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Protein

Probable G-protein coupled receptor 83

Gene

GPR83

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor. Could be a neuropeptide Y receptor.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc
  • neuropeptide Y receptor activity Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000123901-MONOMER.
ReactomeiR-HSA-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 83
Alternative name(s):
G-protein coupled receptor 72
Gene namesi
Name:GPR83
Synonyms:GPR72, KIAA1540
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:4523. GPR83.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 71ExtracellularSequence analysisAdd BLAST54
Transmembranei72 – 92Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini93 – 107CytoplasmicSequence analysisAdd BLAST15
Transmembranei108 – 129Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini130 – 145ExtracellularSequence analysisAdd BLAST16
Transmembranei146 – 167Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini168 – 186CytoplasmicSequence analysisAdd BLAST19
Transmembranei187 – 208Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini209 – 238ExtracellularSequence analysisAdd BLAST30
Transmembranei239 – 260Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini261 – 293CytoplasmicSequence analysisAdd BLAST33
Transmembranei294 – 315Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini316 – 327ExtracellularSequence analysisAdd BLAST12
Transmembranei328 – 348Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini349 – 423CytoplasmicSequence analysisAdd BLAST75

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10888.
OpenTargetsiENSG00000123901.
PharmGKBiPA28927.

Polymorphism and mutation databases

BioMutaiGPR83.
DMDMi212276435.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000001280317 – 423Probable G-protein coupled receptor 83Add BLAST407

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi37N-linked (GlcNAc...)Sequence analysis1
Glycosylationi46N-linked (GlcNAc...)Sequence analysis1
Glycosylationi134N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi144 ↔ 224PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9NYM4.
PeptideAtlasiQ9NYM4.
PRIDEiQ9NYM4.

PTM databases

iPTMnetiQ9NYM4.
PhosphoSitePlusiQ9NYM4.

Expressioni

Tissue specificityi

Brain specific.

Gene expression databases

BgeeiENSG00000123901.
CleanExiHS_GPR83.
ExpressionAtlasiQ9NYM4. baseline and differential.
GenevisibleiQ9NYM4. HS.

Organism-specific databases

HPAiHPA044493.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000243673.

Structurei

3D structure databases

ProteinModelPortaliQ9NYM4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000112793.
HOVERGENiHBG051819.
InParanoidiQ9NYM4.
KOiK04210.
OMAiNENFRIE.
OrthoDBiEOG091G0YEQ.
PhylomeDBiQ9NYM4.
TreeFamiTF315303.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01012. NRPEPTIDEYR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NYM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPHLLLLCL LPLVRATEPH EGRADEQSAE AALAVPNASH FFSWNNYTFS
60 70 80 90 100
DWQNFVGRRR YGAESQNPTV KALLIVAYSF IIVFSLFGNV LVCHVIFKNQ
110 120 130 140 150
RMHSATSLFI VNLAVADIMI TLLNTPFTLV RFVNSTWIFG KGMCHVSRFA
160 170 180 190 200
QYCSLHVSAL TLTAIAVDRH QVIMHPLKPR ISITKGVIYI AVIWTMATFF
210 220 230 240 250
SLPHAICQKL FTFKYSEDIV RSLCLPDFPE PADLFWKYLD LATFILLYIL
260 270 280 290 300
PLLIISVAYA RVAKKLWLCN MIGDVTTEQY FALRRKKKKT IKMLMLVVVL
310 320 330 340 350
FALCWFPLNC YVLLLSSKVI RTNNALYFAF HWFAMSSTCY NPFIYCWLNE
360 370 380 390 400
NFRIELKALL SMCQRPPKPQ EDRPPSPVPS FRVAWTEKND GQRAPLANNL
410 420
LPTSQLQSGK TDLSSVEPIV TMS
Length:423
Mass (Da):48,339
Last modified:November 4, 2008 - v2
Checksum:iD9E2D96ADC1B44AA
GO

Sequence cautioni

The sequence BAA96064 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti373R → G in AAF43705 (PubMed:10760605).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047079374P → Q.3 PublicationsCorresponds to variant rs3740868dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF236081 mRNA. Translation: AAF43705.1.
AB040973 mRNA. Translation: BAA96064.1. Different initiation.
AK315161 mRNA. Translation: BAG37605.1.
EU432120 mRNA. Translation: ABY87919.1.
BC067473 mRNA. Translation: AAH67473.1.
CH471065 Genomic DNA. Translation: EAW66929.1.
CCDSiCCDS8297.1.
RefSeqiNP_057624.3. NM_016540.3.
UniGeneiHs.272385.

Genome annotation databases

EnsembliENST00000243673; ENSP00000243673; ENSG00000123901.
GeneIDi10888.
KEGGihsa:10888.
UCSCiuc001pet.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF236081 mRNA. Translation: AAF43705.1.
AB040973 mRNA. Translation: BAA96064.1. Different initiation.
AK315161 mRNA. Translation: BAG37605.1.
EU432120 mRNA. Translation: ABY87919.1.
BC067473 mRNA. Translation: AAH67473.1.
CH471065 Genomic DNA. Translation: EAW66929.1.
CCDSiCCDS8297.1.
RefSeqiNP_057624.3. NM_016540.3.
UniGeneiHs.272385.

3D structure databases

ProteinModelPortaliQ9NYM4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000243673.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9NYM4.
PhosphoSitePlusiQ9NYM4.

Polymorphism and mutation databases

BioMutaiGPR83.
DMDMi212276435.

Proteomic databases

PaxDbiQ9NYM4.
PeptideAtlasiQ9NYM4.
PRIDEiQ9NYM4.

Protocols and materials databases

DNASUi10888.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000243673; ENSP00000243673; ENSG00000123901.
GeneIDi10888.
KEGGihsa:10888.
UCSCiuc001pet.2. human.

Organism-specific databases

CTDi10888.
DisGeNETi10888.
GeneCardsiGPR83.
HGNCiHGNC:4523. GPR83.
HPAiHPA044493.
MIMi605569. gene.
neXtProtiNX_Q9NYM4.
OpenTargetsiENSG00000123901.
PharmGKBiPA28927.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000112793.
HOVERGENiHBG051819.
InParanoidiQ9NYM4.
KOiK04210.
OMAiNENFRIE.
OrthoDBiEOG091G0YEQ.
PhylomeDBiQ9NYM4.
TreeFamiTF315303.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000123901-MONOMER.
ReactomeiR-HSA-418555. G alpha (s) signalling events.

Miscellaneous databases

GeneWikiiGPR83.
GenomeRNAii10888.
PROiQ9NYM4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000123901.
CleanExiHS_GPR83.
ExpressionAtlasiQ9NYM4. baseline and differential.
GenevisibleiQ9NYM4. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01012. NRPEPTIDEYR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPR83_HUMAN
AccessioniPrimary (citable) accession number: Q9NYM4
Secondary accession number(s): B0M0K5, Q6NWR4, Q9P1Y8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 4, 2008
Last modified: November 30, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.