSGLPTPLSM 200
    PSSSSCWNDL PLLQSMTRLP IILKGILTKE DAELAVKHNI RGIIVSNHGG 250
    RQLDEVPASI DALREVVAAV NGKIEVYMDG GVRTGNDVLK ALALGARCIF 300
    LGRPIIWGLA CKGEDGVKEV LDILKEELHT CMALSGCRSV AEISPDLIQF 350
    SRL 353
    Length:353
    Mass (Da):38,700
    Last modified:October 1, 2000 - v1
    Checksum:i0604D529F69DE3C7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti164 – 1641N → H in CAB96380. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF231918 mRNA. Translation: AAF40201.1.
    AF272947 mRNA. Translation: AAF81795.1.
    AJ251820 mRNA. Translation: CAB96380.1.
    AK078908 mRNA. Translation: BAC37452.1.
    CCDSiCCDS17671.1.
    RefSeqiNP_062418.3. NM_019545.4.
    UniGeneiMm.281874.

    Genome annotation databases

    EnsembliENSMUST00000029464; ENSMUSP00000029464; ENSMUSG00000027870.
    GeneIDi56185.
    KEGGimmu:56185.
    UCSCiuc008qqj.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF231918 mRNA. Translation: AAF40201.1 .
    AF272947 mRNA. Translation: AAF81795.1 .
    AJ251820 mRNA. Translation: CAB96380.1 .
    AK078908 mRNA. Translation: BAC37452.1 .
    CCDSi CCDS17671.1.
    RefSeqi NP_062418.3. NM_019545.4.
    UniGenei Mm.281874.

    3D structure databases

    ProteinModelPortali Q9NYQ2.
    SMRi Q9NYQ2. Positions 3-352.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000029464.

    PTM databases

    PhosphoSitei Q9NYQ2.

    Proteomic databases

    MaxQBi Q9NYQ2.
    PaxDbi Q9NYQ2.
    PRIDEi Q9NYQ2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000029464 ; ENSMUSP00000029464 ; ENSMUSG00000027870 .
    GeneIDi 56185.
    KEGGi mmu:56185.
    UCSCi uc008qqj.2. mouse.

    Organism-specific databases

    CTDi 51179.
    MGIi MGI:96012. Hao2.

    Phylogenomic databases

    eggNOGi COG1304.
    GeneTreei ENSGT00390000018717.
    HOGENOMi HOG000217463.
    HOVERGENi HBG051881.
    InParanoidi Q9NYQ2.
    KOi K11517.
    OMAi TAFHSIA.
    OrthoDBi EOG7B5WW0.
    PhylomeDBi Q9NYQ2.
    TreeFami TF313363.

    Miscellaneous databases

    ChiTaRSi HAO2. mouse.
    NextBioi 311970.
    PROi Q9NYQ2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9NYQ2.
    CleanExi MM_HAO3.
    Genevestigatori Q9NYQ2.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR012133. Alpha-hydoxy_acid_DH_FMN.
    IPR000262. FMN-dep_DH.
    IPR008259. FMN_hydac_DH_AS.
    [Graphical view ]
    Pfami PF01070. FMN_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000138. Al-hdrx_acd_dh. 1 hit.
    PROSITEi PS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
    PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of HAOX1, HAOX2, and HAOX3, three human peroxisomal 2-hydroxy acid oxidases."
      Jones J.M., Morrell J.C., Gould S.J.
      J. Biol. Chem. 275:12590-12597(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Mus musculus long-chain L-2-hydroxy acid oxidase."
      Spielbauer B., Conzelmann E.
      Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Search for PTS1-containing protein in mammals."
      Van Veldhoven P.P.
      Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Cecum.

    Entry informationi

    Entry nameiHAOX2_MOUSE
    AccessioniPrimary (citable) accession number: Q9NYQ2
    Secondary accession number(s): Q9JHS7, Q9JI00
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    Was originally thought to originate from human.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3