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Protein

Toll-like receptor 7

Gene

TLR7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • cellular response to mechanical stimulus Source: UniProtKB
  • defense response to virus Source: UniProtKB
  • I-kappaB phosphorylation Source: BHF-UCL
  • inflammatory response Source: GO_Central
  • innate immune response Source: UniProtKB-KW
  • microglial cell activation Source: Ensembl
  • MyD88-dependent toll-like receptor signaling pathway Source: InterPro
  • positive regulation of chemokine production Source: BHF-UCL
  • positive regulation of inflammatory response Source: BHF-UCL
  • positive regulation of interferon-alpha biosynthetic process Source: UniProtKB
  • positive regulation of interferon-beta biosynthetic process Source: UniProtKB
  • positive regulation of interferon-gamma biosynthetic process Source: UniProtKB
  • positive regulation of interleukin-6 production Source: Ensembl
  • positive regulation of interleukin-8 biosynthetic process Source: UniProtKB
  • positive regulation of interleukin-8 production Source: BHF-UCL
  • positive regulation of NF-kappaB import into nucleus Source: BHF-UCL
  • regulation of protein phosphorylation Source: Ensembl
  • toll-like receptor 7 signaling pathway Source: GO_Central
  • toll-like receptor 9 signaling pathway Source: Reactome
  • toll-like receptor signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

BioCyciZFISH:G66-31608-MONOMER.
ReactomeiR-HSA-1679131. Trafficking and processing of endosomal TLR.
R-HSA-168181. Toll Like Receptor 7/8 (TLR7/8) Cascade.
R-HSA-975110. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
R-HSA-975138. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
R-HSA-975155. MyD88 dependent cascade initiated on endosome.
SIGNORiQ9NYK1.

Names & Taxonomyi

Protein namesi
Recommended name:
Toll-like receptor 7
Gene namesi
Name:TLR7
ORF Names:UNQ248/PRO285
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:15631. TLR7.

Subcellular locationi

  • Endoplasmic reticulum membrane By similarity; Single-pass type I membrane protein By similarity
  • Endosome By similarity
  • Lysosome By similarity
  • Cytoplasmic vesiclephagosome By similarity

  • Note: Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 839ExtracellularSequence analysisAdd BLAST813
Transmembranei840 – 860HelicalSequence analysisAdd BLAST21
Topological domaini861 – 1049CytoplasmicSequence analysisAdd BLAST189

GO - Cellular componenti

  • cytoplasm Source: BHF-UCL
  • early phagosome Source: UniProtKB
  • endolysosome membrane Source: Reactome
  • endoplasmic reticulum Source: UniProtKB
  • endoplasmic reticulum membrane Source: Reactome
  • endosome Source: UniProtKB
  • endosome membrane Source: Reactome
  • Golgi membrane Source: Reactome
  • integral component of plasma membrane Source: GO_Central
  • lysosome Source: UniProtKB
  • plasma membrane Source: BHF-UCL
  • receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi51284.
OpenTargetsiENSG00000196664.
PharmGKBiPA38008.

Chemistry databases

ChEMBLiCHEMBL5936.
DrugBankiDB01611. Hydroxychloroquine.
DB00724. Imiquimod.
GuidetoPHARMACOLOGYi1757.

Polymorphism and mutation databases

BioMutaiTLR7.
DMDMi20140876.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000003473327 – 1049Toll-like receptor 7Add BLAST1023

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi66N-linked (GlcNAc...)Sequence analysis1
Glycosylationi69N-linked (GlcNAc...)Sequence analysis1
Glycosylationi167N-linked (GlcNAc...)Sequence analysis1
Glycosylationi202N-linked (GlcNAc...)Sequence analysis1
Glycosylationi215N-linked (GlcNAc...)Sequence analysis1
Glycosylationi361N-linked (GlcNAc...)Sequence analysis1
Glycosylationi413N-linked (GlcNAc...)Sequence analysis1
Glycosylationi488N-linked (GlcNAc...)Sequence analysis1
Glycosylationi523N-linked (GlcNAc...)Sequence analysis1
Glycosylationi534N-linked (GlcNAc...)Sequence analysis1
Glycosylationi590N-linked (GlcNAc...)Sequence analysis1
Glycosylationi679N-linked (GlcNAc...)Sequence analysis1
Glycosylationi720N-linked (GlcNAc...)Sequence analysis1
Glycosylationi799N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9NYK1.
PeptideAtlasiQ9NYK1.
PRIDEiQ9NYK1.

PTM databases

iPTMnetiQ9NYK1.
PhosphoSitePlusiQ9NYK1.

Expressioni

Tissue specificityi

Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells.

Gene expression databases

BgeeiENSG00000196664.
CleanExiHS_TLR7.
ExpressionAtlasiQ9NYK1. baseline and differential.
GenevisibleiQ9NYK1. HS.

Organism-specific databases

HPAiHPA059613.

Interactioni

Subunit structurei

Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1. Interacts with SMPDL3B (By similarity).By similarity

Protein-protein interaction databases

BioGridi119436. 2 interactors.
IntActiQ9NYK1. 8 interactors.
STRINGi9606.ENSP00000370034.

