Q9NYM9 (BET1L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
BET1-like protein

Alternative name(s):
Golgi SNARE with a size of 15 kDa
Short name=GOS-15
Short name=GS15
Vesicle transport protein GOS15

Gene names

Name:	BET1L
Synonyms:	GS15

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	111 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Vesicle SNARE required for targeting and fusion of retrograde transport vesicles with the Golgi complex. Required for the integrity of the Golgi complex By similarity. UniProtKB O35152
Subunit structure	Component of a SNARE complex consisting of STX5, YKT6, GOSR2 and BET1L By similarity. UniProtKB O35152
Subcellular location	Golgi apparatus membrane; Single-pass type IV membrane protein By similarity.
Sequence similarities	Contains 1 t-SNARE coiled-coil homology domain.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Golgi apparatus Membrane
Domain	Coiled coil Transmembrane Transmembrane helix
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein transport Inferred from electronic annotation. Source: UniProtKB-KW retrograde transport, endosome to Golgi Inferred from direct assay PubMed 15215310. Source: HGNC
Cellular_component	Golgi apparatus Inferred from direct assay PubMed 15215310. Source: HGNC Golgi stack Inferred from electronic annotation. Source: Compara SNARE complex Traceable author statement PubMed 15215310. Source: HGNC endosome Inferred from direct assay PubMed 15215310. Source: HGNC integral to Golgi membrane Inferred from electronic annotation. Source: Compara nucleus Inferred from direct assay. Source: HPA
Molecular_function	SNAP receptor activity Inferred from direct assay PubMed 15215310. Source: HGNC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 111	111	BET1-like protein		PRO_0000233056
Regions
	Topological domain	1 – 86	86	Cytoplasmic Potential
	Transmembrane	87 – 107	21	Helical; Anchor for type IV membrane protein; Potential
	Topological domain	108 – 111	4	Lumenal Potential
	Domain	15 – 77	63	t-SNARE coiled-coil homology
Amino acid modifications
	Modified residue	9	1	Phosphoserine Ref.5 Ref.6 Ref.8

Sequences

	Sequence		Length	Mass (Da)
	Q9NYM9 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 76E2C5099EC7EE5E	FASTA	111	12,388
	10 20 30 40 50 60 MADWARAQSP GAVEEILDRE NKRMADSLAS KVTRLKSLAL DIDRDAEDQN RYLDGMDSDF 70 80 90 100 110 TSMTSLLTGS VKRFSTMARS GQDNRKLLCG MAVGLIVAFF ILSYFLSRAR T

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Homo sapiens Golgi SNARE GS15 sequence." Bui T.D., Hong W. Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.
[4]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[5]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[6]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF234160 mRNA. Translation: AAF37877.1. AK022958 mRNA. Translation: BAG51142.1. BC008971 mRNA. Translation: AAH08971.1.
IPI	IPI00009772.
RefSeq	NP_001092257.1. NM_001098787.1.
UniGene	Hs.414418.
3D structure databases
ProteinModelPortal	Q9NYM9.
SMR	Q9NYM9. Positions 22-74.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NYM9. 1 interaction.
STRING	9606.ENSP00000372210.
PTM databases
PhosphoSite	Q9NYM9.
Polymorphism databases
DMDM	74734714.
Proteomic databases
PaxDb	Q9NYM9.
PRIDE	Q9NYM9.
Protocols and materials databases
DNASU	51272.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000382762; ENSP00000372210; ENSG00000177951.
GeneID	51272.
KEGG	hsa:51272.
UCSC	uc001lod.2. human.
Organism-specific databases
CTD	51272.
GeneCards	GC11M000192.
HGNC	HGNC:19348. BET1L.
HPA	HPA039819.
neXtProt	NX_Q9NYM9.
PharmGKB	PA134970036.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG284194.
HOGENOM	HOG000290697.
HOVERGEN	HBG029661.
KO	K08504.
OMA	FSAMARS.
Gene expression databases
ArrayExpress	Q9NYM9.
Bgee	Q9NYM9.
CleanEx	HS_BET1L.
Genevestigator	Q9NYM9.
GermOnline	ENSG00000177951. Homo sapiens.
Family and domain databases
InterPro	IPR000727. T_SNARE_dom. [Graphical view]
Pfam	PF05739. SNARE. 1 hit. [Graphical view]
PROSITE	PS50192. T_SNARE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	BET1L. human.
GenomeRNAi	51272.
NextBio	54475.

Entry information

Entry name

BET1L_HUMAN

Accession

Primary (citable) accession number: Q9NYM9
Secondary accession number(s): B3KMY0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 18, 2006
Last sequence update:	October 1, 2000
Last modified:	April 3, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.