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Protein

U3 small nucleolar RNA-associated protein 6 homolog

Gene

UTP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in nucleolar processing of pre-18S ribosomal RNA.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

rRNA processing

Enzyme and pathway databases

ReactomeiR-HSA-6790901. rRNA modification in the nucleus.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus.

Names & Taxonomyi

Protein namesi
Recommended name:
U3 small nucleolar RNA-associated protein 6 homolog
Alternative name(s):
Hepatocellular carcinoma-associated antigen 66
Multiple hat domains protein
Gene namesi
Name:UTP6
Synonyms:C17orf40, HCA66, MHAT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:18279. UTP6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672224.

Polymorphism and mutation databases

BioMutaiUTP6.
DMDMi134047946.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 597597U3 small nucleolar RNA-associated protein 6 homologPRO_0000205754Add
BLAST

Proteomic databases

EPDiQ9NYH9.
MaxQBiQ9NYH9.
PaxDbiQ9NYH9.
PeptideAtlasiQ9NYH9.
PRIDEiQ9NYH9.

2D gel databases

SWISS-2DPAGEQ9NYH9.

PTM databases

iPTMnetiQ9NYH9.
PhosphoSiteiQ9NYH9.
SwissPalmiQ9NYH9.

Expressioni

Gene expression databases

BgeeiENSG00000108651.
CleanExiHS_UTP6.
ExpressionAtlasiQ9NYH9. baseline and differential.
GenevisibleiQ9NYH9. HS.

Organism-specific databases

HPAiHPA025936.
HPA055806.

Interactioni

Protein-protein interaction databases

BioGridi120923. 28 interactions.
IntActiQ9NYH9. 14 interactions.
MINTiMINT-1435439.
STRINGi9606.ENSP00000261708.

Structurei

3D structure databases

ProteinModelPortaliQ9NYH9.
SMRiQ9NYH9. Positions 354-411.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati121 – 15333HAT 1Add
BLAST
Repeati156 – 18833HAT 2Add
BLAST
Repeati304 – 33532HAT 3Add
BLAST
Repeati488 – 52033HAT 4Add
BLAST
Repeati524 – 55734HAT 5Add
BLAST

Sequence similaritiesi

Belongs to the UTP6 family.Curated
Contains 5 HAT repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2396. Eukaryota.
COG5191. LUCA.
GeneTreeiENSGT00390000016493.
HOGENOMiHOG000285956.
HOVERGENiHBG051886.
InParanoidiQ9NYH9.
KOiK14557.
OMAiRATNKWK.
OrthoDBiEOG091G09F4.
PhylomeDBiQ9NYH9.
TreeFamiTF323957.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR003107. HAT.
IPR011990. TPR-like_helical_dom.
IPR013949. Utp6.
[Graphical view]
PfamiPF08640. U3_assoc_6. 1 hit.
[Graphical view]
SMARTiSM00386. HAT. 7 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9NYH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEIIQERIE DRLPELEQLE RIGLFSHAEI KAIIKKASDL EYKIQRRTLF
60 70 80 90 100
KEDFINYVQY EINLLELIQR RRTRIGYSFK KDEIENSIVH RVQGVFQRAS
110 120 130 140 150
AKWKDDVQLW LSYVAFCKKW ATKTRLSKVF SAMLAIHSNK PALWIMAAKW
160 170 180 190 200
EMEDRLSSES ARQLFLRALR FHPECPKLYK EYFRMELMHA EKLRKEKEEF
210 220 230 240 250
EKASMDVENP DYSEEILKGE LAWIIYKNSV SIIKGAEFHV SLLSIAQLFD
260 270 280 290 300
FAKDLQKEIY DDLQALHTDD PLTWDYVARR ELEIESQTEE QPTTKQAKAV
310 320 330 340 350
EVGRKEERCC AVYEEAVKTL PTEAMWKCYI TFCLERFTKK SNSGFLRGKR
360 370 380 390 400
LERTMTVFRK AHELKLLSEC QYKQLSVSLL CYNFLREALE VAVAGTELFR
410 420 430 440 450
DSGTMWQLKL QVLIESKSPD IAMLFEEAFV HLKPQVCLPL WISWAEWSEG
460 470 480 490 500
AKSQEDTEAV FKKALLAVIG ADSVTLKNKY LDWAYRSGGY KKARAVFKSL
510 520 530 540 550
QESRPFSVDF FRKMIQFEKE QESCNMANIR EYYERALREF GSADSDLWMD
560 570 580 590
YMKEELNHPL GRPENCGQIY WRAMKMLQGE SAEAFVAKHA MHQTGHL
Length:597
Mass (Da):70,194
Last modified:March 20, 2007 - v2
Checksum:iB5254063791E52FF
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti35 – 351K → R.
Corresponds to variant rs16967042 [ dbSNP | Ensembl ].
VAR_031222
Natural varianti69 – 691Q → R.2 Publications
Corresponds to variant rs3760454 [ dbSNP | Ensembl ].
VAR_026668
Natural varianti134 – 1341L → V.
Corresponds to variant rs34859443 [ dbSNP | Ensembl ].
VAR_049322

