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Protein

Peptidyl-prolyl cis-trans isomerase FKBP11

Gene

FKBP11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins during protein synthesis.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Enzyme and pathway databases

BioCyciZFISH:HS05851-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP11 (EC:5.2.1.8)
Short name:
PPIase FKBP11
Alternative name(s):
19 kDa FK506-binding protein
Short name:
19 kDa FKBP
Short name:
FKBP-19
FK506-binding protein 11
Short name:
FKBP-11
Rotamase
Gene namesi
Name:FKBP11
Synonyms:FKBP19
ORF Names:UNQ336/PRO535
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:18624. FKBP11.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei156 – 176HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: GO_Central
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi51303.
OpenTargetsiENSG00000134285.
PharmGKBiPA38607.

Polymorphism and mutation databases

BioMutaiFKBP11.
DMDMi23396601.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000002551928 – 201Peptidyl-prolyl cis-trans isomerase FKBP11Add BLAST174

Proteomic databases

MaxQBiQ9NYL4.
PaxDbiQ9NYL4.
PeptideAtlasiQ9NYL4.
PRIDEiQ9NYL4.

PTM databases

iPTMnetiQ9NYL4.
PhosphoSitePlusiQ9NYL4.

Expressioni

Gene expression databases

BgeeiENSG00000134285.
CleanExiHS_FKBP11.
ExpressionAtlasiQ9NYL4. baseline and differential.
GenevisibleiQ9NYL4. HS.

Organism-specific databases

HPAiHPA041709.

Interactioni

Subunit structurei

Interacts with IFITM5.By similarity

Protein-protein interaction databases

BioGridi119454. 6 interactors.
IntActiQ9NYL4. 1 interactor.
STRINGi9606.ENSP00000449751.

Structurei

3D structure databases

ProteinModelPortaliQ9NYL4.
SMRiQ9NYL4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 144PPIase FKBP-typePROSITE-ProRule annotationAdd BLAST88

Sequence similaritiesi

Belongs to the FKBP-type PPIase family.Curated
Contains 1 PPIase FKBP-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0549. Eukaryota.
COG0545. LUCA.
GeneTreeiENSGT00530000062784.
HOGENOMiHOG000154887.
HOVERGENiHBG051623.
InParanoidiQ9NYL4.
KOiK09576.
OMAiSLIGVCE.
OrthoDBiEOG091G02W1.
PhylomeDBiQ9NYL4.
TreeFamiTF105296.

Family and domain databases

InterProiIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NYL4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTLRPSLLPL HLLLLLLLSA AVCRAEAGLE TESPVRTLQV ETLVEPPEPC
60 70 80 90 100
AEPAAFGDTL HIHYTGSLVD GRIIDTSLTR DPLVIELGQK QVIPGLEQSL
110 120 130 140 150
LDMCVGEKRR AIIPSHLAYG KRGFPPSVPA DAVVQYDVEL IALIRANYWL
160 170 180 190 200
KLVKGILPLV GMAMVPALLG LIGYHLYRKA NRPKVSKKKL KEEKRNKSKK

K
Length:201
Mass (Da):22,180
Last modified:October 1, 2000 - v1
Checksum:i586E430B9D2DC0A2
GO
Isoform 2 (identifier: Q9NYL4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     130-201: ADAVVQYDVE...EEKRNKSKKK → GTKDNLMRPPGMTSSSQ

Note: No experimental confirmation available.
Show »
Length:146
Mass (Da):15,769
Checksum:i2DF2A884019591BD
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_043037130 – 201ADAVV…KSKKK → GTKDNLMRPPGMTSSSQ in isoform 2. 1 PublicationAdd BLAST72

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF238079 mRNA. Translation: AAF63478.1.
AY358998 mRNA. Translation: AAQ89357.1.
AK301455 mRNA. Translation: BAG62979.1.
AC073610 Genomic DNA. No translation available.
BC027973 mRNA. Translation: AAH27973.1.
CCDSiCCDS44871.1. [Q9NYL4-2]
CCDS8773.1. [Q9NYL4-1]
RefSeqiNP_001137253.1. NM_001143781.1.
NP_001137254.1. NM_001143782.1. [Q9NYL4-2]
NP_057678.1. NM_016594.2. [Q9NYL4-1]
UniGeneiHs.655103.

Genome annotation databases

EnsembliENST00000453172; ENSP00000396874; ENSG00000134285. [Q9NYL4-2]
ENST00000550765; ENSP00000449751; ENSG00000134285. [Q9NYL4-1]
GeneIDi51303.
KEGGihsa:51303.
UCSCiuc001rsp.4. human. [Q9NYL4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF238079 mRNA. Translation: AAF63478.1.
AY358998 mRNA. Translation: AAQ89357.1.
AK301455 mRNA. Translation: BAG62979.1.
AC073610 Genomic DNA. No translation available.
BC027973 mRNA. Translation: AAH27973.1.
CCDSiCCDS44871.1. [Q9NYL4-2]
CCDS8773.1. [Q9NYL4-1]
RefSeqiNP_001137253.1. NM_001143781.1.
NP_001137254.1. NM_001143782.1. [Q9NYL4-2]
NP_057678.1. NM_016594.2. [Q9NYL4-1]
UniGeneiHs.655103.

3D structure databases

ProteinModelPortaliQ9NYL4.
SMRiQ9NYL4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119454. 6 interactors.
IntActiQ9NYL4. 1 interactor.
STRINGi9606.ENSP00000449751.

PTM databases

iPTMnetiQ9NYL4.
PhosphoSitePlusiQ9NYL4.

Polymorphism and mutation databases

BioMutaiFKBP11.
DMDMi23396601.

Proteomic databases

MaxQBiQ9NYL4.
PaxDbiQ9NYL4.
PeptideAtlasiQ9NYL4.
PRIDEiQ9NYL4.

Protocols and materials databases

DNASUi51303.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000453172; ENSP00000396874; ENSG00000134285. [Q9NYL4-2]
ENST00000550765; ENSP00000449751; ENSG00000134285. [Q9NYL4-1]
GeneIDi51303.
KEGGihsa:51303.
UCSCiuc001rsp.4. human. [Q9NYL4-1]

Organism-specific databases

CTDi51303.
DisGeNETi51303.
GeneCardsiFKBP11.
HGNCiHGNC:18624. FKBP11.
HPAiHPA041709.
MIMi610571. gene.
neXtProtiNX_Q9NYL4.
OpenTargetsiENSG00000134285.
PharmGKBiPA38607.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0549. Eukaryota.
COG0545. LUCA.
GeneTreeiENSGT00530000062784.
HOGENOMiHOG000154887.
HOVERGENiHBG051623.
InParanoidiQ9NYL4.
KOiK09576.
OMAiSLIGVCE.
OrthoDBiEOG091G02W1.
PhylomeDBiQ9NYL4.
TreeFamiTF105296.

Enzyme and pathway databases

BioCyciZFISH:HS05851-MONOMER.

Miscellaneous databases

ChiTaRSiFKBP11. human.
GenomeRNAii51303.
PROiQ9NYL4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000134285.
CleanExiHS_FKBP11.
ExpressionAtlasiQ9NYL4. baseline and differential.
GenevisibleiQ9NYL4. HS.

Family and domain databases

InterProiIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFKB11_HUMAN
AccessioniPrimary (citable) accession number: Q9NYL4
Secondary accession number(s): B4DWB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.