Q9NYL4 (FKB11_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 96.
History...
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Peptidyl-prolyl cis-trans isomerase FKBP11 Short name=PPIase FKBP11 EC=5.2.1.8 Alternative name(s): 19 kDa FK506-binding protein Short name=19 kDa FKBP Short name=FKBP-19 FK506-binding protein 11 Short name=FKBP-11 Rotamase | ||||||
| Gene names |
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| Organism | Homo sapiens (Human) [Reference proteome] | ||||||
| Taxonomic identifier | 9606 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo![]() |
Protein attributes
| Sequence length | 201 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | PPIases accelerate the folding of proteins during protein synthesis. |
| Catalytic activity | Peptidylproline (omega=180) = peptidylproline (omega=0). |
| Subcellular location | Membrane; Single-pass membrane protein Potential. |
| Sequence similarities | Belongs to the FKBP-type PPIase family. Contains 1 PPIase FKBP-type domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane |
| Coding sequence diversity | Alternative splicing |
| Domain | Signal Transmembrane Transmembrane helix |
| Molecular function | Isomerase Rotamase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | protein folding Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular_component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW membraneInferred from Biological aspect of Ancestor. Source: RefGenome |
| Molecular_function | FK506 binding Inferred from Biological aspect of Ancestor. Source: RefGenome peptidyl-prolyl cis-trans isomerase activityInferred from Biological aspect of Ancestor. Source: RefGenome |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q9NYL4-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q9NYL4-2) The sequence of this isoform differs from the canonical sequence as follows: 130-201: ADAVVQYDVE...EEKRNKSKKK → GTKDNLMRPPGMTSSSQ | ||||||
| Note: No experimental confirmation available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 27 | 27 | Potential | ||||||
| Chain | 28 – 201 | 174 | Peptidyl-prolyl cis-trans isomerase FKBP11 | PRO_0000025519 | |||||
Regions | |||||||||
| Transmembrane | 156 – 176 | 21 | Helical; Potential | ||||||
| Domain | 57 – 144 | 88 | PPIase FKBP-type | ||||||
Natural variations | |||||||||
| Alternative sequence | 130 – 201 | 72 | ADAVV…KSKKK → GTKDNLMRPPGMTSSSQ in isoform 2. | VSP_043037 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Identification of novel FKBP genes." Rulten S., Kay J.E., Robinson C. Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). |
| [2] | "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. Gray A.M.Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). |
| [3] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Synovium. |
| [4] | "The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. Gibbs R.A.Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Pancreas and Spleen. |
| [6] | "Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF238079 mRNA. Translation: AAF63478.1. AY358998 mRNA. Translation: AAQ89357.1. AK301455 mRNA. Translation: BAG62979.1. AC073610 Genomic DNA. No translation available. BC027973 mRNA. Translation: AAH27973.1. |
| IPI | IPI00009885. IPI00789642. |
| RefSeq | NP_001137253.1. NM_001143781.1. NP_001137254.1. NM_001143782.1. NP_057678.1. NM_016594.2. |
| UniGene | Hs.655103. |
3D structure databases | |
| ProteinModelPortal | Q9NYL4. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q9NYL4. 1 interaction. |
| STRING | 9606.ENSP00000256680. |
PTM databases | |
| PhosphoSite | Q9NYL4. |
Polymorphism databases | |
| DMDM | 23396601. |
Proteomic databases | |
| PaxDb | Q9NYL4. |
| PRIDE | Q9NYL4. |
Protocols and materials databases | |
| DNASU | 51303. |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000453172; ENSP00000396874; ENSG00000134285. ENST00000550765; ENSP00000449751; ENSG00000134285. |
| GeneID | 51303. |
| KEGG | hsa:51303. |
| UCSC | uc001rsp.3. human. |
Organism-specific databases | |
| CTD | 51303. |
| GeneCards | GC12M049315. |
| HGNC | HGNC:18624. FKBP11. |
| HPA | HPA041709. |
| MIM | 610571. gene. |
| neXtProt | NX_Q9NYL4. |
| PharmGKB | PA38607. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | COG0545. |
| HOGENOM | HOG000154887. |
| HOVERGEN | HBG051623. |
| InParanoid | Q9NYL4. |
| KO | K09576. |
| OMA | SRPKVSK. |
| OrthoDB | EOG4T784J. |
| PhylomeDB | Q9NYL4. |
Gene expression databases | |
| ArrayExpress | Q9NYL4. |
| Bgee | Q9NYL4. |
| CleanEx | HS_FKBP11. |
| Genevestigator | Q9NYL4. |
| GermOnline | ENSG00000134285. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR023566. PPIase_FKBP. IPR001179. PPIase_FKBP_dom. [Graphical view] |
| PANTHER | PTHR10516. PTHR10516. 1 hit. |
| Pfam | PF00254. FKBP_C. 1 hit. [Graphical view] |
| PROSITE | PS50059. FKBP_PPIASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| ChiTaRS | FKBP11. human. |
| GenomeRNAi | 51303. |
| NextBio | 54609. |
| SOURCE | Search... |
Entry information
| Entry name | FKB11_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9NYL4 Secondary accession number(s): B4DWB7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 12 Human chromosome 12: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with
