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Protein

Palmitoyltransferase ZDHHC3

Gene

ZDHHC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Palmitoyltransferase with broad specificity. Palmitoylates GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3), which regulates synaptic clustering and/or cell surface stability. Palmitoylates glutamate receptors GRIA1 and GRIA2, which leads to their retention in Golgi. May also palmitoylate DLG4, DNAJC5 and SNAP25.By similarity1 Publication

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.1 Publication

GO - Molecular functioni

GO - Biological processi

  • protein palmitoylation Source: UniProtKB
  • protein targeting Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163812-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC3Curated (EC:2.3.1.2251 Publication)
Alternative name(s):
Protein DHHC1Imported
Zinc finger DHHC domain-containing protein 3Imported
Short name:
DHHC-3Imported
Gene namesi
Name:ZDHHC3Imported
ORF Names:HSD49Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:18470. ZDHHC3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 47CytoplasmicSequence analysisAdd BLAST47
Transmembranei48 – 68HelicalSequence analysisAdd BLAST21
Topological domaini69 – 72ExtracellularSequence analysis4
Transmembranei73 – 93HelicalSequence analysisAdd BLAST21
Topological domaini94 – 171CytoplasmicSequence analysisAdd BLAST78
Transmembranei172 – 192HelicalSequence analysisAdd BLAST21
Topological domaini193 – 214ExtracellularSequence analysisAdd BLAST22
Transmembranei215 – 235HelicalSequence analysisAdd BLAST21
Topological domaini236 – 299CytoplasmicSequence analysisAdd BLAST64

GO - Cellular componenti

  • Golgi apparatus Source: UniProtKB
  • Golgi membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000163812.
ENSG00000280674.
PharmGKBiPA38544.

Polymorphism and mutation databases

BioMutaiZDHHC3.
DMDMi476007823.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004220641 – 299Palmitoyltransferase ZDHHC3Add BLAST299

Post-translational modificationi

Autopalmitoylated.By similarity

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

EPDiQ9NYG2.
MaxQBiQ9NYG2.
PeptideAtlasiQ9NYG2.
PRIDEiQ9NYG2.

PTM databases

iPTMnetiQ9NYG2.
PhosphoSitePlusiQ9NYG2.
SwissPalmiQ9NYG2.

Expressioni

Gene expression databases

BgeeiENSG00000163812.
CleanExiHS_ZDHHC3.
ExpressionAtlasiQ9NYG2. baseline and differential.
GenevisibleiQ9NYG2. HS.

Organism-specific databases

HPAiCAB012465.
HPA016616.

Interactioni

Protein-protein interaction databases

BioGridi119455. 5 interactors.
IntActiQ9NYG2. 4 interactors.
MINTiMINT-1185015.

Structurei

3D structure databases

ProteinModelPortaliQ9NYG2.
SMRiQ9NYG2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini127 – 177DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated
Contains 1 DHHC domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00850000132259.
HOGENOMiHOG000234755.
HOVERGENiHBG056583.
InParanoidiQ9NYG2.
KOiK20029.
OMAiAMLTDPX.
TreeFamiTF319798.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. DHHC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NYG2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMLIPTHHFR NIERKPEYLQ PEKCVPPPYP GPVGTMWFIR DGCGIACAIV
60 70 80 90 100
TWFLVLYAEF VVLFVMLIPS RDYVYSIING IVFNLLAFLA LASHCRAMLT
110 120 130 140 150
DPGAVPKGNA TKEFIESLQL KPGQVVYKCP KCCSIKPDRA HHCSVCKRCI
160 170 180 190 200
RKMDHHCPWV NNCVGENNQK YFVLFTMYIA LISLHALIMV GFHFLHCFEE
210 220 230 240 250
DWTKCSSFSP PTTVILLILL CFEGLLFLIF TSVMFGTQVH SICTDETGIE
260 270 280 290
QLKKEERRWA KKTKWMNMKA VFGHPFSLGW ASPFATPDQG KADPYQYVV
Length:299
Mass (Da):34,170
Last modified:April 3, 2013 - v2
Checksum:i345A960FCB46E0E1
GO
Isoform 2 (identifier: Q9NYG2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     204-204: K → TYGLNREEMAETGISLHEKMQPLNFSSTE

