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Protein

39S ribosomal protein L39, mitochondrial

Gene

MRPL39

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciZFISH:ENSG00000154719-MONOMER.
ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L39, mitochondrial
Short name:
L39mt
Short name:
MRP-L39
Alternative name(s):
39S ribosomal protein L5, mitochondrial
Short name:
L5mt
Short name:
MRP-L5
Gene namesi
Name:MRPL39
Synonyms:C21orf92, MRPL5, RPML5
ORF Names:MSTP003, PRED22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:14027. MRPL39.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial inner membrane Source: Reactome
  • mitochondrial large ribosomal subunit Source: UniProtKB
  • mitochondrial ribosome Source: UniProtKB
  • mitochondrion Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi54148.
OpenTargetsiENSG00000154719.
PharmGKBiPA30970.

Polymorphism and mutation databases

BioMutaiMRPL39.
DMDMi296452977.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000876841 – 33839S ribosomal protein L39, mitochondrialAdd BLAST338

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei126N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9NYK5.
MaxQBiQ9NYK5.
PaxDbiQ9NYK5.
PeptideAtlasiQ9NYK5.
PRIDEiQ9NYK5.

PTM databases

iPTMnetiQ9NYK5.
PhosphoSitePlusiQ9NYK5.

Expressioni

Tissue specificityi

Isoform 1 is ubiquitously expressed. Isoform 2 is heart-specific.

Gene expression databases

BgeeiENSG00000154719.
CleanExiHS_MRPL39.
ExpressionAtlasiQ9NYK5. baseline and differential.
GenevisibleiQ9NYK5. HS.

Organism-specific databases

HPAiHPA018331.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.2 Publications

Protein-protein interaction databases

BioGridi119918. 80 interactors.
IntActiQ9NYK5. 11 interactors.
STRINGi9606.ENSP00000305682.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.4071-338[»]
3J9Melectron microscopy3.5071-338[»]
ProteinModelPortaliQ9NYK5.
SMRiQ9NYK5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L39 family.Curated

Phylogenomic databases

eggNOGiKOG1637. Eukaryota.
COG0441. LUCA.
GeneTreeiENSGT00390000002149.
HOVERGENiHBG023123.
InParanoidiQ9NYK5.
KOiK17420.
OMAiPYNCAMH.
OrthoDBiEOG091G0CTH.
PhylomeDBiQ9NYK5.
TreeFamiTF300858.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR012675. Beta-grasp_dom.
IPR012676. TGS-like.
IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
[Graphical view]
SUPFAMiSSF55186. SSF55186. 1 hit.
SSF81271. SSF81271. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NYK5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEALAMGSRA LRLWLVAPGG GIKWRFIATS SASQLSPTEL TEMRNDLFNK
60 70 80 90 100
EKARQLSLTP RTEKIEVKHV GKTDPGTVFV MNKNISTPYS CAMHLSEWYC
110 120 130 140 150
RKSILALVDG QPWDMYKPLT KSCEIKFLTF KDCDPGEVNK AYWRSCAMMM
160 170 180 190 200
GCVIERAFKD EYMVNLVRAP EVPVISGAFC YDVVLDSKLD EWMPTKENLR
210 220 230 240 250
SFTKDAHALI YKDLPFETLE VEAKVALEIF QHSKYKVDFI EEKASQNPER
260 270 280 290 300
IVKLHRIGDF IDVSEGPLIP RTSICFQYEV SAVHNLQPTQ PSLIRRFQGV
310 320 330
SLPVHLRAHF TIWDKLLERS RKMVTEDQSK ATEECTST
Length:338
Mass (Da):38,712
Last modified:May 18, 2010 - v3
Checksum:iBB0139678F72B63D
GO
Isoform 2 (identifier: Q9NYK5-2) [UniParc]FASTAAdd to basket
Also known as: MRP-L5V1

The sequence of this isoform differs from the canonical sequence as follows:
     324-338: VTEDQSKATEECTST → TPFPILLLFTTQSFFTTSPESYLLHGTVSE

