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Q9NYJ8

- TAB2_HUMAN

UniProt

Q9NYJ8 - TAB2_HUMAN

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Protein
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
Gene
TAB2, KIAA0733, MAP3K7IP2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development.3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri663 – 69331RanBP2-type
Add
BLAST

GO - Molecular functioni

  1. K63-linked polyubiquitin binding Source: UniProtKB
  2. protein binding Source: UniProtKB
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. Fc-epsilon receptor signaling pathway Source: Reactome
  2. I-kappaB kinase/NF-kappaB signaling Source: Reactome
  3. JNK cascade Source: Reactome
  4. MyD88-dependent toll-like receptor signaling pathway Source: Reactome
  5. MyD88-independent toll-like receptor signaling pathway Source: Reactome
  6. T cell receptor signaling pathway Source: Reactome
  7. TRIF-dependent toll-like receptor signaling pathway Source: Reactome
  8. activation of MAPK activity Source: Reactome
  9. heart development Source: UniProtKB
  10. innate immune response Source: Reactome
  11. nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway Source: Reactome
  12. nucleotide-binding oligomerization domain containing signaling pathway Source: Reactome
  13. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  14. positive regulation of NF-kappaB transcription factor activity Source: Reactome
  15. positive regulation of protein kinase activity Source: UniProtKB
  16. stress-activated MAPK cascade Source: Reactome
  17. toll-like receptor 10 signaling pathway Source: Reactome
  18. toll-like receptor 2 signaling pathway Source: Reactome
  19. toll-like receptor 3 signaling pathway Source: Reactome
  20. toll-like receptor 4 signaling pathway Source: Reactome
  21. toll-like receptor 5 signaling pathway Source: Reactome
  22. toll-like receptor 9 signaling pathway Source: Reactome
  23. toll-like receptor TLR1:TLR2 signaling pathway Source: Reactome
  24. toll-like receptor TLR6:TLR2 signaling pathway Source: Reactome
  25. toll-like receptor signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_116022. Nuclear signaling by ERBB4.
REACT_12555. Downstream TCR signaling.
REACT_163994. FCERI mediated NF-kB activation.
REACT_21281. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
REACT_21368. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
REACT_21399. activated TAK1 mediates p38 MAPK activation.
REACT_22442. Interleukin-1 signaling.
REACT_25018. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.
REACT_25351. TRAF6 mediated induction of TAK1 complex.
REACT_25380. IRAK2 mediated activation of TAK1 complex.
REACT_75776. NOD1/2 Signaling Pathway.
SignaLinkiQ9NYJ8.

Names & Taxonomyi

Protein namesi
Recommended name:
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
Alternative name(s):
Mitogen-activated protein kinase kinase kinase 7-interacting protein 2
TAK1-binding protein 2
Short name:
TAB-2
TGF-beta-activated kinase 1-binding protein 2
Gene namesi
Name:TAB2
Synonyms:KIAA0733, MAP3K7IP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:17075. TAB2.

Subcellular locationi

Membrane; Peripheral membrane protein. Cytoplasmcytosol
Note: Following IL1 stimulation, translocation occurs from the membrane to cytosol.1 Publication

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. endosome membrane Source: Reactome
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Involvement in diseasei

Congenital heart defects, multiple types, 2 (CHTD2) [MIM:614980]: A disease characterized by congenital developmental abnormalities involving structures of the heart. CHTD2 patients have left ventricular outflow tract obstruction, subaortic stenosis, residual aortic regurgitation, atrial fibrillation, bicuspid aortic valve and aortic dilation.
Note: The disease is caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving TAB2 has been found in a family with congenital heart disease. Translocation t(2;6)(q21;q25).1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti208 – 2081P → S in CHTD2. 1 Publication
Corresponds to variant rs267607101 [ dbSNP | Ensembl ].
VAR_063774
Natural varianti230 – 2301Q → K in CHTD2. 1 Publication
Corresponds to variant rs267607100 [ dbSNP | Ensembl ].
VAR_063775

