Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9NYG5

- APC11_HUMAN

UniProt

Q9NYG5 - APC11_HUMAN

Protein

Anaphase-promoting complex subunit 11

Gene

ANAPC11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.2 Publications

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi23 – 231Zinc 1By similarity
    Metal bindingi26 – 261Zinc 1By similarity
    Metal bindingi34 – 341Zinc 3By similarity
    Metal bindingi37 – 371Zinc 3By similarity
    Metal bindingi44 – 441Zinc 3By similarity
    Metal bindingi51 – 511Zinc 2By similarity
    Metal bindingi53 – 531Zinc 2By similarity
    Metal bindingi56 – 561Zinc 1By similarity
    Metal bindingi58 – 581Zinc 3By similarity
    Metal bindingi59 – 591Zinc 1By similarity
    Metal bindingi73 – 731Zinc 2By similarity
    Metal bindingi76 – 761Zinc 2By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri34 – 7744RING-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ubiquitin-protein transferase activity Source: InterPro
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process Source: Reactome
    2. mitotic cell cycle Source: Reactome
    3. mitotic nuclear division Source: UniProtKB
    4. mitotic spindle assembly checkpoint Source: Reactome
    5. negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Source: Reactome
    6. positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Source: Reactome
    7. protein K11-linked ubiquitination Source: UniProtKB
    8. protein ubiquitination Source: UniProtKB
    9. regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Source: Reactome

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_1072. Inactivation of APC/C via direct inhibition of the APC/C complex.
    REACT_150471. Separation of Sister Chromatids.
    REACT_169168. Senescence-Associated Secretory Phenotype (SASP).
    REACT_6761. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
    REACT_6781. APC/C:Cdc20 mediated degradation of mitotic proteins.
    REACT_6785. Autodegradation of Cdh1 by Cdh1:APC/C.
    REACT_6820. APC/C:Cdc20 mediated degradation of Cyclin B.
    REACT_6837. Regulation of APC/C activators between G1/S and early anaphase.
    REACT_6867. Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase.
    REACT_6871. APC/C:Cdc20 mediated degradation of Securin.
    REACT_6904. Phosphorylation of the APC/C.
    REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Anaphase-promoting complex subunit 11
    Short name:
    APC11
    Alternative name(s):
    Cyclosome subunit 11
    Hepatocellular carcinoma-associated RING finger protein
    Gene namesi
    Name:ANAPC11
    ORF Names:HSPC214
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:14452. ANAPC11.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. anaphase-promoting complex Source: UniProtKB
    2. cytosol Source: Reactome
    3. nucleolus Source: HPA
    4. nucleoplasm Source: Reactome
    5. nucleus Source: HPA

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi23 – 231C → S: Greatly reduces autoubiquitination activity; in isoform 1. 1 Publication
    Mutagenesisi26 – 261C → S: Greatly reduces autoubiquitination activity; in isoform 1. 1 Publication
    Mutagenesisi34 – 341C → S: Slightly reduces autoubiquitination activity; in isoform 1. 1 Publication
    Mutagenesisi37 – 371C → S: Slightly reduces autoubiquitination activity; in isoform 1. 1 Publication
    Mutagenesisi44 – 441C → S: Slightly reduces autoubiquitination activity; in isoform 1. 1 Publication
    Mutagenesisi51 – 511C → S: Greatly reduces autoubiquitination activity; in isoform 1. 1 Publication
    Mutagenesisi53 – 531H → S: Greatly reduces autoubiquitination activity; in isoform 1. 1 Publication
    Mutagenesisi56 – 561H → S: Greatly reduces autoubiquitination activity; in isoform 1. 1 Publication
    Mutagenesisi58 – 581H → S: Slightly reduces autoubiquitination activity; in isoform 1. 1 Publication
    Mutagenesisi59 – 591C → S: Greatly reduces autoubiquitination activity; in isoform 1. 1 Publication
    Mutagenesisi73 – 731C → S: Greatly reduces autoubiquitination activity; in isoform 1. 1 Publication
    Mutagenesisi76 – 761C → S: Greatly reduces autoubiquitination activity; in isoform 1. 1 Publication

    Organism-specific databases

    PharmGKBiPA24787.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 8484Anaphase-promoting complex subunit 11PRO_0000055747Add
    BLAST

    Post-translational modificationi

    Auto-ubiquitinated.

