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Protein

Protein EURL homolog

Gene

EURL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein EURL homolog
Gene namesi
Name:EURL
Synonyms:C21orf14, C21orf38, C21orf7, C21orf91, YG81
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:16459. C21orf91.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25879.

Polymorphism and mutation databases

BioMutaiEURL.
DMDMi224471889.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297Protein EURL homologPRO_0000087077Add
BLAST

Proteomic databases

MaxQBiQ9NYK6.
PaxDbiQ9NYK6.
PeptideAtlasiQ9NYK6.
PRIDEiQ9NYK6.

PTM databases

iPTMnetiQ9NYK6.
PhosphoSiteiQ9NYK6.

Expressioni

Gene expression databases

BgeeiENSG00000154642.
CleanExiHS_C21orf7.
HS_C21orf91.
ExpressionAtlasiQ9NYK6. baseline and differential.
GenevisibleiQ9NYK6. HS.

Organism-specific databases

HPAiHPA018288.
HPA049030.

Interactioni

Protein-protein interaction databases

BioGridi119919. 7 interactions.
IntActiQ9NYK6. 3 interactions.
MINTiMINT-1480111.
STRINGi9606.ENSP00000284881.

Structurei

3D structure databases

ProteinModelPortaliQ9NYK6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EURL family.Curated

Phylogenomic databases

eggNOGiENOG410IGQ2. Eukaryota.
ENOG41110T8. LUCA.
GeneTreeiENSGT00390000002429.
HOGENOMiHOG000059622.
HOVERGENiHBG018986.
InParanoidiQ9NYK6.
OMAiGATLCHN.
OrthoDBiEOG091G0D9O.
PhylomeDBiQ9NYK6.
TreeFamiTF331712.

Family and domain databases

InterProiIPR009704. EURL_prot.
[Graphical view]
PfamiPF06937. EURL. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NYK6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNEEEQFVNI DLNDDNICSV CKLGTDKETL SFCHICFELN IEGVPKSDLL
60 70 80 90 100
HTKSLRGHKD CFEKYHLIAN QGCPRSKLSK STYEEVKTIL SKKINWIVQY
110 120 130 140 150
AQNKDLDSDS ECSKNPQHHL FNFRHKPEEK LLPQFDSQVP KYSAKWIDGS
160 170 180 190 200
AGGISNCTQR ILEQRENTDF GLSMLQDSGA TLCRNSVLWP HSHNQAQKKE
210 220 230 240 250
ETISSPEANV QTQHPHYSRE ELNSMTLGEV EQLNAKLLQQ IQEVFEELTH
260 270 280 290
QVQEKDSLAS QLHVRHVAIE QLLKNCSKLP CLQVGRTGMK SHLPINN
Length:297
Mass (Da):33,948
Last modified:March 3, 2009 - v3
Checksum:i01602977BEA83B8F
GO
Isoform 2 (identifier: Q9NYK6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     222-297: Missing.

Show »
Length:221
Mass (Da):25,365
Checksum:i9B3E4F75D7E0B484
GO
Isoform 3 (identifier: Q9NYK6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     243-243: Missing.

Show »
Length:296
Mass (Da):33,819
Checksum:iE50277CD1AD5FEAA
GO

Sequence cautioni

The sequence BAB14691 differs from that shown. Reason: Erroneous termination at position 164. Translated as Gln.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 241G → E in BAB14691 (PubMed:14702039).Curated
Sequence conflicti102 – 1021Q → K in AAF44695 (Ref. 1) Curated
Sequence conflicti214 – 2141H → Y in BAB14691 (PubMed:14702039).Curated
Sequence conflicti249 – 2491T → P in BAB14691 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti115 – 1151N → K.
Corresponds to variant rs2824495 [ dbSNP | Ensembl ].
VAR_054506
Natural varianti117 – 1171Q → R.
Corresponds to variant rs1047976 [ dbSNP | Ensembl ].
VAR_011631
Natural varianti136 – 1361D → E.2 Publications
Corresponds to variant rs1047978 [ dbSNP | Ensembl ].
VAR_011632
Natural varianti195 – 1951Q → H.
Corresponds to variant rs8128004 [ dbSNP | Ensembl ].
VAR_054507
Natural varianti217 – 2171Y → H.
Corresponds to variant rs2824494 [ dbSNP | Ensembl ].
VAR_054508

