Q9NYF0 (DACT1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dapper homolog 1
Short name=hDPR1

Alternative name(s):
Hepatocellular carcinoma novel gene 3 protein

Gene names

Name:	DACT1
Synonyms:	DPR1, HNG3

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	836 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Positively regulates DVL2-mediated signaling pathways during development. Binds to DVL2 and impedes the degradation of CTNNB1/beta-catenin, thereby enhancing the transcriptional activation of target genes of the Wnt signaling pathway By similarity.
Subunit structure	Interacts with DVL1 and DVL2 By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Domain	The C-terminal PDZ-binding motif mediates interaction with the PDZ domains of DSH (Dishevelled) family proteins By similarity.
Sequence similarities	Belongs to the dapper family.
Sequence caution	The sequence AAF65569.1 differs from that shown. Reason: Erroneous initiation. The sequence CAD61905.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Wnt signaling pathway
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Polymorphism
Domain	Coiled coil
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	Wnt receptor signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 836	836	Dapper homolog 1		PRO_0000191353
Regions
	Coiled coil	92 – 156	65	Potential
	Motif	826 – 836	11	PDZ-binding By similarity
Natural variations
	Natural variant	124	1	G → C in a colorectal cancer sample; somatic mutation. Ref.5		VAR_036461
	Natural variant	446	1	D → N. Corresponds to variant rs34015825 [ dbSNP | Ensembl ].		VAR_053057
	Natural variant	464	1	A → V. Ref.3 Corresponds to variant rs17832998 [ dbSNP | Ensembl ].		VAR_053058
	Natural variant	628	1	S → A. Corresponds to variant rs17094821 [ dbSNP | Ensembl ].		VAR_053059
	Natural variant	682	1	S → L in a colorectal cancer sample; somatic mutation. Ref.5		VAR_036462
	Natural variant	697	1	G → S. Corresponds to variant rs698025 [ dbSNP | Ensembl ].		VAR_053060

Sequences

	Sequence		Length	Mass (Da)
	Q9NYF0 [UniParc]. Last modified August 15, 2003. Version 2. Checksum: 10B77DC5B7C73485	FASTA	836	90,174
	10 20 30 40 50 60 MKPSPAGTAK ELEPPAPARG EQRTAEPEGR WREKGEADTE RQRTRERQEA TLAGLAELEY 70 80 90 100 110 120 LRQRQELLVR GALRGAGGAG AAAPRAGELL GEAAQRSRLE EKFLEENILL LRKQLNCLRR 130 140 150 160 170 180 RDAGLLNQLQ ELDKQISDLR LDVEKTSEEH LETDSRPSSG FYELSDGASG SLSNSSNSVF 190 200 210 220 230 240 SECLSSCHSS TCFCSPLEAT LSLSDGCPKS ADLIGLLEYK EGHCEDQASG AVCRSLSTPQ 250 260 270 280 290 300 FNSLDVIADV NPKYQCDLVS KNGNDVYRYP SPLHAVAVQS PMFLLCLTGN PLREEDRLGN 310 320 330 340 350 360 HASDICGGSE LDAVKTDSSL PSPSSLWSAS HPSSSKKMDG YILSLVQKKT HPVRTNKPRT 370 380 390 400 410 420 SVNADPTKGL LRNGSVCVRA PGGVSQGNSV NLKNSKQACL PSGGIPSLNN GTFSPPKQWS 430 440 450 460 470 480 KESKAEQAES KRVPLPEGCP SGAASDLQSK HLPKTAKPAS QEHARCSAIG TGESPKESAQ 490 500 510 520 530 540 LSGASPKESP SRGPAPPQEN KVVQPLKKMS QKNSLQGVPP ATPPLLSTAF PVEERPALDF 550 560 570 580 590 600 KSEGSSQSLE EAHLVKAQFI PGQQPSVRLH RGHRNMGVVK NSSLKHRGPA LQGLENGLPT 610 620 630 640 650 660 VREKTRAGSK KCRFPDDLDT NKKLKKASSK GRKSGGGPEA GVPGRPAGGG HRAGSRAHGH 670 680 690 700 710 720 GREAVVAKPK HKRTDYRRWK SSAEISYEEA LRRARRGRRE NVGLYPAPVP LPYASPYAYV 730 740 750 760 770 780 ASDSEYSAEC ESLFHSTVVD TSEDEQSNYT TNCFGDSESS VSEGEFVGES TTTSDSEESG 790 800 810 820 830 GLIWSQFVQT LPIQTVTAPD LHNHPAKTFV KIKASHNLKK KILRFRSGSL KLMTTV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed: 12508121] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Full-length cDNA libraries and normalization." Li W.B., Gruber C., Jessee J., Polayes D. Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 212-836. Tissue: Placenta.
[3]	"Cloning of a murine cDNA and its human homolog encoding transcription factor-like proteins." Gong S., Qian X., Fu W., Chen W. Zhongguo Sheng Wu Hua Xue Yu Fen Zi Sheng Wu Xue Bao 17:280-287(2001) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 248-836, VARIANT VAL-464.
[4]	"Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation." Cheyette B.N.R., Waxman J.S., Miller J.R., Takemaru K., Sheldahl L.C., Khlebtsova N., Fox E.P., Earnest T.N., Moon R.T. Dev. Cell 2:449-461(2002) [PubMed: 11970895] [Abstract] Cited for: IDENTIFICATION.
[5]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] CYS-124 AND LEU-682.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL133312 Genomic DNA. No translation available. BX161433 mRNA. Translation: CAD61905.1. Different initiation. AF251079 mRNA. Translation: AAF65569.1. Different initiation. BK000256 mRNA. Translation: DAA00310.1.
IPI	IPI00171594.
RefSeq	NP_057735.2. NM_016651.5.
UniGene	Hs.48950. Hs.714204.
3D structure databases
ProteinModelPortal	Q9NYF0.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NYF0. 2 interactions.
STRING	Q9NYF0.
PTM databases
PhosphoSite	Q9NYF0.
Polymorphism databases
DMDM	34098740.
Proteomic databases
PRIDE	Q9NYF0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000335867; ENSP00000337439; ENSG00000165617.
GeneID	51339.
KEGG	hsa:51339.
UCSC	uc001xdw.1. human.
Organism-specific databases
CTD	51339.
GeneCards	GC14P059100.
HGNC	HGNC:17748. DACT1.
HPA	HPA003016.
MIM	607861. gene.
neXtProt	NX_Q9NYF0.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00530000063890.
HOGENOM	HBG280157.
HOVERGEN	HBG051286.
InParanoid	Q9NYF0.
OMA	LNCLRRR.
PhylomeDB	Q9NYF0.
Gene expression databases
ArrayExpress	Q9NYF0.
Bgee	Q9NYF0.
CleanEx	HS_DACT1.
Genevestigator	Q9NYF0.
GermOnline	ENSG00000165617. Homo sapiens.
Family and domain databases
InterPro	IPR024848. Dact1. IPR024843. Dapper. [Graphical view]
PANTHER	PTHR15919. PTHR15919. 1 hit. PTHR15919:SF5. PTHR15919:SF5. 1 hit.
ProtoNet	Search...
Other
NextBio	54776.
SOURCE	Search...

Entry information

Entry name

DACT1_HUMAN

Accession

Primary (citable) accession number: Q9NYF0
Secondary accession number(s): Q86TY0

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 15, 2003
Last sequence update:	August 15, 2003
Last modified:	January 25, 2012
This is version 81 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.