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Protein

Protein downstream neighbor of Son

Gene

DONSON

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Essential for DNA amplification in the ovary and required for cell proliferation during development.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Protein downstream neighbor of Son
Alternative name(s):
B17
Gene namesi
Name:DONSON
Synonyms:C21orf60
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:2993. DONSON.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27459.

Polymorphism and mutation databases

BioMutaiDONSON.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 566566Protein downstream neighbor of SonPRO_0000079979Add
BLAST

Proteomic databases

MaxQBiQ9NYP3.
PaxDbiQ9NYP3.
PRIDEiQ9NYP3.

PTM databases

iPTMnetiQ9NYP3.
PhosphoSiteiQ9NYP3.

Expressioni

Gene expression databases

BgeeiQ9NYP3.
CleanExiHS_DONSON.
ExpressionAtlasiQ9NYP3. baseline and differential.
GenevisibleiQ9NYP3. HS.

Organism-specific databases

HPAiHPA039558.
HPA049033.

Interactioni

Protein-protein interaction databases

BioGridi119008. 3 interactions.
STRINGi9606.ENSP00000307143.

Structurei

3D structure databases

ProteinModelPortaliQ9NYP3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DONSON family.Curated

Phylogenomic databases

eggNOGiKOG4734. Eukaryota.
ENOG410ZEEQ. LUCA.
GeneTreeiENSGT00390000000447.
HOGENOMiHOG000293183.
HOVERGENiHBG005518.
InParanoidiQ9NYP3.
OMAiVIQHCRA.
PhylomeDBiQ9NYP3.
TreeFamiTF318976.

Family and domain databases

InterProiIPR024861. Donson.
[Graphical view]
PANTHERiPTHR12972. PTHR12972. 1 hit.
PRINTSiPR02064. DONSON.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Experimental confirmation may be lacking for some isoforms.

Isoform 1 (identifier: Q9NYP3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALSVPGYSP GFRKPPEVVR LRRKRARSRG AAASPPRELT EPAARRAALV
60 70 80 90 100
AGLPLRPFPA AGGRGGGSGG GPAAARRNPF ARLDNRPRVA AEPPDGPARE
110 120 130 140 150
QPEAPVPFLD SNQENDLLWE EKFPERTTVT ELPQTSHVSF SEPDIPSSKS
160 170 180 190 200
TELPVDWSIK TRLLFTSSQP FTWADHLKAQ EEAQGLVQHC RATEVTLPKS
210 220 230 240 250
IQDPKLSSEL RCTFQQSLIY WLHPALSWLP LFPRIGADRK MAGKTSPWSN
260 270 280 290 300
DATLQHVLMS DWSVSFTSLY NLLKTKLCPY FYVCTYQFTV LFRAAGLAGS
310 320 330 340 350
DLITALISPT TRGLREAMRN EGIEFSLPLI KESGHKKETA SGTSLGYGEE
360 370 380 390 400
QAISDEDEEE SFSWLEEMGV QDKIKKPDIL SIKLRKEKHE VQMDHRPESV
410 420 430 440 450
VLVKGINTFT LLNFLINSKS LVATSGPQAG LPPTLLSPVA FRGATMQMLK
460 470 480 490 500
ARSVNVKTQA LSGYRDQFSL EITGPIMPHS LHSLTMLLKS SQSGSFSAVL
510 520 530 540 550
YPHEPTAVFN ICLQMDKVLD MEVVHKELTN CGLHPNTLEQ LSQIPLLGKS
560
SLRNVVLRDY IYNWRS
Length:566
Mass (Da):62,747
Last modified:January 11, 2001 - v2
Checksum:i5421C43C1E2A03F4
GO
Isoform 2 (identifier: Q9NYP3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     263-263: S → Y
     264-566: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:263
Mass (Da):29,069
Checksum:iB827022C0AC004BF
GO
Isoform 3 (identifier: Q9NYP3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     263-265: SVS → HGV
     266-566: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:265
Mass (Da):29,199
Checksum:i74F42297022C0AC0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti224 – 2241P → L in AAF72948 (PubMed:10773462).Curated
Sequence conflicti437 – 4371S → Y in AAF72947 (PubMed:10773462).Curated
Sequence conflicti557 – 5571L → Q in BAC11320 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei263 – 2653SVS → HGV in isoform 3. 1 PublicationVSP_004194
Alternative sequencei263 – 2631S → Y in isoform 2. 1 PublicationVSP_004192
Alternative sequencei264 – 566303Missing in isoform 2. 1 PublicationVSP_004193Add
BLAST
Alternative sequencei266 – 566301Missing in isoform 3. 1 PublicationVSP_004195Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074964 mRNA. Translation: BAC11320.1.
AL157441 mRNA. Translation: CAB75661.1.
BC048266 mRNA. Translation: AAH48266.1.
AF232673 mRNA. Translation: AAF72947.1.
AF232674 mRNA. Translation: AAF72948.1.
AF232675 mRNA. Translation: AAF72949.1.
CCDSiCCDS13632.1. [Q9NYP3-1]
PIRiT46933.
RefSeqiNP_060083.1. NM_017613.3. [Q9NYP3-1]
UniGeneiHs.436341.