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    MaxQBiQ9NYG5.
    PaxDbiQ9NYG5.
    PRIDEiQ9NYG5.

    PTM databases

    PhosphoSiteiQ9NYG5.

    Expressioni

    Tissue specificityi

    Expressed at high levels in skeletal muscle and heart; in moderate levels in brain, kidney, and liver; and at low levels in colon, thymus, spleen, small intestine, placenta, lung and peripheral blood leukocyte.1 Publication

    Gene expression databases

    BgeeiQ9NYG5.
    CleanExiHS_ANAPC11.
    GenevestigatoriQ9NYG5.

    Organism-specific databases

    HPAiHPA021989.
    HPA027838.

    Interactioni

    Subunit structurei

    The APC/C is composed of at least 12 subunits. Interacts with the cullin domain of ANAPC2. Interacts with UBE2D2.2 Publications

    Protein-protein interaction databases

    BioGridi119591. 36 interactions.
    IntActiQ9NYG5. 12 interactions.
    STRINGi9606.ENSP00000349957.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NYG5.
    SMRiQ9NYG5. Positions 5-84.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The RING-type zinc finger domain coordinates an additional third zinc ion.

    Sequence similaritiesi

    Belongs to the RING-box family.Curated
    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri34 – 7744RING-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG316465.
    HOGENOMiHOG000171951.
    HOVERGENiHBG097038.
    KOiK03358.
    OMAiCCPDCPL.
    OrthoDBiEOG7ZKSDB.
    PhylomeDBiQ9NYG5.
    TreeFamiTF354219.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR024991. Apc11.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF12861. zf-Apc11. 1 hit.
    [Graphical view]
    SMARTiSM00184. RING. 1 hit.
    [Graphical view]
    PROSITEiPS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NYG5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKVKIKCWNG VATWLWVAND ENCGICRMAF NGCCPDCKVP GDDCPLVWGQ   50
    CSHCFHMHCI LKWLHAQQVQ QHCPMCRQEW KFKE 84
    Length:84
    Mass (Da):9,841
    Last modified:October 1, 2000 - v1
    Checksum:iEACBD5A54FDC11AE
    GO
    Isoform 2 (identifier: Q9NYG5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         38-84: KVPGDDCPLV...MCRQEWKFKE → PLHGESISRC...PDLALAGGAS

    Note: No experimental confirmation available.

