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Q9NYK1

- TLR7_HUMAN

UniProt

Q9NYK1 - TLR7_HUMAN

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Protein
Toll-like receptor 7
Gene
TLR7, UNQ248/PRO285
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response By similarity.1 Publication

GO - Molecular functioni

  1. double-stranded RNA binding Source: UniProtKB
  2. drug binding Source: Ensembl
  3. siRNA binding Source: UniProtKB
  4. single-stranded RNA binding Source: UniProtKB
  5. transmembrane signaling receptor activity Source: InterPro

GO - Biological processi

  1. I-kappaB phosphorylation Source: BHF-UCL
  2. MyD88-dependent toll-like receptor signaling pathway Source: InterPro
  3. cellular response to mechanical stimulus Source: UniProtKB
  4. defense response to virus Source: UniProtKB
  5. inflammatory response Source: UniProtKB-KW
  6. innate immune response Source: Reactome
  7. microglial cell activation involved in immune response Source: Ensembl
  8. pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response Source: Ensembl
  9. positive regulation of NF-kappaB import into nucleus Source: BHF-UCL
  10. positive regulation of chemokine production Source: BHF-UCL
  11. positive regulation of inflammatory response Source: BHF-UCL
  12. positive regulation of interferon-alpha biosynthetic process Source: UniProtKB
  13. positive regulation of interferon-beta biosynthetic process Source: UniProtKB
  14. positive regulation of interferon-gamma biosynthetic process Source: UniProtKB
  15. positive regulation of interleukin-6 production Source: Ensembl
  16. positive regulation of interleukin-8 biosynthetic process Source: UniProtKB
  17. positive regulation of interleukin-8 production Source: BHF-UCL
  18. toll-like receptor 7 signaling pathway Source: Ensembl
  19. toll-like receptor 9 signaling pathway Source: Reactome
  20. toll-like receptor signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

ReactomeiREACT_118632. Trafficking and processing of endosomal TLR.
REACT_25024. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
REACT_25120. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
REACT_25222. MyD88 dependent cascade initiated on endosome.
REACT_9020. Toll Like Receptor 7/8 (TLR7/8) Cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Toll-like receptor 7
Gene namesi
Name:TLR7
ORF Names:UNQ248/PRO285
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:15631. TLR7.

Subcellular locationi

Endoplasmic reticulum membrane; Single-pass type I membrane protein By similarity. Endosome By similarity. Lysosome By similarity. Cytoplasmic vesiclephagosome
Note: Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 839813Extracellular Reviewed prediction
Add
BLAST
Transmembranei840 – 86021Helical; Reviewed prediction
Add
BLAST
Topological domaini861 – 1049189Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi membrane Source: Reactome
  2. cytoplasm Source: BHF-UCL
  3. early phagosome Source: UniProtKB
  4. endolysosome membrane Source: Reactome
  5. endoplasmic reticulum Source: UniProtKB
  6. endoplasmic reticulum membrane Source: Reactome
  7. endosome Source: UniProtKB
  8. endosome membrane Source: Reactome
  9. integral component of membrane Source: UniProtKB-KW
  10. lysosome Source: UniProtKB
  11. plasma membrane Source: BHF-UCL
  12. receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38008.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 Reviewed prediction
Add
BLAST
Chaini27 – 10491023Toll-like receptor 7
PRO_0000034733Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi66 – 661N-linked (GlcNAc...) Reviewed prediction
Glycosylationi69 – 691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi167 – 1671N-linked (GlcNAc...) Reviewed prediction
Glycosylationi202 – 2021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi215 – 2151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi361 – 3611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi413 – 4131N-linked (GlcNAc...) Reviewed prediction
Glycosylationi488 – 4881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi523 – 5231N-linked (GlcNAc...) Reviewed prediction
Glycosylationi534 – 5341N-linked (GlcNAc...) Reviewed prediction
Glycosylationi590 – 5901N-linked (GlcNAc...) Reviewed prediction
Glycosylationi679 – 6791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi720 – 7201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi799 – 7991N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9NYK1.
PeptideAtlasiQ9NYK1.
PRIDEiQ9NYK1.

