Q9NYC9 (DYH9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dynein heavy chain 9, axonemal

Alternative name(s):
Axonemal beta dynein heavy chain 9
Ciliary dynein heavy chain 9

Gene names

Name:	DNAH9
Synonyms:	DNAH17L, DNAL1, KIAA0357

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	4486 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP.
Subunit structure	Consists of at least two heavy chains and a number of intermediate and light chains.
Subcellular location	Cytoplasm › cytoskeleton › cilium axoneme.
Domain	Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function.
Sequence similarities	Belongs to the dynein heavy chain family.

Ontologies

Keywords
Biological process	Cilium biogenesis/degradation
Cellular component	Cell projection Cilium Cytoplasm Cytoskeleton Dynein Microtubule
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Repeat
Ligand	ATP-binding Nucleotide-binding
Molecular function	Motor protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ATP catabolic process Inferred from electronic annotation. Source: GOC cell projection organization Inferred from electronic annotation. Source: UniProtKB-KW cellular component movement Traceable author statement PubMed 8812413. Source: ProtInc microtubule-based movement Inferred from electronic annotation. Source: InterPro spermatogenesis Traceable author statement PubMed 8703119. Source: ProtInc
Cellular_component	axonemal dynein complex Non-traceable author statement. Source: UniProtKB cilium axoneme Inferred from direct assay Ref.8. Source: MGI microtubule Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from electronic annotation. Source: InterPro microtubule motor activity Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NYC9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NYC9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     3961-4036: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q9NYC9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-3688: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 4486	4486	Dynein heavy chain 9, axonemal		PRO_0000114632
Regions
	Nucleotide binding	1870 – 1877	8	ATP Potential
	Nucleotide binding	2151 – 2158	8	ATP Potential
	Nucleotide binding	2478 – 2485	8	ATP Potential
	Nucleotide binding	2825 – 2832	8	ATP Potential
	Region	1 – 1831	1831	Stem By similarity
	Region	1832 – 2053	222	AAA 1 By similarity
	Region	2113 – 2334	222	AAA 2 By similarity
	Region	2440 – 2688	249	AAA 3 By similarity
	Region	2787 – 3036	250	AAA 4 By similarity
	Region	3051 – 3341	291	Stalk By similarity
	Region	3429 – 3656	228	AAA 5 By similarity
	Region	3866 – 4092	227	AAA 6 By similarity
	Coiled coil	381 – 410	30	Potential
	Coiled coil	504 – 529	26	Potential
	Coiled coil	639 – 662	24	Potential
	Coiled coil	752 – 823	72	Potential
	Coiled coil	1326 – 1355	30	Potential
	Coiled coil	3051 – 3154	104	Potential
	Coiled coil	3285 – 3341	57	Potential
	Coiled coil	3640 – 3675	36	Potential
Natural variations
