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Q9NYD6

- HXC10_HUMAN

UniProt

Q9NYD6 - HXC10_HUMAN

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Protein

Homeobox protein Hox-C10

Gene
HOXC10, HOX3I
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi268 – 32760HomeoboxAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. anterior/posterior pattern specification Source: Ensembl
  2. embryonic limb morphogenesis Source: Ensembl
  3. neuromuscular process Source: Ensembl
  4. positive regulation of cell proliferation Source: ProtInc
  5. proximal/distal pattern formation Source: Ensembl
  6. skeletal system development Source: Ensembl
  7. spinal cord motor neuron cell fate specification Source: Ensembl
  8. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-C10
Alternative name(s):
Homeobox protein Hox-3I
Gene namesi
Name:HOXC10
Synonyms:HOX3I
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:5122. HOXC10.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29397.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 342342Homeobox protein Hox-C10PRO_0000200190Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei189 – 1891Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9NYD6.
PaxDbiQ9NYD6.
PRIDEiQ9NYD6.

PTM databases

PhosphoSiteiQ9NYD6.

Expressioni

Gene expression databases

ArrayExpressiQ9NYD6.
BgeeiQ9NYD6.
CleanExiHS_HOXC10.
GenevestigatoriQ9NYD6.

Organism-specific databases

HPAiCAB046474.
HPA053919.

Interactioni

Protein-protein interaction databases

BioGridi109466. 6 interactions.
IntActiQ9NYD6. 3 interactions.
STRINGi9606.ENSP00000307321.

Structurei

3D structure databases

ProteinModelPortaliQ9NYD6.
SMRiQ9NYD6. Positions 269-327.

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG269631.
HOGENOMiHOG000231182.
HOVERGENiHBG052934.
InParanoidiQ9NYD6.
KOiK17444.
OMAiCPRNVTP.
PhylomeDBiQ9NYD6.
TreeFamiTF317819.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NYD6-1 [UniParc]FASTAAdd to Basket

« Hide

MTCPRNVTPN SYAEPLAAPG GGERYSRSAG MYMQSGSDFN CGVMRGCGLA    50
PSLSKRDEGS SPSLALNTYP SYLSQLDSWG DPKAAYRLEQ PVGRPLSSCS 100
YPPSVKEENV CCMYSAEKRA KSGPEAALYS HPLPESCLGE HEVPVPSYYR 150
ASPSYSALDK TPHCSGANDF EAPFEQRASL NPRAEHLESP QLGGKVSFPE 200
TPKSDSQTPS PNEIKTEQSL AGPKGSPSES EKERAKAADS SPDTSDNEAK 250
EEIKAENTTG NWLTAKSGRK KRCPYTKHQT LELEKEFLFN MYLTRERRLE 300
ISKTINLTDR QVKIWFQNRR MKLKKMNREN RIRELTSNFN FT 342
Length:342
Mass (Da):38,073
Last modified:January 23, 2002 - v2
Checksum:iBD8127FD43C2A37B
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti118 – 1181K → N in AAF67759. 1 Publication
Sequence conflicti265 – 2651A → G in CAA68000. 1 Publication
Sequence conflicti271 – 2711Missing in CAA68000. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF255675 mRNA. Translation: AAF67759.1.
BC001293 mRNA. Translation: AAH01293.1.
X99684 mRNA. Translation: CAA67999.1.
X99685 mRNA. Translation: CAA68000.1.
CCDSiCCDS8868.1.
PIRiB60941.
RefSeqiNP_059105.2. NM_017409.3.
UniGeneiHs.44276.

Genome annotation databases

EnsembliENST00000303460; ENSP00000307321; ENSG00000180818.
GeneIDi3226.
KEGGihsa:3226.
UCSCiuc001sen.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF255675 mRNA. Translation: AAF67759.1 .
BC001293 mRNA. Translation: AAH01293.1 .
X99684 mRNA. Translation: CAA67999.1 .
X99685 mRNA. Translation: CAA68000.1 .
CCDSi CCDS8868.1.
PIRi B60941.
RefSeqi NP_059105.2. NM_017409.3.
UniGenei Hs.44276.

3D structure databases

ProteinModelPortali Q9NYD6.
SMRi Q9NYD6. Positions 269-327.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109466. 6 interactions.
IntActi Q9NYD6. 3 interactions.
STRINGi 9606.ENSP00000307321.

PTM databases

PhosphoSitei Q9NYD6.

Proteomic databases

MaxQBi Q9NYD6.
PaxDbi Q9NYD6.
PRIDEi Q9NYD6.

Protocols and materials databases

DNASUi 3226.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000303460 ; ENSP00000307321 ; ENSG00000180818 .
GeneIDi 3226.
KEGGi hsa:3226.
UCSCi uc001sen.3. human.

Organism-specific databases

CTDi 3226.
GeneCardsi GC12P054378.
HGNCi HGNC:5122. HOXC10.
HPAi CAB046474.
HPA053919.
MIMi 605560. gene.
neXtProti NX_Q9NYD6.
PharmGKBi PA29397.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG269631.
HOGENOMi HOG000231182.
HOVERGENi HBG052934.
InParanoidi Q9NYD6.
KOi K17444.
OMAi CPRNVTP.
PhylomeDBi Q9NYD6.
TreeFami TF317819.

Miscellaneous databases

GeneWikii HOXC10.
GenomeRNAii 3226.
NextBioi 12839.
PROi Q9NYD6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9NYD6.
Bgeei Q9NYD6.
CleanExi HS_HOXC10.
Genevestigatori Q9NYD6.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Selection of homeotic proteins for binding to a human DNA replication origin."
    de Stanchina E., Gabellini D., Norio P., Giacca M., Peverali F.A., Riva S., Falaschi A., Biamonti G.
    J. Mol. Biol. 299:667-680(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cervix.
  3. "Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines."
    Flagiello D., Gibaud A., Dutrillaux B., Poupon M.-F., Malfoy B.
    FEBS Lett. 415:263-267(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 94-106 AND 258-297.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-189, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiHXC10_HUMAN
AccessioniPrimary (citable) accession number: Q9NYD6
Secondary accession number(s): O15219, O15220, Q9BVD5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: January 23, 2002
Last modified: July 9, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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