Chemistry databases

BindingDBiQ9NYK1.

Structurei

3D structure databases

ProteinModelPortaliQ9NYK1.
SMRiQ9NYK1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati43 – 64LRR 1Add BLAST22
Repeati65 – 87LRR 2Add BLAST23
Repeati110 – 126LRR 3Add BLAST17
Repeati127 – 149LRR 4Add BLAST23
Repeati151 – 170LRR 5Add BLAST20
Repeati171 – 195LRR 6Add BLAST25
Repeati203 – 226LRR 7Add BLAST24
Repeati228 – 247LRR 8Add BLAST20
Repeati248 – 275LRR 9Add BLAST28
Repeati289 – 312LRR 10Add BLAST24
Repeati314 – 337LRR 11Add BLAST24
Repeati339 – 368LRR 12Add BLAST30
Repeati369 – 392LRR 13Add BLAST24
Repeati396 – 419LRR 14Add BLAST24
Repeati421 – 443LRR 15Add BLAST23
Repeati492 – 515LRR 16Add BLAST24
Repeati516 – 540LRR 17Add BLAST25
Repeati541 – 564LRR 18Add BLAST24
Repeati566 – 588LRR 19Add BLAST23
Repeati595 – 618LRR 20Add BLAST24
Repeati619 – 644LRR 21Add BLAST26
Repeati649 – 672LRR 22Add BLAST24
Repeati674 – 697LRR 23Add BLAST24
Repeati698 – 721LRR 24Add BLAST24
Repeati723 – 745LRR 25Add BLAST23
Repeati746 – 769LRR 26Add BLAST24
Repeati772 – 795LRR 27Add BLAST24
Domaini889 – 1036TIRPROSITE-ProRule annotationAdd BLAST148

Sequence similaritiesi

Belongs to the Toll-like receptor family.Curated
Contains 27 LRR (leucine-rich) repeats.Curated
Contains 1 TIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4641. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000119006.
HOGENOMiHOG000230468.
HOVERGENiHBG018601.
InParanoidiQ9NYK1.
KOiK05404.
OMAiSKNNMCI.
OrthoDBiEOG091G023M.
PhylomeDBiQ9NYK1.
TreeFamiTF325595.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.80.10.10. 5 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR026906. LRR_5.
IPR000157. TIR_dom.
IPR026880. TLR7.
[Graphical view]
PANTHERiPTHR24365:SF222. PTHR24365:SF222. 3 hits.
PfamiPF13306. LRR_5. 1 hit.
PF13855. LRR_8. 3 hits.
PF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 12 hits.
SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 4 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 18 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NYK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVFPMWTLKR QILILFNIIL ISKLLGARWF PKTLPCDVTL DVPKNHVIVD
60 70 80 90 100
CTDKHLTEIP GGIPTNTTNL TLTINHIPDI SPASFHRLDH LVEIDFRCNC
110 120 130 140 150
VPIPLGSKNN MCIKRLQIKP RSFSGLTYLK SLYLDGNQLL EIPQGLPPSL
160 170 180 190 200
QLLSLEANNI FSIRKENLTE LANIEILYLG QNCYYRNPCY VSYSIEKDAF
210 220 230 240 250
LNLTKLKVLS LKDNNVTAVP TVLPSTLTEL YLYNNMIAKI QEDDFNNLNQ
260 270 280 290 300
LQILDLSGNC PRCYNAPFPC APCKNNSPLQ IPVNAFDALT ELKVLRLHSN
310 320 330 340 350
SLQHVPPRWF KNINKLQELD LSQNFLAKEI GDAKFLHFLP SLIQLDLSFN
360 370 380 390 400
FELQVYRASM NLSQAFSSLK SLKILRIRGY VFKELKSFNL SPLHNLQNLE
410 420 430 440 450
VLDLGTNFIK IANLSMFKQF KRLKVIDLSV NKISPSGDSS EVGFCSNART
460 470 480 490 500
SVESYEPQVL EQLHYFRYDK YARSCRFKNK EASFMSVNES CYKYGQTLDL
510 520 530 540 550
SKNSIFFVKS SDFQHLSFLK CLNLSGNLIS QTLNGSEFQP LAELRYLDFS
560 570 580 590 600
NNRLDLLHST AFEELHKLEV LDISSNSHYF QSEGITHMLN FTKNLKVLQK
610 620 630 640 650
LMMNDNDISS STSRTMESES LRTLEFRGNH LDVLWREGDN RYLQLFKNLL
660 670 680 690 700
KLEELDISKN SLSFLPSGVF DGMPPNLKNL SLAKNGLKSF SWKKLQCLKN
710 720 730 740 750
LETLDLSHNQ LTTVPERLSN CSRSLKNLIL KNNQIRSLTK YFLQDAFQLR
760 770 780 790 800
YLDLSSNKIQ MIQKTSFPEN VLNNLKMLLL HHNRFLCTCD AVWFVWWVNH
810 820 830 840 850
TEVTIPYLAT DVTCVGPGAH KGQSVISLDL YTCELDLTNL ILFSLSISVS
860 870 880 890 900
LFLMVMMTAS HLYFWDVWYI YHFCKAKIKG YQRLISPDCC YDAFIVYDTK
910 920 930 940 950
DPAVTEWVLA ELVAKLEDPR EKHFNLCLEE RDWLPGQPVL ENLSQSIQLS
960 970 980 990 1000
KKTVFVMTDK YAKTENFKIA FYLSHQRLMD EKVDVIILIF LEKPFQKSKF
1010 1020 1030 1040
LQLRKRLCGS SVLEWPTNPQ AHPYFWQCLK NALATDNHVA YSQVFKETV
Length:1,049
Mass (Da):120,922
Last modified:October 1, 2000 - v1
Checksum:i8C701E9E437F2721
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti725L → H in AAF78035 (PubMed:11022120).Curated1
Sequence conflicti738L → P in AAF78035 (PubMed:11022120).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03455411Q → L.1 PublicationCorresponds to variant rs179008dbSNPEnsembl.1
Natural variantiVAR_024665448A → V.Corresponds to variant rs5743781dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF240467 mRNA. Translation: AAF60188.1.
AF245702 mRNA. Translation: AAF78035.1.
DQ022185 Genomic DNA. Translation: AAZ99026.1.
AY358292 mRNA. Translation: AAQ88659.1.
BC033651 mRNA. Translation: AAH33651.1.
CCDSiCCDS14151.1.
RefSeqiNP_057646.1. NM_016562.3.
UniGeneiHs.659215.

