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Q9NYK1

- TLR7_HUMAN

UniProt

Q9NYK1 - TLR7_HUMAN

Protein

Toll-like receptor 7

Gene

TLR7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 140 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response By similarity.By similarity

    GO - Molecular functioni

    1. double-stranded RNA binding Source: UniProtKB
    2. drug binding Source: Ensembl
    3. single-stranded RNA binding Source: UniProtKB
    4. siRNA binding Source: UniProtKB
    5. transmembrane signaling receptor activity Source: InterPro

    GO - Biological processi

    1. cellular response to mechanical stimulus Source: UniProtKB
    2. defense response to virus Source: UniProtKB
    3. I-kappaB phosphorylation Source: BHF-UCL
    4. inflammatory response Source: UniProtKB-KW
    5. innate immune response Source: Reactome
    6. microglial cell activation involved in immune response Source: Ensembl
    7. MyD88-dependent toll-like receptor signaling pathway Source: InterPro
    8. pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response Source: Ensembl
    9. positive regulation of chemokine production Source: BHF-UCL
    10. positive regulation of inflammatory response Source: BHF-UCL
    11. positive regulation of interferon-alpha biosynthetic process Source: UniProtKB
    12. positive regulation of interferon-beta biosynthetic process Source: UniProtKB
    13. positive regulation of interferon-gamma biosynthetic process Source: UniProtKB
    14. positive regulation of interleukin-6 production Source: Ensembl
    15. positive regulation of interleukin-8 biosynthetic process Source: UniProtKB
    16. positive regulation of interleukin-8 production Source: BHF-UCL
    17. positive regulation of NF-kappaB import into nucleus Source: BHF-UCL
    18. toll-like receptor 7 signaling pathway Source: Ensembl
    19. toll-like receptor 9 signaling pathway Source: Reactome
    20. toll-like receptor signaling pathway Source: Reactome

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Immunity, Inflammatory response, Innate immunity

    Enzyme and pathway databases

    ReactomeiREACT_118632. Trafficking and processing of endosomal TLR.
    REACT_25024. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
    REACT_25120. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
    REACT_25222. MyD88 dependent cascade initiated on endosome.
    REACT_9020. Toll Like Receptor 7/8 (TLR7/8) Cascade.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Toll-like receptor 7
    Gene namesi
    Name:TLR7
    ORF Names:UNQ248/PRO285
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:15631. TLR7.

    Subcellular locationi

    Endoplasmic reticulum membrane By similarity; Single-pass type I membrane protein By similarity. Endosome By similarity. Lysosome By similarity. Cytoplasmic vesiclephagosome
    Note: Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: BHF-UCL
    2. early phagosome Source: UniProtKB
    3. endolysosome membrane Source: Reactome
    4. endoplasmic reticulum Source: UniProtKB
    5. endoplasmic reticulum membrane Source: Reactome
    6. endosome Source: UniProtKB
    7. endosome membrane Source: Reactome
    8. Golgi membrane Source: Reactome
    9. integral component of membrane Source: UniProtKB-KW
    10. lysosome Source: UniProtKB
    11. plasma membrane Source: BHF-UCL
    12. receptor complex Source: MGI

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Lysosome, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38008.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 10491023Toll-like receptor 7PRO_0000034733Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi66 – 661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi69 – 691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi215 – 2151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi361 – 3611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi413 – 4131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi488 – 4881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi523 – 5231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi534 – 5341N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi590 – 5901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi679 – 6791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi720 – 7201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi799 – 7991N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9NYK1.
    PeptideAtlasiQ9NYK1.
    PRIDEiQ9NYK1.

    PTM databases

    PhosphoSiteiQ9NYK1.

    Expressioni

    Tissue specificityi

    Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells.

    Gene expression databases

    ArrayExpressiQ9NYK1.
    BgeeiQ9NYK1.
    CleanExiHS_TLR7.
    GenevestigatoriQ9NYK1.

    Organism-specific databases

    HPAiHPA059613.