PTM databases

PhosphoSiteiQ9NYK1.

Expressioni

Tissue specificityi

Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells.

Gene expression databases

ArrayExpressiQ9NYK1.
BgeeiQ9NYK1.
CleanExiHS_TLR7.
GenevestigatoriQ9NYK1.

Organism-specific databases

HPAiHPA059613.

Interactioni

Subunit structurei

Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1 By similarity.

Protein-protein interaction databases

BioGridi119436. 2 interactions.
IntActiQ9NYK1. 3 interactions.
STRINGi9606.ENSP00000370034.

Structurei

3D structure databases

ProteinModelPortaliQ9NYK1.
SMRiQ9NYK1. Positions 32-829, 891-1035.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati43 – 6422LRR 1
Add
BLAST
Repeati65 – 8723LRR 2
Add
BLAST
Repeati110 – 12617LRR 3
Add
BLAST
Repeati127 – 14923LRR 4
Add
BLAST
Repeati151 – 17020LRR 5
Add
BLAST
Repeati171 – 19525LRR 6
Add
BLAST
Repeati203 – 22624LRR 7
Add
BLAST
Repeati228 – 24720LRR 8
Add
BLAST
Repeati248 – 27528LRR 9
Add
BLAST
Repeati289 – 31224LRR 10
Add
BLAST
Repeati314 – 33724LRR 11
Add
BLAST
Repeati339 – 36830LRR 12
Add
BLAST
Repeati369 – 39224LRR 13
Add
BLAST
Repeati396 – 41924LRR 14
Add
BLAST
Repeati421 – 44323LRR 15
Add
BLAST
Repeati492 – 51524LRR 16
Add
BLAST
Repeati516 – 54025LRR 17
Add
BLAST
Repeati541 – 56424LRR 18
Add
BLAST
Repeati566 – 58823LRR 19
Add
BLAST
Repeati595 – 61824LRR 20
Add
BLAST
Repeati619 – 64426LRR 21
Add
BLAST
Repeati649 – 67224LRR 22
Add
BLAST
Repeati674 – 69724LRR 23
Add
BLAST
Repeati698 – 72124LRR 24
Add
BLAST
Repeati723 – 74523LRR 25
Add
BLAST
Repeati746 – 76924LRR 26
Add
BLAST
Repeati772 – 79524LRR 27
Add
BLAST
Domaini889 – 1036148TIR
Add
BLAST

Sequence similaritiesi

Contains 1 TIR domain.

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG286662.
HOGENOMiHOG000230468.
HOVERGENiHBG018601.
InParanoidiQ9NYK1.
KOiK05404.
OMAiSEGITHM.
OrthoDBiEOG7VB2DM.
PhylomeDBiQ9NYK1.
TreeFamiTF325595.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
IPR026906. LRR_5.
IPR000157. TIR_dom.
IPR026880. TLR7.
[Graphical view]
PANTHERiPTHR24365:SF222. PTHR24365:SF222. 1 hit.
PfamiPF00560. LRR_1. 3 hits.
PF13306. LRR_5. 1 hit.
PF13855. LRR_8. 2 hits.
PF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 3 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 18 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NYK1-1 [UniParc]FASTAAdd to Basket

