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Protein

Protein FAM53C

Gene

FAM53C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000120709-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM53C
Gene namesi
Name:FAM53C
Synonyms:C5orf6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:1336. FAM53C.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000120709.
PharmGKBiPA25917.

Polymorphism and mutation databases

BioMutaiFAM53C.
DMDMi66774134.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001895461 – 392Protein FAM53CAdd BLAST392

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei122PhosphoserineCombined sources1
Modified residuei162PhosphoserineCombined sources1
Modified residuei232PhosphoserineCombined sources1
Modified residuei234PhosphoserineCombined sources1
Modified residuei255PhosphoserineCombined sources1
Modified residuei273PhosphoserineCombined sources1
Modified residuei299PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9NYF3.
MaxQBiQ9NYF3.
PaxDbiQ9NYF3.
PeptideAtlasiQ9NYF3.
PRIDEiQ9NYF3.

PTM databases

iPTMnetiQ9NYF3.
PhosphoSitePlusiQ9NYF3.

Expressioni

Gene expression databases

BgeeiENSG00000120709.
CleanExiHS_FAM53C.
ExpressionAtlasiQ9NYF3. baseline and differential.
GenevisibleiQ9NYF3. HS.

Organism-specific databases

HPAiHPA042796.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HEL2V9HW983EBI-1644252,EBI-10190883
NCK2O436393EBI-1644252,EBI-713635
SFNP319473EBI-1644252,EBI-476295
YWHAGP619814EBI-1644252,EBI-359832

Protein-protein interaction databases

BioGridi119458. 12 interactors.
IntActiQ9NYF3. 13 interactors.
STRINGi9606.ENSP00000239906.

Structurei

3D structure databases

ProteinModelPortaliQ9NYF3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM53 family.Curated

Phylogenomic databases

eggNOGiENOG410IIF0. Eukaryota.
ENOG410YEWD. LUCA.
GeneTreeiENSGT00530000063371.
HOGENOMiHOG000059662.
HOVERGENiHBG051537.
InParanoidiQ9NYF3.
OMAiNSPQEQP.
OrthoDBiEOG091G091O.
PhylomeDBiQ9NYF3.
TreeFamiTF332095.

Family and domain databases

InterProiIPR029356. FAM53.
[Graphical view]
PfamiPF15242. FAM53. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NYF3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITLITEQLQ KQTLDELKCT RFSISLPLPD HADISNCGNS FQLVSEGASW
60 70 80 90 100
RGLPHCSCAE FQDSLNFSYH PSGLSLHLRP PSRGNSPKEQ PFSQVLRPEP
110 120 130 140 150
PDPEKLPVPP APPSKRHCRS LSVPVDLSRW QPVWRPAPSK LWTPIKHRGS
160 170 180 190 200
GGGGGPQVPH QSPPKRVSSL RFLQAPSASS QCAPAHRPYS PPFFSLALAQ
210 220 230 240 250
DSSRPCAASP QSGSWESDAE SLSPCPPQRR FSLSPSLGPQ ASRFLPSARS
260 270 280 290 300
SPASSPELPW RPRGLRNLPR SRSQPCDLDA RKTGVKRRHE EDPRRLRPSL
310 320 330 340 350
DFDKMNQKPY SGGLCLQETA REGSSISPPW FMACSPPPLS ASCSPTGGSS
360 370 380 390
QVLSESEEEE EGAVRWGRQA LSKRTLCQRD FGDLDLNLIE EN
Length:392
Mass (Da):43,091
Last modified:October 1, 2000 - v1
Checksum:i28ED288D94D81073
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05308921R → C.Corresponds to variant rs35360938dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251040 mRNA. Translation: AAF63766.1.
AK315567 mRNA. Translation: BAG37942.1.
CH471062 Genomic DNA. Translation: EAW62143.1.
CH471062 Genomic DNA. Translation: EAW62144.1.
BC000259 mRNA. Translation: AAH00259.1.
BC052993 mRNA. Translation: AAH52993.1.
CCDSiCCDS4204.1.
RefSeqiNP_001129119.1. NM_001135647.1.
NP_057689.1. NM_016605.2.
UniGeneiHs.54056.

Genome annotation databases

EnsembliENST00000239906; ENSP00000239906; ENSG00000120709.
ENST00000434981; ENSP00000403705; ENSG00000120709.
GeneIDi51307.
KEGGihsa:51307.
UCSCiuc003lcv.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251040 mRNA. Translation: AAF63766.1.
AK315567 mRNA. Translation: BAG37942.1.
CH471062 Genomic DNA. Translation: EAW62143.1.
CH471062 Genomic DNA. Translation: EAW62144.1.
BC000259 mRNA. Translation: AAH00259.1.
BC052993 mRNA. Translation: AAH52993.1.
CCDSiCCDS4204.1.
RefSeqiNP_001129119.1. NM_001135647.1.
NP_057689.1. NM_016605.2.
UniGeneiHs.54056.

3D structure databases

ProteinModelPortaliQ9NYF3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119458. 12 interactors.
IntActiQ9NYF3. 13 interactors.
STRINGi9606.ENSP00000239906.

PTM databases

iPTMnetiQ9NYF3.
PhosphoSitePlusiQ9NYF3.

Polymorphism and mutation databases

BioMutaiFAM53C.
DMDMi66774134.

Proteomic databases

EPDiQ9NYF3.
MaxQBiQ9NYF3.
PaxDbiQ9NYF3.
PeptideAtlasiQ9NYF3.
PRIDEiQ9NYF3.

Protocols and materials databases

DNASUi51307.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000239906; ENSP00000239906; ENSG00000120709.
ENST00000434981; ENSP00000403705; ENSG00000120709.
GeneIDi51307.
KEGGihsa:51307.
UCSCiuc003lcv.4. human.

Organism-specific databases

CTDi51307.
GeneCardsiFAM53C.
H-InvDBHIX0200731.
HGNCiHGNC:1336. FAM53C.
HPAiHPA042796.
MIMi609372. gene.
neXtProtiNX_Q9NYF3.
OpenTargetsiENSG00000120709.
PharmGKBiPA25917.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIF0. Eukaryota.
ENOG410YEWD. LUCA.
GeneTreeiENSGT00530000063371.
HOGENOMiHOG000059662.
HOVERGENiHBG051537.
InParanoidiQ9NYF3.
OMAiNSPQEQP.
OrthoDBiEOG091G091O.
PhylomeDBiQ9NYF3.
TreeFamiTF332095.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000120709-MONOMER.

Miscellaneous databases

ChiTaRSiFAM53C. human.
GenomeRNAii51307.
PROiQ9NYF3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000120709.
CleanExiHS_FAM53C.
ExpressionAtlasiQ9NYF3. baseline and differential.
GenevisibleiQ9NYF3. HS.

Family and domain databases

InterProiIPR029356. FAM53.
[Graphical view]
PfamiPF15242. FAM53. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFA53C_HUMAN
AccessioniPrimary (citable) accession number: Q9NYF3
Secondary accession number(s): B2RDJ5, D3DQB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.