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi675 – 6751F → A: Abolishes ubiquitin binding. 1 Publication
Mutagenesisi678 – 6781H → A: Abolishes ubiquitin binding. 1 Publication
Mutagenesisi681 – 6811L → A: Abolishes ubiquitin binding. 1 Publication
Mutagenesisi685 – 6851E → A: Abolishes ubiquitin binding. 1 Publication

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi614980. phenotype.
PharmGKBiPA30605.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 693693TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
PRO_0000225695Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei372 – 3721Phosphoserine1 Publication
Modified residuei450 – 4501Phosphoserine1 Publication
Modified residuei524 – 5241Phosphoserine1 Publication

Post-translational modificationi

Ubiquitinated; following IL1 stimulation or TRAF6 overexpression. Ubiquitination involves RBCK1 leading to proteasomal degradation.2 Publications
Phosphorylated Inferred.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9NYJ8.
PaxDbiQ9NYJ8.
PRIDEiQ9NYJ8.

PTM databases

PhosphoSiteiQ9NYJ8.

Expressioni

Tissue specificityi

Widely expressed. In the embryo, expressed in the ventricular trabeculae, endothelial cells of the conotruncal cushions of the outflow tract and in the endothelial cells lining the developing aortic valves.2 Publications

Gene expression databases

ArrayExpressiQ9NYJ8.
BgeeiQ9NYJ8.
CleanExiHS_MAP3K7IP2.
GenevestigatoriQ9NYJ8.

Interactioni

Subunit structurei

Interacts with MAP3K7 and TRAF6. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2. Binds 'Lys-63'-linked polyubiquitin chains. Interacts with NCOR1 and HDAC3 to form a ternary complex. Interacts (via C-terminal) with NUMBL (via PTB domain). Interacts (via the C-terminus) with WDR34 (via WD domains). Interacts with RBCK1. Interacts with TRIM5.8 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BECN1Q1445711EBI-358708,EBI-949378
MAP3K7O433185EBI-358708,EBI-358684
MAP3K7O43318-22EBI-358708,EBI-358700
TAB1Q157504EBI-358708,EBI-358643
ZBTB16Q055163EBI-358708,EBI-711925

Protein-protein interaction databases

BioGridi116740. 72 interactions.
DIPiDIP-27525N.
IntActiQ9NYJ8. 30 interactions.
MINTiMINT-1132340.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi10 – 1910
Beta strandi20 – 234
Helixi25 – 328
Turni33 – 364
Helixi40 – 5314
Turni54 – 563
Turni671 – 6733
Turni685 – 6873

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DAENMR-A7-68[»]
2WWZX-ray1.40C662-693[»]
2WX0X-ray2.40C/G663-693[»]
2WX1X-ray3.00C663-693[»]
ProteinModelPortaliQ9NYJ8.
SMRiQ9NYJ8. Positions 5-70, 662-693.

Miscellaneous databases

EvolutionaryTraceiQ9NYJ8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 5144CUE
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni675 – 68511Interaction with polyubiquitin
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili532 – 61988 Reviewed prediction
Add
BLAST

Domaini

The RanBP2-type zinc finger (NZF) mediates binding to two consecutive 'Lys-63'-linked ubiquitins By similarity.

Sequence similaritiesi

Contains 1 CUE domain.

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiNOG47991.
HOVERGENiHBG056952.
InParanoidiQ9NYJ8.
KOiK04404.
OMAiVYHHGRE.
OrthoDBiEOG776SPP.
PhylomeDBiQ9NYJ8.
TreeFamiTF332021.