    Interactioni

    Subunit structurei

    Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi119436. 2 interactions.
    IntActiQ9NYK1. 8 interactions.
    STRINGi9606.ENSP00000370034.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NYK1.
    SMRiQ9NYK1. Positions 32-829, 891-1035.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini27 – 839813ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini861 – 1049189CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei840 – 86021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati43 – 6422LRR 1Add
    BLAST
    Repeati65 – 8723LRR 2Add
    BLAST
    Repeati110 – 12617LRR 3Add
    BLAST
    Repeati127 – 14923LRR 4Add
    BLAST
    Repeati151 – 17020LRR 5Add
    BLAST
    Repeati171 – 19525LRR 6Add
    BLAST
    Repeati203 – 22624LRR 7Add
    BLAST
    Repeati228 – 24720LRR 8Add
    BLAST
    Repeati248 – 27528LRR 9Add
    BLAST
    Repeati289 – 31224LRR 10Add
    BLAST
    Repeati314 – 33724LRR 11Add
    BLAST
    Repeati339 – 36830LRR 12Add
    BLAST
    Repeati369 – 39224LRR 13Add
    BLAST
    Repeati396 – 41924LRR 14Add
    BLAST
    Repeati421 – 44323LRR 15Add
    BLAST
    Repeati492 – 51524LRR 16Add
    BLAST
    Repeati516 – 54025LRR 17Add
    BLAST
    Repeati541 – 56424LRR 18Add
    BLAST
    Repeati566 – 58823LRR 19Add
    BLAST
    Repeati595 – 61824LRR 20Add
    BLAST
    Repeati619 – 64426LRR 21Add
    BLAST
    Repeati649 – 67224LRR 22Add
    BLAST
    Repeati674 – 69724LRR 23Add
    BLAST
    Repeati698 – 72124LRR 24Add
    BLAST
    Repeati723 – 74523LRR 25Add
    BLAST
    Repeati746 – 76924LRR 26Add
    BLAST
    Repeati772 – 79524LRR 27Add
    BLAST
    Domaini889 – 1036148TIRPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Toll-like receptor family.Curated
    Contains 27 LRR (leucine-rich) repeats.Curated
    Contains 1 TIR domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG286662.
    HOGENOMiHOG000230468.
    HOVERGENiHBG018601.
    InParanoidiQ9NYK1.
    KOiK05404.
    OMAiSEGITHM.
    OrthoDBiEOG7VB2DM.
    PhylomeDBiQ9NYK1.
    TreeFamiTF325595.