Show »
Length:353
Mass (Da):40,458
Checksum:iB6371F87123E62EC
GO

Sequence cautioni

The sequence AAF44696 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAQ13505 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA91177 differs from that shown. Reason: Frameshift at position 72.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti140K → E in AAF44696 (Ref. 1) Curated1
Sequence conflicti140K → E in BAA91177 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05204131S → P.4 PublicationsCorresponds to variant rs3989369dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_005718324 – 338VTEDQ…ECTST → TPFPILLLFTTQSFFTTSPE SYLLHGTVSE in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF239727 mRNA. Translation: AAF44696.1. Different initiation.
AK000458 mRNA. Translation: BAA91177.1. Frameshift.
AP000223 Genomic DNA. No translation available.
BC004896 mRNA. Translation: AAH04896.2.
BC107719 mRNA. Translation: AAI07720.1.
AF109357 mRNA. Translation: AAQ13505.1. Different initiation.
AF270511 mRNA. Translation: AAK12856.1.
AB051346 Genomic DNA. Translation: BAB54936.1.
CCDSiCCDS13573.1. [Q9NYK5-1]
CCDS33522.1. [Q9NYK5-2]
RefSeqiNP_059142.2. NM_017446.3.
NP_542984.2. NM_080794.3.
XP_006724089.1. XM_006724026.3. [Q9NYK5-2]
UniGeneiHs.420696.

Genome annotation databases

EnsembliENST00000307301; ENSP00000305682; ENSG00000154719. [Q9NYK5-2]
ENST00000352957; ENSP00000284967; ENSG00000154719. [Q9NYK5-1]
GeneIDi54148.
KEGGihsa:54148.
UCSCiuc002yln.4. human. [Q9NYK5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF239727 mRNA. Translation: AAF44696.1. Different initiation.
AK000458 mRNA. Translation: BAA91177.1. Frameshift.
AP000223 Genomic DNA. No translation available.
BC004896 mRNA. Translation: AAH04896.2.
BC107719 mRNA. Translation: AAI07720.1.
AF109357 mRNA. Translation: AAQ13505.1. Different initiation.
AF270511 mRNA. Translation: AAK12856.1.
AB051346 Genomic DNA. Translation: BAB54936.1.
CCDSiCCDS13573.1. [Q9NYK5-1]
CCDS33522.1. [Q9NYK5-2]
RefSeqiNP_059142.2. NM_017446.3.
NP_542984.2. NM_080794.3.
XP_006724089.1. XM_006724026.3. [Q9NYK5-2]
UniGeneiHs.420696.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.4071-338[»]
3J9Melectron microscopy3.5071-338[»]
ProteinModelPortaliQ9NYK5.
SMRiQ9NYK5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119918. 80 interactors.
IntActiQ9NYK5. 11 interactors.
STRINGi9606.ENSP00000305682.

PTM databases

iPTMnetiQ9NYK5.
PhosphoSitePlusiQ9NYK5.

Polymorphism and mutation databases

BioMutaiMRPL39.
DMDMi296452977.

Proteomic databases

EPDiQ9NYK5.
MaxQBiQ9NYK5.
PaxDbiQ9NYK5.
PeptideAtlasiQ9NYK5.
PRIDEiQ9NYK5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307301; ENSP00000305682; ENSG00000154719. [Q9NYK5-2]
ENST00000352957; ENSP00000284967; ENSG00000154719. [Q9NYK5-1]
GeneIDi54148.
KEGGihsa:54148.
UCSCiuc002yln.4. human. [Q9NYK5-1]

Organism-specific databases

CTDi54148.
DisGeNETi54148.
GeneCardsiMRPL39.
HGNCiHGNC:14027. MRPL39.
HPAiHPA018331.
MIMi611845. gene.
neXtProtiNX_Q9NYK5.
OpenTargetsiENSG00000154719.
PharmGKBiPA30970.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1637. Eukaryota.
COG0441. LUCA.
GeneTreeiENSGT00390000002149.
HOVERGENiHBG023123.
InParanoidiQ9NYK5.
KOiK17420.
OMAiPYNCAMH.
OrthoDBiEOG091G0CTH.
PhylomeDBiQ9NYK5.
TreeFamiTF300858.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000154719-MONOMER.
ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Miscellaneous databases

ChiTaRSiMRPL39. human.
GeneWikiiMRPL39.
GenomeRNAii54148.
PROiQ9NYK5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000154719.
CleanExiHS_MRPL39.
ExpressionAtlasiQ9NYK5. baseline and differential.
GenevisibleiQ9NYK5. HS.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR012675. Beta-grasp_dom.
IPR012676. TGS-like.
IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
[Graphical view]
SUPFAMiSSF55186. SSF55186. 1 hit.
SSF81271. SSF81271. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRM39_HUMAN
AccessioniPrimary (citable) accession number: Q9NYK5
Secondary accession number(s): C9JYA5
, Q32Q74, Q5QTR3, Q96Q65, Q9BSQ7, Q9BZV6, Q9NX44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 142 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Ref. 1 indicates C21orf8 as a synonym for this orf, this is incorrect, C21orf8 is already assigned to another chromosome 21 region.Curated
It is uncertain whether Met-1 or Met-6 is the initiator.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.