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei222 – 29776Missing in isoform 2. 2 PublicationsVSP_036451Add
BLAST
Alternative sequencei243 – 2431Missing in isoform 3. 1 PublicationVSP_036452

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF239726 mRNA. Translation: AAF44695.1.
AK023825 mRNA. Translation: BAB14691.1. Sequence problems.
AK314471 mRNA. Translation: BAG37077.1.
AL109761 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX10020.1.
BC015468 mRNA. Translation: AAH15468.1.
CCDSiCCDS42907.1. [Q9NYK6-1]
CCDS42908.1. [Q9NYK6-3]
CCDS42909.1. [Q9NYK6-2]
RefSeqiNP_001093890.1. NM_001100420.1. [Q9NYK6-1]
NP_001093891.1. NM_001100421.1. [Q9NYK6-2]
NP_059143.3. NM_017447.3. [Q9NYK6-3]
UniGeneiHs.293811.

Genome annotation databases

EnsembliENST00000284881; ENSP00000284881; ENSG00000154642. [Q9NYK6-1]
ENST00000400558; ENSP00000383403; ENSG00000154642. [Q9NYK6-2]
ENST00000400559; ENSP00000383404; ENSG00000154642. [Q9NYK6-3]
GeneIDi54149.
KEGGihsa:54149.
UCSCiuc002yko.4. human. [Q9NYK6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF239726 mRNA. Translation: AAF44695.1.
AK023825 mRNA. Translation: BAB14691.1. Sequence problems.
AK314471 mRNA. Translation: BAG37077.1.
AL109761 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX10020.1.
BC015468 mRNA. Translation: AAH15468.1.
CCDSiCCDS42907.1. [Q9NYK6-1]
CCDS42908.1. [Q9NYK6-3]
CCDS42909.1. [Q9NYK6-2]
RefSeqiNP_001093890.1. NM_001100420.1. [Q9NYK6-1]
NP_001093891.1. NM_001100421.1. [Q9NYK6-2]
NP_059143.3. NM_017447.3. [Q9NYK6-3]
UniGeneiHs.293811.

3D structure databases

ProteinModelPortaliQ9NYK6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119919. 7 interactions.
IntActiQ9NYK6. 3 interactions.
MINTiMINT-1480111.
STRINGi9606.ENSP00000284881.

PTM databases

iPTMnetiQ9NYK6.
PhosphoSiteiQ9NYK6.

Polymorphism and mutation databases

BioMutaiEURL.
DMDMi224471889.

Proteomic databases

MaxQBiQ9NYK6.
PaxDbiQ9NYK6.
PeptideAtlasiQ9NYK6.
PRIDEiQ9NYK6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000284881; ENSP00000284881; ENSG00000154642. [Q9NYK6-1]
ENST00000400558; ENSP00000383403; ENSG00000154642. [Q9NYK6-2]
ENST00000400559; ENSP00000383404; ENSG00000154642. [Q9NYK6-3]
GeneIDi54149.
KEGGihsa:54149.
UCSCiuc002yko.4. human. [Q9NYK6-1]

Organism-specific databases

CTDi54149.
GeneCardsiC21orf91.
HGNCiHGNC:16459. C21orf91.
HPAiHPA018288.
HPA049030.
neXtProtiNX_Q9NYK6.
PharmGKBiPA25879.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGQ2. Eukaryota.
ENOG41110T8. LUCA.
GeneTreeiENSGT00390000002429.
HOGENOMiHOG000059622.
HOVERGENiHBG018986.
InParanoidiQ9NYK6.
OMAiGATLCHN.
OrthoDBiEOG091G0D9O.
PhylomeDBiQ9NYK6.
TreeFamiTF331712.

Miscellaneous databases

GenomeRNAii54149.
PROiQ9NYK6.

Gene expression databases

BgeeiENSG00000154642.
CleanExiHS_C21orf7.
HS_C21orf91.
ExpressionAtlasiQ9NYK6. baseline and differential.
GenevisibleiQ9NYK6. HS.

Family and domain databases

InterProiIPR009704. EURL_prot.
[Graphical view]
PfamiPF06937. EURL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEURL_HUMAN
AccessioniPrimary (citable) accession number: Q9NYK6
Secondary accession number(s): B2RB30, Q96BK9, Q9H8C6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: March 3, 2009
Last modified: September 7, 2016
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.