Family and domain databases

InterProiIPR003892. CUE.
IPR001876. Znf_RanBP2.
[Graphical view]
PfamiPF02845. CUE. 1 hit.
PF00641. zf-RanBP. 1 hit.
[Graphical view]
SMARTiSM00546. CUE. 1 hit.
SM00547. ZnF_RBZ. 1 hit.
[Graphical view]
PROSITEiPS51140. CUE. 1 hit.
PS01358. ZF_RANBP2_1. 1 hit.
PS50199. ZF_RANBP2_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NYJ8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAQGSHQIDF QVLHDLRQKF PEVPEVVVSR CMLQNNNNLD ACCAVLSQES    50
TRYLYGEGDL NFSDDSGISG LRNHMTSLNL DLQSQNIYHH GREGSRMNGS 100
RTLTHSISDG QLQGGQSNSE LFQQEPQTAP AQVPQGFNVF GMSSSSGASN 150
SAPHLGFHLG SKGTSSLSQQ TPRFNPIMVT LAPNIQTGRN TPTSLHIHGV 200
PPPVLNSPQG NSIYIRPYIT TPGGTTRQTQ QHSGWVSQFN PMNPQQVYQP 250
SQPGPWTTCP ASNPLSHTSS QQPNQQGHQT SHVYMPISSP TTSQPPTIHS 300
SGSSQSSAHS QYNIQNISTG PRKNQIEIKL EPPQRNNSSK LRSSGPRTSS 350
TSSSVNSQTL NRNQPTVYIA ASPPNTDELM SRSQPKVYIS ANAATGDEQV 400
MRNQPTLFIS TNSGASAASR NMSGQVSMGP AFIHHHPPKS RAIGNNSATS 450
PRVVVTQPNT KYTFKITVSP NKPPAVSPGV VSPTFELTNL LNHPDHYVET 500
ENIQHLTDPT LAHVDRISET RKLSMGSDDA AYTQALLVHQ KARMERLQRE 550
LEIQKKKLDK LKSEVNEMEN NLTRRRLKRS NSISQIPSLE EMQQLRSCNR 600
QLQIDIDCLT KEIDLFQARG PHFNPSAIHN FYDNIGFVGP VPPKPKDQRS 650
IIKTPKTQDT EDDEGAQWNC TACTFLNHPA LIRCEQCEMP RHF 693
Length:693
Mass (Da):76,494
Last modified:October 1, 2000 - v1
Checksum:i47BB8709320084D7
GO
Isoform 2 (identifier: Q9NYJ8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     535-536: AL → DI
     537-693: Missing.

Show »
Length:536
Mass (Da):58,131
Checksum:iD74074A216D23425
GO

Sequence cautioni

The sequence BAA34453.2 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti208 – 2081P → S in CHTD2. 1 Publication
Corresponds to variant rs267607101 [ dbSNP | Ensembl ].
VAR_063774
Natural varianti230 – 2301Q → K in CHTD2. 1 Publication
Corresponds to variant rs267607100 [ dbSNP | Ensembl ].
VAR_063775

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei535 – 5362AL → DI in isoform 2.
VSP_017419
Alternative sequencei537 – 693157Missing in isoform 2.
VSP_017420Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti196 – 1961H → R in CAG33668. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF241230 mRNA. Translation: AAF67176.1.
AB018276 mRNA. Translation: BAA34453.2. Different initiation.
AK315038 mRNA. Translation: BAG37521.1.
CR457387 mRNA. Translation: CAG33668.1.
DQ314877 Genomic DNA. Translation: ABC40736.1.
AL117407 mRNA. Translation: CAB55907.1.
AL031133, AL138727, AL139103 Genomic DNA. Translation: CAI20026.1.
AL139103, AL031133, AL138727 Genomic DNA. Translation: CAI20971.1.
AL138727, AL031133, AL139103 Genomic DNA. Translation: CAI19581.1.
CH471051 Genomic DNA. Translation: EAW47805.1.
CH471051 Genomic DNA. Translation: EAW47806.1.
CH471051 Genomic DNA. Translation: EAW47807.1.
BC035910 mRNA. Translation: AAH35910.1.
CCDSiCCDS5214.1. [Q9NYJ8-1]
PIRiT17217.
RefSeqiNP_055908.1. NM_015093.5. [Q9NYJ8-1]
XP_006715466.1. XM_006715403.1. [Q9NYJ8-1]
UniGeneiHs.269775.

Genome annotation databases

EnsembliENST00000286332; ENSP00000286332; ENSG00000055208. [Q9NYJ8-1]
ENST00000367456; ENSP00000356426; ENSG00000055208. [Q9NYJ8-1]
ENST00000392282; ENSP00000376106; ENSG00000055208. [Q9NYJ8-2]
ENST00000470466; ENSP00000432709; ENSG00000055208. [Q9NYJ8-2]
ENST00000538427; ENSP00000445752; ENSG00000055208. [Q9NYJ8-1]
GeneIDi23118.
KEGGihsa:23118.
UCSCiuc003qmj.3. human. [Q9NYJ8-1]

Polymorphism databases

DMDMi74753070.

