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Q9NYK5

- RM39_HUMAN

UniProt

Q9NYK5 - RM39_HUMAN

Protein

39S ribosomal protein L39, mitochondrial

Gene

MRPL39

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. nucleotide binding Source: InterPro
    2. poly(A) RNA binding Source: UniProtKB

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    39S ribosomal protein L39, mitochondrial
    Short name:
    L39mt
    Short name:
    MRP-L39
    Alternative name(s):
    39S ribosomal protein L5, mitochondrial
    Short name:
    L5mt
    Short name:
    MRP-L5
    Gene namesi
    Name:MRPL39
    Synonyms:C21orf92, MRPL5, RPML5
    ORF Names:MSTP003, PRED22
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 21

    Organism-specific databases

    HGNCiHGNC:14027. MRPL39.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial ribosome Source: UniProtKB

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30970.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 33833839S ribosomal protein L39, mitochondrialPRO_0000087684Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei126 – 1261N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9NYK5.
    PaxDbiQ9NYK5.
    PRIDEiQ9NYK5.

    PTM databases

    PhosphoSiteiQ9NYK5.

    Expressioni

    Tissue specificityi

    Isoform 1 is ubiquitously expressed. Isoform 2 is heart-specific.

    Gene expression databases

    ArrayExpressiQ9NYK5.
    BgeeiQ9NYK5.
    CleanExiHS_MRPL39.
    GenevestigatoriQ9NYK5.

    Organism-specific databases

    HPAiHPA018331.

    Interactioni

    Protein-protein interaction databases

    BioGridi119918. 32 interactions.
    IntActiQ9NYK5. 3 interactions.
    STRINGi9606.ENSP00000305682.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NYK5.
    SMRiQ9NYK5. Positions 86-327.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L39 family.Curated

    Phylogenomic databases

    eggNOGiCOG0441.
    HOVERGENiHBG023123.
    KOiK17420.
    OMAiNCAMHLS.
    OrthoDBiEOG7T1RCK.
    PhylomeDBiQ9NYK5.
    TreeFamiTF300858.

    Family and domain databases

    Gene3Di3.10.20.30. 1 hit.
    InterProiIPR012675. Beta-grasp_dom.
    IPR012676. TGS-like.
    IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
    [Graphical view]
    SUPFAMiSSF55186. SSF55186. 1 hit.
    SSF81271. SSF81271. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NYK5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEALAMGSRA LRLWLVAPGG GIKWRFIATS SASQLSPTEL TEMRNDLFNK    50
    EKARQLSLTP RTEKIEVKHV GKTDPGTVFV MNKNISTPYS CAMHLSEWYC 100
    RKSILALVDG QPWDMYKPLT KSCEIKFLTF KDCDPGEVNK AYWRSCAMMM 150
    GCVIERAFKD EYMVNLVRAP EVPVISGAFC YDVVLDSKLD EWMPTKENLR 200
    SFTKDAHALI YKDLPFETLE VEAKVALEIF QHSKYKVDFI EEKASQNPER 250
    IVKLHRIGDF IDVSEGPLIP RTSICFQYEV SAVHNLQPTQ PSLIRRFQGV 300
    SLPVHLRAHF TIWDKLLERS RKMVTEDQSK ATEECTST 338
    Length:338
    Mass (Da):38,712
    Last modified:May 18, 2010 - v3
    Checksum:iBB0139678F72B63D
    GO
    Isoform 2 (identifier: Q9NYK5-2) [UniParc]FASTAAdd to Basket

    Also known as: MRP-L5V1

    The sequence of this isoform differs from the canonical sequence as follows:
         324-338: VTEDQSKATEECTST → TPFPILLLFTTQSFFTTSPESYLLHGTVSE

    Show »
    Length:353
    Mass (Da):40,458
    Checksum:iB6371F87123E62EC
    GO

    Sequence cautioni

    The sequence BAA91177.1 differs from that shown. Reason: Frameshift at position 72.
    The sequence AAF44696.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAQ13505.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti140 – 1401K → E in AAF44696. 1 PublicationCurated
    Sequence conflicti140 – 1401K → E in BAA91177. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti31 – 311S → P.4 Publications
    Corresponds to variant rs3989369 [ dbSNP | Ensembl ].
    VAR_052041

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei324 – 33815VTEDQ…ECTST → TPFPILLLFTTQSFFTTSPE SYLLHGTVSE in isoform 2. 1 PublicationVSP_005718Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF239727 mRNA. Translation: AAF44696.1. Different initiation.
    AK000458 mRNA. Translation: BAA91177.1. Frameshift.
    AP000223 Genomic DNA. No translation available.
    BC004896 mRNA. Translation: AAH04896.2.
    BC107719 mRNA. Translation: AAI07720.1.
    AF109357 mRNA. Translation: AAQ13505.1. Different initiation.
    AF270511 mRNA. Translation: AAK12856.1.
    AB051346 Genomic DNA. Translation: BAB54936.1.
    CCDSiCCDS13573.1. [Q9NYK5-1]
    CCDS33522.1. [Q9NYK5-2]
    RefSeqiNP_059142.2. NM_017446.3.
    NP_542984.2. NM_080794.3.
    XP_006724089.1. XM_006724026.1. [Q9NYK5-2]
    UniGeneiHs.420696.

    Genome annotation databases

    EnsembliENST00000307301; ENSP00000305682; ENSG00000154719. [Q9NYK5-2]
    ENST00000352957; ENSP00000284967; ENSG00000154719. [Q9NYK5-1]
    GeneIDi54148.
    KEGGihsa:54148.
    UCSCiuc002yln.3. human. [Q9NYK5-2]
    uc002ylo.3. human. [Q9NYK5-1]

    Polymorphism databases

    DMDMi296452977.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF239727 mRNA. Translation: AAF44696.1 . Different initiation.
    AK000458 mRNA. Translation: BAA91177.1 . Frameshift.
    AP000223 Genomic DNA. No translation available.
    BC004896 mRNA. Translation: AAH04896.2 .
    BC107719 mRNA. Translation: AAI07720.1 .
    AF109357 mRNA. Translation: AAQ13505.1 . Different initiation.
    AF270511 mRNA. Translation: AAK12856.1 .
    AB051346 Genomic DNA. Translation: BAB54936.1 .
    CCDSi CCDS13573.1. [Q9NYK5-1 ]
    CCDS33522.1. [Q9NYK5-2 ]
    RefSeqi NP_059142.2. NM_017446.3.
    NP_542984.2. NM_080794.3.
    XP_006724089.1. XM_006724026.1. [Q9NYK5-2 ]
    UniGenei Hs.420696.

    3D structure databases

    ProteinModelPortali Q9NYK5.
    SMRi Q9NYK5. Positions 86-327.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119918. 32 interactions.
    IntActi Q9NYK5. 3 interactions.
    STRINGi 9606.ENSP00000305682.

    PTM databases

    PhosphoSitei Q9NYK5.

    Polymorphism databases

    DMDMi 296452977.

    Proteomic databases

    MaxQBi Q9NYK5.
    PaxDbi Q9NYK5.
    PRIDEi Q9NYK5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000307301 ; ENSP00000305682 ; ENSG00000154719 . [Q9NYK5-2 ]
    ENST00000352957 ; ENSP00000284967 ; ENSG00000154719 . [Q9NYK5-1 ]
    GeneIDi 54148.
    KEGGi hsa:54148.
    UCSCi uc002yln.3. human. [Q9NYK5-2 ]
    uc002ylo.3. human. [Q9NYK5-1 ]

    Organism-specific databases

    CTDi 54148.
    GeneCardsi GC21M026957.
    HGNCi HGNC:14027. MRPL39.
    HPAi HPA018331.
    MIMi 611845. gene.
    neXtProti NX_Q9NYK5.
    PharmGKBi PA30970.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0441.
    HOVERGENi HBG023123.
    KOi K17420.
    OMAi NCAMHLS.
    OrthoDBi EOG7T1RCK.
    PhylomeDBi Q9NYK5.
    TreeFami TF300858.

    Miscellaneous databases

    ChiTaRSi MRPL39. human.
    GeneWikii MRPL39.
    GenomeRNAii 54148.
    NextBioi 56504.
    PROi Q9NYK5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NYK5.
    Bgeei Q9NYK5.
    CleanExi HS_MRPL39.
    Genevestigatori Q9NYK5.

    Family and domain databases

    Gene3Di 3.10.20.30. 1 hit.
    InterProi IPR012675. Beta-grasp_dom.
    IPR012676. TGS-like.
    IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
    [Graphical view ]
    SUPFAMi SSF55186. SSF55186. 1 hit.
    SSF81271. SSF81271. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Construction of a transcript map in the LL56-APP region of chromosome 21q21.1-21.2."
      Choi D.K., Taylor T.D., Hattori M., Sakaki Y.
      Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT PRO-31.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT PRO-31.
    3. "The DNA sequence of human chromosome 21."
      Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
      , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
      Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT PRO-31.
      Tissue: Muscle.
    5. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-338 (ISOFORM 1), VARIANT PRO-31.
      Tissue: Heart.
    6. "Heart-specific splice-variant of a human mitochondrial ribosomal protein (mRNA processing; tissue specific splicing)."
      Spirina O., Bykhovskaya Y., Kajava A.V., O'Brien T.W., Nierlich D.P., Mougey E.B., Sylvester J.E., Graack H.-R., Wittmann-Liebold B., Fischel-Ghodsian N.
      Gene 261:229-234(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 150-338 (ISOFORM 2).
      Tissue: Heart.
    7. "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
      Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
      Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 175-183.
    8. "Mammalian mitochondrial ribosomal proteins (2). Amino acid sequencing, characterization, and identification of corresponding gene sequences."
      O'Brien T.W., Fiesler S.E., Denslow N.D., Thiede B., Wittmann-Liebold B., Mougey E.B., Sylvester J.E., Graack H.R.
      J. Biol. Chem. 274:36043-36051(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    9. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-126, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRM39_HUMAN
    AccessioniPrimary (citable) accession number: Q9NYK5
    Secondary accession number(s): C9JYA5
    , Q32Q74, Q5QTR3, Q96Q65, Q9BSQ7, Q9BZV6, Q9NX44
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 120 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    PubMed:14702039 indicates C21orf8 as a synonym for this orf, this is incorrect, C21orf8 is already assigned to another chromosome 21 region.Curated
    It is uncertain whether Met-1 or Met-6 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 21
      Human chromosome 21: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Ribosomal proteins
      Ribosomal proteins families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3