Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9NYM9

- BET1L_HUMAN

UniProt

Q9NYM9 - BET1L_HUMAN

Protein

BET1-like protein

Gene

BET1L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Vesicle SNARE required for targeting and fusion of retrograde transport vesicles with the Golgi complex. Required for the integrity of the Golgi complex By similarity.By similarity

    GO - Molecular functioni

    1. SNAP receptor activity Source: HGNC

    GO - Biological processi

    1. protein transport Source: UniProtKB-KW
    2. retrograde transport, endosome to Golgi Source: HGNC

    Keywords - Biological processi

    Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    BET1-like protein
    Alternative name(s):
    Golgi SNARE with a size of 15 kDa
    Short name:
    GOS-15
    Short name:
    GS15
    Vesicle transport protein GOS15
    Gene namesi
    Name:BET1LImported
    Synonyms:GS15Imported
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:19348. BET1L.

    Subcellular locationi

    Golgi apparatus membrane By similarity; Single-pass type IV membrane protein By similarity. Golgi apparatustrans-Golgi network membrane By similarity
    Note: Present throughout the Golgi apparatus, with increasing concentration from cis-Golgi to the trans-Golgi face of the stacks.By similarity

    GO - Cellular componenti

    1. endosome Source: HGNC
    2. Golgi apparatus Source: HGNC
    3. Golgi stack Source: Ensembl
    4. integral component of Golgi membrane Source: Ensembl
    5. membrane Source: UniProtKB
    6. SNARE complex Source: HGNC

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134970036.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 111111BET1-like proteinPRO_0000233056Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei9 – 91Phosphoserine3 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9NYM9.
    PaxDbiQ9NYM9.
    PRIDEiQ9NYM9.

    PTM databases

    PhosphoSiteiQ9NYM9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NYM9.
    BgeeiQ9NYM9.
    CleanExiHS_BET1L.
    GenevestigatoriQ9NYM9.

    Organism-specific databases

    HPAiHPA039819.

    Interactioni

    Subunit structurei

    Component of a SNARE complex consisting of STX5, YKT6, GOSR2 and BET1L.By similarity

    Protein-protein interaction databases

    BioGridi119425. 9 interactions.
    IntActiQ9NYM9. 1 interaction.
    STRINGi9606.ENSP00000372210.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NYM9.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 8686CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini108 – 1114LumenalSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei87 – 10721Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini15 – 7763t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG284194.
    HOGENOMiHOG000290697.
    HOVERGENiHBG029661.
    KOiK08504.
    OMAiSMDSDFT.
    PhylomeDBiQ9NYM9.
    TreeFamiTF323307.

    Family and domain databases

    InterProiIPR000727. T_SNARE_dom.
    [Graphical view]
    PfamiPF05739. SNARE. 1 hit.
    [Graphical view]
    PROSITEiPS50192. T_SNARE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NYM9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADWARAQSP GAVEEILDRE NKRMADSLAS KVTRLKSLAL DIDRDAEDQN    50
    RYLDGMDSDF TSMTSLLTGS VKRFSTMARS GQDNRKLLCG MAVGLIVAFF 100
    ILSYFLSRAR T 111
    Length:111
    Mass (Da):12,388
    Last modified:October 1, 2000 - v1
    Checksum:i76E2C5099EC7EE5E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF234160 mRNA. Translation: AAF37877.1.
    AK022958 mRNA. Translation: BAG51142.1.
    BC008971 mRNA. Translation: AAH08971.1.
    CCDSiCCDS41582.1.
    RefSeqiNP_001092257.1. NM_001098787.1.
    UniGeneiHs.414418.

    Genome annotation databases

    EnsembliENST00000382762; ENSP00000372210; ENSG00000177951.
    GeneIDi51272.
    KEGGihsa:51272.
    UCSCiuc001lod.2. human.

    Polymorphism databases

    DMDMi74734714.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF234160 mRNA. Translation: AAF37877.1 .
    AK022958 mRNA. Translation: BAG51142.1 .
    BC008971 mRNA. Translation: AAH08971.1 .
    CCDSi CCDS41582.1.
    RefSeqi NP_001092257.1. NM_001098787.1.
    UniGenei Hs.414418.

    3D structure databases

    ProteinModelPortali Q9NYM9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119425. 9 interactions.
    IntActi Q9NYM9. 1 interaction.
    STRINGi 9606.ENSP00000372210.

    PTM databases

    PhosphoSitei Q9NYM9.

    Polymorphism databases

    DMDMi 74734714.

    Proteomic databases

    MaxQBi Q9NYM9.
    PaxDbi Q9NYM9.
    PRIDEi Q9NYM9.

    Protocols and materials databases

    DNASUi 51272.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000382762 ; ENSP00000372210 ; ENSG00000177951 .
    GeneIDi 51272.
    KEGGi hsa:51272.
    UCSCi uc001lod.2. human.

    Organism-specific databases

    CTDi 51272.
    GeneCardsi GC11M000192.
    HGNCi HGNC:19348. BET1L.
    HPAi HPA039819.
    MIMi 615417. gene.
    neXtProti NX_Q9NYM9.
    PharmGKBi PA134970036.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG284194.
    HOGENOMi HOG000290697.
    HOVERGENi HBG029661.
    KOi K08504.
    OMAi SMDSDFT.
    PhylomeDBi Q9NYM9.
    TreeFami TF323307.

    Miscellaneous databases

    ChiTaRSi BET1L. human.
    GeneWikii BET1L.
    GenomeRNAii 51272.
    NextBioi 54475.
    PROi Q9NYM9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NYM9.
    Bgeei Q9NYM9.
    CleanExi HS_BET1L.
    Genevestigatori Q9NYM9.

    Family and domain databases

    InterProi IPR000727. T_SNARE_dom.
    [Graphical view ]
    Pfami PF05739. SNARE. 1 hit.
    [Graphical view ]
    PROSITEi PS50192. T_SNARE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Homo sapiens Golgi SNARE GS15 sequence."
      Bui T.D., Hong W.
      Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: SkinImported.
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiBET1L_HUMAN
    AccessioniPrimary (citable) accession number: Q9NYM9
    Secondary accession number(s): B3KMY0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 18, 2006
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3