    Show »
    Length:196
    Mass (Da):20,644
    Checksum:iE28CB66699B5B937
    GO

    Sequence cautioni

    The sequence AAF36134.1 differs from that shown. Reason: Frameshift at position 67.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei38 – 8447KVPGD…WKFKE → PLHGESISRCLGWCPQPVPV LGGRAHPQVPINTASPTPGQ HTGSLMSREESSRSPDPTPP ALDQETSSLLRCTSPWCLDH SCDLFGITDQVSADGPRACR QGARRRLPAGVGPVLPLLPH ALHPQVAARTAGAAALPHVP PGMEVQGVRPDLALAGGAS in isoform 2. 1 PublicationVSP_012347Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF247565 mRNA. Translation: AAF65816.1.
    AF247789 mRNA. Translation: AAL95694.1.
    AF151048 mRNA. Translation: AAF36134.1. Frameshift.
    AC145207 Genomic DNA. No translation available.
    BC000607 mRNA. Translation: AAH00607.2.
    BC066308 mRNA. Translation: AAH66308.1.
    BC095454 mRNA. Translation: AAH95454.1.
    BC104641 mRNA. Translation: AAI04642.1.
    BC171892 mRNA. Translation: AAI71892.1.
    BC171898 mRNA. Translation: AAI71898.1.
    BC171899 mRNA. Translation: AAI71899.1.
    BC171900 mRNA. Translation: AAI71900.1.
    CCDSiCCDS11789.1. [Q9NYG5-1]
    CCDS32769.1. [Q9NYG5-2]
    RefSeqiNP_001002244.1. NM_001002244.2. [Q9NYG5-2]
    NP_001002245.1. NM_001002245.2. [Q9NYG5-1]
    NP_001002246.1. NM_001002246.2. [Q9NYG5-1]
    NP_001002247.1. NM_001002247.2. [Q9NYG5-1]
    NP_001002248.1. NM_001002248.2. [Q9NYG5-1]
    NP_001002249.1. NM_001002249.2. [Q9NYG5-1]
    NP_001276343.1. NM_001289414.1. [Q9NYG5-1]
    NP_001276344.1. NM_001289415.1. [Q9NYG5-1]
    NP_001276345.1. NM_001289416.1. [Q9NYG5-1]
    NP_001276346.1. NM_001289417.1. [Q9NYG5-1]
    NP_001276349.1. NM_001289420.1.
    NP_057560.8. NM_016476.11. [Q9NYG5-1]
    UniGeneiHs.534456.

    Genome annotation databases

    GeneIDi51529.
    KEGGihsa:51529.
    UCSCiuc002kbv.1. human. [Q9NYG5-1]
    uc002kby.1. human. [Q9NYG5-2]

    Polymorphism databases

    DMDMi19924286.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF247565 mRNA. Translation: AAF65816.1 .
    AF247789 mRNA. Translation: AAL95694.1 .
    AF151048 mRNA. Translation: AAF36134.1 . Frameshift.
    AC145207 Genomic DNA. No translation available.
    BC000607 mRNA. Translation: AAH00607.2 .
    BC066308 mRNA. Translation: AAH66308.1 .
    BC095454 mRNA. Translation: AAH95454.1 .
    BC104641 mRNA. Translation: AAI04642.1 .
    BC171892 mRNA. Translation: AAI71892.1 .
    BC171898 mRNA. Translation: AAI71898.1 .
    BC171899 mRNA. Translation: AAI71899.1 .
    BC171900 mRNA. Translation: AAI71900.1 .
    CCDSi CCDS11789.1. [Q9NYG5-1 ]
    CCDS32769.1. [Q9NYG5-2 ]
    RefSeqi NP_001002244.1. NM_001002244.2. [Q9NYG5-2 ]
    NP_001002245.1. NM_001002245.2. [Q9NYG5-1 ]
    NP_001002246.1. NM_001002246.2. [Q9NYG5-1 ]
    NP_001002247.1. NM_001002247.2. [Q9NYG5-1 ]
    NP_001002248.1. NM_001002248.2. [Q9NYG5-1 ]
    NP_001002249.1. NM_001002249.2. [Q9NYG5-1 ]
    NP_001276343.1. NM_001289414.1. [Q9NYG5-1 ]
    NP_001276344.1. NM_001289415.1. [Q9NYG5-1 ]
    NP_001276345.1. NM_001289416.1. [Q9NYG5-1 ]
    NP_001276346.1. NM_001289417.1. [Q9NYG5-1 ]
    NP_001276349.1. NM_001289420.1.
    NP_057560.8. NM_016476.11. [Q9NYG5-1 ]
    UniGenei Hs.534456.

    3D structure databases

    ProteinModelPortali Q9NYG5.
    SMRi Q9NYG5. Positions 5-84.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119591. 36 interactions.
    IntActi Q9NYG5. 12 interactions.
    STRINGi 9606.ENSP00000349957.

    PTM databases

    PhosphoSitei Q9NYG5.

    Polymorphism databases

    DMDMi 19924286.

