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Protein

Mitogen-activated protein kinase kinase kinase MLT

Gene

ZAK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2 (PubMed:10924358, PubMed:11836244, PubMed:15342622, PubMed:21224381). Involved in limb development (PubMed:26755636).5 Publications
Isoform 1: Phosphorylates histone H3 at 'Ser-28' (PubMed:15684425). May have role in neoplastic cell transformation and cancer development (PubMed:15172994). Causes cell shrinkage and disruption of actin stress fibers (PubMed:11042189).3 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.1 Publication

Cofactori

Mg2+1 Publication

Enzyme regulationi

Activated by phosphorylation by PKN1 and autophosphorylation on Thr-161 and Ser-165.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei45ATPPROSITE-ProRule annotation1 Publication1
Active sitei133Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi22 – 30ATPPROSITE-ProRule annotationBy similarity9

GO - Molecular functioni

  • ATP binding Source: UniProtKB
  • magnesium ion binding Source: UniProtKB
  • MAP kinase kinase kinase activity Source: UniProtKB
  • poly(A) RNA binding Source: UniProtKB
  • protein serine/threonine kinase activity Source: UniProtKB

GO - Biological processi

  • activation of JUN kinase activity Source: UniProtKB
  • activation of MAPKK activity Source: UniProtKB
  • cell cycle arrest Source: UniProtKB
  • cell cycle checkpoint Source: UniProtKB
  • cell death Source: UniProtKB
  • cell differentiation Source: UniProtKB
  • cell proliferation Source: UniProtKB
  • cytoskeleton organization Source: Ensembl
  • DNA damage checkpoint Source: UniProtKB
  • embryonic digit morphogenesis Source: UniProtKB
  • intracellular signal transduction Source: UniProtKB
  • limb development Source: UniProtKB
  • positive regulation of apoptotic process Source: UniProtKB
  • protein phosphorylation Source: UniProtKB
  • response to radiation Source: UniProtKB
  • response to stress Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS01733-MONOMER.
SignaLinkiQ9NYL2.
SIGNORiQ9NYL2.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase kinase kinase MLT (EC:2.7.11.25)
Alternative name(s):
Human cervical cancer suppressor gene 4 protein
Short name:
HCCS-4
Leucine zipper- and sterile alpha motif-containing kinase
MLK-like mitogen-activated protein triple kinase
Mixed lineage kinase-related kinase
Short name:
MLK-related kinase
Short name:
MRK
Sterile alpha motif- and leucine zipper-containing kinase AZK
Gene namesi
Name:ZAK
Synonyms:MLTK
ORF Names:HCCS4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Subcellular locationi

  • Cytoplasm 1 Publication
  • Nucleus 1 Publication

  • Note: Translocates to the nucleus upon ultraviolet B irradiation.1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Split-foot malformation with mesoaxial polydactyly (SFMMP)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by a split-foot defect, mesoaxial polydactyly, nail abnormalities of the hands, and sensorineural hearing loss.
See also OMIM:616890
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_076448368F → C in SFMMP; produces protein aggregation. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi45K → M: Loss of kinase activity. 1 Publication1
Mutagenesisi161T → A: Loss of autophosphorylation activity. 1 Publication1
Mutagenesisi162T → A: Slight loss of autophosphorylation activity. 1 Publication1
Mutagenesisi165S → A: Loss of autophosphorylation activity. 1 Publication1

Organism-specific databases

DisGeNETi51776.
MIMi616890. phenotype.
OpenTargetsiENSG00000091436.

Chemistry databases

ChEMBLiCHEMBL3886.
GuidetoPHARMACOLOGYi2289.

Polymorphism and mutation databases

BioMutaiMLTK.
DMDMi313104215.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000863381 – 800Mitogen-activated protein kinase kinase kinase MLTAdd BLAST800

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei161Phosphothreonine; by autocatalysis1 Publication1
Modified residuei165Phosphoserine; by autocatalysis1 Publication1
Modified residuei567PhosphoserineCombined sources1
Modified residuei593PhosphoserineCombined sources1
Modified residuei599PhosphoserineCombined sources1
Modified residuei628PhosphothreonineCombined sources1
Modified residuei633PhosphoserineCombined sources1
Modified residuei637PhosphoserineCombined sources1
Modified residuei648PhosphoserineCombined sources1
Modified residuei649PhosphoserineCombined sources1
Modified residuei685PhosphoserineCombined sources1
Modified residuei727PhosphoserineCombined sources1
Modified residuei733PhosphoserineCombined sources1
Isoform 21 Publication (identifier: Q9NYL2-2)
Modified residuei429Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NYL2.
MaxQBiQ9NYL2.
PaxDbiQ9NYL2.
PeptideAtlasiQ9NYL2.
PRIDEiQ9NYL2.

