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Protein

Tropomodulin-3

Gene

TMOD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

ReactomeiR-HSA-390522. Striated Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Tropomodulin-3
Alternative name(s):
Ubiquitous tropomodulin
Short name:
U-Tmod
Gene namesi
Name:TMOD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000138594.12.
HGNCiHGNC:11873. TMOD3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi29766.
OpenTargetsiENSG00000138594.
PharmGKBiPA36574.

Polymorphism and mutation databases

BioMutaiTMOD3.
DMDMi23396884.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001861341 – 352Tropomodulin-3Add BLAST352

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NYL9.
MaxQBiQ9NYL9.
PaxDbiQ9NYL9.
PeptideAtlasiQ9NYL9.
PRIDEiQ9NYL9.
TopDownProteomicsiQ9NYL9.

2D gel databases

OGPiQ9NYL9.

PTM databases

iPTMnetiQ9NYL9.
PhosphoSitePlusiQ9NYL9.
SwissPalmiQ9NYL9.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000138594.
CleanExiHS_TMOD3.
ExpressionAtlasiQ9NYL9. baseline and differential.
GenevisibleiQ9NYL9. HS.

Organism-specific databases

HPAiHPA001849.

Interactioni

Subunit structurei

Binds to the N-terminus of tropomyosin and to actin.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi118899. 124 interactors.
IntActiQ9NYL9. 56 interactors.
MINTiMINT-1149880.
STRINGi9606.ENSP00000308753.

Structurei

3D structure databases

ProteinModelPortaliQ9NYL9.
SMRiQ9NYL9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tropomodulin family.Curated

Phylogenomic databases

eggNOGiKOG3735. Eukaryota.
ENOG410YAHM. LUCA.
GeneTreeiENSGT00760000119226.
HOGENOMiHOG000261624.
HOVERGENiHBG056172.
InParanoidiQ9NYL9.
KOiK10370.
OMAiNTHVKNF.
OrthoDBiEOG091G0C3H.
PhylomeDBiQ9NYL9.
TreeFamiTF315841.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiView protein in InterPro
IPR032675. L_dom-like.
IPR004934. TMOD.
IPR030133. TMOD3.
PANTHERiPTHR10901. PTHR10901. 1 hit.
PTHR10901:SF18. PTHR10901:SF18. 1 hit.
PfamiView protein in Pfam
PF03250. Tropomodulin. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NYL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPFRKDLE KYKDLDEDEL LGNLSETELK QLETVLDDLD PENALLPAGF
60 70 80 90 100
RQKNQTSKST TGPFDREHLL SYLEKEALEH KDREDYVPYT GEKKGKIFIP
110 120 130 140 150
KQKPVQTFTE EKVSLDPELE EALTSASDTE LCDLAAILGM HNLITNTKFC
160 170 180 190 200
NIMGSSNGVD QEHFSNVVKG EKILPVFDEP PNPTNVEESL KRTKENDAHL
210 220 230 240 250
VEVNLNNIKN IPIPTLKDFA KALETNTHVK CFSLAATRSN DPVATAFAEM
260 270 280 290 300
LKVNKTLKSL NVESNFITGV GILALIDALR DNETLAELKI DNQRQQLGTA
310 320 330 340 350
VELEMAKMLE ENTNILKFGY QFTQQGPRTR AANAITKNND LVRKRRVEGD

HQ
Length:352
Mass (Da):39,595
Last modified:October 1, 2000 - v1
Checksum:i8B7F2122C1BE9855
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27T → S in AAF31670 (PubMed:10662549).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF237631 mRNA. Translation: AAF45299.1.
AF177171 mRNA. Translation: AAF31670.1.
AK312569 mRNA. Translation: BAG35464.1.
BC020542 mRNA. Translation: AAH20542.1.
AL137543 mRNA. Translation: CAB70801.1.
CCDSiCCDS10145.1.
PIRiT46384.
RefSeqiNP_055362.1. NM_014547.4.
XP_016877576.1. XM_017022087.1.
XP_016877577.1. XM_017022088.1.
UniGeneiHs.4998.

Genome annotation databases

EnsembliENST00000308580; ENSP00000308753; ENSG00000138594.
GeneIDi29766.
KEGGihsa:29766.
UCSCiuc002abn.4. human.

Similar proteinsi

Entry informationi

Entry nameiTMOD3_HUMAN
AccessioniPrimary (citable) accession number: Q9NYL9
Secondary accession number(s): B2R6G7, Q9NT43, Q9NZR0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: October 1, 2000
Last modified: October 25, 2017
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families