	Alternative sequence	1 – 3688	3688	Missing in isoform 3.		VSP_043443
	Alternative sequence	3961 – 4036	76	Missing in isoform 2.		VSP_035285
	Natural variant	151	1	R → H. Corresponds to variant rs17599639 [ dbSNP | Ensembl ].		VAR_046312
	Natural variant	445	1	Q → R. Ref.1 Ref.2 Corresponds to variant rs9892256 [ dbSNP | Ensembl ].		VAR_046313
	Natural variant	771	1	R → L in a breast cancer sample; somatic mutation. Ref.9		VAR_036214
	Natural variant	842	1	R → W. Corresponds to variant rs16945138 [ dbSNP | Ensembl ].		VAR_046314
	Natural variant	1158	1	R → W. Corresponds to variant rs8070501 [ dbSNP | Ensembl ].		VAR_046315
	Natural variant	1221	1	T → A. Corresponds to variant rs9916482 [ dbSNP | Ensembl ].		VAR_046316
	Natural variant	2087	1	M → V. Corresponds to variant rs9892290 [ dbSNP | Ensembl ].		VAR_046317
	Natural variant	2195	1	N → S. Corresponds to variant rs3744581 [ dbSNP | Ensembl ].		VAR_046318
	Natural variant	2438	1	Q → H. Corresponds to variant rs2277658 [ dbSNP | Ensembl ].		VAR_046319
	Natural variant	2653	1	D → H in a breast cancer sample; somatic mutation. Ref.9		VAR_036215
	Natural variant	2961	1	K → R. Corresponds to variant rs11870983 [ dbSNP | Ensembl ].		VAR_046320
	Natural variant	2968	1	K → N. Corresponds to variant rs11871037 [ dbSNP | Ensembl ].		VAR_046321
	Natural variant	3664	1	T → N in a breast cancer sample; somatic mutation. Ref.9		VAR_036216
	Natural variant	3726	1	R → Q. Corresponds to variant rs16945431 [ dbSNP | Ensembl ].		VAR_046322
	Natural variant	3726	1	R → W. Corresponds to variant rs3760436 [ dbSNP | Ensembl ].		VAR_046323
	Natural variant	4036	1	D → N. Corresponds to variant rs17612861 [ dbSNP | Ensembl ].		VAR_046324
	Natural variant	4374	1	M → I. Ref.1 Corresponds to variant rs1990236 [ dbSNP | Ensembl ].		VAR_046325
	Natural variant	4443	1	R → C. Corresponds to variant rs9913494 [ dbSNP | Ensembl ].		VAR_046326
	Natural variant	4462	1	W → R. Corresponds to variant rs8074656 [ dbSNP | Ensembl ].		VAR_046327
Experimental info
	Sequence conflict	2216	1	I → T in BAA21573. Ref.5
	Sequence conflict	2505	1	V → L in AAF69004. Ref.1
	Sequence conflict	3678	1	A → T in AAF69004. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 2, 2010. Version 3. Checksum: 27EB53C39FA3A293	FASTA	4,486	511,877
	10 20 30 40 50 60 MRLAEERAAL AAENADGEPG ADRRLRLLGT YVAMSLRPAA GAWERCAGSA EAEQLLQAFL 70 80 90 100 110 120 GRDAAEGPRP LLVVRPGPRG LAIRPGLEVG PESGLAGAKA LFFLRTGPEP PGPDSFRGAV 130 140 150 160 170 180 VCGDLPAAPL EHLAALFSEV VLPVLANEKN RLNWPHMICE DVRRHAHSLQ CDLSVILEQV 190 200 210 220 230 240 KGKTLLPLPA GSEKMEFADS KSETVLDSID KSVIYAIESA VIKWSYQVQV VLKRESSQPL 250 260 270 280 290 300 LQGENPTPKV ELEFWKSRYE DLKYIYNQLR TITVRGMAKL LDKLQSSYFP AFKAMYRDVV 310 320 330 340 350 360 AALAEAQDIH VHLIPLQRHL EALENAEFPE VKPQLRPLLH VVCLIWATCK SYRSPGRLTV 370 380 390 400 410 420 LLQEICNLLI QQASNYLSPE DLLRSEVEES QRKLQVVSDT LSFFKQEFQD RRENLHTYFK 430 440 450 460 470 480 ENQEVKEWDF QSSLVFVRLD GFLGQLHVVE GLLKTALDFH KLGKVEFSGV RGNALSQQVQ 490 500 510 