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF241230 mRNA. Translation: AAF67176.1 .
AB018276 mRNA. Translation: BAA34453.2 . Different initiation.
AK315038 mRNA. Translation: BAG37521.1 .
CR457387 mRNA. Translation: CAG33668.1 .
DQ314877 Genomic DNA. Translation: ABC40736.1 .
AL117407 mRNA. Translation: CAB55907.1 .
AL031133 , AL138727 , AL139103 Genomic DNA. Translation: CAI20026.1 .
AL139103 , AL031133 , AL138727 Genomic DNA. Translation: CAI20971.1 .
AL138727 , AL031133 , AL139103 Genomic DNA. Translation: CAI19581.1 .
CH471051 Genomic DNA. Translation: EAW47805.1 .
CH471051 Genomic DNA. Translation: EAW47806.1 .
CH471051 Genomic DNA. Translation: EAW47807.1 .
BC035910 mRNA. Translation: AAH35910.1 .
CCDSi CCDS5214.1. [Q9NYJ8-1 ]
PIRi T17217.
RefSeqi NP_055908.1. NM_015093.5. [Q9NYJ8-1 ]
XP_006715466.1. XM_006715403.1. [Q9NYJ8-1 ]
UniGenei Hs.269775.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2DAE NMR - A 7-68 [» ]
2WWZ X-ray 1.40 C 662-693 [» ]
2WX0 X-ray 2.40 C/G 663-693 [» ]
2WX1 X-ray 3.00 C 663-693 [» ]
ProteinModelPortali Q9NYJ8.
SMRi Q9NYJ8. Positions 5-70, 662-693.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116740. 72 interactions.
DIPi DIP-27525N.
IntActi Q9NYJ8. 30 interactions.
MINTi MINT-1132340.

PTM databases

PhosphoSitei Q9NYJ8.

Polymorphism databases

DMDMi 74753070.

Proteomic databases

MaxQBi Q9NYJ8.
PaxDbi Q9NYJ8.
PRIDEi Q9NYJ8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000286332 ; ENSP00000286332 ; ENSG00000055208 . [Q9NYJ8-1 ]
ENST00000367456 ; ENSP00000356426 ; ENSG00000055208 . [Q9NYJ8-1 ]
ENST00000392282 ; ENSP00000376106 ; ENSG00000055208 . [Q9NYJ8-2 ]
ENST00000470466 ; ENSP00000432709 ; ENSG00000055208 . [Q9NYJ8-2 ]
ENST00000538427 ; ENSP00000445752 ; ENSG00000055208 . [Q9NYJ8-1 ]
GeneIDi 23118.
KEGGi hsa:23118.
UCSCi uc003qmj.3. human. [Q9NYJ8-1 ]

Organism-specific databases

CTDi 23118.
GeneCardsi GC06P149543.
HGNCi HGNC:17075. TAB2.
MIMi 605101. gene.
614980. phenotype.
neXtProti NX_Q9NYJ8.
PharmGKBi PA30605.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG47991.
HOVERGENi HBG056952.
InParanoidi Q9NYJ8.
KOi K04404.
OMAi VYHHGRE.
OrthoDBi EOG776SPP.
PhylomeDBi Q9NYJ8.
TreeFami TF332021.

Enzyme and pathway databases

Reactomei REACT_116022. Nuclear signaling by ERBB4.
REACT_12555. Downstream TCR signaling.
REACT_163994. FCERI mediated NF-kB activation.
REACT_21281. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
REACT_21368. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
REACT_21399. activated TAK1 mediates p38 MAPK activation.
REACT_22442. Interleukin-1 signaling.
REACT_25018. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.
REACT_25351. TRAF6 mediated induction of TAK1 complex.
REACT_25380. IRAK2 mediated activation of TAK1 complex.
REACT_75776. NOD1/2 Signaling Pathway.
SignaLinki Q9NYJ8.

Miscellaneous databases

ChiTaRSi TAB2. human.
EvolutionaryTracei Q9NYJ8.
GeneWikii MAP3K7IP2.
GenomeRNAii 23118.
NextBioi 44335.
PROi Q9NYJ8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9NYJ8.
Bgeei Q9NYJ8.
CleanExi HS_MAP3K7IP2.
Genevestigatori Q9NYJ8.

Family and domain databases

InterProi IPR003892. CUE.
IPR001876. Znf_RanBP2.
[Graphical view ]
Pfami PF02845. CUE. 1 hit.
PF00641. zf-RanBP. 1 hit.
[Graphical view ]
SMARTi SM00546. CUE. 1 hit.
SM00547. ZnF_RBZ. 1 hit.
[Graphical view ]
PROSITEi PS51140. CUE. 1 hit.
PS01358. ZF_RANBP2_1. 1 hit.
PS50199. ZF_RANBP2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway."
    Takaesu G., Kishida S., Hiyama A., Yamaguchi K., Shibuya H., Irie K., Ninomiya-Tsuji J., Matsumoto K.
    Mol. Cell 5:649-658(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION, INTERACTION WITH TAK1 AND TRAF6.
    Tissue: Kidney.
  2. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  7. NHLBI resequencing and genotyping service (RS&G)
    Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  8. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Eye.
  11. "TAK1 is a ubiquitin-dependent kinase of MKK and IKK."
    Wang C., Deng L., Hong M., Akkaraju G.R., Inoue J., Chen Z.J.
    Nature 412:346-351(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, IDENTIFICATION IN THE TRIKA2 COMPLEX.
  12. "Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling."
    Ishitani T., Takaesu G., Ninomiya-Tsuji J., Shibuya H., Gaynor R.B., Matsumoto K.
    EMBO J. 22:6277-6288(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION.
    Tissue: Kidney.
  13. "RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation."
    Tian Y., Zhang Y., Zhong B., Wang Y.Y., Diao F.C., Wang R.P., Zhang M., Chen D.Y., Zhai Z.H., Shu H.B.
    J. Biol. Chem. 282:16776-16782(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION, INTERACTION WITH RBCK1.
  14. "NUMBL interacts with TAB2 and inhibits TNFalpha and IL-1beta-induced NF-kappaB activation."
    Ma Q., Zhou L., Shi H., Huo K.
    Cell. Signal. 20:1044-1051(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NUMBL.
  15. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-372, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  16. "WDR34 is a novel TAK1-associated suppressor of the IL-1R/TLR3/TLR4-induced NF-kappaB activation pathway."
    Gao D., Wang R., Li B., Yang Y., Zhai Z., Chen D.Y.
    Cell. Mol. Life Sci. 66:2573-2584(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH WDR34.
  17. "Direct activation of protein kinases by unanchored polyubiquitin chains."
    Xia Z.-P., Sun L., Chen X., Pineda G., Jiang X., Adhikari A., Zeng W., Chen Z.J.
    Nature 461:114-119(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH POLYUBIQUITIN.
  18. Cited for: FUNCTION IN HEART DEVELOPMENT, TISSUE SPECIFICITY, VARIANTS CHTD2 SER-208 AND LYS-230, CHROMOSOMAL TRANSLOCATION.
  19. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-450 AND SER-524, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  20. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  21. Cited for: INTERACTION WITH TRIM5.
  22. "Solution structure of the N-terminal CUE domain in the human mitogen-activated protein kinase kinase kinase 7-interacting protein 2 (MAP3K7IP2)."
    RIKEN structural genomics initiative (RSGI)
    Submitted (FEB-2007) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 5-70.
  23. "Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain."
    Kulathu Y., Akutsu M., Bremm A., Hofmann K., Komander D.
    Nat. Struct. Mol. Biol. 16:1328-1330(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS) OF 662-693 IN COMPLEX WITH POLYUBIQUITIN CHAINS, MUTAGENESIS OF PHE-675; HIS-678; LEU-681 AND GLU-685, SUBUNIT.

Entry informationi

Entry nameiTAB2_HUMAN
AccessioniPrimary (citable) accession number: Q9NYJ8
Secondary accession number(s): B2RCC4
, E1P5A0, O94838, Q6I9W8, Q76N06, Q9UFP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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