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MVFPMWTLKR QILILFNIIL ISKLLGARWF PKTLPCDVTL DVPKNHVIVD     50
CTDKHLTEIP GGIPTNTTNL TLTINHIPDI SPASFHRLDH LVEIDFRCNC 100
VPIPLGSKNN MCIKRLQIKP RSFSGLTYLK SLYLDGNQLL EIPQGLPPSL 150
QLLSLEANNI FSIRKENLTE LANIEILYLG QNCYYRNPCY VSYSIEKDAF 200
LNLTKLKVLS LKDNNVTAVP TVLPSTLTEL YLYNNMIAKI QEDDFNNLNQ 250
LQILDLSGNC PRCYNAPFPC APCKNNSPLQ IPVNAFDALT ELKVLRLHSN 300
SLQHVPPRWF KNINKLQELD LSQNFLAKEI GDAKFLHFLP SLIQLDLSFN 350
FELQVYRASM NLSQAFSSLK SLKILRIRGY VFKELKSFNL SPLHNLQNLE 400
VLDLGTNFIK IANLSMFKQF KRLKVIDLSV NKISPSGDSS EVGFCSNART 450
SVESYEPQVL EQLHYFRYDK YARSCRFKNK EASFMSVNES CYKYGQTLDL 500
SKNSIFFVKS SDFQHLSFLK CLNLSGNLIS QTLNGSEFQP LAELRYLDFS 550
NNRLDLLHST AFEELHKLEV LDISSNSHYF QSEGITHMLN FTKNLKVLQK 600
LMMNDNDISS STSRTMESES LRTLEFRGNH LDVLWREGDN RYLQLFKNLL 650
KLEELDISKN SLSFLPSGVF DGMPPNLKNL SLAKNGLKSF SWKKLQCLKN 700
LETLDLSHNQ LTTVPERLSN CSRSLKNLIL KNNQIRSLTK YFLQDAFQLR 750
YLDLSSNKIQ MIQKTSFPEN VLNNLKMLLL HHNRFLCTCD AVWFVWWVNH 800
TEVTIPYLAT DVTCVGPGAH KGQSVISLDL YTCELDLTNL ILFSLSISVS 850
LFLMVMMTAS HLYFWDVWYI YHFCKAKIKG YQRLISPDCC YDAFIVYDTK 900
DPAVTEWVLA ELVAKLEDPR EKHFNLCLEE RDWLPGQPVL ENLSQSIQLS 950
KKTVFVMTDK YAKTENFKIA FYLSHQRLMD EKVDVIILIF LEKPFQKSKF 1000
LQLRKRLCGS SVLEWPTNPQ AHPYFWQCLK NALATDNHVA YSQVFKETV 1049
Length:1,049
Mass (Da):120,922
Last modified:October 1, 2000 - v1
Checksum:i8C701E9E437F2721
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti11 – 111Q → L.1 Publication
Corresponds to variant rs179008 [ dbSNP | Ensembl ].
VAR_034554
Natural varianti448 – 4481A → V.
Corresponds to variant rs5743781 [ dbSNP | Ensembl ].
VAR_024665

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti725 – 7251L → H in AAF78035. 1 Publication
Sequence conflicti738 – 7381L → P in AAF78035. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF240467 mRNA. Translation: AAF60188.1.
AF245702 mRNA. Translation: AAF78035.1.
DQ022185 Genomic DNA. Translation: AAZ99026.1.
AY358292 mRNA. Translation: AAQ88659.1.
BC033651 mRNA. Translation: AAH33651.1.
CCDSiCCDS14151.1.
RefSeqiNP_057646.1. NM_016562.3.
UniGeneiHs.659215.

Genome annotation databases

EnsembliENST00000380659; ENSP00000370034; ENSG00000196664.
GeneIDi51284.
KEGGihsa:51284.
UCSCiuc004cvc.3. human.

Polymorphism databases

DMDMi20140876.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF240467 mRNA. Translation: AAF60188.1 .
AF245702 mRNA. Translation: AAF78035.1 .
DQ022185 Genomic DNA. Translation: AAZ99026.1 .
AY358292 mRNA. Translation: AAQ88659.1 .
BC033651 mRNA. Translation: AAH33651.1 .
CCDSi CCDS14151.1.
RefSeqi NP_057646.1. NM_016562.3.
UniGenei Hs.659215.