520 530 540 QMHEEFQEMY RLLSGSSSDC LYLQSTDFEN DVSEFNQKVE DLDRRLGTIF IQAFDDAPGL 550 560 570 580 590 600 EHAFKLLDIA GNLLERPLVA RDTSDKYLVL IQMFNKDLDA VRMIYSQHVQ EEAELGFSPV 610 620 630 640 650 660 HKNMPTVAGG LRWAQELRQR IQGPFSNFGR ITHPCMESAE GKRMQQKYED MLSLLEKYET 670 680 690 700 710 720 RLYEDWCRTV SEKSQYNLSQ PLLKRDPETK EITINFNPQL ISVLKEMSYL EPREMKHMPE 730 740 750 760 770 780 TAAAMFSSRD FYRQLVANLE LMANWYNKVM KTLLEVEFPL VEEELQNIDL RLRAAEETLN 790 800 810 820 830 840 WKTEGICDYV TEITSSIHDL EQRIQKTKDN VEEIQNIMKT WVTPIFKTKD GKRESLLSLD 850 860 870 880 890 900 DRHDRMEKYY NLIKESGLKI HALVQENLGL FSADPTSNIW KTYVNSIDNL LLNGFFLAIE 910 920 930 940 950 960 CSLKYLLENT ECKAGLTPIF EAQLSLAIPE LVFYPSLESG VKGGFCDIVE GLITSIFRIP 970 980 990 1000 1010 1020 SLVPRLSPQN GSPHYQVDLD GIPDLANMRR TLMERVQRMM GLCCGYQSTF SQYSYLYVED 1030 1040 1050 1060 1070 1080 RKEVLGQFLL YGHILTPEEI EDHVEDGIPE NPPLLSQFKV QIDSYETLYE EVCRLEPIKV 1090 1100 1110 1120 1130 1140 FDGWMKIDIR PFKASLLNII KRWSLLFKQH LVDHVTHSLA NLDAFIKKSE SGLLKKVEKG 1150 1160 1170 1180 1190 1200 DFQGLVEIMG HLMAVKERQS NTDEMFEPLK QTIELLKTYE QELPETVFKQ LEELPEKWNN 1210 1220 1230 1240 1250 1260 IKKVAITVKQ QVAPLQANEV TLLRQRCTAF DAEQQQFWEQ FHKEAPFRFD SIHPHQMLDA 1270 1280 1290 1300 1310 1320 RHIEIQQMES TMASISESAS LFEVNVPDYK QLRQCRKEVC QLKELWDTIG MVTSSIHAWE 1330 1340 1350 1360 1370 1380 TTPWRNINVE AMELECKQFA RHIRNLDKEV RAWDAFTGLE STVWNTLSSL RAVAELQNPA 1390 1400 1410 1420 1430 1440 IRERHWRQLM QATGVSFTMD QDTTLAHLLQ LQLHHYEDEV RGIVDKAAKE MGMEKTLKEL 1450 1460 1470 1480 1490 1500 QTTWAGMEFQ YEPHPRTNVP LLCSDEDLIE VLEDNQVQLQ NLVMSKYVAF FLEEVSGWQK 1510 1520 1530 1540 1550 1560 KLSTVDAVIS IWFEVQRTWT HLESIFTGSE DIRAQLPQDS KRFEGIDIDF KELAYDAQKI 1570 1580 1590 1600 1610 1620 PNVVQTTNKP GLYEKLEDIQ GRLCLCEKAL AEYLDTKRLA FPRFYFLSSS DLLDILSNGT 1630 1640 1650 1660 1670 1680 APQQVQRHLS KLFDNMAKMR FQLDASGEPT KTSLGMYSKE EEYVAFSEPC DCSGQVEIWL 1690 1700 1710 1720 1730 1740 NHVLGHMKAT VRHEMTEGVT AYEEKPREQW LFDHPAQVAL TCTQIWWTTE VGMAFARLEE 1750 1760 1770 1780 1790 1800 GYESAMKDYY KKQVAQLKTL ITMLIGQLSK GDRQKIMTIC TIDVHARDVV AKMIAQKVDN 1810 1820 1830 1840 1850 1860 AQAFLWLSQL RHRWDDEVKH CFANICDAQF LYSYEYLGNT PRLVITPLTD RCYITLTQSL 1870 1880 1890 1900 1910 1920 HLTMSGAPAG PAGTGKTETT KDLGRALGIL VYVFNCSEQM DYKSCGNIYK GLAQTGAWGC 1930 1940 1950 1960 1970 1980 FDEFNRISVE VLSVVAVQVK SIQDAIRDKK QWFSFLGEEI SLNPSVGIFI TMNPGYAGRT 1990 2000 2010 2020 2030 2040 ELPENLKSLF RPCAMVVPDF ELICEIMLVA EGFIEAQSLA RKFITLYQLC KELLSKQDHY 2050 2060 2070 2080 2090 2100 DWGLRAIKSV LVVAGSLKRG DPDRPEDQVL MRSLRDFNIP KIVTDDMPIF MGLIGDLFPA 2110 2120 2130 2140 2150 2160 LDVPRRRDPN FEALVRKAIV DLKLQAEDNF VLKVVQLEEL LAVRHSVFVV GGAGTGKSQV 2170 2180 2190 2200 2210 2220 LRSLHKTYQI MKRRPVWTDL NPKAVTNDEL FGIINPATGE WKDGLFSSIM RELANITHDG 2230 2240 2250 2260 2270 2280 PKWILLDGDI DPMWIESLNT VMDDNKVLTL ASNERIPLNP TMKLLFEISH LRTATPATVS 2290 2300 2310 2320 2330 2340 RAGILYINPA DLGWNPPVSS WIEKREIQTE RANLTILFDK YLPTCLDTLR TRFKKIIPIP 2350 2360 2370 2380 2390 2400 EQSMVQMVCH LLECLLTTED IPADCPKEIY EHYFVFAAIW