PTM databases

iPTMnetiQ9NYL2.
PhosphoSitePlusiQ9NYL2.

Expressioni

Tissue specificityi

Ubiquitously expressed. Isoform 2 is the predominant form in all tissues examined, except for liver, in which isoform 1 is more highly expressed.2 Publications

Gene expression databases

BgeeiENSG00000091436.
ExpressionAtlasiQ9NYL2. baseline and differential.
GenevisibleiQ9NYL2. HS.

Organism-specific databases

HPAiHPA017205.

Interactioni

Subunit structurei

Homodimer (PubMed:10924358, PubMed:26755636). Interacts with PKN1 and ZNF33A (PubMed:12535642, PubMed:12761180). Component of a signaling complex containing at least AKAP13, PKN1, MAPK14, ZAK and MAP2K3. Within this complex, AKAP13 interacts directly with PKN1, which in turn recruits MAPK14, MAP2K3 and ZAK (PubMed:21224381).5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PKN1Q165122EBI-687346,EBI-602382
RPS6KA5O755824EBI-602273,EBI-73869
YWHAZP631044EBI-602273,EBI-347088
ZFP2Q6ZN573EBI-10255081,EBI-7236323
ZNF567Q8N1843EBI-10255081,EBI-749400

Protein-protein interaction databases

BioGridi119725. 44 interactors.
IntActiQ9NYL2. 36 interactors.
MINTiMINT-1465549.
STRINGi9606.ENSP00000364361.

Chemistry databases

BindingDBiQ9NYL2.

Structurei

Secondary structure

1800
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi13 – 15Combined sources3
Beta strandi16 – 21Combined sources6
Helixi22 – 25Combined sources4
Beta strandi29 – 35Combined sources7
Helixi36 – 38Combined sources3
Beta strandi40 – 48Combined sources9
Helixi53 – 57Combined sources5
Beta strandi68 – 74Combined sources7
Beta strandi77 – 83Combined sources7
Helixi90 – 94Combined sources5
Helixi97 – 101Combined sources5
Helixi104 – 123Combined sources20
Beta strandi125 – 127Combined sources3
Helixi136 – 138Combined sources3
Beta strandi139 – 141Combined sources3
Beta strandi147 – 149Combined sources3
Turni152 – 159Combined sources8
Helixi170 – 172Combined sources3
Helixi175 – 178Combined sources4
Helixi186 – 201Combined sources16
Turni205 – 208Combined sources4
Helixi211 – 220Combined sources10
Helixi233 – 242Combined sources10
Helixi247 – 249Combined sources3
Helixi253 – 265Combined sources13
Helixi269 – 278Combined sources10
Helixi280 – 298Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5HESX-ray2.14A/B5-309[»]
ProteinModelPortaliQ9NYL2.
SMRiQ9NYL2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 277Protein kinasePROSITE-ProRule annotationAdd BLAST262
Domaini339 – 410SAMPROSITE-ProRule annotationAdd BLAST72

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni287 – 308Leucine-zipperAdd BLAST22

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0192. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118807.
HOVERGENiHBG080445.
InParanoidiQ9NYL2.
KOiK04424.
OMAiGHSGMQV.
OrthoDBiEOG091G037E.
PhylomeDBiQ9NYL2.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR032938. MLTK.
IPR000719. Prot_kinase_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR23257:SF424. PTHR23257:SF424. 1 hit.
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00220. S_TKc. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q9NYL2-1) [UniParc]FASTAAdd to basket
Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSLGASFVQ IKFDDLQFFE NCGGGSFGSV YRAKWISQDK EVAVKKLLKI
60 70 80 90 100
EKEAEILSVL SHRNIIQFYG VILEPPNYGI VTEYASLGSL YDYINSNRSE
110 120 130 140 150
EMDMDHIMTW ATDVAKGMHY LHMEAPVKVI HRDLKSRNVV IAADGVLKIC
160 170 180 190 200
DFGASRFHNH TTHMSLVGTF PWMAPEVIQS LPVSETCDTY SYGVVLWEML
210 220 230 240 250
TREVPFKGLE GLQVAWLVVE KNERLTIPSS CPRSFAELLH QCWEADAKKR
260 270 280 290 300
PSFKQIISIL ESMSNDTSLP DKCNSFLHNK AEWRCEIEAT LERLKKLERD
310 320 330 340 350
LSFKEQELKE RERRLKMWEQ KLTEQSNTPL LPSFEIGAWT EDDVYCWVQQ
360 370 380 390 400
LVRKGDSSAE MSVYASLFKE NNITGKRLLL LEEEDLKDMG IVSKGHIIHF
410 420 430 440 450
KSAIEKLTHD YINLFHFPPL IKDSGGEPEE NEEKIVNLEL VFGFHLKPGT
460 470 480 490 500
GPQDCKWKMY MEMDGDEIAI TYIKDVTFNT NLPDAEILKM TKPPFVMEKW
510 520 530 540 550
IVGIAKSQTV ECTVTYESDV RTPKSTKHVH SIQWSRTKPQ DEVKAVQLAI
560 570 580 590 600
QTLFTNSDGN PGSRSDSSAD CQWLDTLRMR QIASNTSLQR SQSNPILGSP
610 620 630 640 650
FFSHFDGQDS YAAAVRRPQV PIKYQQITPV NQSRSSSPTQ YGLTKNFSSL
660 670 680 690 700
HLNSRDSGFS SGNTDTSSER GRYSDRSRNK YGRGSISLNS SPRGRYSGKS
710 720 730 740 750
QHSTPSRGRY PGKFYRVSQS ALNPHQSPDF KRSPRDLHQP NTIPGMPLHP
760 770 780 790 800
ETDSRASEED SKVSEGGWTK VEYRKKPHRP SPAKTNKERA RGDHRGWRNF
Length:800
Mass (Da):91,155
Last modified:November 30, 2010 - v3
Checksum:iB2814509EC54B07A
GO
Isoform 21 Publication (identifier: Q9NYL2-2) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     332-455: PSFEIGAWTE...LKPGTGPQDC → LPLAARMSEE...EEDNDMDNSE
     456-800: Missing.