Genome annotation databases

EnsembliENST00000380659; ENSP00000370034; ENSG00000196664.
GeneIDi51284.
KEGGihsa:51284.
UCSCiuc004cvc.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF240467 mRNA. Translation: AAF60188.1.
AF245702 mRNA. Translation: AAF78035.1.
DQ022185 Genomic DNA. Translation: AAZ99026.1.
AY358292 mRNA. Translation: AAQ88659.1.
BC033651 mRNA. Translation: AAH33651.1.
CCDSiCCDS14151.1.
RefSeqiNP_057646.1. NM_016562.3.
UniGeneiHs.659215.

3D structure databases

ProteinModelPortaliQ9NYK1.
SMRiQ9NYK1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119436. 2 interactors.
IntActiQ9NYK1. 8 interactors.
STRINGi9606.ENSP00000370034.

Chemistry databases

BindingDBiQ9NYK1.
ChEMBLiCHEMBL5936.
DrugBankiDB01611. Hydroxychloroquine.
DB00724. Imiquimod.
GuidetoPHARMACOLOGYi1757.

PTM databases

iPTMnetiQ9NYK1.
PhosphoSitePlusiQ9NYK1.

Polymorphism and mutation databases

BioMutaiTLR7.
DMDMi20140876.

Proteomic databases

PaxDbiQ9NYK1.
PeptideAtlasiQ9NYK1.
PRIDEiQ9NYK1.

Protocols and materials databases

DNASUi51284.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380659; ENSP00000370034; ENSG00000196664.
GeneIDi51284.
KEGGihsa:51284.
UCSCiuc004cvc.4. human.

Organism-specific databases

CTDi51284.
DisGeNETi51284.
GeneCardsiTLR7.
HGNCiHGNC:15631. TLR7.
HPAiHPA059613.
MIMi300365. gene.
neXtProtiNX_Q9NYK1.
OpenTargetsiENSG00000196664.
PharmGKBiPA38008.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4641. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000119006.
HOGENOMiHOG000230468.
HOVERGENiHBG018601.
InParanoidiQ9NYK1.
KOiK05404.
OMAiSKNNMCI.
OrthoDBiEOG091G023M.
PhylomeDBiQ9NYK1.
TreeFamiTF325595.

Enzyme and pathway databases

BioCyciZFISH:G66-31608-MONOMER.
ReactomeiR-HSA-1679131. Trafficking and processing of endosomal TLR.
R-HSA-168181. Toll Like Receptor 7/8 (TLR7/8) Cascade.
R-HSA-975110. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
R-HSA-975138. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
R-HSA-975155. MyD88 dependent cascade initiated on endosome.
SIGNORiQ9NYK1.

Miscellaneous databases

ChiTaRSiTLR7. human.
GeneWikiiTLR_7.
GenomeRNAii51284.
PROiQ9NYK1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196664.
CleanExiHS_TLR7.
ExpressionAtlasiQ9NYK1. baseline and differential.
GenevisibleiQ9NYK1. HS.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.80.10.10. 5 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR026906. LRR_5.
IPR000157. TIR_dom.
IPR026880. TLR7.
[Graphical view]
PANTHERiPTHR24365:SF222. PTHR24365:SF222. 3 hits.
PfamiPF13306. LRR_5. 1 hit.
PF13855. LRR_8. 3 hits.
PF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 12 hits.
SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 4 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 18 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTLR7_HUMAN
AccessioniPrimary (citable) accession number: Q9NYK1
Secondary accession number(s): D1CS69, Q9NR98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 158 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.