AFGGAMVQDQ LVDYRAEFSK 2410 2420 2430 2440 2450 2460 WWLTEFKTVK FPSQGTIFDY YIDPETKKFE PWSKLVPQFE FDPEMPLQAC LVHTSETIRV 2470 2480 2490 2500 2510 2520 CYFMERLMAR QRPVMLVGTA GTGKSVLVGA KLASLDPEAY LVKNVPFNYY TTSAMLQAVL 2530 2540 2550 2560 2570 2580 EKPLEKKAGR NYGPPGNKKL IYFIDDMNMP EVDAYGTVQP HTIIRQHLDY GHWYDRSKLS 2590 2600 2610 2620 2630 2640 LKEITNVQYV SCMNPTAGSF TINPRLQRHF SVFVLSFPGA DALSSIYSII LTQHLKLGNF 2650 2660 2670 2680 2690 2700 PASLQKSIPP LIDLALAFHQ KIATTFLPTG IKFHYIFNLR DFANIFQGIL FSSVECVKST 2710 2720 2730 2740 2750 2760 WDLIRLYLHE SNRVYRDKMV EEKDFDLFDK IQTEVLKKTF DDIEDPVEQT QSPNLYCHFA 2770 2780 2790 2800 2810 2820 NGIGEPKYMP VQSWELLTQT LVEALENHNE VNTVMDLVLF EDAMRHVCHI NRILESPRGN 2830 2840 2850 2860 2870 2880 ALLVGVGGSG KQSLTRLAAF ISSMDVFQIT LRKGYQIQDF KMDLASLCLK AGVKNLNTVF 2890 2900 2910 2920 2930 2940 LMTDAQVADE RFLVLINDLL ASGEIPDLYS DDEVENIISN VRNEVKSQGL VDNRENCWKF 2950 2960 2970 2980 2990 3000 FIDRIRRQLK VTLCFSPVGN KLRVRSRKFP AIVNCTAIHW FHEWPQQALE SVSLRFLQNT 3010 3020 3030 3040 3050 3060 EGIEPTVKQS ISKFMAFVHT SVNQTSQSYL SNEQRYNYTT PKSFLEFIRL YQSLLHRHRK 3070 3080 3090 3100 3110 3120 ELKCKTERLE NGLLKLHSTS AQVDDLKAKL AAQEVELKQK NEDADKLIQV VGVETDKVSR 3130 3140 3150 3160 3170 3180 EKAMADEEEQ KVAVIMLEVK QKQKDCEEDL AKAEPALTAA QAALNTLNKT NLTELKSFGS 3190 3200 3210 3220 3230 3240 PPLAVSNVSA AVMVLMAPRG RVPKDRSWKA AKVTMAKVDG FLDSLINFNK ENIHENCLKA 3250 3260 3270 3280 3290 3300 IRPYLQDPEF NPEFVATKSY AAAGLCSWVI NIVRFYEVFC DVEPKRQALN KATADLTAAQ 3310 3320 3330 3340 3350 3360 EKLAAIKAKI AHLNENLAKL TARFEKATAD KLKCQQEAEV TAVTISLANR LVGGLASENV 3370 3380 3390 3400 3410 3420 RWADAVQNFK QQERTLCGDI LLITAFISYL GFFTKKYRQS LLDRTWRPYL SQLKTPIPVT 3430 3440 3450 3460 3470 3480 PALDPLRMLM DDADVAAWQN EGLPADRMSV ENATILINCE RWPLMVDPQL QGIKWIKNKY 3490 3500 3510 3520 3530 3540 GEDLRVTQIG QKGYLQIIEQ ALEAGAVVLI ENLEESIDPV LGPLLGREVI KKGRFIKIGD 3550 3560 3570 3580 3590 3600 KECEYNPKFR LILHTKLANP HYQPELQAQA TLINFTVTRD GLEDQLLAAV VSMERPDLEQ 3610 3620 3630 3640 3650 3660 LKSDLTKQQN GFKITLKTLE DSLLSRLSSA SGNFLGETVL VENLEITKQT AAEVEKKVQE 3670 3680 3690 3700 3710 3720 AKVTEVKINE AREHYRPAAA RASLLYFIMN DLSKIHPMYQ FSLKAFSIVF QKAVERAAPD 3730 3740 3750 3760 3770 3780 ESLRERVANL IDSITFSVYQ YTIRGLFECD KLTYLAQLTF QILLMNREVN AVELDFLLRS 3790 3800 3810 3820 3830 3840 PVQTGTASPV EFLSHQAWGA VKVLSSMEEF SNLDRDIEGS AKSWKKFVES ECPEKEKLPQ 3850 3860 3870 3880 3890 3900 EWKNKTALQR LCMLRAMRPD RMTYALRDFV EEKLGSKYVV GRALDFATSF EESGPATPMF 3910 3920 3930 3940 3950 3960 FILSPGVDPL KDVESQGRKL GYTFNNQNFH NVSLGQGQEV VAEAALDLAA KKGHWVILQN 3970 3980 3990 4000 4010 4020 IHLVAKWLST LEKKLEEHSE NSHPEFRVFM SAEPAPSPEG HIIPQGILEN SIKITNEPPT 4030 4040 4050 4060 4070 4080 GMHANLHKAL DNFTQDTLEM CSRETEFKSI LFALCYFHAV VAERRKFGPQ GWNRSYPFNT 4090 4100 4110 4120 4130 4140 GDLTISVNVL YNFLEANAKV PYDDLRYLFG EIMYGGHITD DWDRRLCRTY LGEFIRPEML 4150 4160 4170 4180 4190 4200 EGELSLAPGF PLPGNMDYNG YHQYIDAELP PESPYLYGLH PNAEIGFLTQ TSEKLFRTVL 4210 4220 4230 4240 4250 4260 ELQPRDSQAR DGAGATREEK VKALLEEILE RVTDEFNIPE LMAKVEERTP YIVVAFQECG 4270 4280 4290 4300 4310 4320 RMNILTREIQ RSLRELELGL KGELTMTSHM ENLQNALYFD MVPESWARRA YPSTAGLAAW 4330 4340 4350 4360 4370 4380 FPDLLNRIKE LEAWTGDFTM PSTVWLTGFF NPQSFLTAIM QSTARKNEWP LDQMALQCDM 4390 4400 4410 4420 4430 4440 TKKNREEFRS PPREGAYIHG LFMEGACWDT QAGIITEAKL KDLTPPMPVM FIKAIPADKQ 4450 4460 4470 4480 DCRSVYSCPV YKTSQRGPTY VWTFNLKTKE NPSKWVLAGV ALLLQI
