Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Palmitoyltransferase ZDHHC3

Gene

ZDHHC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Palmitoyltransferase with broad specificity. Palmitoylates GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3), which regulates synaptic clustering and/or cell surface stability. Palmitoylates glutamate receptors GRIA1 and GRIA2, which leads to their retention in Golgi. May also palmitoylate DLG4, DNAJC5 and SNAP25.By similarity1 Publication

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri127 – 17751DHHC-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • protein palmitoylation Source: UniProtKB
  • protein targeting Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC3Curated (EC:2.3.1.2251 Publication)
Alternative name(s):
Protein DHHC1Imported
Zinc finger DHHC domain-containing protein 3Imported
Short name:
DHHC-3Imported
Gene namesi
Name:ZDHHC3Imported
ORF Names:HSD49Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:18470. ZDHHC3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4747CytoplasmicSequence analysisAdd
BLAST
Transmembranei48 – 6821HelicalSequence analysisAdd
BLAST
Topological domaini69 – 724ExtracellularSequence analysis
Transmembranei73 – 9321HelicalSequence analysisAdd
BLAST
Topological domaini94 – 17178CytoplasmicSequence analysisAdd
BLAST
Transmembranei172 – 19221HelicalSequence analysisAdd
BLAST
Topological domaini193 – 21422ExtracellularSequence analysisAdd
BLAST
Transmembranei215 – 23521HelicalSequence analysisAdd
BLAST
Topological domaini236 – 29964CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • Golgi apparatus Source: UniProtKB
  • Golgi membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38544.

Polymorphism and mutation databases

BioMutaiZDHHC3.
DMDMi476007823.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299Palmitoyltransferase ZDHHC3PRO_0000422064Add
BLAST

Post-translational modificationi

Autopalmitoylated.By similarity

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

EPDiQ9NYG2.
MaxQBiQ9NYG2.
PRIDEiQ9NYG2.

PTM databases

PhosphoSiteiQ9NYG2.
SwissPalmiQ9NYG2.

Expressioni

Gene expression databases

BgeeiQ9NYG2.
CleanExiHS_ZDHHC3.
ExpressionAtlasiQ9NYG2. baseline and differential.
GenevisibleiQ9NYG2. HS.

Organism-specific databases

HPAiCAB012465.
HPA016616.

Interactioni

Protein-protein interaction databases

BioGridi119455. 5 interactions.
IntActiQ9NYG2. 4 interactions.
MINTiMINT-1185015.

Structurei

3D structure databases

ProteinModelPortaliQ9NYG2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated
Contains 1 DHHC-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri127 – 17751DHHC-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00840000129737.
HOGENOMiHOG000234755.
HOVERGENiHBG056583.
InParanoidiQ9NYG2.
KOiK18932.
OMAiISHALIM.
TreeFamiTF319798.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. ZF_DHHC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NYG2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMLIPTHHFR NIERKPEYLQ PEKCVPPPYP GPVGTMWFIR DGCGIACAIV
60 70 80 90 100
TWFLVLYAEF VVLFVMLIPS RDYVYSIING IVFNLLAFLA LASHCRAMLT
110 120 130 140 150
DPGAVPKGNA TKEFIESLQL KPGQVVYKCP KCCSIKPDRA HHCSVCKRCI
160 170 180 190 200
RKMDHHCPWV NNCVGENNQK YFVLFTMYIA LISLHALIMV GFHFLHCFEE
210 220 230 240 250
DWTKCSSFSP PTTVILLILL CFEGLLFLIF TSVMFGTQVH SICTDETGIE
260 270 280 290
QLKKEERRWA KKTKWMNMKA VFGHPFSLGW ASPFATPDQG KADPYQYVV
Length:299
Mass (Da):34,170
Last modified:April 3, 2013 - v2
Checksum:i345A960FCB46E0E1
GO
Isoform 2 (identifier: Q9NYG2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     204-204: K → TYGLNREEMAETGISLHEKMQPLNFSSTE

Show »
Length:327
Mass (Da):37,338
Checksum:i3982186DE17725F7
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei204 – 2041K → TYGLNREEMAETGISLHEKM QPLNFSSTE in isoform 2. 2 PublicationsVSP_006934

