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Q9NYD6

- HXC10_HUMAN

UniProt

Q9NYD6 - HXC10_HUMAN

Protein

Homeobox protein Hox-C10

Gene

HOXC10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 2 (23 Jan 2002)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi268 – 32760HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. anterior/posterior pattern specification Source: Ensembl
    2. embryonic limb morphogenesis Source: Ensembl
    3. neuromuscular process Source: Ensembl
    4. positive regulation of cell proliferation Source: ProtInc
    5. proximal/distal pattern formation Source: Ensembl
    6. skeletal system development Source: Ensembl
    7. spinal cord motor neuron cell fate specification Source: Ensembl
    8. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-C10
    Alternative name(s):
    Homeobox protein Hox-3I
    Gene namesi
    Name:HOXC10
    Synonyms:HOX3I
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:5122. HOXC10.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29397.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 342342Homeobox protein Hox-C10PRO_0000200190Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei189 – 1891Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9NYD6.
    PaxDbiQ9NYD6.
    PRIDEiQ9NYD6.

    PTM databases

    PhosphoSiteiQ9NYD6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NYD6.
    BgeeiQ9NYD6.
    CleanExiHS_HOXC10.
    GenevestigatoriQ9NYD6.

    Organism-specific databases

    HPAiCAB046474.
    HPA053919.

    Interactioni

    Protein-protein interaction databases

    BioGridi109466. 6 interactions.
    IntActiQ9NYD6. 3 interactions.
    STRINGi9606.ENSP00000307321.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NYD6.
    SMRiQ9NYD6. Positions 269-327.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Abd-B homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG269631.
    HOGENOMiHOG000231182.
    HOVERGENiHBG052934.
    InParanoidiQ9NYD6.
    KOiK17444.
    OMAiCPRNVTP.
    PhylomeDBiQ9NYD6.
    TreeFamiTF317819.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NYD6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTCPRNVTPN SYAEPLAAPG GGERYSRSAG MYMQSGSDFN CGVMRGCGLA    50
    PSLSKRDEGS SPSLALNTYP SYLSQLDSWG DPKAAYRLEQ PVGRPLSSCS 100
    YPPSVKEENV CCMYSAEKRA KSGPEAALYS HPLPESCLGE HEVPVPSYYR 150
    ASPSYSALDK TPHCSGANDF EAPFEQRASL NPRAEHLESP QLGGKVSFPE 200
    TPKSDSQTPS PNEIKTEQSL AGPKGSPSES EKERAKAADS SPDTSDNEAK 250
    EEIKAENTTG NWLTAKSGRK KRCPYTKHQT LELEKEFLFN MYLTRERRLE 300
    ISKTINLTDR QVKIWFQNRR MKLKKMNREN RIRELTSNFN FT 342
    Length:342
    Mass (Da):38,073
    Last modified:January 23, 2002 - v2
    Checksum:iBD8127FD43C2A37B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti118 – 1181K → N in AAF67759. (PubMed:10835276)Curated
    Sequence conflicti265 – 2651A → G in CAA68000. (PubMed:9357979)Curated
    Sequence conflicti271 – 2711Missing in CAA68000. (PubMed:9357979)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF255675 mRNA. Translation: AAF67759.1.
    BC001293 mRNA. Translation: AAH01293.1.
    X99684 mRNA. Translation: CAA67999.1.
    X99685 mRNA. Translation: CAA68000.1.
    CCDSiCCDS8868.1.
    PIRiB60941.
    RefSeqiNP_059105.2. NM_017409.3.
    UniGeneiHs.44276.

    Genome annotation databases

    EnsembliENST00000303460; ENSP00000307321; ENSG00000180818.
    GeneIDi3226.
    KEGGihsa:3226.
    UCSCiuc001sen.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF255675 mRNA. Translation: AAF67759.1 .
    BC001293 mRNA. Translation: AAH01293.1 .
    X99684 mRNA. Translation: CAA67999.1 .
    X99685 mRNA. Translation: CAA68000.1 .
    CCDSi CCDS8868.1.
    PIRi B60941.
    RefSeqi NP_059105.2. NM_017409.3.
    UniGenei Hs.44276.

    3D structure databases

    ProteinModelPortali Q9NYD6.
    SMRi Q9NYD6. Positions 269-327.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109466. 6 interactions.
    IntActi Q9NYD6. 3 interactions.
    STRINGi 9606.ENSP00000307321.

    PTM databases

    PhosphoSitei Q9NYD6.

    Proteomic databases

    MaxQBi Q9NYD6.
    PaxDbi Q9NYD6.
    PRIDEi Q9NYD6.

    Protocols and materials databases

    DNASUi 3226.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000303460 ; ENSP00000307321 ; ENSG00000180818 .
    GeneIDi 3226.
    KEGGi hsa:3226.
    UCSCi uc001sen.3. human.

    Organism-specific databases

    CTDi 3226.
    GeneCardsi GC12P054378.
    HGNCi HGNC:5122. HOXC10.
    HPAi CAB046474.
    HPA053919.
    MIMi 605560. gene.
    neXtProti NX_Q9NYD6.
    PharmGKBi PA29397.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG269631.
    HOGENOMi HOG000231182.
    HOVERGENi HBG052934.
    InParanoidi Q9NYD6.
    KOi K17444.
    OMAi CPRNVTP.
    PhylomeDBi Q9NYD6.
    TreeFami TF317819.

    Miscellaneous databases

    GeneWikii HOXC10.
    GenomeRNAii 3226.
    NextBioi 12839.
    PROi Q9NYD6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NYD6.
    Bgeei Q9NYD6.
    CleanExi HS_HOXC10.
    Genevestigatori Q9NYD6.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Selection of homeotic proteins for binding to a human DNA replication origin."
      de Stanchina E., Gabellini D., Norio P., Giacca M., Peverali F.A., Riva S., Falaschi A., Biamonti G.
      J. Mol. Biol. 299:667-680(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Cervix.
    3. "Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines."
      Flagiello D., Gibaud A., Dutrillaux B., Poupon M.-F., Malfoy B.
      FEBS Lett. 415:263-267(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 94-106 AND 258-297.
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-189, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiHXC10_HUMAN
    AccessioniPrimary (citable) accession number: Q9NYD6
    Secondary accession number(s): O15219, O15220, Q9BVD5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: January 23, 2002
    Last modified: October 1, 2014
    This is version 125 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3