	Isoform 2 [UniParc]. Checksum: 62B16681AF5C0C04	FASTA	4,410	503,345
	10 20 30 40 50 60 MRLAEERAAL AAENADGEPG ADRRLRLLGT YVAMSLRPAA GAWERCAGSA EAEQLLQAFL 70 80 90 100 110 120 GRDAAEGPRP LLVVRPGPRG LAIRPGLEVG PESGLAGAKA LFFLRTGPEP PGPDSFRGAV 130 140 150 160 170 180 VCGDLPAAPL EHLAALFSEV VLPVLANEKN RLNWPHMICE DVRRHAHSLQ CDLSVILEQV 190 200 210 220 230 240 KGKTLLPLPA GSEKMEFADS KSETVLDSID KSVIYAIESA VIKWSYQVQV VLKRESSQPL 250 260 270 280 290 300 LQGENPTPKV ELEFWKSRYE DLKYIYNQLR TITVRGMAKL LDKLQSSYFP AFKAMYRDVV 310 320 330 340 350 360 AALAEAQDIH VHLIPLQRHL EALENAEFPE VKPQLRPLLH VVCLIWATCK SYRSPGRLTV 370 380 390 400 410 420 LLQEICNLLI QQASNYLSPE DLLRSEVEES QRKLQVVSDT LSFFKQEFQD RRENLHTYFK 430 440 450 460 470 480 ENQEVKEWDF QSSLVFVRLD GFLGQLHVVE GLLKTALDFH KLGKVEFSGV RGNALSQQVQ 490 500 510 520 530 540 QMHEEFQEMY RLLSGSSSDC LYLQSTDFEN DVSEFNQKVE DLDRRLGTIF IQAFDDAPGL 550 560 570 580 590 600 EHAFKLLDIA GNLLERPLVA RDTSDKYLVL IQMFNKDLDA VRMIYSQHVQ EEAELGFSPV 610 620 630 640 650 660 HKNMPTVAGG LRWAQELRQR IQGPFSNFGR ITHPCMESAE GKRMQQKYED MLSLLEKYET 670 680 690 700 710 720 RLYEDWCRTV SEKSQYNLSQ PLLKRDPETK EITINFNPQL ISVLKEMSYL EPREMKHMPE 730 740 750 760 770 780 TAAAMFSSRD FYRQLVANLE LMANWYNKVM KTLLEVEFPL VEEELQNIDL RLRAAEETLN 790 800 810 820 830 840 WKTEGICDYV TEITSSIHDL EQRIQKTKDN VEEIQNIMKT WVTPIFKTKD GKRESLLSLD 850 860 870 880 890 900 DRHDRMEKYY NLIKESGLKI HALVQENLGL FSADPTSNIW KTYVNSIDNL LLNGFFLAIE 910 920 930 940 950 960 CSLKYLLENT ECKAGLTPIF EAQLSLAIPE LVFYPSLESG VKGGFCDIVE GLITSIFRIP 970 980 990 1000 1010 1020 SLVPRLSPQN GSPHYQVDLD GIPDLANMRR TLMERVQRMM GLCCGYQSTF SQYSYLYVED 1030 1040 1050 1060 1070 1080 RKEVLGQFLL YGHILTPEEI EDHVEDGIPE NPPLLSQFKV QIDSYETLYE EVCRLEPIKV 1090 1100 1110 1120 1130 1140 FDGWMKIDIR PFKASLLNII KRWSLLFKQH LVDHVTHSLA NLDAFIKKSE SGLLKKVEKG 1150 1160 1170 1180 1190 1200 DFQGLVEIMG HLMAVKERQS NTDEMFEPLK QTIELLKTYE QELPETVFKQ LEELPEKWNN 1210 1220 1230 1240 1250 1260 IKKVAITVKQ QVAPLQANEV TLLRQRCTAF DAEQQQFWEQ FHKEAPFRFD SIHPHQMLDA 1270 1280 1290 1300 1310 1320 RHIEIQQMES TMASISESAS LFEVNVPDYK QLRQCRKEVC QLKELWDTIG MVTSSIHAWE 1330 1340 1350 1360 1370 1380 TTPWRNINVE AMELECKQFA RHIRNLDKEV RAWDAFTGLE STVWNTLSSL RAVAELQNPA 1390 1400 1410 1420 1430 1440 IRERHWRQLM QATGVSFTMD QDTTLAHLLQ LQLHHYEDEV RGIVDKAAKE MGMEKTLKEL 1450 1460 1470 1480 1490 1500 QTTWAGMEFQ YEPHPRTNVP LLCSDEDLIE VLEDNQVQLQ NLVMSKYVAF FLEEVSGWQK 1510 1520 1530 1540 1550 1560 KLSTVDAVIS IWFEVQRTWT HLESIFTGSE DIRAQLPQDS KRFEGIDIDF KELAYDAQKI 1570 1580 1590 1600 1610 1620 PNVVQTTNKP GLYEKLEDIQ GRLCLCEKAL AEYLDTKRLA FPRFYFLSSS DLLDILSNGT 1630 1640 1650 1660 1670 1680 APQQVQRHLS