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF244135 mRNA. Translation: AAF66244.1.
AF334386 mRNA. Translation: AAO15382.1.
BC015454 mRNA. Translation: AAH15454.1.
BC035325 mRNA. Translation: AAH35325.1.
AJ272197 mRNA. Translation: CAB77268.1.
CCDSiCCDS11269.1.
RefSeqiNP_060898.2. NM_018428.2.
UniGeneiHs.589862.

Genome annotation databases

EnsembliENST00000261708; ENSP00000261708; ENSG00000108651.
GeneIDi55813.
KEGGihsa:55813.
UCSCiuc002hgr.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF244135 mRNA. Translation: AAF66244.1.
AF334386 mRNA. Translation: AAO15382.1.
BC015454 mRNA. Translation: AAH15454.1.
BC035325 mRNA. Translation: AAH35325.1.
AJ272197 mRNA. Translation: CAB77268.1.
CCDSiCCDS11269.1.
RefSeqiNP_060898.2. NM_018428.2.
UniGeneiHs.589862.

3D structure databases

ProteinModelPortaliQ9NYH9.
SMRiQ9NYH9. Positions 354-411.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120923. 28 interactions.
IntActiQ9NYH9. 14 interactions.
MINTiMINT-1435439.
STRINGi9606.ENSP00000261708.

PTM databases

iPTMnetiQ9NYH9.
PhosphoSiteiQ9NYH9.
SwissPalmiQ9NYH9.

Polymorphism and mutation databases

BioMutaiUTP6.
DMDMi134047946.

2D gel databases

SWISS-2DPAGEQ9NYH9.

Proteomic databases

EPDiQ9NYH9.
MaxQBiQ9NYH9.
PaxDbiQ9NYH9.
PeptideAtlasiQ9NYH9.
PRIDEiQ9NYH9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261708; ENSP00000261708; ENSG00000108651.
GeneIDi55813.
KEGGihsa:55813.
UCSCiuc002hgr.4. human.

Organism-specific databases

CTDi55813.
GeneCardsiUTP6.
HGNCiHGNC:18279. UTP6.
HPAiHPA025936.
HPA055806.
neXtProtiNX_Q9NYH9.
PharmGKBiPA142672224.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2396. Eukaryota.
COG5191. LUCA.
GeneTreeiENSGT00390000016493.
HOGENOMiHOG000285956.
HOVERGENiHBG051886.
InParanoidiQ9NYH9.
KOiK14557.
OMAiRATNKWK.
OrthoDBiEOG091G09F4.
PhylomeDBiQ9NYH9.
TreeFamiTF323957.

Enzyme and pathway databases

ReactomeiR-HSA-6790901. rRNA modification in the nucleus.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus.

Miscellaneous databases

ChiTaRSiUTP6. human.
GeneWikiiUTP6.
GenomeRNAii55813.
PROiQ9NYH9.

Gene expression databases

BgeeiENSG00000108651.
CleanExiHS_UTP6.
ExpressionAtlasiQ9NYH9. baseline and differential.
GenevisibleiQ9NYH9. HS.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR003107. HAT.
IPR011990. TPR-like_helical_dom.
IPR013949. Utp6.
[Graphical view]
PfamiPF08640. U3_assoc_6. 1 hit.
[Graphical view]
SMARTiSM00386. HAT. 7 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiUTP6_HUMAN
AccessioniPrimary (citable) accession number: Q9NYH9
Secondary accession number(s): Q8IX96, Q96BL2, Q9NQ91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: March 20, 2007
Last modified: September 7, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.