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF247703 mRNA. Translation: AAF63570.1.
AF441791 mRNA. Translation: AAL34547.1.
BC015467 mRNA. Translation: AAH15467.1.
AY605661 mRNA. Translation: AAV83779.1.
CCDSiCCDS2724.1. [Q9NYG2-2]
CCDS46811.1. [Q9NYG2-1]
RefSeqiNP_001128651.1. NM_001135179.1. [Q9NYG2-1]
NP_057682.1. NM_016598.2. [Q9NYG2-2]
UniGeneiHs.61430.

Genome annotation databases

EnsembliENST00000296127; ENSP00000296127; ENSG00000163812. [Q9NYG2-2]
ENST00000424952; ENSP00000395502; ENSG00000163812. [Q9NYG2-1]
GeneIDi51304.
KEGGihsa:51304.
UCSCiuc003cod.4. human. [Q9NYG2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF247703 mRNA. Translation: AAF63570.1.
AF441791 mRNA. Translation: AAL34547.1.
BC015467 mRNA. Translation: AAH15467.1.
AY605661 mRNA. Translation: AAV83779.1.
CCDSiCCDS2724.1. [Q9NYG2-2]
CCDS46811.1. [Q9NYG2-1]
RefSeqiNP_001128651.1. NM_001135179.1. [Q9NYG2-1]
NP_057682.1. NM_016598.2. [Q9NYG2-2]
UniGeneiHs.61430.

3D structure databases

ProteinModelPortaliQ9NYG2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119455. 5 interactions.
IntActiQ9NYG2. 4 interactions.
MINTiMINT-1185015.

PTM databases

PhosphoSiteiQ9NYG2.
SwissPalmiQ9NYG2.

Polymorphism and mutation databases

BioMutaiZDHHC3.
DMDMi476007823.

Proteomic databases

EPDiQ9NYG2.
MaxQBiQ9NYG2.
PRIDEiQ9NYG2.

Protocols and materials databases

DNASUi51304.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296127; ENSP00000296127; ENSG00000163812. [Q9NYG2-2]
ENST00000424952; ENSP00000395502; ENSG00000163812. [Q9NYG2-1]
GeneIDi51304.
KEGGihsa:51304.
UCSCiuc003cod.4. human. [Q9NYG2-1]

Organism-specific databases

CTDi51304.
GeneCardsiZDHHC3.
HGNCiHGNC:18470. ZDHHC3.
HPAiCAB012465.
HPA016616.
neXtProtiNX_Q9NYG2.
PharmGKBiPA38544.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00840000129737.
HOGENOMiHOG000234755.
HOVERGENiHBG056583.
InParanoidiQ9NYG2.
KOiK18932.
OMAiISHALIM.
TreeFamiTF319798.

Miscellaneous databases

ChiTaRSiZDHHC3. human.
GeneWikiiZDHHC3.
GenomeRNAii51304.
NextBioi54613.
PROiQ9NYG2.

Gene expression databases

BgeeiQ9NYG2.
CleanExiHS_ZDHHC3.
ExpressionAtlasiQ9NYG2. baseline and differential.
GenevisibleiQ9NYG2. HS.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. ZF_DHHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DHHC domain-containing protein from human T-cell."
    Hameed K.S., Greenberg A.H.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. Hong G.S., Jung Y.K.
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Thymus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon.
  4. "A new spermatogenesis-related gene."
    Yuan L.G., Tian Y.Q., Qiao Y., Miao S.Y., Wang L.F.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 103-284 (ISOFORM 2).
    Tissue: Testis.
  5. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system."
    Ohno Y., Kashio A., Ogata R., Ishitomi A., Yamazaki Y., Kihara A.
    Mol. Biol. Cell 23:4543-4551(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY.

Entry informationi

Entry nameiZDHC3_HUMAN
AccessioniPrimary (citable) accession number: Q9NYG2
Secondary accession number(s): Q53A17, Q96BL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: April 3, 2013
Last modified: May 11, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.