Show »
Length:455
Mass (Da):51,582
Checksum:iE87DB84A4D58B752
GO
Isoform 3 (identifier: Q9NYL2-3) [UniParc]FASTAAdd to basket
Also known as: HCCS-4

The sequence of this isoform differs from the canonical sequence as follows:
     285-312: CEIEATLERLKKLERDLSFKEQELKERE → WVAPTAGHSVWLSKTITRLNEEVNQRSE
     313-800: Missing.

Show »
Length:312
Mass (Da):35,468
Checksum:iB655E873246339FB
GO

Sequence cautioni

The sequence BAD92211 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti346C → W in AAF63490 (PubMed:10924358).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_040806267T → M.1 PublicationCorresponds to variant rs6758025dbSNPEnsembl.1
Natural variantiVAR_040807281A → T in an ovarian endometrioid sample; somatic mutation. 1 Publication1
Natural variantiVAR_040808281A → V.1 PublicationCorresponds to variant rs34683477dbSNPEnsembl.1
Natural variantiVAR_076448368F → C in SFMMP; produces protein aggregation. 1 Publication1
Natural variantiVAR_022827531S → L.5 PublicationsCorresponds to variant rs3769148dbSNPEnsembl.1
Natural variantiVAR_040809580R → W.1 PublicationCorresponds to variant rs7593622dbSNPEnsembl.1
Natural variantiVAR_040810740P → T.1 PublicationCorresponds to variant rs56202258dbSNPEnsembl.1
Natural variantiVAR_040811773Y → H.1 PublicationCorresponds to variant rs35608243dbSNPEnsembl.1
Natural variantiVAR_040812784K → T.2 PublicationsCorresponds to variant rs55830025dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_051741285 – 312CEIEA…LKERE → WVAPTAGHSVWLSKTITRLN EEVNQRSE in isoform 3. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_051742313 – 800Missing in isoform 3. 1 PublicationAdd BLAST488
Alternative sequenceiVSP_051743332 – 455PSFEI…GPQDC → LPLAARMSEESYFESKTEES NSAEMSCQITATSNGEGHGM NPSLQAMMLMGFGDIFSMNK AGAVMHSGMQINMQAKQNSS KTTSKRRGKKVNMALGFSDF DLSEGDDDDDDDGEEEDNDM DNSE in isoform 2. 5 PublicationsAdd BLAST124
Alternative sequenceiVSP_051744456 – 800Missing in isoform 2. 5 PublicationsAdd BLAST345

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF238255 mRNA. Translation: AAF63490.1.
AB049733 mRNA. Translation: BAB16444.1.
AB049734 mRNA. Translation: BAB16445.1.
AF325454 mRNA. Translation: AAK11615.1.
AF480461 mRNA. Translation: AAL85891.1.
AF480462 mRNA. Translation: AAL85892.1.
AB030034 mRNA. Translation: BAB12040.1.
AF251441 mRNA. Translation: AAF65822.1.
AF465843 mRNA. Translation: AAO33376.1.
AK056310 mRNA. Translation: BAG51674.1.
AB208974 mRNA. Translation: BAD92211.1. Different initiation.
AC092573 Genomic DNA. Translation: AAX82002.1.
AC013461 Genomic DNA. Translation: AAX93067.1.
AC019046 Genomic DNA. No translation available.
CH471058 Genomic DNA. Translation: EAX11164.1.
BC001401 mRNA. Translation: AAH01401.1.
CCDSiCCDS2251.1. [Q9NYL2-2]
CCDS42777.1. [Q9NYL2-1]
RefSeqiNP_057737.2. NM_016653.2. [Q9NYL2-1]
NP_598407.1. NM_133646.2. [Q9NYL2-2]
XP_005246697.1. XM_005246640.2. [Q9NYL2-1]
XP_016859812.1. XM_017004323.1. [Q9NYL2-2]
XP_016859813.1. XM_017004324.1. [Q9NYL2-2]
UniGeneiHs.444451.