    Family and domain databases

    Gene3Di3.40.50.10140. 1 hit.
    InterProiIPR000483. Cys-rich_flank_reg_C.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    IPR026906. LRR_5.
    IPR000157. TIR_dom.
    IPR026880. TLR7.
    [Graphical view]
    PANTHERiPTHR24365:SF222. PTHR24365:SF222. 1 hit.
    PfamiPF00560. LRR_1. 3 hits.
    PF13306. LRR_5. 1 hit.
    PF13855. LRR_8. 2 hits.
    PF01582. TIR. 1 hit.
    [Graphical view]
    SMARTiSM00369. LRR_TYP. 3 hits.
    SM00082. LRRCT. 1 hit.
    SM00013. LRRNT. 1 hit.
    [Graphical view]
    SUPFAMiSSF52200. SSF52200. 1 hit.
    PROSITEiPS51450. LRR. 18 hits.
    PS50104. TIR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9NYK1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVFPMWTLKR QILILFNIIL ISKLLGARWF PKTLPCDVTL DVPKNHVIVD     50
    CTDKHLTEIP GGIPTNTTNL TLTINHIPDI SPASFHRLDH LVEIDFRCNC 100
    VPIPLGSKNN MCIKRLQIKP RSFSGLTYLK SLYLDGNQLL EIPQGLPPSL 150
    QLLSLEANNI FSIRKENLTE LANIEILYLG QNCYYRNPCY VSYSIEKDAF 200
    LNLTKLKVLS LKDNNVTAVP TVLPSTLTEL YLYNNMIAKI QEDDFNNLNQ 250
    LQILDLSGNC PRCYNAPFPC APCKNNSPLQ IPVNAFDALT ELKVLRLHSN 300
    SLQHVPPRWF KNINKLQELD LSQNFLAKEI GDAKFLHFLP SLIQLDLSFN 350
    FELQVYRASM NLSQAFSSLK SLKILRIRGY VFKELKSFNL SPLHNLQNLE 400
    VLDLGTNFIK IANLSMFKQF KRLKVIDLSV NKISPSGDSS EVGFCSNART 450
    SVESYEPQVL EQLHYFRYDK YARSCRFKNK EASFMSVNES CYKYGQTLDL 500
    SKNSIFFVKS SDFQHLSFLK CLNLSGNLIS QTLNGSEFQP LAELRYLDFS 550
    NNRLDLLHST AFEELHKLEV LDISSNSHYF QSEGITHMLN FTKNLKVLQK 600
    LMMNDNDISS STSRTMESES LRTLEFRGNH LDVLWREGDN RYLQLFKNLL 650
    KLEELDISKN SLSFLPSGVF DGMPPNLKNL SLAKNGLKSF SWKKLQCLKN 700
    LETLDLSHNQ LTTVPERLSN CSRSLKNLIL KNNQIRSLTK YFLQDAFQLR 750
    YLDLSSNKIQ MIQKTSFPEN VLNNLKMLLL HHNRFLCTCD AVWFVWWVNH 800
    TEVTIPYLAT DVTCVGPGAH KGQSVISLDL YTCELDLTNL ILFSLSISVS 850
    LFLMVMMTAS HLYFWDVWYI YHFCKAKIKG YQRLISPDCC YDAFIVYDTK 900
    DPAVTEWVLA ELVAKLEDPR EKHFNLCLEE RDWLPGQPVL ENLSQSIQLS 950
    KKTVFVMTDK YAKTENFKIA FYLSHQRLMD EKVDVIILIF LEKPFQKSKF 1000
    LQLRKRLCGS SVLEWPTNPQ AHPYFWQCLK NALATDNHVA YSQVFKETV 1049
    Length:1,049
    Mass (Da):120,922
    Last modified:October 1, 2000 - v1
    Checksum:i8C701E9E437F2721
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti725 – 7251L → H in AAF78035. (PubMed:11022120)Curated
    Sequence conflicti738 – 7381L → P in AAF78035. (PubMed:11022120)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti11 – 111Q → L.1 Publication
    Corresponds to variant rs179008 [ dbSNP | Ensembl ].
    VAR_034554
    Natural varianti448 – 4481A → V.
    Corresponds to variant rs5743781 [ dbSNP | Ensembl ].
    VAR_024665

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF240467 mRNA. Translation: AAF60188.1.
    AF245702 mRNA. Translation: AAF78035.1.
    DQ022185 Genomic DNA. Translation: AAZ99026.1.
    AY358292 mRNA. Translation: AAQ88659.1.
    BC033651 mRNA. Translation: AAH33651.1.
    CCDSiCCDS14151.1.
    RefSeqiNP_057646.1. NM_016562.3.
    UniGeneiHs.659215.

    Genome annotation databases

    EnsembliENST00000380659; ENSP00000370034; ENSG00000196664.
    GeneIDi51284.
    KEGGihsa:51284.
    UCSCiuc004cvc.3. human.

    Polymorphism databases

    DMDMi20140876.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF240467 mRNA. Translation: AAF60188.1 .
    AF245702 mRNA. Translation: AAF78035.1 .
    DQ022185 Genomic DNA. Translation: AAZ99026.1 .
    AY358292 mRNA. Translation: AAQ88659.1 .
    BC033651 mRNA. Translation: AAH33651.1 .
    CCDSi CCDS14151.1.
    RefSeqi NP_057646.1. NM_016562.3.
    UniGenei Hs.659215.

    3D structure databases

    ProteinModelPortali Q9NYK1.
    SMRi Q9NYK1. Positions 32-829, 891-1035.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119436. 2 interactions.
    IntActi Q9NYK1. 8 interactions.
    STRINGi 9606.ENSP00000370034.