3D structure databases

ProteinModelPortali Q9NYK1.
SMRi Q9NYK1. Positions 32-829, 891-1035.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119436. 2 interactions.
IntActi Q9NYK1. 3 interactions.
STRINGi 9606.ENSP00000370034.

Chemistry

BindingDBi Q9NYK1.
ChEMBLi CHEMBL5936.
DrugBanki DB00724. Imiquimod.
GuidetoPHARMACOLOGYi 1757.

PTM databases

PhosphoSitei Q9NYK1.

Polymorphism databases

DMDMi 20140876.

Proteomic databases

PaxDbi Q9NYK1.
PeptideAtlasi Q9NYK1.
PRIDEi Q9NYK1.

Protocols and materials databases

DNASUi 51284.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000380659 ; ENSP00000370034 ; ENSG00000196664 .
GeneIDi 51284.
KEGGi hsa:51284.
UCSCi uc004cvc.3. human.

Organism-specific databases

CTDi 51284.
GeneCardsi GC0XP012885.
HGNCi HGNC:15631. TLR7.
HPAi HPA059613.
MIMi 300365. gene.
neXtProti NX_Q9NYK1.
PharmGKBi PA38008.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG286662.
HOGENOMi HOG000230468.
HOVERGENi HBG018601.
InParanoidi Q9NYK1.
KOi K05404.
OMAi SEGITHM.
OrthoDBi EOG7VB2DM.
PhylomeDBi Q9NYK1.
TreeFami TF325595.

Enzyme and pathway databases

Reactomei REACT_118632. Trafficking and processing of endosomal TLR.
REACT_25024. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
REACT_25120. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
REACT_25222. MyD88 dependent cascade initiated on endosome.
REACT_9020. Toll Like Receptor 7/8 (TLR7/8) Cascade.

Miscellaneous databases

GeneWikii TLR_7.
GenomeRNAii 51284.
NextBioi 35489043.
PROi Q9NYK1.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9NYK1.
Bgeei Q9NYK1.
CleanExi HS_TLR7.
Genevestigatori Q9NYK1.

Family and domain databases

Gene3Di 3.40.50.10140. 1 hit.
InterProi IPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
IPR026906. LRR_5.
IPR000157. TIR_dom.
IPR026880. TLR7.
[Graphical view ]
PANTHERi PTHR24365:SF222. PTHR24365:SF222. 1 hit.
Pfami PF00560. LRR_1. 3 hits.
PF13306. LRR_5. 1 hit.
PF13855. LRR_8. 2 hits.
PF01582. TIR. 1 hit.
[Graphical view ]
SMARTi SM00369. LRR_TYP. 3 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view ]
SUPFAMi SSF52200. SSF52200. 1 hit.
PROSITEi PS51450. LRR. 18 hits.
PS50104. TIR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Three novel mammalian Toll-like receptors: gene structure, expression, and evolution."
    Du X., Poltorak A., Wei Y., Beutler B.
    Eur. Cytokine Netw. 11:362-371(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  2. "Cloning and characterization of a sub-family of human Toll-like receptors: hTLR7, hTLR8 and hTLR9."
    Chuang T.-H., Ulevitch R.J.
    Eur. Cytokine Netw. 11:372-378(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  3. "The heterogeneous allelic repertoire of human Toll-Like receptor (TLR) genes."
    Georgel P., Macquin C., Bahram S.
    PLoS ONE 4:E7803-E7803(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LEU-11.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  6. "TLR7 is involved in sequence-specific sensing of single-stranded RNAs in human macrophages."
    Gantier M.P., Tong S., Behlke M.A., Xu D., Phipps S., Foster P.S., Williams B.R.
    J. Immunol. 180:2117-2124(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiTLR7_HUMAN
AccessioniPrimary (citable) accession number: Q9NYK1
Secondary accession number(s): D1CS69, Q9NR98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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