Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9NYM9

- BET1L_HUMAN

UniProt

Q9NYM9 - BET1L_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

BET1-like protein

Gene

BET1L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Vesicle SNARE required for targeting and fusion of retrograde transport vesicles with the Golgi complex. Required for the integrity of the Golgi complex (By similarity).By similarity

GO - Molecular functioni

  1. SNAP receptor activity Source: HGNC

GO - Biological processi

  1. protein transport Source: UniProtKB-KW
  2. retrograde transport, endosome to Golgi Source: HGNC
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
BET1-like protein
Alternative name(s):
Golgi SNARE with a size of 15 kDa
Short name:
GOS-15
Short name:
GS15
Vesicle transport protein GOS15
Gene namesi
Name:BET1LImported
Synonyms:GS15Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:19348. BET1L.

Subcellular locationi

Golgi apparatus membrane By similarity; Single-pass type IV membrane protein By similarity. Golgi apparatustrans-Golgi network membrane By similarity
Note: Present throughout the Golgi apparatus, with increasing concentration from cis-Golgi to the trans-Golgi face of the stacks.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8686CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei87 – 10721Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
BLAST
Topological domaini108 – 1114LumenalSequence Analysis

GO - Cellular componenti

  1. endosome Source: HGNC
  2. Golgi apparatus Source: HGNC
  3. Golgi stack Source: Ensembl
  4. integral component of Golgi membrane Source: Ensembl
  5. membrane Source: UniProtKB
  6. SNARE complex Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134970036.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 111111BET1-like proteinPRO_0000233056Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei9 – 91Phosphoserine3 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9NYM9.
PaxDbiQ9NYM9.
PRIDEiQ9NYM9.

PTM databases

PhosphoSiteiQ9NYM9.

Expressioni

Gene expression databases

BgeeiQ9NYM9.
CleanExiHS_BET1L.
ExpressionAtlasiQ9NYM9. baseline and differential.
GenevestigatoriQ9NYM9.

Organism-specific databases

HPAiHPA039819.

Interactioni

Subunit structurei

Component of a SNARE complex consisting of STX5, YKT6, GOSR2 and BET1L.By similarity

Protein-protein interaction databases

BioGridi119425. 9 interactions.
IntActiQ9NYM9. 1 interaction.
STRINGi9606.ENSP00000372210.

Structurei

3D structure databases

ProteinModelPortaliQ9NYM9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 7763t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG284194.
GeneTreeiENSGT00570000079186.
HOGENOMiHOG000290697.
HOVERGENiHBG029661.
InParanoidiQ9NYM9.
KOiK08504.
OMAiSMDSDFT.
PhylomeDBiQ9NYM9.
TreeFamiTF323307.

Family and domain databases

InterProiIPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF05739. SNARE. 1 hit.
[Graphical view]
PROSITEiPS50192. T_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NYM9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADWARAQSP GAVEEILDRE NKRMADSLAS KVTRLKSLAL DIDRDAEDQN
60 70 80 90 100
RYLDGMDSDF TSMTSLLTGS VKRFSTMARS GQDNRKLLCG MAVGLIVAFF
110
ILSYFLSRAR T
Length:111
Mass (Da):12,388
Last modified:October 1, 2000 - v1
Checksum:i76E2C5099EC7EE5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF234160 mRNA. Translation: AAF37877.1.
AK022958 mRNA. Translation: BAG51142.1.
BC008971 mRNA. Translation: AAH08971.1.
CCDSiCCDS41582.1.
RefSeqiNP_001092257.1. NM_001098787.1.
UniGeneiHs.414418.

Genome annotation databases

EnsembliENST00000382762; ENSP00000372210; ENSG00000177951.
GeneIDi51272.
KEGGihsa:51272.
UCSCiuc001lod.2. human.

Polymorphism databases

DMDMi74734714.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF234160 mRNA. Translation: AAF37877.1 .
AK022958 mRNA. Translation: BAG51142.1 .
BC008971 mRNA. Translation: AAH08971.1 .
CCDSi CCDS41582.1.
RefSeqi NP_001092257.1. NM_001098787.1.
UniGenei Hs.414418.

3D structure databases

ProteinModelPortali Q9NYM9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119425. 9 interactions.
IntActi Q9NYM9. 1 interaction.
STRINGi 9606.ENSP00000372210.

PTM databases

PhosphoSitei Q9NYM9.

Polymorphism databases

DMDMi 74734714.

Proteomic databases

MaxQBi Q9NYM9.
PaxDbi Q9NYM9.
PRIDEi Q9NYM9.

Protocols and materials databases

DNASUi 51272.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000382762 ; ENSP00000372210 ; ENSG00000177951 .
GeneIDi 51272.
KEGGi hsa:51272.
UCSCi uc001lod.2. human.

Organism-specific databases

CTDi 51272.
GeneCardsi GC11M000192.
HGNCi HGNC:19348. BET1L.
HPAi HPA039819.
MIMi 615417. gene.
neXtProti NX_Q9NYM9.
PharmGKBi PA134970036.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG284194.
GeneTreei ENSGT00570000079186.
HOGENOMi HOG000290697.
HOVERGENi HBG029661.
InParanoidi Q9NYM9.
KOi K08504.
OMAi SMDSDFT.
PhylomeDBi Q9NYM9.
TreeFami TF323307.

Miscellaneous databases

ChiTaRSi BET1L. human.
GeneWikii BET1L.
GenomeRNAii 51272.
NextBioi 54475.
PROi Q9NYM9.
SOURCEi Search...

Gene expression databases

Bgeei Q9NYM9.
CleanExi HS_BET1L.
ExpressionAtlasi Q9NYM9. baseline and differential.
Genevestigatori Q9NYM9.

Family and domain databases

InterProi IPR000727. T_SNARE_dom.
[Graphical view ]
Pfami PF05739. SNARE. 1 hit.
[Graphical view ]
PROSITEi PS50192. T_SNARE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Homo sapiens Golgi SNARE GS15 sequence."
    Bui T.D., Hong W.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: SkinImported.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiBET1L_HUMAN
AccessioniPrimary (citable) accession number: Q9NYM9
Secondary accession number(s): B3KMY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3