Genome annotation databases

GeneIDi51776.
KEGGihsa:51776.
UCSCiuc002uhz.4. human. [Q9NYL2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF238255 mRNA. Translation: AAF63490.1.
AB049733 mRNA. Translation: BAB16444.1.
AB049734 mRNA. Translation: BAB16445.1.
AF325454 mRNA. Translation: AAK11615.1.
AF480461 mRNA. Translation: AAL85891.1.
AF480462 mRNA. Translation: AAL85892.1.
AB030034 mRNA. Translation: BAB12040.1.
AF251441 mRNA. Translation: AAF65822.1.
AF465843 mRNA. Translation: AAO33376.1.
AK056310 mRNA. Translation: BAG51674.1.
AB208974 mRNA. Translation: BAD92211.1. Different initiation.
AC092573 Genomic DNA. Translation: AAX82002.1.
AC013461 Genomic DNA. Translation: AAX93067.1.
AC019046 Genomic DNA. No translation available.
CH471058 Genomic DNA. Translation: EAX11164.1.
BC001401 mRNA. Translation: AAH01401.1.
CCDSiCCDS2251.1. [Q9NYL2-2]
CCDS42777.1. [Q9NYL2-1]
RefSeqiNP_057737.2. NM_016653.2. [Q9NYL2-1]
NP_598407.1. NM_133646.2. [Q9NYL2-2]
XP_005246697.1. XM_005246640.2. [Q9NYL2-1]
XP_016859812.1. XM_017004323.1. [Q9NYL2-2]
XP_016859813.1. XM_017004324.1. [Q9NYL2-2]
UniGeneiHs.444451.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5HESX-ray2.14A/B5-309[»]
ProteinModelPortaliQ9NYL2.
SMRiQ9NYL2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119725. 44 interactors.
IntActiQ9NYL2. 36 interactors.
MINTiMINT-1465549.
STRINGi9606.ENSP00000364361.

Chemistry databases

BindingDBiQ9NYL2.
ChEMBLiCHEMBL3886.
GuidetoPHARMACOLOGYi2289.

PTM databases

iPTMnetiQ9NYL2.
PhosphoSitePlusiQ9NYL2.

Polymorphism and mutation databases

BioMutaiMLTK.
DMDMi313104215.

Proteomic databases

EPDiQ9NYL2.
MaxQBiQ9NYL2.
PaxDbiQ9NYL2.
PeptideAtlasiQ9NYL2.
PRIDEiQ9NYL2.

Protocols and materials databases

DNASUi51776.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi51776.
KEGGihsa:51776.
UCSCiuc002uhz.4. human. [Q9NYL2-1]

Organism-specific databases

CTDi51776.
DisGeNETi51776.
GeneCardsiZAK.
H-InvDBHIX0030332.
HPAiHPA017205.
MIMi609479. gene.
616890. phenotype.
neXtProtiNX_Q9NYL2.
OpenTargetsiENSG00000091436.

Phylogenomic databases

eggNOGiKOG0192. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118807.
HOVERGENiHBG080445.
InParanoidiQ9NYL2.
KOiK04424.
OMAiGHSGMQV.
OrthoDBiEOG091G037E.
PhylomeDBiQ9NYL2.

Enzyme and pathway databases

BioCyciZFISH:HS01733-MONOMER.
SignaLinkiQ9NYL2.
SIGNORiQ9NYL2.

Miscellaneous databases

ChiTaRSiZAK. human.
GeneWikiiZAK.
GenomeRNAii51776.
PROiQ9NYL2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000091436.
ExpressionAtlasiQ9NYL2. baseline and differential.
GenevisibleiQ9NYL2. HS.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR032938. MLTK.
IPR000719. Prot_kinase_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR23257:SF424. PTHR23257:SF424. 1 hit.
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00220. S_TKc. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMLTK_HUMAN
AccessioniPrimary (citable) accession number: Q9NYL2
Secondary accession number(s): B3KPG2
, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: November 30, 2010
Last modified: November 2, 2016
This is version 150 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.