KLFDNMAKMR FQLDASGEPT KTSLGMYSKE EEYVAFSEPC DCSGQVEIWL 1690 1700 1710 1720 1730 1740 NHVLGHMKAT VRHEMTEGVT AYEEKPREQW LFDHPAQVAL TCTQIWWTTE VGMAFARLEE 1750 1760 1770 1780 1790 1800 GYESAMKDYY KKQVAQLKTL ITMLIGQLSK GDRQKIMTIC TIDVHARDVV AKMIAQKVDN 1810 1820 1830 1840 1850 1860 AQAFLWLSQL RHRWDDEVKH CFANICDAQF LYSYEYLGNT PRLVITPLTD RCYITLTQSL 1870 1880 1890 1900 1910 1920 HLTMSGAPAG PAGTGKTETT KDLGRALGIL VYVFNCSEQM DYKSCGNIYK GLAQTGAWGC 1930 1940 1950 1960 1970 1980 FDEFNRISVE VLSVVAVQVK SIQDAIRDKK QWFSFLGEEI SLNPSVGIFI TMNPGYAGRT 1990 2000 2010 2020 2030 2040 ELPENLKSLF RPCAMVVPDF ELICEIMLVA EGFIEAQSLA RKFITLYQLC KELLSKQDHY 2050 2060 2070 2080 2090 2100 DWGLRAIKSV LVVAGSLKRG DPDRPEDQVL MRSLRDFNIP KIVTDDMPIF MGLIGDLFPA 2110 2120 2130 2140 2150 2160 LDVPRRRDPN FEALVRKAIV DLKLQAEDNF VLKVVQLEEL LAVRHSVFVV GGAGTGKSQV 2170 2180 2190 2200 2210 2220 LRSLHKTYQI MKRRPVWTDL NPKAVTNDEL FGIINPATGE WKDGLFSSIM RELANITHDG 2230 2240 2250 2260 2270 2280 PKWILLDGDI DPMWIESLNT VMDDNKVLTL ASNERIPLNP TMKLLFEISH LRTATPATVS 2290 2300 2310 2320 2330 2340 RAGILYINPA DLGWNPPVSS WIEKREIQTE RANLTILFDK YLPTCLDTLR TRFKKIIPIP 2350 2360 2370 2380 2390 2400 EQSMVQMVCH LLECLLTTED IPADCPKEIY EHYFVFAAIW AFGGAMVQDQ LVDYRAEFSK 2410 2420 2430 2440 2450 2460 WWLTEFKTVK FPSQGTIFDY YIDPETKKFE PWSKLVPQFE FDPEMPLQAC LVHTSETIRV 2470 2480 2490 2500 2510 2520 CYFMERLMAR QRPVMLVGTA GTGKSVLVGA KLASLDPEAY LVKNVPFNYY TTSAMLQAVL 2530 2540 2550 2560 2570 2580 EKPLEKKAGR NYGPPGNKKL IYFIDDMNMP EVDAYGTVQP HTIIRQHLDY GHWYDRSKLS 2590 2600 2610 2620 2630 2640 LKEITNVQYV SCMNPTAGSF TINPRLQRHF SVFVLSFPGA DALSSIYSII LTQHLKLGNF 2650 2660 2670 2680 2690 2700 PASLQKSIPP LIDLALAFHQ KIATTFLPTG IKFHYIFNLR DFANIFQGIL FSSVECVKST 2710 2720 2730 2740 2750 2760 WDLIRLYLHE SNRVYRDKMV EEKDFDLFDK IQTEVLKKTF DDIEDPVEQT QSPNLYCHFA 2770 2780 2790 2800 2810 2820 NGIGEPKYMP VQSWELLTQT LVEALENHNE VNTVMDLVLF EDAMRHVCHI NRILESPRGN 2830 2840 2850 2860 2870 2880 ALLVGVGGSG KQSLTRLAAF ISSMDVFQIT LRKGYQIQDF KMDLASLCLK AGVKNLNTVF 2890 2900 2910 2920 2930 2940 LMTDAQVADE RFLVLINDLL ASGEIPDLYS DDEVENIISN VRNEVKSQGL VDNRENCWKF 2950 2960 2970 2980 2990 3000 FIDRIRRQLK VTLCFSPVGN KLRVRSRKFP AIVNCTAIHW FHEWPQQALE SVSLRFLQNT 3010 3020 3030 3040 3050 3060 EGIEPTVKQS ISKFMAFVHT SVNQTSQSYL SNEQRYNYTT PKSFLEFIRL YQSLLHRHRK 3070 3080 3090 3100 3110 3120 ELKCKTERLE NGLLKLHSTS AQVDDLKAKL AAQEVELKQK NEDADKLIQV VGVETDKVSR 3130 3140 3150 3160 3170 3180 EKAMADEEEQ KVAVIMLEVK QKQKDCEEDL AKAEPALTAA QAALNTLNKT NLTELKSFGS 3190 3200 3210 3220 3230 3240 PPLAVSNVSA AVMVLMAPRG RVPKDRSWKA AKVTMAKVDG FLDSLINFNK ENIHENCLKA 3250 3260 3270 3280 3290 3300 IRPYLQDPEF NPEFVATKSY AAAGLCSWVI NIVRFYEVFC DVEPKRQALN KATADLTAAQ 3310 3320 3330 3340 3350 3360 EKLAAIKAKI AHLNENLAKL TARFEKATAD KLKCQQEAEV TAVTISLANR LVGGLASENV 3370 3380 3390 3400 3410 3420 RWADAVQNFK QQERTLCGDI LLITAFISYL GFFTKKYRQS LLDRTWRPYL SQLKTPIPVT 3430 3440 3450 3460 3470 3480 PALDPLRMLM DDADVAAWQN EGLPADRMSV ENATILINCE RWPLMVDPQL QGIKWIKNKY 3490 3500 3510 3520 3530 3540 GEDLRVTQIG QKGYLQIIEQ ALEAGAVVLI ENLEESIDPV LGPLLGREVI KKGRFIKIGD 3550 3560 3570 3580 3590 3600 KECEYNPKFR LILHTKLANP HYQPELQAQA TLINFTVTRD GLEDQLLAAV VSMERPDLEQ 3610 3620 3630 3640 3650 3660 LKSDLTKQQN GFKITLKTLE DSLLSRLSSA SGNFLGETVL VENLEITKQT AAEVEKKVQE 3670 3680 3690 3700 3710 3720 AKVTEVKINE AREHYRPAAA RASLLYFIMN DLSKIHPMYQ FSLKAFSIVF QKAVERAAPD 3730 3740 3750 3760 3770 3780 ESLRERVANL IDSITFSVYQ YTIRGLFECD KLTYLAQLTF QILLMNREVN AVELDFLLRS 3790 3800 3810 3820 3830 3840 PVQTGTASPV EFLSHQAWGA VKVLSSMEEF SNLDRDIEGS AKSWKKFVES ECPEKEKLPQ 3850 3860 3870 3880 3890 3900 EWKNKTALQR LCMLRAMRPD RMTYALRDFV EEKLGSKYVV GRALDFATSF EESGPATPMF 3910 3920 3930 3940 3950 3960 FILSPGVDPL KDVESQGRKL GYTFNNQNFH NVSLGQGQEV VAEAALDLAA KKGHWVILQN 3970 3980 3990 4000 4010 4020 TLEMCSRETE FKSILFALCY FHAVVAERRK FGPQGWNRSY PFNTGDLTIS VNVLYNFLEA 4030 4040 4050 4060 4070 4080 NAKVPYDDLR YLFGEIMYGG HITDDWDRRL CRTYLGEFIR PEMLEGELSL APGFPLPGNM 4090 4100 4110 4120 4130 4140 DYNGYHQYID AELPPESPYL YGLHPNAEIG FLTQTSEKLF RTVLELQPRD SQARDGAGAT 4150 4160 4170 4180 4190 4200 REEKVKALLE EILERVTDEF NIPELMAKVE ERTPYIVVAF QECGRMNILT REIQRSLREL 4210 4220 4230 4240 4250 4260 ELGLKGELTM TSHMENLQNA LYFDMVPESW ARRAYPSTAG LAAWFPDLLN RIKELEAWTG 4270 4280 4290 4300 4310 4320 DFTMPSTVWL TGFFNPQSFL TAIMQSTARK NEWPLDQMAL QCDMTKKNRE EFRSPPREGA 4330 4340 4350 4360 4370 4380 YIHGLFMEGA CWDTQAGIIT EAKLKDLTPP MPVMFIKAIP ADKQDCRSVY SCPVYKTSQR 4390 4400 4410 GPTYVWTFNL KTKENPSKWV LAGVALLLQI
	Isoform 3 [UniParc]. Checksum: CAC7718F47D65599	FASTA	798	91,135
	10 20 30 40 50 60 MNDLSKIHPM YQFSLKAFSI VFQKAVERAA PDESLRERVA NLIDSITFSV YQYTIRGLFE 70 80 90 100 110 120 CDKLTYLAQL TFQILLMNRE VNAVELDFLL RSPVQTGTAS PVEFLSHQAW GAVKVLSSME 130 140 150 160 170 180 EFSNLDRDIE GSAKSWKKFV ESECPEKEKL PQEWKNKTAL QRLCMLRAMR PDRMTYALRD 190 200 210 220 230 240 FVEEKLGSKY VVGRALDFAT SFEESGPATP MFFILSPGVD PLKDVESQGR KLGYTFNNQN 250 260 270 280 290 300 FHNVSLGQGQ EVVAEAALDL AAKKGHWVIL QNIHLVAKWL STLEKKLEEH SENSHPEFRV 310 320 330 340 350 360 FMSAEPAPSP EGHIIPQGIL ENSIKITNEP PTGMHANLHK ALDNFTQDTL EMCSRETEFK 370 380 390 400 410 420 SILFALCYFH AVVAERRKFG PQGWNRSYPF NTGDLTISVN VLYNFLEANA KVPYDDLRYL 430 440 450 460 470 480 FGEIMYGGHI TDDWDRRLCR TYLGEFIRPE MLEGELSLAP GFPLPGNMDY NGYHQYIDAE 490 500 510 520 530 540 LPPESPYLYG LHPNAEIGFL TQTSEKLFRT VLELQPRDSQ ARDGAGATRE EKVKALLEEI 550 560 570 580 590 600 LERVTDEFNI PELMAKVEER TPYIVVAFQE CGRMNILTRE IQRSLRELEL GLKGELTMTS 610 620 630 640 650 660 HMENLQNALY FDMVPESWAR RAYPSTAGLA AWFPDLLNRI KELEAWTGDF TMPSTVWLTG 670 680 690 700 710 720 FFNPQSFLTA IMQSTARKNE WPLDQMALQC DMTKKNREEF RSPPREGAYI HGLFMEGACW 730 740 750 760 770 780 DTQAGIITEA KLKDLTPPMP VMFIKAIPAD KQDCRSVYSC PVYKTSQRGP TYVWTFNLKT 790 KENPSKWVLA GVALLLQI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A ciliary dynein heavy chain whose expression is upregulated in differentiating airway epithelium." Reed W., Moats-Staats B.M., Carson J.L., Leigh M.W., Collier A.M. Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ARG-445 AND ILE-4374.
