ID   FKB11_HUMAN             Reviewed;         201 AA.
AC   Q9NYL4;
DT   19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-JAN-2012, entry version 83.
DE   RecName: Full=Peptidyl-prolyl cis-trans isomerase FKBP11;
DE            Short=PPIase FKBP11;
DE            EC=5.2.1.8;
DE   AltName: Full=19 kDa FK506-binding protein;
DE            Short=19 kDa FKBP;
DE            Short=FKBP-19;
DE   AltName: Full=FK506-binding protein 11;
DE            Short=FKBP-11;
DE   AltName: Full=Rotamase;
DE   Flags: Precursor;
GN   Name=FKBP11; Synonyms=FKBP19; ORFNames=UNQ336/PRO535;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Rulten S., Kay J.E., Robinson C.;
RT   "Identification of novel FKBP genes.";
RL   Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   MEDLINE=22887296; PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA   Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA   Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA   Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA   Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA   Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA   Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale
RT   effort to identify novel human secreted and transmembrane proteins: a
RT   bioinformatics assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Pancreas, and Spleen;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
CC   -!- FUNCTION: PPIases accelerate the folding of proteins during
CC       protein synthesis.
CC   -!- CATALYTIC ACTIVITY: Peptidylproline (omega=180) = peptidylproline
CC       (omega=0).
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein
CC       (Potential).
CC   -!- SIMILARITY: Belongs to the FKBP-type PPIase family.
CC   -!- SIMILARITY: Contains 1 PPIase FKBP-type domain.
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DR   EMBL; AF238079; AAF63478.1; -; mRNA.
DR   EMBL; AY358998; AAQ89357.1; -; mRNA.
DR   EMBL; BC027973; AAH27973.1; -; mRNA.
DR   IPI; IPI00009885; -.
DR   RefSeq; NP_001137253.1; NM_001143781.1.
DR   RefSeq; NP_057678.1; NM_016594.2.
DR   UniGene; Hs.655103; -.
DR   ProteinModelPortal; Q9NYL4; -.
DR   SMR; Q9NYL4; 50-147.
DR   IntAct; Q9NYL4; 1.
DR   STRING; Q9NYL4; -.
DR   DMDM; 23396601; -.
DR   PRIDE; Q9NYL4; -.
DR   Ensembl; ENST00000256680; ENSP00000256680; ENSG00000134285.
DR   GeneID; 51303; -.
DR   KEGG; hsa:51303; -.
DR   UCSC; uc001rsp.1; human.
DR   CTD; 51303; -.
DR   GeneCards; GC12M049315; -.
DR   H-InvDB; HIX0010591; -.
DR   HGNC; HGNC:18624; FKBP11.
DR   HPA; HPA041709; -.
DR   MIM; 610571; gene.
DR   neXtProt; NX_Q9NYL4; -.
DR   GeneTree; ENSGT00530000062784; -.
DR   HOGENOM; HBG731200; -.
DR   HOVERGEN; HBG051623; -.
DR   InParanoid; Q9NYL4; -.
DR   OMA; SRPKVSK; -.
DR   OrthoDB; EOG4T784J; -.
DR   PhylomeDB; Q9NYL4; -.
DR   NextBio; 54609; -.
DR   ArrayExpress; Q9NYL4; -.
DR   Bgee; Q9NYL4; -.
DR   CleanEx; HS_FKBP11; -.
DR   Genevestigator; Q9NYL4; -.
DR   GermOnline; ENSG00000134285; Homo sapiens.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005528; F:FK506 binding; IBA:RefGenome.
DR   GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IBA:RefGenome.
DR   GO; GO:0006457; P:protein folding; IEA:UniProtKB-KW.
DR   InterPro; IPR023566; PPIase_FKBP.
DR   InterPro; IPR001179; PPIase_FKBP_dom.
DR   KO; K09576; -.
DR   PANTHER; PTHR10516; PPIase_FKBP; 1.
DR   Pfam; PF00254; FKBP_C; 1.
DR   PROSITE; PS50059; FKBP_PPIASE; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Isomerase; Membrane; Reference proteome; Rotamase;
KW   Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL        1     27       Potential.
FT   CHAIN        28    201       Peptidyl-prolyl cis-trans isomerase
FT                                FKBP11.
FT                                /FTId=PRO_0000025519.
FT   TRANSMEM    156    176       Helical; (Potential).
FT   DOMAIN       57    144       PPIase FKBP-type.
SQ   SEQUENCE   201 AA;  22180 MW;  586E430B9D2DC0A2 CRC64;
     MTLRPSLLPL HLLLLLLLSA AVCRAEAGLE TESPVRTLQV ETLVEPPEPC AEPAAFGDTL
     HIHYTGSLVD GRIIDTSLTR DPLVIELGQK QVIPGLEQSL LDMCVGEKRR AIIPSHLAYG
     KRGFPPSVPA DAVVQYDVEL IALIRANYWL KLVKGILPLV GMAMVPALLG LIGYHLYRKA
     NRPKVSKKKL KEEKRNKSKK K
//