Genome annotation databases

EnsembliENST00000303071; ENSP00000307143; ENSG00000159147. [Q9NYP3-1]
GeneIDi29980.
KEGGihsa:29980.
UCSCiuc002ysk.5. human. [Q9NYP3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074964 mRNA. Translation: BAC11320.1.
AL157441 mRNA. Translation: CAB75661.1.
BC048266 mRNA. Translation: AAH48266.1.
AF232673 mRNA. Translation: AAF72947.1.
AF232674 mRNA. Translation: AAF72948.1.
AF232675 mRNA. Translation: AAF72949.1.
CCDSiCCDS13632.1. [Q9NYP3-1]
PIRiT46933.
RefSeqiNP_060083.1. NM_017613.3. [Q9NYP3-1]
UniGeneiHs.436341.

3D structure databases

ProteinModelPortaliQ9NYP3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119008. 3 interactions.
STRINGi9606.ENSP00000307143.

PTM databases

iPTMnetiQ9NYP3.
PhosphoSiteiQ9NYP3.

Polymorphism and mutation databases

BioMutaiDONSON.

Proteomic databases

MaxQBiQ9NYP3.
PaxDbiQ9NYP3.
PRIDEiQ9NYP3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303071; ENSP00000307143; ENSG00000159147. [Q9NYP3-1]
GeneIDi29980.
KEGGihsa:29980.
UCSCiuc002ysk.5. human. [Q9NYP3-1]

Organism-specific databases

CTDi29980.
GeneCardsiDONSON.
HGNCiHGNC:2993. DONSON.
HPAiHPA039558.
HPA049033.
MIMi611428. gene.
neXtProtiNX_Q9NYP3.
PharmGKBiPA27459.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4734. Eukaryota.
ENOG410ZEEQ. LUCA.
GeneTreeiENSGT00390000000447.
HOGENOMiHOG000293183.
HOVERGENiHBG005518.
InParanoidiQ9NYP3.
OMAiVIQHCRA.
PhylomeDBiQ9NYP3.
TreeFamiTF318976.

Miscellaneous databases

ChiTaRSiDONSON. human.
GenomeRNAii29980.
PROiQ9NYP3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NYP3.
CleanExiHS_DONSON.
ExpressionAtlasiQ9NYP3. baseline and differential.
GenevisibleiQ9NYP3. HS.

Family and domain databases

InterProiIPR024861. Donson.
[Graphical view]
PANTHERiPTHR12972. PTHR12972. 1 hit.
PRINTSiPR02064. DONSON.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Teratocarcinoma.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Mammary gland.
  4. "Criteria for gene identification and features of genome organization: analysis of 6.5 Mb of DNA sequence from human chromosome 21."
    Slavov D., Hattori M., Sakaki Y., Rosenthal A., Shimizu N., Minoshima S., Kudoh J., Yaspo M.-L., Ramser J., Reinhardt R., Reimer C., Clancy K., Rynditch A., Gardiner K.
    Gene 247:215-232(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 108-566 (ISOFORMS 1; 2 AND 3).
  5. Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiDONS_HUMAN
AccessioniPrimary (citable) accession number: Q9NYP3
Secondary accession number(s): Q8NC53
, Q9NSR9, Q9NVZ5, Q9NYP1, Q9NYP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 11, 2001
Last modified: June 8, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.