    Chemistry

    BindingDBi Q9NYK1.
    ChEMBLi CHEMBL5936.
    DrugBanki DB00724. Imiquimod.
    GuidetoPHARMACOLOGYi 1757.

    PTM databases

    PhosphoSitei Q9NYK1.

    Polymorphism databases

    DMDMi 20140876.

    Proteomic databases

    PaxDbi Q9NYK1.
    PeptideAtlasi Q9NYK1.
    PRIDEi Q9NYK1.

    Protocols and materials databases

    DNASUi 51284.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000380659 ; ENSP00000370034 ; ENSG00000196664 .
    GeneIDi 51284.
    KEGGi hsa:51284.
    UCSCi uc004cvc.3. human.

    Organism-specific databases

    CTDi 51284.
    GeneCardsi GC0XP012885.
    HGNCi HGNC:15631. TLR7.
    HPAi HPA059613.
    MIMi 300365. gene.
    neXtProti NX_Q9NYK1.
    PharmGKBi PA38008.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG286662.
    HOGENOMi HOG000230468.
    HOVERGENi HBG018601.
    InParanoidi Q9NYK1.
    KOi K05404.
    OMAi SEGITHM.
    OrthoDBi EOG7VB2DM.
    PhylomeDBi Q9NYK1.
    TreeFami TF325595.

    Enzyme and pathway databases

    Reactomei REACT_118632. Trafficking and processing of endosomal TLR.
    REACT_25024. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
    REACT_25120. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
    REACT_25222. MyD88 dependent cascade initiated on endosome.
    REACT_9020. Toll Like Receptor 7/8 (TLR7/8) Cascade.

    Miscellaneous databases

    GeneWikii TLR_7.
    GenomeRNAii 51284.
    NextBioi 35489043.
    PROi Q9NYK1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NYK1.
    Bgeei Q9NYK1.
    CleanExi HS_TLR7.
    Genevestigatori Q9NYK1.

    Family and domain databases

    Gene3Di 3.40.50.10140. 1 hit.
    InterProi IPR000483. Cys-rich_flank_reg_C.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    IPR026906. LRR_5.
    IPR000157. TIR_dom.
    IPR026880. TLR7.
    [Graphical view ]
    PANTHERi PTHR24365:SF222. PTHR24365:SF222. 1 hit.
    Pfami PF00560. LRR_1. 3 hits.
    PF13306. LRR_5. 1 hit.
    PF13855. LRR_8. 2 hits.
    PF01582. TIR. 1 hit.
    [Graphical view ]
    SMARTi SM00369. LRR_TYP. 3 hits.
    SM00082. LRRCT. 1 hit.
    SM00013. LRRNT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52200. SSF52200. 1 hit.
    PROSITEi PS51450. LRR. 18 hits.
    PS50104. TIR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Three novel mammalian Toll-like receptors: gene structure, expression, and evolution."
      Du X., Poltorak A., Wei Y., Beutler B.
      Eur. Cytokine Netw. 11:362-371(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Placenta.
    2. "Cloning and characterization of a sub-family of human Toll-like receptors: hTLR7, hTLR8 and hTLR9."
      Chuang T.-H., Ulevitch R.J.
      Eur. Cytokine Netw. 11:372-378(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Placenta.
    3. "The heterogeneous allelic repertoire of human Toll-Like receptor (TLR) genes."
      Georgel P., Macquin C., Bahram S.
      PLoS ONE 4:E7803-E7803(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LEU-11.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    6. "TLR7 is involved in sequence-specific sensing of single-stranded RNAs in human macrophages."
      Gantier M.P., Tong S., Behlke M.A., Xu D., Phipps S., Foster P.S., Williams B.R.
      J. Immunol. 180:2117-2124(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiTLR7_HUMAN
    AccessioniPrimary (citable) accession number: Q9NYK1
    Secondary accession number(s): D1CS69, Q9NR98
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 31, 2002
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 140 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3