Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9NYD6 (HXC10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-C10
Alternative name(s):
Homeobox protein Hox-3I
Gene names
Name:HOXC10
Synonyms:HOX3I
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length342 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the Abd-B homeobox family.

Contains 1 homeobox DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 342342Homeobox protein Hox-C10
PRO_0000200190

Regions

DNA binding268 – 32760Homeobox

Amino acid modifications

Modified residue1891Phosphoserine Ref.5

Experimental info

Sequence conflict1181K → N in AAF67759. Ref.1
Sequence conflict2651A → G in CAA68000. Ref.3
Sequence conflict2711Missing in CAA68000. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9NYD6 [UniParc].

Last modified January 23, 2002. Version 2.
Checksum: BD8127FD43C2A37B

FASTA34238,073
        10         20         30         40         50         60 
MTCPRNVTPN SYAEPLAAPG GGERYSRSAG MYMQSGSDFN CGVMRGCGLA PSLSKRDEGS 

        70         80         90        100        110        120 
SPSLALNTYP SYLSQLDSWG DPKAAYRLEQ PVGRPLSSCS YPPSVKEENV CCMYSAEKRA 

       130        140        150        160        170        180 
KSGPEAALYS HPLPESCLGE HEVPVPSYYR ASPSYSALDK TPHCSGANDF EAPFEQRASL 

       190        200        210        220        230        240 
NPRAEHLESP QLGGKVSFPE TPKSDSQTPS PNEIKTEQSL AGPKGSPSES EKERAKAADS 

       250        260        270        280        290        300 
SPDTSDNEAK EEIKAENTTG NWLTAKSGRK KRCPYTKHQT LELEKEFLFN MYLTRERRLE 

       310        320        330        340 
ISKTINLTDR QVKIWFQNRR MKLKKMNREN RIRELTSNFN FT 

« Hide

References

« Hide 'large scale' references
[1]"Selection of homeotic proteins for binding to a human DNA replication origin."
de Stanchina E., Gabellini D., Norio P., Giacca M., Peverali F.A., Riva S., Falaschi A., Biamonti G.
J. Mol. Biol. 299:667-680(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Cervix.
[3]"Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines."
Flagiello D., Gibaud A., Dutrillaux B., Poupon M.-F., Malfoy B.
FEBS Lett. 415:263-267(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 94-106 AND 258-297.
[4]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[5]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-189, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF255675 mRNA. Translation: AAF67759.1.
BC001293 mRNA. Translation: AAH01293.1.
X99684 mRNA. Translation: CAA67999.1.
X99685 mRNA. Translation: CAA68000.1.
CCDSCCDS8868.1.
PIRB60941.
RefSeqNP_059105.2. NM_017409.3.
UniGeneHs.44276.

3D structure databases

ProteinModelPortalQ9NYD6.
SMRQ9NYD6. Positions 269-327.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109466. 6 interactions.
IntActQ9NYD6. 3 interactions.
STRING9606.ENSP00000307321.

PTM databases

PhosphoSiteQ9NYD6.

Proteomic databases

MaxQBQ9NYD6.
PaxDbQ9NYD6.
PRIDEQ9NYD6.

Protocols and materials databases

DNASU3226.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000303460; ENSP00000307321; ENSG00000180818.
GeneID3226.
KEGGhsa:3226.
UCSCuc001sen.3. human.

Organism-specific databases

CTD3226.
GeneCardsGC12P054378.
HGNCHGNC:5122. HOXC10.
HPACAB046474.
HPA053919.
MIM605560. gene.
neXtProtNX_Q9NYD6.
PharmGKBPA29397.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG269631.
HOGENOMHOG000231182.
HOVERGENHBG052934.
InParanoidQ9NYD6.
KOK17444.
OMACPRNVTP.
PhylomeDBQ9NYD6.
TreeFamTF317819.

Gene expression databases

ArrayExpressQ9NYD6.
BgeeQ9NYD6.
CleanExHS_HOXC10.
GenevestigatorQ9NYD6.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiHOXC10.
GenomeRNAi3226.
NextBio12839.
PROQ9NYD6.
SOURCESearch...

Entry information

Entry nameHXC10_HUMAN
AccessionPrimary (citable) accession number: Q9NYD6
Secondary accession number(s): O15219, O15220, Q9BVD5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: January 23, 2002
Last modified: July 9, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries