Reviewed, UniProtKB/Swiss-Prot Q9NYL4 (FKB11_HUMAN)

Names and origin

Protein names

Recommended name:
    FK506-binding protein 11
    EC=5.2.1.8
Alternative name(s):
    Peptidyl-prolyl cis-trans isomerase
      Short name=PPIase
      Short name=Rotamase
    19 kDa FK506-binding protein
    FKBP-19

Gene names

Name:	FKBP11
Synonyms:	FKBP19
ORF Names:	UNQ336/PRO535

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	201 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	PPIases accelerate the folding of proteins during protein synthesis.
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the FKBP-type PPIase family. Contains 1 PPIase FKBP-type domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane
Molecular function	Isomerase Rotamase
Gene Ontology (GO)
Biological process	protein folding Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	peptidyl-prolyl cis-trans isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 27	27	Potential
	Chain	28 – 201	174	FK506-binding protein 11		PRO_0000025519
Regions
	Transmembrane	156 – 176	21	Potential
	Domain	57 – 144	88	PPIase FKBP-type

Sequences

	Sequence		Length	Mass (Da)
	Q9NYL4-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 586E430B9D2DC0A2	FASTA	201	22,180
	10 20 30 40 50 60 MTLRPSLLPL HLLLLLLLSA AVCRAEAGLE TESPVRTLQV ETLVEPPEPC AEPAAFGDTL 70 80 90 100 110 120 HIHYTGSLVD GRIIDTSLTR DPLVIELGQK QVIPGLEQSL LDMCVGEKRR AIIPSHLAYG 130 140 150 160 170 180 KRGFPPSVPA DAVVQYDVEL IALIRANYWL KLVKGILPLV GMAMVPALLG LIGYHLYRKA 190 200 NRPKVSKKKL KEEKRNKSKK K

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of novel FKBP genes." Rulten S., Kay J.E., Robinson C. Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas and Spleen.
[4]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF238079 mRNA. Translation: AAF63478.1. AY358998 mRNA. Translation: AAQ89357.1. BC027973 mRNA. Translation: AAH27973.1.
IPI	IPI00009885.
RefSeq	NP_001137253.1. NP_057678.1.
UniGene	Hs.655103
3D structure databases
HSSP	HSSP built from PDB template 1PBK based on UniProtKB Q00688.
ModBase	Search...
Proteomic databases
PRIDE	Q9NYL4.
Genome annotation databases
Ensembl	ENSG00000134285. Homo sapiens. [Contig view]
GeneID	51303.
KEGG	hsa:51303.
Organism-specific databases
GeneCards	GC12M047602.
H-InvDB	HIX0010591.
HGNC	HGNC:18624. FKBP11.
MIM	610571. gene.
PharmGKB	PA38607.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9NYL4.
HOVERGEN	Q9NYL4.
OMA	Q9NYL4. SRPKVSK.
Enzyme and pathway databases
BRENDA	5.2.1.8. 247.
Gene expression databases
ArrayExpress	Q9NYL4.
Bgee	Q9NYL4.
CleanEx	HS_FKBP11.
GermOnline	ENSG00000134285. Homo sapiens.
Family and domain databases
InterPro	IPR001179. PPIase_FKBP. [Graphical view]
PANTHER	PTHR10516. PPIase_FKBP. 1 hit.
Pfam	PF00254. FKBP_C. 1 hit. [Graphical view]
PROSITE	PS50059. FKBP_PPIASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	54609.
SOURCE	Search...

Entry information

Entry name

FKB11_HUMAN

Accession

Primary (citable) accession number: Q9NYL4

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2002
Last sequence update:	October 1, 2000
Last modified:	June 16, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)