[2]	"Axonemal beta heavy chain dynein DNAH9: cDNA sequence, genomic structure, and investigation of its role in primary ciliary dyskinesia." Bartoloni L., Blouin J.-L., Maiti A.K., Sainsbury A., Rossier C., Gehrig C., She J.X., Marron M.P., Lander E.S., Meeks M., Chung E.M.K., Armengot M., Jorissen M., Scott H.S., Delozier-Blanchet C.D., Gardiner R.M., Antonarakis S.E. Genomics 72:21-33(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-445. Tissue: Nasal epithelium.
[3]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[5]	"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1419-4486 (ISOFORM 2). Tissue: Brain.
[6]	Ohara O., Nagase T., Kikuno R., Yamakawa H., Nomura N. Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[7]	"Chromosomal localization of human dynein heavy chain genes." Maiti A.K., Mattei M.-G., Jorissen M., Volz A., Ziegler A., Bouvagnet P. Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1874-1974 (ISOFORM 1). Tissue: Nasal polyp.
[8]	"Characterization of an axonemal dynein heavy chain expressed early in airway epithelial ciliogenesis." Reed W., Carson J.L., Moats-Staats B.M., Lucier T., Hu P.C., Brighton L., Gambling T.M., Huang C.H., Leigh M.W., Collier A.M. Am. J. Respir. Cell Mol. Biol. 23:734-741(2000) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION.
[9]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-771; HIS-2653 AND ASN-3664.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF257737 mRNA. Translation: AAF69004.1. AJ404468 mRNA. Translation: CAB94756.1. AC005209 Genomic DNA. No translation available. AC005410 Genomic DNA. No translation available. AC005701 Genomic DNA. No translation available. BC128421 mRNA. Translation: AAI28422.1. AB002355 mRNA. Translation: BAA21573.2. AJ132088 mRNA. Translation: CAA10561.1.
IPI	IPI00005823. IPI00302453. IPI00795394.
RefSeq	NP_001363.2. NM_001372.3. NP_004653.2. NM_004662.2.
UniGene	Hs.567259.
3D structure databases
ProteinModelPortal	Q9NYC9.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NYC9. 1 interaction.
STRING	9606.ENSP00000262442.
PTM databases
PhosphoSite	Q9NYC9.
Polymorphism databases
DMDM	311033454.
Proteomic databases
PaxDb	Q9NYC9.
PRIDE	Q9NYC9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000262442; ENSP00000262442; ENSG00000007174. ENST00000396001; ENSP00000379323; ENSG00000007174.
GeneID	1770.
KEGG	hsa:1770.
UCSC	uc002gne.3. human.
Organism-specific databases
CTD	1770.
GeneCards	GC17P011501.
H-InvDB	HIX0013543.
HGNC	HGNC:2953. DNAH9.
HPA	HPA020639.
MIM	603330. gene.
neXtProt	NX_Q9NYC9.
PharmGKB	PA27406.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5245.
HOGENOM	HOG000237309.
HOVERGEN	HBG107831.
InParanoid	Q9NYC9.
OMA	NIWKTYV.
OrthoDB	EOG4PC9R8.
PhylomeDB	Q9NYC9.
Gene expression databases
ArrayExpress	Q9NYC9.
Bgee	Q9NYC9.
CleanEx	HS_DNAH9. HS_DNAL1.
Genevestigator	Q9NYC9.
GermOnline	ENSG00000007174. Homo sapiens.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR011704. ATPase_dyneun-rel_AAA. IPR026983. DHC_fam. IPR024743. Dynein_HC_stalk. IPR024317. Dynein_heavy_chain_D4_dom. IPR004273. Dynein_heavy_dom. IPR013594. Dynein_heavy_dom-1. IPR013602. Dynein_heavy_dom-2. [Graphical view]
PANTHER	PTHR10676. PTHR10676. 1 hit.
Pfam	PF07728. AAA_5. 1 hit. PF12780. AAA_8. 1 hit. PF08385. DHC_N1. 1 hit. PF08393. DHC_N2. 1 hit. PF03028. Dynein_heavy. 1 hit. PF12777. MT. 1 hit. [Graphical view]
SMART	SM00382. AAA. 4 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	1770.
NextBio	7205.
SOURCE	Search...

Entry information

Entry name

DYH9_HUMAN

Accession

Primary (citable) accession number: Q9NYC9
Secondary accession number(s): A2VCQ8 , O15064, O95494, Q9NQ28

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	November 2, 2010
Last modified:	April 3, 2013
This is version 106 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.