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Protein

39S ribosomal protein L39, mitochondrial

Gene

MRPL39

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Ref. 1 indicates C21orf8 as a synonym for this orf, this is incorrect, C21orf8 is already assigned to another chromosome 21 region.Curated
It is uncertain whether Met-1 or Met-6 is the initiator.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L39, mitochondrial
Short name:
L39mt
Short name:
MRP-L39
Alternative name(s):
39S ribosomal protein L5, mitochondrial
Short name:
L5mt
Short name:
MRP-L5
Mitochondrial large ribosomal subunit protein mL391 Publication
Gene namesi
Name:MRPL39
Synonyms:C21orf92, MRPL5, RPML5
ORF Names:MSTP003, PRED22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000154719.13
HGNCiHGNC:14027 MRPL39
MIMi611845 gene
neXtProtiNX_Q9NYK5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000154719
PharmGKBiPA30970

Polymorphism and mutation databases

BioMutaiMRPL39
DMDMi296452977

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000876841 – 33839S ribosomal protein L39, mitochondrialAdd BLAST338

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei126N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9NYK5
MaxQBiQ9NYK5
PaxDbiQ9NYK5
PeptideAtlasiQ9NYK5
PRIDEiQ9NYK5

PTM databases

iPTMnetiQ9NYK5
PhosphoSitePlusiQ9NYK5

Expressioni

Tissue specificityi

Isoform 1 is ubiquitously expressed. Isoform 2 is heart-specific.

Gene expression databases

BgeeiENSG00000154719
CleanExiHS_MRPL39
ExpressionAtlasiQ9NYK5 baseline and differential
GenevisibleiQ9NYK5 HS

Organism-specific databases

HPAiHPA018331

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.2 Publications

Protein-protein interaction databases

BioGridi119918, 88 interactors
CORUMiQ9NYK5
IntActiQ9NYK5, 21 interactors
MINTiQ9NYK5
STRINGi9606.ENSP00000305682

Structurei

Secondary structure

1338
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi37 – 57Combined sources21
Beta strandi64 – 68Combined sources5
Beta strandi72 – 74Combined sources3
Beta strandi78 – 82Combined sources5
Turni83 – 85Combined sources3
Helixi88 – 95Combined sources8
Helixi98 – 101Combined sources4
Beta strandi105 – 108Combined sources4
Beta strandi111 – 113Combined sources3
Beta strandi115 – 117Combined sources3
Beta strandi124 – 128Combined sources5
Beta strandi132 – 134Combined sources3
Helixi136 – 155Combined sources20
Beta strandi164 – 168Combined sources5
Helixi174 – 176Combined sources3
Beta strandi177 – 185Combined sources9
Helixi187 – 191Combined sources5
Helixi196 – 211Combined sources16
Beta strandi217 – 222Combined sources6
Helixi223 – 229Combined sources7
Turni230 – 232Combined sources3
Helixi234 – 244Combined sources11
Beta strandi247 – 249Combined sources3
Beta strandi251 – 259Combined sources9
Beta strandi261 – 263Combined sources3
Helixi272 – 274Combined sources3
Beta strandi275 – 285Combined sources11
Beta strandi290 – 292Combined sources3
Beta strandi295 – 306Combined sources12
Helixi310 – 319Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.4071-338[»]
3J9Melectron microscopy3.5071-338[»]
5OOLelectron microscopy3.0671-338[»]
5OOMelectron microscopy3.0371-338[»]
ProteinModelPortaliQ9NYK5
SMRiQ9NYK5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1637 Eukaryota
COG0441 LUCA
GeneTreeiENSGT00390000002149
HOVERGENiHBG023123
InParanoidiQ9NYK5
KOiK17420
OMAiPYNCAMH
OrthoDBiEOG091G0CTH
PhylomeDBiQ9NYK5
TreeFamiTF300858

Family and domain databases

Gene3Di3.10.20.30, 1 hit
InterProiView protein in InterPro
IPR012675 Beta-grasp_dom_sf
IPR012676 TGS-like
IPR018163 Thr/Ala-tRNA-synth_IIc_edit
SUPFAMiSSF55186 SSF55186, 1 hit
SSF81271 SSF81271, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NYK5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEALAMGSRA LRLWLVAPGG GIKWRFIATS SASQLSPTEL TEMRNDLFNK
60 70 80 90 100
EKARQLSLTP RTEKIEVKHV GKTDPGTVFV MNKNISTPYS CAMHLSEWYC
110 120 130 140 150
RKSILALVDG QPWDMYKPLT KSCEIKFLTF KDCDPGEVNK AYWRSCAMMM
160 170 180 190 200
GCVIERAFKD EYMVNLVRAP EVPVISGAFC YDVVLDSKLD EWMPTKENLR
210 220 230 240 250
SFTKDAHALI YKDLPFETLE VEAKVALEIF QHSKYKVDFI EEKASQNPER
260 270 280 290 300
IVKLHRIGDF IDVSEGPLIP RTSICFQYEV SAVHNLQPTQ PSLIRRFQGV
310 320 330
SLPVHLRAHF TIWDKLLERS RKMVTEDQSK ATEECTST
Length:338
Mass (Da):38,712
Last modified:May 18, 2010 - v3
Checksum:iBB0139678F72B63D
GO
Isoform 2 (identifier: Q9NYK5-2) [UniParc]FASTAAdd to basket
Also known as: MRP-L5V1

The sequence of this isoform differs from the canonical sequence as follows:
     324-338: VTEDQSKATEECTST → TPFPILLLFTTQSFFTTSPESYLLHGTVSE

Show »
Length:353
Mass (Da):40,458
Checksum:iB6371F87123E62EC
GO

Sequence cautioni

The sequence AAF44696 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAQ13505 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA91177 differs from that shown. Reason: Frameshift at position 72.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti140K → E in AAF44696 (Ref. 1) Curated1
Sequence conflicti140K → E in BAA91177 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05204131S → P4 PublicationsCorresponds to variant dbSNP:rs3989369Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_005718324 – 338VTEDQ…ECTST → TPFPILLLFTTQSFFTTSPE SYLLHGTVSE in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF239727 mRNA Translation: AAF44696.1 Different initiation.
AK000458 mRNA Translation: BAA91177.1 Frameshift.
AP000223 Genomic DNA No translation available.
BC004896 mRNA Translation: AAH04896.2
BC107719 mRNA Translation: AAI07720.1
AF109357 mRNA Translation: AAQ13505.1 Different initiation.
AF270511 mRNA Translation: AAK12856.1
AB051346 Genomic DNA Translation: BAB54936.1
CCDSiCCDS13573.1 [Q9NYK5-1]
CCDS33522.1 [Q9NYK5-2]
RefSeqiNP_059142.2, NM_017446.3
NP_542984.2, NM_080794.3
XP_006724089.1, XM_006724026.3 [Q9NYK5-2]
UniGeneiHs.420696

Genome annotation databases

EnsembliENST00000307301; ENSP00000305682; ENSG00000154719 [Q9NYK5-2]
ENST00000352957; ENSP00000284967; ENSG00000154719 [Q9NYK5-1]
GeneIDi54148
KEGGihsa:54148
UCSCiuc002yln.4 human [Q9NYK5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRM39_HUMAN
AccessioniPrimary (citable) accession number: Q9NYK5
Secondary accession number(s): C9JYA5
, Q32Q74, Q5QTR3, Q96Q65, Q9BSQ7, Q9BZV6, Q9NX44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 18, 2010
Last modified: May 23, 2018
This is version 152 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

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