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Protein

Protein EURL homolog

Gene

EURL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in cortical progenitor cell proliferation and differentiation. Promotes dendritic spine development of post-migratory cortical projection neurons by modulating the beta-catenin signaling pathway.By similarity

GO - Biological processi

Keywordsi

Biological processDifferentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein EURL homologCurated
Gene namesi
Name:EURLBy similarity
Synonyms:C21orf14Imported, C21orf38Imported, C21orf91Imported, YG81
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000154642.10
HGNCiHGNC:16459 C21orf91
neXtProtiNX_Q9NYK6

Pathology & Biotechi

Organism-specific databases

DisGeNETi54149
OpenTargetsiENSG00000154642
PharmGKBiPA25879

Polymorphism and mutation databases

BioMutaiEURL
DMDMi224471889

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000870771 – 297Protein EURL homologAdd BLAST297

Proteomic databases

EPDiQ9NYK6
MaxQBiQ9NYK6
PaxDbiQ9NYK6
PeptideAtlasiQ9NYK6
PRIDEiQ9NYK6

PTM databases

iPTMnetiQ9NYK6
PhosphoSitePlusiQ9NYK6

Expressioni

Tissue specificityi

Expressed in the brain (PubMed:27404227). Expressed in cortical cells of the germinal ventricular zone and the cortical plate. Underexpressed in the dorsolateral prefrontal cortex, primary visual cortex and cerebellar cortex compared with Down Syndrome patients (at protein level) (PubMed:27404227).1 Publication

Gene expression databases

BgeeiENSG00000154642
CleanExiHS_C21orf7
HS_C21orf91
ExpressionAtlasiQ9NYK6 baseline and differential
GenevisibleiQ9NYK6 HS

Organism-specific databases

HPAiHPA018288
HPA049030

Interactioni

Subunit structurei

Interacts with CCDC85B.By similarity

Protein-protein interaction databases

BioGridi119919, 7 interactors
IntActiQ9NYK6, 4 interactors

Structurei

3D structure databases

ProteinModelPortaliQ9NYK6
SMRiQ9NYK6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili227 – 256Sequence analysisAdd BLAST30

Sequence similaritiesi

Belongs to the EURL family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGQ2 Eukaryota
ENOG41110T8 LUCA
GeneTreeiENSGT00390000002429
HOGENOMiHOG000059622
HOVERGENiHBG018986
InParanoidiQ9NYK6
OMAiCFEKFHL
OrthoDBiEOG091G0D9O
PhylomeDBiQ9NYK6
TreeFamiTF331712

Family and domain databases

InterProiView protein in InterPro
IPR009704 EURL_prot
PANTHERiPTHR15961 PTHR15961, 1 hit
PfamiView protein in Pfam
PF06937 EURL, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NYK6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNEEEQFVNI DLNDDNICSV CKLGTDKETL SFCHICFELN IEGVPKSDLL
60 70 80 90 100
HTKSLRGHKD CFEKYHLIAN QGCPRSKLSK STYEEVKTIL SKKINWIVQY
110 120 130 140 150
AQNKDLDSDS ECSKNPQHHL FNFRHKPEEK LLPQFDSQVP KYSAKWIDGS
160 170 180 190 200
AGGISNCTQR ILEQRENTDF GLSMLQDSGA TLCRNSVLWP HSHNQAQKKE
210 220 230 240 250
ETISSPEANV QTQHPHYSRE ELNSMTLGEV EQLNAKLLQQ IQEVFEELTH
260 270 280 290
QVQEKDSLAS QLHVRHVAIE QLLKNCSKLP CLQVGRTGMK SHLPINN
Length:297
Mass (Da):33,948
Last modified:March 3, 2009 - v3
Checksum:i01602977BEA83B8F
GO
Isoform 2 (identifier: Q9NYK6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     222-297: Missing.

Show »
Length:221
Mass (Da):25,365
Checksum:i9B3E4F75D7E0B484
GO
Isoform 3 (identifier: Q9NYK6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     243-243: Missing.

Show »
Length:296
Mass (Da):33,819
Checksum:iE50277CD1AD5FEAA
GO

Sequence cautioni

The sequence BAB14691 differs from that shown. Reason: Erroneous termination at position 164. Translated as Gln.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24G → E in BAB14691 (PubMed:14702039).Curated1
Sequence conflicti102Q → K in AAF44695 (Ref. 1) Curated1
Sequence conflicti214H → Y in BAB14691 (PubMed:14702039).Curated1
Sequence conflicti249T → P in BAB14691 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054506115N → K. Corresponds to variant dbSNP:rs2824495Ensembl.1
Natural variantiVAR_011631117Q → R. Corresponds to variant dbSNP:rs1047976Ensembl.1
Natural variantiVAR_011632136D → E2 PublicationsCorresponds to variant dbSNP:rs1047978Ensembl.1
Natural variantiVAR_054507195Q → H. Corresponds to variant dbSNP:rs8128004Ensembl.1
Natural variantiVAR_054508217Y → H. Corresponds to variant dbSNP:rs2824494Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_036451222 – 297Missing in isoform 2. 2 PublicationsAdd BLAST76
Alternative sequenceiVSP_036452243Missing in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF239726 mRNA Translation: AAF44695.1
AK023825 mRNA Translation: BAB14691.1 Sequence problems.
AK314471 mRNA Translation: BAG37077.1
AL109761 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX10020.1
BC015468 mRNA Translation: AAH15468.1
CCDSiCCDS42907.1 [Q9NYK6-1]
CCDS42908.1 [Q9NYK6-3]
CCDS42909.1 [Q9NYK6-2]
RefSeqiNP_001093890.1, NM_001100420.1 [Q9NYK6-1]
NP_001093891.1, NM_001100421.1 [Q9NYK6-2]
NP_059143.3, NM_017447.3 [Q9NYK6-3]
UniGeneiHs.293811

Genome annotation databases

EnsembliENST00000284881; ENSP00000284881; ENSG00000154642 [Q9NYK6-1]
ENST00000400558; ENSP00000383403; ENSG00000154642 [Q9NYK6-2]
ENST00000400559; ENSP00000383404; ENSG00000154642 [Q9NYK6-3]
GeneIDi54149
KEGGihsa:54149
UCSCiuc002yko.4 human [Q9NYK6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiEURL_HUMAN
AccessioniPrimary (citable) accession number: Q9NYK6
Secondary accession number(s): B2RB30, Q96BK9, Q9H8C6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: March 3, 2009
Last modified: March 28, 2018
This is version 123 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health