ID   FKB11_HUMAN             Reviewed;         201 AA.
AC   Q9NYL4;
DT   19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   19-JAN-2010, entry version 67.
DE   RecName: Full=FK506-binding protein 11;
DE            EC=5.2.1.8;
DE   AltName: Full=Peptidyl-prolyl cis-trans isomerase;
DE            Short=PPIase;
DE            Short=Rotamase;
DE   AltName: Full=19 kDa FK506-binding protein;
DE   AltName: Full=FKBP-19;
DE   Flags: Precursor;
GN   Name=FKBP11; Synonyms=FKBP19; ORFNames=UNQ336/PRO535;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Rulten S., Kay J.E., Robinson C.;
RT   "Identification of novel FKBP genes.";
RL   Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   MEDLINE=22887296; PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA   Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA   Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA   Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA   Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA   Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA   Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale
RT   effort to identify novel human secreted and transmembrane proteins: a
RT   bioinformatics assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Pancreas, and Spleen;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
RA   Colinge J., Superti-Furga G., Bennett K.L.;
RL   Submitted (OCT-2008) to UniProtKB.
CC   -!- FUNCTION: PPIases accelerate the folding of proteins during
CC       protein synthesis.
CC   -!- CATALYTIC ACTIVITY: Peptidylproline (omega=180) = peptidylproline
CC       (omega=0).
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein
CC       (Potential).
CC   -!- SIMILARITY: Belongs to the FKBP-type PPIase family.
CC   -!- SIMILARITY: Contains 1 PPIase FKBP-type domain.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AF238079; AAF63478.1; -; mRNA.
DR   EMBL; AY358998; AAQ89357.1; -; mRNA.
DR   EMBL; BC027973; AAH27973.1; -; mRNA.
DR   IPI; IPI00009885; -.
DR   RefSeq; NP_001137253.1; -.
DR   RefSeq; NP_057678.1; -.
DR   UniGene; Hs.655103; -.
DR   SMR; Q9NYL4; 38-144.
DR   STRING; Q9NYL4; -.
DR   PRIDE; Q9NYL4; -.
DR   Ensembl; ENST00000256680; ENSP00000256680; ENSG00000134285; Homo sapiens.
DR   GeneID; 51303; -.
DR   KEGG; hsa:51303; -.
DR   UCSC; uc001rsp.1; human.
DR   CTD; 51303; -.
DR   GeneCards; GC12M047602; -.
DR   H-InvDB; HIX0010591; -.
DR   HGNC; HGNC:18624; FKBP11.
DR   MIM; 610571; gene.
DR   PharmGKB; PA38607; -.
DR   HOGENOM; HBG731200; -.
DR   HOVERGEN; Q9NYL4; -.
DR   InParanoid; Q9NYL4; -.
DR   OMA; SRPKVSK; -.
DR   OrthoDB; EOG9Z91GF; -.
DR   PhylomeDB; Q9NYL4; -.
DR   BRENDA; 5.2.1.8; 247.
DR   NextBio; 54609; -.
DR   ArrayExpress; Q9NYL4; -.
DR   Bgee; Q9NYL4; -.
DR   CleanEx; HS_FKBP11; -.
DR   Genevestigator; Q9NYL4; -.
DR   GermOnline; ENSG00000134285; Homo sapiens.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006457; P:protein folding; IEA:UniProtKB-KW.
DR   InterPro; IPR001179; PPIase_FKBP.
DR   PANTHER; PTHR10516; PPIase_FKBP; 1.
DR   Pfam; PF00254; FKBP_C; 1.
DR   PROSITE; PS50059; FKBP_PPIASE; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Isomerase; Membrane; Rotamase; Signal;
KW   Transmembrane.
FT   SIGNAL        1     27       Potential.
FT   CHAIN        28    201       FK506-binding protein 11.
FT                                /FTId=PRO_0000025519.
FT   TRANSMEM    156    176       Potential.
FT   DOMAIN       57    144       PPIase FKBP-type.
SQ   SEQUENCE   201 AA;  22180 MW;  586E430B9D2DC0A2 CRC64;
     MTLRPSLLPL HLLLLLLLSA AVCRAEAGLE TESPVRTLQV ETLVEPPEPC AEPAAFGDTL
     HIHYTGSLVD GRIIDTSLTR DPLVIELGQK QVIPGLEQSL LDMCVGEKRR AIIPSHLAYG
     KRGFPPSVPA DAVVQYDVEL IALIRANYWL KLVKGILPLV GMAMVPALLG LIGYHLYRKA
     NRPKVSKKKL KEEKRNKSKK K
//