Show »
Length:327
Mass (Da):37,338
Checksum:i3982186DE17725F7
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006934204K → TYGLNREEMAETGISLHEKM QPLNFSSTE in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF247703 mRNA. Translation: AAF63570.1.
AF441791 mRNA. Translation: AAL34547.1.
BC015467 mRNA. Translation: AAH15467.1.
AY605661 mRNA. Translation: AAV83779.1.
CCDSiCCDS2724.1. [Q9NYG2-2]
CCDS46811.1. [Q9NYG2-1]
RefSeqiNP_001128651.1. NM_001135179.1. [Q9NYG2-1]
NP_057682.1. NM_016598.2. [Q9NYG2-2]
XP_016862055.1. XM_017006566.1. [Q9NYG2-1]
XP_016862056.1. XM_017006567.1. [Q9NYG2-1]
UniGeneiHs.61430.

Genome annotation databases

EnsembliENST00000296127; ENSP00000296127; ENSG00000163812. [Q9NYG2-2]
ENST00000424952; ENSP00000395502; ENSG00000163812. [Q9NYG2-1]
ENST00000628351; ENSP00000486386; ENSG00000280674. [Q9NYG2-1]
ENST00000630389; ENSP00000485706; ENSG00000280674. [Q9NYG2-2]
GeneIDi51304.
KEGGihsa:51304.
UCSCiuc003cod.4. human. [Q9NYG2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF247703 mRNA. Translation: AAF63570.1.
AF441791 mRNA. Translation: AAL34547.1.
BC015467 mRNA. Translation: AAH15467.1.
AY605661 mRNA. Translation: AAV83779.1.
CCDSiCCDS2724.1. [Q9NYG2-2]
CCDS46811.1. [Q9NYG2-1]
RefSeqiNP_001128651.1. NM_001135179.1. [Q9NYG2-1]
NP_057682.1. NM_016598.2. [Q9NYG2-2]
XP_016862055.1. XM_017006566.1. [Q9NYG2-1]
XP_016862056.1. XM_017006567.1. [Q9NYG2-1]
UniGeneiHs.61430.

3D structure databases

ProteinModelPortaliQ9NYG2.
SMRiQ9NYG2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119455. 5 interactors.
IntActiQ9NYG2. 4 interactors.
MINTiMINT-1185015.

PTM databases

iPTMnetiQ9NYG2.
PhosphoSitePlusiQ9NYG2.
SwissPalmiQ9NYG2.

Polymorphism and mutation databases

BioMutaiZDHHC3.
DMDMi476007823.

Proteomic databases

EPDiQ9NYG2.
MaxQBiQ9NYG2.
PeptideAtlasiQ9NYG2.
PRIDEiQ9NYG2.

Protocols and materials databases

DNASUi51304.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296127; ENSP00000296127; ENSG00000163812. [Q9NYG2-2]
ENST00000424952; ENSP00000395502; ENSG00000163812. [Q9NYG2-1]
ENST00000628351; ENSP00000486386; ENSG00000280674. [Q9NYG2-1]
ENST00000630389; ENSP00000485706; ENSG00000280674. [Q9NYG2-2]
GeneIDi51304.
KEGGihsa:51304.
UCSCiuc003cod.4. human. [Q9NYG2-1]

Organism-specific databases

CTDi51304.
GeneCardsiZDHHC3.
HGNCiHGNC:18470. ZDHHC3.
HPAiCAB012465.
HPA016616.
neXtProtiNX_Q9NYG2.
OpenTargetsiENSG00000163812.
ENSG00000280674.
PharmGKBiPA38544.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00850000132259.
HOGENOMiHOG000234755.
HOVERGENiHBG056583.
InParanoidiQ9NYG2.
KOiK20029.
OMAiAMLTDPX.
TreeFamiTF319798.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163812-MONOMER.

Miscellaneous databases

ChiTaRSiZDHHC3. human.
GeneWikiiZDHHC3.
GenomeRNAii51304.
PROiQ9NYG2.

Gene expression databases

BgeeiENSG00000163812.
CleanExiHS_ZDHHC3.
ExpressionAtlasiQ9NYG2. baseline and differential.
GenevisibleiQ9NYG2. HS.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. DHHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZDHC3_HUMAN
AccessioniPrimary (citable) accession number: Q9NYG2
Secondary accession number(s): Q53A17, Q96BL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: April 3, 2013
Last modified: November 2, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.