Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Homeobox protein Hox-C10

Gene

HOXC10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi268 – 327HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000180818-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-C10
Alternative name(s):
Homeobox protein Hox-3I
Gene namesi
Name:HOXC10
Synonyms:HOX3I
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:5122. HOXC10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3226.
OpenTargetsiENSG00000180818.
PharmGKBiPA29397.

Polymorphism and mutation databases

BioMutaiHOXC10.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001901 – 342Homeobox protein Hox-C10Add BLAST342

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8PhosphothreonineCombined sources1
Modified residuei189PhosphoserineCombined sources1
Cross-linki254Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9NYD6.
PaxDbiQ9NYD6.
PeptideAtlasiQ9NYD6.
PRIDEiQ9NYD6.

PTM databases

iPTMnetiQ9NYD6.
PhosphoSitePlusiQ9NYD6.

Expressioni

Gene expression databases

BgeeiENSG00000180818.
CleanExiHS_HOXC10.
ExpressionAtlasiQ9NYD6. baseline and differential.
GenevisibleiQ9NYD6. HS.

Organism-specific databases

HPAiCAB046474.
HPA053919.

Interactioni

Protein-protein interaction databases

BioGridi109466. 10 interactors.
IntActiQ9NYD6. 3 interactors.
STRINGi9606.ENSP00000307321.

Structurei

3D structure databases

ProteinModelPortaliQ9NYD6.
SMRiQ9NYD6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0487. Eukaryota.
ENOG4111FJP. LUCA.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231182.
HOVERGENiHBG052934.
InParanoidiQ9NYD6.
KOiK17444.
OMAiLDKTPHC.
OrthoDBiEOG091G0LON.
PhylomeDBiQ9NYD6.
TreeFamiTF317819.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NYD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTCPRNVTPN SYAEPLAAPG GGERYSRSAG MYMQSGSDFN CGVMRGCGLA
60 70 80 90 100
PSLSKRDEGS SPSLALNTYP SYLSQLDSWG DPKAAYRLEQ PVGRPLSSCS
110 120 130 140 150
YPPSVKEENV CCMYSAEKRA KSGPEAALYS HPLPESCLGE HEVPVPSYYR
160 170 180 190 200
ASPSYSALDK TPHCSGANDF EAPFEQRASL NPRAEHLESP QLGGKVSFPE
210 220 230 240 250
TPKSDSQTPS PNEIKTEQSL AGPKGSPSES EKERAKAADS SPDTSDNEAK
260 270 280 290 300
EEIKAENTTG NWLTAKSGRK KRCPYTKHQT LELEKEFLFN MYLTRERRLE
310 320 330 340
ISKTINLTDR QVKIWFQNRR MKLKKMNREN RIRELTSNFN FT
Length:342
Mass (Da):38,073
Last modified:January 23, 2002 - v2
Checksum:iBD8127FD43C2A37B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti118K → N in AAF67759 (PubMed:10835276).Curated1
Sequence conflicti265A → G in CAA68000 (PubMed:9357979).Curated1
Sequence conflicti271Missing in CAA68000 (PubMed:9357979).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF255675 mRNA. Translation: AAF67759.1.
BC001293 mRNA. Translation: AAH01293.1.
X99684 mRNA. Translation: CAA67999.1.
X99685 mRNA. Translation: CAA68000.1.
CCDSiCCDS8868.1.
PIRiB60941.
RefSeqiNP_059105.2. NM_017409.3.
UniGeneiHs.44276.

Genome annotation databases

EnsembliENST00000303460; ENSP00000307321; ENSG00000180818.
GeneIDi3226.
KEGGihsa:3226.
UCSCiuc001sen.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF255675 mRNA. Translation: AAF67759.1.
BC001293 mRNA. Translation: AAH01293.1.
X99684 mRNA. Translation: CAA67999.1.
X99685 mRNA. Translation: CAA68000.1.
CCDSiCCDS8868.1.
PIRiB60941.
RefSeqiNP_059105.2. NM_017409.3.
UniGeneiHs.44276.

3D structure databases

ProteinModelPortaliQ9NYD6.
SMRiQ9NYD6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109466. 10 interactors.
IntActiQ9NYD6. 3 interactors.
STRINGi9606.ENSP00000307321.

PTM databases

iPTMnetiQ9NYD6.
PhosphoSitePlusiQ9NYD6.

Polymorphism and mutation databases

BioMutaiHOXC10.

Proteomic databases

MaxQBiQ9NYD6.
PaxDbiQ9NYD6.
PeptideAtlasiQ9NYD6.
PRIDEiQ9NYD6.

Protocols and materials databases

DNASUi3226.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303460; ENSP00000307321; ENSG00000180818.
GeneIDi3226.
KEGGihsa:3226.
UCSCiuc001sen.4. human.

Organism-specific databases

CTDi3226.
DisGeNETi3226.
GeneCardsiHOXC10.
HGNCiHGNC:5122. HOXC10.
HPAiCAB046474.
HPA053919.
MIMi605560. gene.
neXtProtiNX_Q9NYD6.
OpenTargetsiENSG00000180818.
PharmGKBiPA29397.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0487. Eukaryota.
ENOG4111FJP. LUCA.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231182.
HOVERGENiHBG052934.
InParanoidiQ9NYD6.
KOiK17444.
OMAiLDKTPHC.
OrthoDBiEOG091G0LON.
PhylomeDBiQ9NYD6.
TreeFamiTF317819.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000180818-MONOMER.

Miscellaneous databases

GeneWikiiHOXC10.
GenomeRNAii3226.
PROiQ9NYD6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000180818.
CleanExiHS_HOXC10.
ExpressionAtlasiQ9NYD6. baseline and differential.
GenevisibleiQ9NYD6. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHXC10_HUMAN
AccessioniPrimary (citable) accession number: Q9NYD6
Secondary accession number(s): O15219, O15220, Q9BVD5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: January 23, 2002
Last modified: November 2, 2016
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.