    Proteomic databases

    MaxQBi Q9NYG5.
    PaxDbi Q9NYG5.
    PRIDEi Q9NYG5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 51529.
    KEGGi hsa:51529.
    UCSCi uc002kbv.1. human. [Q9NYG5-1 ]
    uc002kby.1. human. [Q9NYG5-2 ]

    Organism-specific databases

    CTDi 51529.
    GeneCardsi GC17P079849.
    HGNCi HGNC:14452. ANAPC11.
    HPAi HPA021989.
    HPA027838.
    MIMi 614534. gene.
    neXtProti NX_Q9NYG5.
    PharmGKBi PA24787.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG316465.
    HOGENOMi HOG000171951.
    HOVERGENi HBG097038.
    KOi K03358.
    OMAi CCPDCPL.
    OrthoDBi EOG7ZKSDB.
    PhylomeDBi Q9NYG5.
    TreeFami TF354219.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .
    Reactomei REACT_1072. Inactivation of APC/C via direct inhibition of the APC/C complex.
    REACT_150471. Separation of Sister Chromatids.
    REACT_169168. Senescence-Associated Secretory Phenotype (SASP).
    REACT_6761. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
    REACT_6781. APC/C:Cdc20 mediated degradation of mitotic proteins.
    REACT_6785. Autodegradation of Cdh1 by Cdh1:APC/C.
    REACT_6820. APC/C:Cdc20 mediated degradation of Cyclin B.
    REACT_6837. Regulation of APC/C activators between G1/S and early anaphase.
    REACT_6867. Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase.
    REACT_6871. APC/C:Cdc20 mediated degradation of Securin.
    REACT_6904. Phosphorylation of the APC/C.
    REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.

    Miscellaneous databases

    GeneWikii ANAPC11.
    GenomeRNAii 51529.
    NextBioi 55250.
    PROi Q9NYG5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9NYG5.
    CleanExi HS_ANAPC11.
    Genevestigatori Q9NYG5.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR024991. Apc11.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF12861. zf-Apc11. 1 hit.
    [Graphical view ]
    SMARTi SM00184. RING. 1 hit.
    [Graphical view ]
    PROSITEi PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of a RING-H2 finger protein, ANAPC11, the human homolog of yeast Apc11p."
      Chan A.H., Lee S.M.Y., Chim S.S., Kok L.D., Waye M.M.Y., Lee C.Y., Fung K.P., Tsui S.K.W.
      J. Cell. Biochem. 83:249-258(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    2. "Novel human APC11 anaphase-promoting complex subunit."
      Li N., Wan T., Zhang W., Cao X.
      Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
      Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
      , Gu J., Chen S.-J., Chen Z.
      Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Umbilical cord blood.
    4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain, Skin and Testis.
    6. "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex."
      Gmachl M., Gieffers C., Podtelejnikov A.V., Mann M., Peters J.-M.
      Proc. Natl. Acad. Sci. U.S.A. 97:8973-8978(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN APC/C COMPLEX.
    7. "APC2 cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex."
      Tang Z., Li B., Bharadwaj R., Zhu H., Oezkan E., Hakala K., Deisenhofer J., Yu H.
      Mol. Biol. Cell 12:3839-3851(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, MUTAGENESIS, INTERACTION WITH ANAPC2 AND UBE2D2.
    8. "Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex."
      Jin L., Williamson A., Banerjee S., Philipp I., Rape M.
      Cell 133:653-665(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION OF THE APC/C.
    9. "Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C."
      Dube P., Herzog F., Gieffers C., Sander B., Riedel D., Mueller S.A., Engel A., Peters J.-M., Stark H.
      Mol. Cell 20:867-879(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: ELECTRON MICROSCOPY OF THE APC/C.

    Entry informationi

    Entry nameiAPC11_HUMAN
    AccessioniPrimary (citable) accession number: Q9NYG5
    Secondary accession number(s): A8MTT2
    , B7ZW64, Q502X9, Q9BW64, Q9P0R2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 131 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3